当前位置： SCI文献检索 > NATURE期刊下所有文献 > DMY is a Y-specific DM-domain gene required for male development in the medaka fish.

DMY is a Y-specific DM-domain gene required for male development in the medaka fish.

Abstract：

:Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion analysis of the Y chromosome of a congenic XY female further shortened the region to 250 kb. Shotgun sequencing of this region predicted 27 genes. Three of these genes were expressed during sexual differentiation. However, only the DM-related PG17 was Y specific; we thus named it DMY. Two naturally occurring mutations establish DMY's critical role in male development. The first heritable mutant--a single insertion in exon 3 and the subsequent truncation of DMY--resulted in all XY female offspring. Similarly, the second XY mutant female showed reduced DMY expression with a high proportion of XY female offspring. During normal development, DMY is expressed only in somatic cells of XY gonads. These findings strongly suggest that the sex-specific DMY is required for testicular development and is a prime candidate for the medaka sex-determining gene.

journal_name

Nature

journal_title

Nature

authors

Matsuda M,Nagahama Y,Shinomiya A,Sato T,Matsuda C,Kobayashi T,Morrey CE,Shibata N,Asakawa S,Shimizu N,Hori H,Hamaguchi S,Sakaizumi M

doi

10.1038/nature751

keywords:

subject

Has Abstract

pub_date

2002-05-30 00:00:00

pages

559-63

issue

6888

eissn

0028-0836

issn

1476-4687

pii

nature751

journal_volume

417

pub_type

杂志文章

相关文献

NATURE文献大全
  • DNA cloning in Streptomyces: resistance genes from antibiotic-producing species.

    abstract：:The biochemical and morphological differentiation of actinomycetes makes them academically and economically interesting. Their secondary metabolites provide the majority of medically and agriculturally important antibiotics (streptomycete genes may also be the primary source of clinically important antibiotic resistan...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/286525a0

    authors： Thompson CJ,Ward JM,Hopwood DA

    更新日期：1980-07-31 00:00:00

  • A role for Wnt signalling in self-renewal of haematopoietic stem cells.

    abstract：:Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated beta-catenin expands t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature01593

    authors： Reya T,Duncan AW,Ailles L,Domen J,Scherer DC,Willert K,Hintz L,Nusse R,Weissman IL

    更新日期：2003-05-22 00:00:00

  • Relatives of rubella virus in diverse mammals.

    abstract：:Since 1814, when rubella was first described, the origins of the disease and its causative agent, rubella virus (Matonaviridae: Rubivirus), have remained unclear1. Here we describe ruhugu virus and rustrela virus in Africa and Europe, respectively, which are, to our knowledge, the first known relatives of rubella viru...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2812-9

    authors： Bennett AJ,Paskey AC,Ebinger A,Pfaff F,Priemer G,Höper D,Breithaupt A,Heuser E,Ulrich RG,Kuhn JH,Bishop-Lilly KA,Beer M,Goldberg TL

    更新日期：2020-10-01 00:00:00

  • Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres.

    abstract：:The most basic objection to human embryonic stem (ES) cell research is rooted in the fact that ES cell derivation deprives embryos of any further potential to develop into a complete human being. ES cell lines are conventionally isolated from the inner cell mass of blastocysts and, in a few instances, from cleavage st...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature04277

    authors： Chung Y,Klimanskaya I,Becker S,Marh J,Lu SJ,Johnson J,Meisner L,Lanza R

    更新日期：2006-01-12 00:00:00

  • Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses.

    abstract：:The characterization of HIV-1 (HTLV-III/LAV), the human retrovirus associated with AIDS (acquired immune deficiency syndrome) has led to the identification of a group of related human and simian retroviruses which also infect CD4-bearing T lymphocytes. Simian T-lymphotropic virus type III (simian immodeficiency virus)...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/328539a0

    authors： Franchini G,Gurgo C,Guo HG,Gallo RC,Collalti E,Fargnoli KA,Hall LF,Wong-Staal F,Reitz MS Jr

