Novel clonal strains from adult rat anterior pituitary producing S-100 protein.

abstract：:Dehydration or desiccation is one of the most frequent and severe challenges to living cells. The bacterium Deinococcus radiodurans is the best known extremophile among the few organisms that can survive extremely high exposures to desiccation and ionizing radiation, which shatter its genome into hundreds of short DNA...

journal_title：Nature

authors： Zahradka K,Slade D,Bailone A,Sommer S,Averbeck D,Petranovic M,Lindner AB,Radman M

更新日期：2006-10-05 00:00:00

abstract：:Betelgeuse, a nearby red supergiant, is a fast-moving star with a powerful stellar wind that drives a bow shock into its surroundings. This picture has been challenged by the discovery of a dense and almost static shell that is three times closer to the star than the bow shock and has been decelerated by some external...

journal_title：Nature

authors： Mackey J,Mohamed S,Gvaramadze VV,Kotak R,Langer N,Meyer DM,Moriya TJ,Neilson HR

更新日期：2014-08-21 00:00:00

abstract：:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5...

journal_title：Nature

authors： Walsh JJ,Christoffel DJ,Heifets BD,Ben-Dor GA,Selimbeyoglu A,Hung LW,Deisseroth K,Malenka RC

更新日期：2018-08-01 00:00:00

abstract：:Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...

journal_title：Nature

authors： Allen AE,Dupont CL,Oborník M,Horák A,Nunes-Nesi A,McCrow JP,Zheng H,Johnson DA,Hu H,Fernie AR,Bowler C

更新日期：2011-05-12 00:00:00

abstract：:Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...

journal_title：Nature

authors： Raaijmakers MH,Mukherjee S,Guo S,Zhang S,Kobayashi T,Schoonmaker JA,Ebert BL,Al-Shahrour F,Hasserjian RP,Scadden EO,Aung Z,Matza M,Merkenschlager M,Lin C,Rommens JM,Scadden DT

更新日期：2010-04-08 00:00:00

abstract：:Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...

journal_title：Nature

authors： Murphy E,Löfdahl S

更新日期：1984-01-19 00:00:00

abstract：:Angiotensin II is an important effector molecule controlling blood pressure and volume in the cardiovascular system. Its importance is manifested by the efficacy of angiotensin-converting enzyme inhibitors in the treatment of hypertension and congestive heart failure. Angiotensin II interacts with two pharmacologicall...

journal_title：Nature

authors： Murphy TJ,Alexander RW,Griendling KK,Runge MS,Bernstein KE

更新日期：1991-05-16 00:00:00

abstract：:Drosophila mutants transformed with a chimaeric gene that expresses the ocellar visual pigment in the major class of photoreceptor cells of the retina were used to investigate the properties of this minor pigment. The photoreceptor cells in which this opsin was misexpressed showed new spectral characteristics and phys...

journal_title：Nature

authors： Feiler R,Harris WA,Kirschfeld K,Wehrhahn C,Zuker CS

更新日期：1988-06-23 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:The observation of the superfluid to Mott insulator phase transition of ultracold atoms in optical lattices was an enabling discovery in experimental many-body physics, providing the first tangible example of a quantum phase transition (one that occurs even at zero temperature) in an ultracold atomic gas. For a trappe...

journal_title：Nature

authors： Gemelke N,Zhang X,Hung CL,Chin C

更新日期：2009-08-20 00:00:00

abstract：:Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

journal_title：Nature

authors： Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

更新日期：2000-08-17 00:00:00

abstract：:T-lymphocyte co-recognition of antigen and major histocompatibility complex (MHC)-encoded molecules (such as murine Ia molecules) is thought to be mediated by a single cell-surface receptor, although the molecular mechanism by which this occurs is controversial (reviewed in ref. 1). One possibility is that the antigen...

journal_title：Nature

authors： Ashwell JD,Schwartz RH

更新日期：1986-03-13 00:00:00

abstract：:The Notch genes encode single-pass transmembrane receptors that transduce the extracellular signals responsible for cell fate determination during several steps of metazoan development. The mechanism by which extracellular signals affect gene transcription and ultimately cell fate decisions is beginning to emerge for ...

journal_title：Nature

authors： Huppert SS,Le A,Schroeter EH,Mumm JS,Saxena MT,Milner LA,Kopan R

更新日期：2000-06-22 00:00:00

abstract：:Observations show that the seismic normal modes of the Earth at frequencies near 10 mHz are excited at a nearly constant level in the absence of large earthquakes. This background level of excitation has been called the 'hum' of the Earth, and is equivalent to the maximum excitation from a magnitude 5.75 earthquake. I...

journal_title：Nature

authors： Webb SC

更新日期：2007-02-15 00:00:00

abstract：:Neurons in the visual cortex typically respond selectively to the orientation, and velocity and direction of movement, of moving-bar stimuli. These responses are generally thought to provide information about the orientation and position of lines and edges in the visual field. Some cells are also endstopped, that is s...

journal_title：Nature

authors： Dobbins A,Zucker SW,Cynader MS

更新日期：1987-10-01 00:00:00

abstract：:The benzodiazepines are a class of drugs used to alleviate anxiety. As such they constitute one of the most commonly prescribed compounds, due in part to their efficacy and safety. The physiological effect of these drugs is probably through interactions with a low affinity benzodiazepine binding site and two (types 1 ...

journal_title：Nature

authors： Barr GA,Lithgow T

更新日期：1983-03-31 00:00:00

abstract：:Hepatocellularcarcinoma (HCC) that occur in woodchucks chronically infected with woodchuck hepatitis virus (WHV) were screened for activation of cellular oncogenes. Enhanced expression and allelic alterations of the c-myc oncogene were found in three HCC out of nine. Variations in the size of the c-myc transcripts, ra...

