Abstract:
:Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in this respect than prostaglandin E1. PGX contracted some gastrointestinal smooth muscle and relaxed certain isolated blood vessels. Prostaglandin endoperoxides cause platelet aggregation possibly through the generation by platelets of thromboxane A2. Generation of PGX by vessel walls could be the biochemical mechanism underlying their unique ability to resist platelet adhesion. A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
journal_name
Naturejournal_title
Natureauthors
Moncada S,Gryglewski R,Bunting S,Vane JRdoi
10.1038/263663a0subject
Has Abstractpub_date
1976-10-21 00:00:00pages
663-5issue
5579eissn
0028-0836issn
1476-4687journal_volume
263pub_type
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