    更新日期：1987-08-06 00:00:00

  • Distinct modes of cell competition shape mammalian tissue morphogenesis.

    abstract：:Cell competition-the sensing and elimination of less fit 'loser' cells by neighbouring 'winner' cells-was first described in Drosophila. Although cell competition has been proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by using live imagin...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-1199-y

    authors： Ellis SJ,Gomez NC,Levorse J,Mertz AF,Ge Y,Fuchs E

    更新日期：2019-05-01 00:00:00

  • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.

    abstract：:Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokin...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature08636

    authors： Moro K,Yamada T,Tanabe M,Takeuchi T,Ikawa T,Kawamoto H,Furusawa J,Ohtani M,Fujii H,Koyasu S

    更新日期：2010-01-28 00:00:00

  • Quantum information and computation

    abstract：:In information processing, as in physics, our classical world view provides an incomplete approximation to an underlying quantum reality. Quantum effects like interference and entanglement play no direct role in conventional information processing, but they can--in principle now, but probably eventually in practice--b...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35005001

    authors： Bennett CH,DiVincenzo DP

    更新日期：2000-03-16 00:00:00

  • Intracellular calcium dependence of transmitter release rates at a fast central synapse.

    abstract：:Calcium-triggered fusion of synaptic vesicles and neurotransmitter release are fundamental signalling steps in the central nervous system. It is generally assumed that fast transmitter release is triggered by elevations in intracellular calcium concentration ([Ca2+]i) to at least 100 microM near the sites of vesicle f...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35022702

    authors： Schneggenburger R,Neher E

    更新日期：2000-08-24 00:00:00

  • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

    abstract：:Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major genetic risk factor for Alzheimer's disease and is associated with Down's syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage. Neurovascular dysfunction is present in normal APOE4 carriers and i...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11087

    authors： Bell RD,Winkler EA,Singh I,Sagare AP,Deane R,Wu Z,Holtzman DM,Betsholtz C,Armulik A,Sallstrom J,Berk BC,Zlokovic BV

    更新日期：2012-05-16 00:00:00

  • Study of allosteric communication between protomers by immunotagging.

    abstract：:Ligand-induced allosteric changes in proteins are important in their cellular functions and regulation, and both concerted and sequential examples are known. The distinction has entailed elaborate analysis, however, and only a few systems have been unequivocally analysed. We have investigated the coupling between ATP ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/361749a0

    authors： Lindsley JE,Wang JC

    更新日期：1993-02-25 00:00:00

  • A distance to the Large Magellanic Cloud that is precise to one per cent.

    abstract：:In the era of precision cosmology, it is essential to determine the Hubble constant empirically with an accuracy of one per cent or better1. At present, the uncertainty on this constant is dominated by the uncertainty in the calibration of the Cepheid period-luminosity relationship2,3 (also known as the Leavitt law). ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-0999-4

    authors： Pietrzyński G,Graczyk D,Gallenne A,Gieren W,Thompson IB,Pilecki B,Karczmarek P,Górski M,Suchomska K,Taormina M,Zgirski B,Wielgórski P,Kołaczkowski Z,Konorski P,Villanova S,Nardetto N,Kervella P,Bresolin F,Kudritzki RP

    更新日期：2019-03-01 00:00:00

  • The spring in the arch of the human foot.

    abstract：:Large mammals, including humans, save much of the energy needed for running by means of elastic structures in their legs and feet. Kinetic and potential energy removed from the body in the first half of the stance phase is stored briefly as elastic strain energy and then returned in the second half by elastic recoil. ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/325147a0

    authors： Ker RF,Bennett MB,Bibby SR,Kester RC,Alexander RM

    更新日期：1987-01-08 00:00:00

  • Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors.

    abstract：:The classical view of fast chemical synaptic transmission is that released neurotransmitter acts locally on postsynaptic receptors and is cleared from the synaptic cleft within a few milliseconds by diffusion and by specific reuptake mechanisms. This rapid clearance restricts the spread of neurotransmitter and, combin...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/385630a0

    authors： Scanziani M,Salin PA,Vogt KE,Malenka RC,Nicoll RA

    更新日期：1997-02-13 00:00:00

  • Infrared emission spectra of candidate interstellar aromatic molecules.

