Axonal transport of vasoactive intestinal peptide in sciatic nerve.

abstract：:Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo. Its low error rate may be achieved by means of a 'proofreading' mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several base pairs, which ca...

journal_title：Nature

authors： Shaevitz JW,Abbondanzieri EA,Landick R,Block SM

更新日期：2003-12-11 00:00:00

abstract：:Major histocompatibility complex class II molecules and their peptide ligands show unusual interaction kinetics, with slow association and dissociation rates that yield an apparent equilibrium constant of approximately 10(-6)-10(-8) M (refs 1-5). However, there is evidence for a specific, rapidly formed, short-lived c...

journal_title：Nature

authors： Sadegh-Nasseri S,Stern LJ,Wiley DC,Germain RN

更新日期：1994-08-25 00:00:00

abstract：:The multi-disciplinary role of intermediate energy proton accelerators in pure and applied nuclear physics is discussed with particular reference to the experimental programmes at LAMPF (Los Alamos Meson Physics Facility) and SIN (Swiss Institute for Nuclear Research, Zurich). ...

journal_title：Nature

authors： Davies JD,Batty CJ,Green K

更新日期：1977-12-22 00:00:00

abstract：:A high degree of polymorphism for the length and copy number of rDNA spacers, in both the X and Y chromosome clusters, has been found in a wild population of Drosophila melanogaster. The genetic behaviour of rDNA structural variants in separate and mixed populations derived from isofemale lines suggest that they are n...

journal_title：Nature

authors： Coen ES,Thoday JM,Dover G

更新日期：1982-02-18 00:00:00

abstract：:There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularly controversial. Although there are some well-characterized examples, most (>95%) show little evidence of evolutionary conservation and...

journal_title：Nature

authors： Guttman M,Amit I,Garber M,French C,Lin MF,Feldser D,Huarte M,Zuk O,Carey BW,Cassady JP,Cabili MN,Jaenisch R,Mikkelsen TS,Jacks T,Hacohen N,Bernstein BE,Kellis M,Regev A,Rinn JL,Lander ES

更新日期：2009-03-12 00:00:00

abstract：:The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragmen...

journal_title：Nature

authors： Koopman P,Gubbay J,Vivian N,Goodfellow P,Lovell-Badge R

更新日期：1991-05-09 00:00:00

abstract：:Despite active transport into Earth's mantle, water has been present on our planet's surface for most of geological time. Yet water disappeared from the Martian surface soon after its formation. Although some of the water on Mars was lost to space via photolysis following the collapse of the planet's magnetic field, t...

journal_title：Nature

authors： Wade J,Dyck B,Palin RM,Moore JDP,Smye AJ

更新日期：2017-12-20 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-10-01 00:00:00

abstract：:Chromatin reorganization is governed by multiple post-translational modifications of chromosomal proteins and DNA. These histone modifications are reversible, dynamic events that can regulate DNA-driven cellular processes. However, the molecular mechanisms that coordinate histone modification patterns remain largely u...

journal_title：Nature

authors： Fujiki R,Hashiba W,Sekine H,Yokoyama A,Chikanishi T,Ito S,Imai Y,Kim J,He HH,Igarashi K,Kanno J,Ohtake F,Kitagawa H,Roeder RG,Brown M,Kato S

更新日期：2011-11-27 00:00:00

abstract：:Ants travelling to and fro between their nest and a foraging area may follow stereotyped foodward and homeward routes that are guided by different visual and directional memory sequences. Honeybees are known to fly a feeder-to-hive or hive-to-feeder vector according to whether or not they have recently fed--their feed...

journal_title：Nature

authors： Harris RA,Hempel de Ibarra N,Graham P,Collett TS

更新日期：2005-11-17 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature22794. ...

journal_title：Nature

authors： Shaffer SM,Dunagin MC,Torborg SR,Torre EA,Emert B,Krepler C,Beqiri M,Sproesser K,Brafford PA,Xiao M,Eggan E,Anastopoulos IN,Vargas-Garcia CA,Singh A,Nathanson KL,Herlyn M,Raj A

更新日期：2018-03-08 00:00:00

abstract：:Sex chromosomes in males of most eutherian mammals share only a small homologous segment, the pseudoautosomal region (PAR), in which the formation of double-strand breaks (DSBs), pairing and crossing over must occur for correct meiotic segregation1,2. How cells ensure that recombination occurs in the PAR is unknown. H...

journal_title：Nature

authors： Acquaviva L,Boekhout M,Karasu ME,Brick K,Pratto F,Li T,van Overbeek M,Kauppi L,Camerini-Otero RD,Jasin M,Keeney S

更新日期：2020-06-01 00:00:00

abstract：:The four-chambered mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiotemporal patterns of differentiation and contributions to the definitive heart. The first heart field differentiates earlier in lateral plate mesoderm, generates the linear heart tube and ultimately giv...

journal_title：Nature

authors： Zhou Y,Cashman TJ,Nevis KR,Obregon P,Carney SA,Liu Y,Gu A,Mosimann C,Sondalle S,Peterson RE,Heideman W,Burns CE,Burns CG

更新日期：2011-05-29 00:00:00

abstract：:Toxoplasma gondii, an obligate intracellular parasite of the phylum Apicomplexa, can cause severe disease in humans with an immature or suppressed immune system. The outcome of Toxoplasma infection is highly dependent on the strain type, as are many of its in vitro growth properties. Here we use genetic crosses betwee...

journal_title：Nature

authors： Saeij JP,Coller S,Boyle JP,Jerome ME,White MW,Boothroyd JC

更新日期：2007-01-18 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disorder that affects approximately 2-3% of the population worldwide and has severe effects on patients' physical and psychological well-being. The discovery that psoriasis is an immune-mediated disease has led to more targeted, effective therapies; recent advances have focused...