journal_title：Nature

authors： Möröy T,Marchio A,Etiemble J,Trépo C,Tiollais P,Buendia MA

更新日期：1986-11-20 00:00:00

abstract：:A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate th...

journal_title：Nature

authors： Yamamoto KK,Gonzalez GA,Biggs WH 3rd,Montminy MR

更新日期：1988-08-11 00:00:00

abstract：:Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here ...

journal_title：Nature

authors： Mosialou I,Shikhel S,Liu JM,Maurizi A,Luo N,He Z,Huang Y,Zong H,Friedman RA,Barasch J,Lanzano P,Deng L,Leibel RL,Rubin M,Nickolas T,Chung W,Zeltser LM,Williams KW,Pessin JE,Kousteni S

更新日期：2017-03-16 00:00:00

abstract：:Ionic currents from individual K+ channels in squid axon membrane have been recorded. At hyperpolarizing membrane voltages, unit events occur as widely spaced rectangular pulses with short interruptions. The frequency of occurrence of the units increases strongly when the membrane is depolarized. ...

journal_title：Nature

authors： Conti F,Neher E

更新日期：1980-05-15 00:00:00

abstract：:Evolutionary relationships among the eight major lineages of Mollusca have remained unresolved despite their diversity and importance. Previous investigations of molluscan phylogeny, based primarily on nuclear ribosomal gene sequences or morphological data, have been unsuccessful at elucidating these relationships. Re...

journal_title：Nature

authors： Kocot KM,Cannon JT,Todt C,Citarella MR,Kohn AB,Meyer A,Santos SR,Schander C,Moroz LL,Lieb B,Halanych KM

更新日期：2011-09-04 00:00:00

abstract：:Systems governed by time reversible equations of motion often give rise to irreversible behaviour. The transition from reversible to irreversible behaviour is fundamental to statistical physics, but has not been observed experimentally in many-body systems. The flow of a newtonian fluid at low Reynolds number can be r...

journal_title：Nature

authors： Pine DJ,Gollub JP,Brady JF,Leshansky AM

更新日期：2005-12-15 00:00:00

abstract：:Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion anal...

journal_title：Nature

authors： Matsuda M,Nagahama Y,Shinomiya A,Sato T,Matsuda C,Kobayashi T,Morrey CE,Shibata N,Asakawa S,Shimizu N,Hori H,Hamaguchi S,Sakaizumi M

更新日期：2002-05-30 00:00:00

abstract：:Cutaneous melanoma is a type of cancer with an inherent potential for lymph node colonization, which is generally preceded by neolymphangiogenesis. However, sentinel lymph node removal does not necessarily extend the overall survival of patients with melanoma. Moreover, lymphatic vessels collapse and become dysfunctio...

journal_title：Nature

authors： Olmeda D,Cerezo-Wallis D,Riveiro-Falkenbach E,Pennacchi PC,Contreras-Alcalde M,Ibarz N,Cifdaloz M,Catena X,Calvo TG,Cañón E,Alonso-Curbelo D,Suarez J,Osterloh L,Graña O,Mulero F,Megías D,Cañamero M,Martínez-Torrecuadrad

更新日期：2017-06-28 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are zinc endopeptidases that are required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling. Their proteolytic activities are precisely regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). D...

journal_title：Nature

authors： Gomis-Rüth FX,Maskos K,Betz M,Bergner A,Huber R,Suzuki K,Yoshida N,Nagase H,Brew K,Bourenkov GP,Bartunik H,Bode W

更新日期：1997-09-04 00:00:00

abstract：:Natural composite materials are renowned for their mechanical strength and toughness: despite being highly mineralized, with the organic component constituting not more than a few per cent of the composite material, the fracture toughness exceeds that of single crystals of the pure mineral by two to three orders of ma...

journal_title：Nature

authors： Kamat S,Su X,Ballarini R,Heuer AH

更新日期：2000-06-29 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...

journal_title：Nature

authors： Pijnappel WW,Esch D,Baltissen MP,Wu G,Mischerikow N,Bergsma AJ,van der Wal E,Han DW,Bruch Hv,Moritz S,Lijnzaad P,Altelaar AF,Sameith K,Zaehres H,Heck AJ,Holstege FC,Schöler HR,Timmers HT

更新日期：2013-03-28 00:00:00

abstract：:Chondrules and Ca-Al-rich inclusions (CAIs) are high-temperature components of meteorites that formed during transient heating events in the early Solar System. A major unresolved issue is the relative timing of CAI and chondrule formation. From the presence of chondrule fragments in an igneous CAI, it was concluded t...

journal_title：Nature

authors： Krot AN,Yurimoto H,Hutcheon ID,MacPherson GJ

更新日期：2005-04-21 00:00:00

abstract：:The TGF-beta/activin/BMP superfamily of growth factors signals through heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. The signal originated by TGF-beta-like molecules appears to be transduced by a set of evolutionarily conserved proteins known as SMADs, which upon activation di...

journal_title：Nature

authors： Lagna G,Hata A,Hemmati-Brivanlou A,Massagué J

更新日期：1996-10-31 00:00:00

abstract：:Several organisms have evolved the ability to measure daylength, or photoperiod, allowing them to adjust their development in anticipation of annual seasonal changes. Daylength measurement requires the integration of temporal information, provided by the circadian system, with light/dark discrimination, initiated by s...

journal_title：Nature

authors： Yanovsky MJ,Kay SA

更新日期：2002-09-19 00:00:00