    abstract：:Interstellar dust is responsible, through surface reactions, for the creation of molecular hydrogen, the main component of the interstellar clouds in which new stars form. Intermediate between small, gas-phase molecules and dust are the polycyclic aromatic hydrocarbons (PAHs). Such molecules could account for 2-30% of...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/380227a0

    authors： Cook DJ,Schlemmer S,Balucani N,Wagner DR,Steiner B,Saykally RJ

    更新日期：1996-03-21 00:00:00

  • Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form.

    abstract：:Troponin is essential in Ca(2+) regulation of skeletal and cardiac muscle contraction. It consists of three subunits (TnT, TnC and TnI) and, together with tropomyosin, is located on the actin filament. Here we present crystal structures of the core domains (relative molecular mass of 46,000 and 52,000) of human cardia...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature01780

    authors： Takeda S,Yamashita A,Maeda K,Maéda Y

    更新日期：2003-07-03 00:00:00

  • Effects of mechanical forces on maintenance and adaptation of form in trabecular bone.

    abstract：:The architecture of trabecular bone, the porous bone found in the spine and at articulating joints, provides the requirements for optimal load transfer, by pairing suitable strength and stiffness to minimal weight according to rules of mathematical design. But, as it is unlikely that the architecture is fully pre-prog...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35015116

    authors： Huiskes R,Ruimerman R,van Lenthe GH,Janssen JD

    更新日期：2000-06-08 00:00:00

  • Elevated CO2 increases productivity and invasive species success in an arid ecosystem.

    abstract：:Arid ecosystems, which occupy about 20% of the earth's terrestrial surface area, have been predicted to be one of the most responsive ecosystem types to elevated atmospheric CO2 and associated global climate change. Here we show, using free-air CO2 enrichment (FACE) technology in an intact Mojave Desert ecosystem, tha...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35040544

    authors： Smith SD,Huxman TE,Zitzer SF,Charlet TN,Housman DC,Coleman JS,Fenstermaker LK,Seemann JR,Nowak RS

    更新日期：2000-11-02 00:00:00

  • TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.

    abstract：:Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...

    journal_title：Nature

    pub_type： 信件

    doi：10.1038/nature05732

    authors： Gack MU,Shin YC,Joo CH,Urano T,Liang C,Sun L,Takeuchi O,Akira S,Chen Z,Inoue S,Jung JU

    更新日期：2007-04-19 00:00:00

  • HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.

    abstract：:Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands. In hum...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11316

    authors： Deardorff MA,Bando M,Nakato R,Watrin E,Itoh T,Minamino M,Saitoh K,Komata M,Katou Y,Clark D,Cole KE,De Baere E,Decroos C,Di Donato N,Ernst S,Francey LJ,Gyftodimou Y,Hirashima K,Hullings M,Ishikawa Y,Jaulin C,Kaur

    更新日期：2012-09-13 00:00:00

  • Mitochondrial complex III is essential for suppressive function of regulatory T cells.

    abstract：:Regulatory T cells (Treg cells), a distinct subset of CD4+ T cells, are necessary for the maintenance of immune self-tolerance and homeostasis1,2. Recent studies have demonstrated that Treg cells exhibit a unique metabolic profile, characterized by an increase in mitochondrial metabolism relative to other CD4+ effecto...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0846-z

    authors： Weinberg SE,Singer BD,Steinert EM,Martinez CA,Mehta MM,Martínez-Reyes I,Gao P,Helmin KA,Abdala-Valencia H,Sena LA,Schumacker PT,Turka LA,Chandel NS

    更新日期：2019-01-01 00:00:00

  • Energy dependence and reversibility of membrane alterations induced by polyene macrolide antibiotics in Chlorella vulgaris.

