Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.


:Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and multicellular organisms, and is produced extracellularly in response to external stresses and internal cues1-4. H2O2 enters cells through aquaporin membrane proteins and covalently modifies cytoplasmic proteins to regulate signalling and cellular processes. However, whether sensors for H2O2 also exist on the cell surface remains unknown. In plant cells, H2O2 triggers an influx of Ca2+ ions, which is thought to be involved in H2O2 sensing and signalling. Here, by using forward genetic screens based on Ca2+ imaging, we isolated hydrogen-peroxide-induced Ca2+ increases (hpca) mutants in Arabidopsis, and identified HPCA1 as a leucine-rich-repeat receptor kinase belonging to a previously uncharacterized subfamily that features two extra pairs of cysteine residues in the extracellular domain. HPCA1 is localized to the plasma membrane and is activated by H2O2 via covalent modification of extracellular cysteine residues, which leads to autophosphorylation of HPCA1. HPCA1 mediates H2O2-induced activation of Ca2+ channels in guard cells and is required for stomatal closure. Our findings help to identify how the perception of extracellular H2O2 is integrated with responses to various external stresses and internal cues in plants, and have implications for the design of crops with enhanced fitness.






Wu F,Chi Y,Jiang Z,Xu Y,Xie L,Huang F,Wan D,Ni J,Yuan F,Wu X,Zhang Y,Wang L,Ye R,Byeon B,Wang W,Zhang S,Sima M,Chen S,Zhu M,Pei J,Johnson DM,Zhu S,Cao X,Pei C,Zai Z,Liu Y,Liu T,Swift GB,Zhang W,Y




Has Abstract


2020-02-01 00:00:00
















  • Australopithecus ramidus, a new species of early hominid from Aramis, Ethiopia.

    abstract::Seventeen hominoid fossils recovered from Pliocene strata at Aramis, Middle Awash, Ethiopia make up a series comprising dental, cranial and postcranial specimens dated to around 4.4 million years ago. When compared with Australopithecus afarensis and with modern and fossil apes the Aramis fossil hominids are recognize...


    pub_type: 杂志文章


    authors: White TD,Suwa G,Asfaw B

    更新日期:1994-09-22 00:00:00

  • Restoration by a 35K membrane protein of peroxisome assembly in a peroxisome-deficient mammalian cell mutant.

    abstract::Peroxisomes are among the intracellular organelles of eukaryotic cells that contain specialized sets of enzymes with specific functions. Little is known of membranous components involved in assembly of the intracellular compartments. We isolated two peroxisome-deficient and mutually complementary, Chinese hamster ovar...


    pub_type: 杂志文章


    authors: Tsukamoto T,Miura S,Fujiki Y

    更新日期:1991-03-07 00:00:00

  • Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle.

    abstract::To understand the molecular basis of microtubule-associated motility during mitosis, the mechanochemical factors that generate the relevant motile force must be identified. Myosin, the ATPase that interacts with actin to produce the force for muscle contraction and other forms of cell motility, is believed to be invol...


    pub_type: 杂志文章


    authors: Scholey JM,Porter ME,Grissom PM,McIntosh JR

    更新日期:1985-12-05 00:00:00

  • The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase.

    abstract::The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...


    pub_type: 杂志文章


    authors: Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

    更新日期:1991-02-21 00:00:00

  • Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.

    abstract::Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...


    pub_type: 杂志文章


    authors: Kimple RJ,Kimple ME,Betts L,Sondek J,Siderovski DP

    更新日期:2002-04-25 00:00:00

  • Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.

    abstract::The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor po...


    pub_type: 杂志文章


    authors: Derynck R,Jarrett JA,Chen EY,Eaton DH,Bell JR,Assoian RK,Roberts AB,Sporn MB,Goeddel DV

    更新日期:1985-08-22 00:00:00

  • Self-organizing neural network that discovers surfaces in random-dot stereograms.

    abstract::The standard form of back-propagation learning is implausible as a model of perceptual learning because it requires an external teacher to specify the desired output of the network. We show how the external teacher can be replaced by internally derived teaching signals. These signals are generated by using the assumpt...


    pub_type: 杂志文章


    authors: Becker S,Hinton GE

    更新日期:1992-01-09 00:00:00

  • Template-free RNA synthesis by Q beta replicase.

    abstract::In the absence of extraneously added template, standard preparations of Q beta replicase spontaneously synthesize RNA in vitro, possibly as a result of RNA contamination. Using special enzyme purifications, Sumper and Luce presented evidence that self-replicating RNA not present ab initio can grow out of 'template-fre...


    pub_type: 杂志文章


    authors: Biebricher CK,Eigen M,Luce R

    更新日期:1986-05-01 00:00:00

  • Independent rate and temporal coding in hippocampal pyramidal cells.

    abstract::In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour. The temporal code takes the form of a phase relationship to the concurrent cycle of the hippocampal electroencephalogram theta rhythm. These two codes could each represent a...


    pub_type: 杂志文章


    authors: Huxter J,Burgess N,O'Keefe J

    更新日期:2003-10-23 00:00:00

  • Heinrich events triggered by ocean forcing and modulated by isostatic adjustment.

    abstract::During the last glacial period, the Laurentide Ice Sheet sporadically discharged huge numbers of icebergs through the Hudson Strait into the North Atlantic Ocean, leaving behind distinct layers of ice-rafted debris in the ocean sediments. Perplexingly, these massive discharge events-Heinrich events-occurred during the...


    pub_type: 杂志文章


    authors: Bassis JN,Petersen SV,Mac Cathles L

    更新日期:2017-02-15 00:00:00

  • Patterns of colonization in a metapopulation of grey seals.

    abstract::The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...


    pub_type: 杂志文章


    authors: Gaggiotti OE,Jones F,Lee WM,Amos W,Harwood J,Nichols RA

    更新日期:2002-03-28 00:00:00

  • 4S oop RNA is a leader sequence for the immunity-establishment transcription in coliphage lambda.

    abstract::oop RNA, which is initiated at the po promoter and is 81 nucleotides long, can function as a leader sequence for the lambda immunity establishment transcription, previously believed to originate at a special promoter pre located in the y region. Thus, oop RNA seems to have a dual role, either favouring the lytic cycle...


    pub_type: 杂志文章


    authors: Honigman A,Hu SL,Chase R,Szybalski W

    更新日期:1976-07-08 00:00:00

  • Cryo-EM structures of apo and antagonist-bound human Cav3.1.

    abstract::Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....


    pub_type: 杂志文章


    authors: Zhao Y,Huang G,Wu Q,Wu K,Li R,Lei J,Pan X,Yan N

    更新日期:2019-12-01 00:00:00

  • Cell-type-specific asynchronous modulation of PKA by dopamine in learning.

    abstract::Reinforcement learning models postulate that neurons that release dopamine encode information about action and action outcome, and provide a teaching signal to striatal spiny projection neurons in the form of dopamine release1. Dopamine is thought to guide learning via dynamic and differential modulation of protein ki...


    pub_type: 杂志文章


    authors: Lee SJ,Lodder B,Chen Y,Patriarchi T,Tian L,Sabatini BL

    更新日期:2020-12-23 00:00:00

  • Monoclonal antibody production by receptor-mediated electrically induced cell fusion.

    abstract::Fusion of myeloma cells and B lymphocytes to form hybridomas which produce monoclonal antibodies has been a major advance, but the poor efficiency and randomness of viral or polyethylene glycol fusion techniques generally gives poor yields of specific, high affinity antibodies. High voltage electrical fields with diel...


    pub_type: 杂志文章


    authors: Lo MM,Tsong TY,Conrad MK,Strittmatter SM,Hester LD,Snyder SH

    更新日期:1984-08-30 00:00:00

  • Similar level of polyteny in bands and interbands of Drosophila giant chromosomes.

    abstract::The giant polytene chromosomes of Drosophila melanogaster have long been of interest to the geneticist because of the visible map of the genome provided by their characteristic banding patterns. An issue in the understanding of the molecular basis of chromosome banding has been whether the chromosomal DNA is replicate...


    pub_type: 杂志文章


    authors: Spierer A,Spierer P

    更新日期:1984-01-12 00:00:00

  • Genetic information and life insurance.

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    pub_type: 杂志文章


    authors: Pokorski RJ

    更新日期:1995-07-06 00:00:00

  • Na channels in skeletal muscle concentrated near the neuromuscular junction.