    abstract：:The requirement of metabolic energy for the interaction of polyene macrolide antibiotics with eukaryotic organisms remains a controversial subject (for review see ref. 1) It has been claimed that the lethal binding of these antibiotics to the sterol target component of the hydrophobic core of the membrane, in accordan...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/281080a0

    authors： Malewicz B,Borowski E

    更新日期：1979-09-06 00:00:00

  • Enhanced strength and ductility in a high-entropy alloy via ordered oxygen complexes.

    abstract：:Oxygen, one of the most abundant elements on Earth, often forms an undesired interstitial impurity or ceramic phase (such as an oxide particle) in metallic materials. Even when it adds strength, oxygen doping renders metals brittle1-3. Here we show that oxygen can take the form of ordered oxygen complexes, a state in ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-018-0685-y

    authors： Lei Z,Liu X,Wu Y,Wang H,Jiang S,Wang S,Hui X,Wu Y,Gault B,Kontis P,Raabe D,Gu L,Zhang Q,Chen H,Wang H,Liu J,An K,Zeng Q,Nieh TG,Lu Z

    更新日期：2018-11-01 00:00:00

  • Histone H2A.Z subunit exchange controls consolidation of recent and remote memory.

    abstract：:Memory formation is a multi-stage process that initially requires cellular consolidation in the hippocampus, after which memories are downloaded to the cortex for maintenance, in a process termed systems consolidation. Epigenetic mechanisms regulate both types of consolidation, but histone variant exchange, in which c...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13707

    authors： Zovkic IB,Paulukaitis BS,Day JJ,Etikala DM,Sweatt JD

    更新日期：2014-11-27 00:00:00

  • The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

    abstract：:Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-toxic lipid alcohols3,4. Ferroptosis has previously been implica...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-1705-2

    authors： Bersuker K,Hendricks JM,Li Z,Magtanong L,Ford B,Tang PH,Roberts MA,Tong B,Maimone TJ,Zoncu R,Bassik MC,Nomura DK,Dixon SJ,Olzmann JA

    更新日期：2019-11-01 00:00:00

  • Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.

    abstract：:Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues1-4. H2O2 enters cells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate signalling and ce...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2032-3

    authors： Wu F,Chi Y,Jiang Z,Xu Y,Xie L,Huang F,Wan D,Ni J,Yuan F,Wu X,Zhang Y,Wang L,Ye R,Byeon B,Wang W,Zhang S,Sima M,Chen S,Zhu M,Pei J,Johnson DM,Zhu S,Cao X,Pei C,Zai Z,Liu Y,Liu T,Swift GB,Zhang W,Y

    更新日期：2020-02-01 00:00:00

  • A test of reciprocal X-Y interactions as a cause of hybrid sterility in Drosophila.

    abstract：:Elucidation of the nature of the gene interactions that underly the sterility of interspecific hybrids is important in evolutionary biology. The interactions between the heterospecific X and Y (or Z and W) chromosomes are often used as an explanation for two reasons. First, the fertility of the hybrids of the heteroga...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/358751a0

    authors： Johnson NA,Perez DE,Cabot EL,Hollocher H,Wu CI

    更新日期：1992-08-27 00:00:00

  • ovo/svb integrates Wingless and DER pathways to control epidermis differentiation.

    abstract：:In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/22330

    authors： Payre F,Vincent A,Carreno S

    更新日期：1999-07-15 00:00:00

  • HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.

    abstract：:Major histocompatibility complex (MHC) class II molecules are highly polymorphic cell-surface glycoproteins that present antigenic peptides to CD4+ T lymphocytes. The normal assembly of class II molecules with cognate peptides for antigen presentation requires an accessory function provided by a gene mapping to the cl...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/368554a0

    authors： Fling SP,Arp B,Pious D

    更新日期：1994-04-07 00:00:00

  • Mars rover, French research integrity and NIPS renamed.

    abstract：: ...

    journal_title：Nature

    pub_type： 新闻

    doi：10.1038/d41586-018-07480-0

    authors：

    更新日期：2018-11-01 00:00:00