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    pub_type: 杂志文章


    authors: Beam KG,Caldwell JH,Campbell DT

    更新日期:1985-02-14 00:00:00

  • Antibody-based protection against HIV infection by vectored immunoprophylaxis.

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    pub_type: 杂志文章


    authors: Balazs AB,Chen J,Hong CM,Rao DS,Yang L,Baltimore D

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    pub_type: 杂志文章


    authors: Wilhelms A,Larter SR,Head I,Farrimond P,di-Primio R,Zwach C

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  • The Wnt/beta-catenin pathway regulates cardiac valve formation.

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    pub_type: 杂志文章


    authors: Hurlstone AF,Haramis AP,Wienholds E,Begthel H,Korving J,Van Eeden F,Cuppen E,Zivkovic D,Plasterk RH,Clevers H

    更新日期:2003-10-09 00:00:00

  • Policies designed for drugs won't work for AI.

    abstract:: ...


    pub_type: 杂志文章


    authors: Smallman M

    更新日期:2019-03-01 00:00:00

  • Coherent spin manipulation without magnetic fields in strained semiconductors.

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    pub_type: 杂志文章


    authors: Kato Y,Myers RC,Gossard AC,Awschalom DD

    更新日期:2004-01-01 00:00:00

  • Solar eclipses of Phobos and Deimos observed from the surface of Mars.

    abstract::The small martian satellites Phobos and Deimos orbit in synchronous rotation with inclinations of only 0.01 degrees and 0.92 degrees , respectively, relative to the planet's equatorial plane. Thus, an observer at near-equatorial latitudes on Mars could occasionally observe solar eclipses by these satellites (see ref. ...


    pub_type: 杂志文章


    authors: Bell JF 3rd,Lemmon MT,Duxbury TC,Hubbard MY,Wolff MJ,Squyres SW,Craig L,Ludwinski JM

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  • Antibody-mediated enhancement of Flavivirus replication in macrophage-like cell lines.

    abstract::Interactions between animal viruses and antiviral antisera may exceptionally result in an apparent increase in viral infectivity. Halstead and coworkers demonstrated enhanced replication of dengue virus (a Flavivirus, family Togaviridae) in human or simian peripheral blood leucocytes carrying Fc receptors at subneutra...


    pub_type: 杂志文章


    authors: Peiris JS,Porterfield JS

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  • A spin transition mechanism for cooperative adsorption in metal-organic frameworks.

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    pub_type: 杂志文章


    authors: Reed DA,Keitz BK,Oktawiec J,Mason JA,Runčevski T,Xiao DJ,Darago LE,Crocellà V,Bordiga S,Long JR

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  • 5-HT release in nucleus accumbens rescues social deficits in mouse autism model.

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    pub_type: 杂志文章


    authors: Walsh JJ,Christoffel DJ,Heifets BD,Ben-Dor GA,Selimbeyoglu A,Hung LW,Deisseroth K,Malenka RC

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  • Global threats to human water security and river biodiversity.

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    pub_type: 杂志文章


    authors: Vörösmarty CJ,McIntyre PB,Gessner MO,Dudgeon D,Prusevich A,Green P,Glidden S,Bunn SE,Sullivan CA,Liermann CR,Davies PM

    更新日期:2010-09-30 00:00:00

  • Practical quantum key distribution protocol without monitoring signal disturbance.

    abstract::Quantum cryptography exploits the fundamental laws of quantum mechanics to provide a secure way to exchange private information. Such an exchange requires a common random bit sequence, called a key, to be shared secretly between the sender and the receiver. The basic idea behind quantum key distribution (QKD) has wide...


    pub_type: 杂志文章


    authors: Sasaki T,Yamamoto Y,Koashi M

    更新日期:2014-05-22 00:00:00

  • HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus.

    abstract::Over half of the inherited predisposition to insulin-dependent diabetes mellitus maps to the region of chromosome 6 that contains the highly polymorphic HLA class II genes which determine immune responsiveness. Analysis of DNA sequences from diabetics indicates that alleles of HLA-DQ beta determine both disease suscep...


    pub_type: 杂志文章


    authors: Todd JA,Bell JI,McDevitt HO

    更新日期:1987-10-15 00:00:00