journal_title：Nature

authors： Kopp T,Riedl E,Bangert C,Bowman EP,Greisenegger E,Horowitz A,Kittler H,Blumenschein WM,McClanahan TK,Marbury T,Zachariae C,Xu D,Hou XS,Mehta A,Zandvliet AS,Montgomery D,van Aarle F,Khalilieh S

更新日期：2015-05-14 00:00:00

abstract：:Oxygen, one of the most abundant elements on Earth, often forms an undesired interstitial impurity or ceramic phase (such as an oxide particle) in metallic materials. Even when it adds strength, oxygen doping renders metals brittle1-3. Here we show that oxygen can take the form of ordered oxygen complexes, a state in ...

journal_title：Nature

authors： Lei Z,Liu X,Wu Y,Wang H,Jiang S,Wang S,Hui X,Wu Y,Gault B,Kontis P,Raabe D,Gu L,Zhang Q,Chen H,Wang H,Liu J,An K,Zeng Q,Nieh TG,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains of this gene. A phylogeny of these species based on the Adh sequence data is consistent with that based on polytene chromos...

journal_title：Nature

authors： Bodmer M,Ashburner M

更新日期：1984-05-31 00:00:00

abstract：:How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...

journal_title：Nature

authors： Wimmer RD,Schmitt LI,Davidson TJ,Nakajima M,Deisseroth K,Halassa MM

更新日期：2015-10-29 00:00:00

abstract：:Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unlike other chemokines, neurotactin has a unique cysteine pattern, Cys-X...

journal_title：Nature

authors： Pan Y,Lloyd C,Zhou H,Dolich S,Deeds J,Gonzalo JA,Vath J,Gosselin M,Ma J,Dussault B,Woolf E,Alperin G,Culpepper J,Gutierrez-Ramos JC,Gearing D

更新日期：1997-06-05 00:00:00

abstract：:Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...

journal_title：Nature

authors： Eelkema R,Pollard MM,Vicario J,Katsonis N,Ramon BS,Bastiaansen CW,Broer DJ,Feringa BL

更新日期：2006-03-09 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) promotes the survival of several populations of neurons, including sensory and motor neurons. Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor. The identificatio...

journal_title：Nature

authors： Curtis R,Adryan KM,Zhu Y,Harkness PJ,Lindsay RM,DiStefano PS

更新日期：1993-09-16 00:00:00

abstract：:The role of magnetic domains (and the walls between domains) in determining the electrical properties of ferromagnetic materials has been investigated in great detail for many years, not least because control over domains offers a means of manipulating electron spin to control charge transport in 'spintronic' devices....

journal_title：Nature

authors： Kummamuru RK,Soh YA

更新日期：2008-04-17 00:00:00

abstract：:In nature, organisms are exposed to chronic low-dose ultraviolet light (CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA repair by the nucleotide excision repair pathway and for checkpoin...

journal_title：Nature

authors： Hishida T,Kubota Y,Carr AM,Iwasaki H

更新日期：2009-01-29 00:00:00

abstract：:The evolution of animal personalities is a topic of primary importance in behavioural ecology. An intriguing empirical fact is the consistency of animal responses to repeated stresses or threats. Wolf et al. propose an evolutionary model to explain the emergence of consistent personalities. They show that a population...

journal_title：Nature

authors： Massol F,Crochet PA

更新日期：2008-02-28 00:00:00

abstract：:A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...

journal_title：Nature

authors： Montell C,Fisher EF,Caruthers MH,Berk AJ

更新日期：1983-10-13 00:00:00

abstract：:Ubiquitin (Ub) has important roles in a wide range of intracellular signalling pathways. In the conventional view, ubiquitin alters the signalling activity of the target protein through covalent modification, but accumulating evidence points to the emerging role of non-covalent interaction between ubiquitin and the ta...

journal_title：Nature

authors： Peisley A,Wu B,Xu H,Chen ZJ,Hur S

更新日期：2014-05-01 00:00:00

abstract：:Mycorrhizae, the symbiotic associations of plant roots and fungal hyphae, are classic examples of mutualisms. In these ecologically important associations, the fungi derive photosynthetic sugars from their plant hosts, which in turn benefit from fungus-mediated uptake of mineral nutrients. Early views on the evolution...

journal_title：Nature

authors： Hibbett DS,Gilbert LB,Donoghue MJ

更新日期：2000-09-28 00:00:00

abstract：:CD4 and CD8 antigens are simultaneously expressed on most of the cortical thymocytes, that weakly express the T-cell antigen receptor(TCR)/CD3 complex. Mature peripheral T cells, however, strongly express the TCR complex and are positive for either CD4 or CD8. Nevertheless, a small percentage of peripheral CD3+ T cell...

journal_title：Nature

authors： Paliard X,Malefijt RW,de Vries JE,Spits H

更新日期：1988-10-13 00:00:00

abstract：:Prized for their ability to rapidly generate chemical complexity by building new ring systems and stereocentres1, cycloaddition reactions have featured in numerous total syntheses2 and are a key component in the education of chemistry students3. Similarly, carbon-carbon (C-C) cross-coupling methods are integral to syn...

journal_title：Nature

authors： Chen TG,Barton LM,Lin Y,Tsien J,Kossler D,Bastida I,Asai S,Bi C,Chen JS,Shan M,Fang H,Fang FG,Choi HW,Hawkins L,Qin T,Baran PS

更新日期：2018-08-01 00:00:00

abstract：:Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure. Bacteria comprising the Chlamydiales were thought to be one of the few exceptions. Chlamydia harbour genes for PG biosynthesis and exhibit suscept...

journal_title：Nature

authors： Liechti GW,Kuru E,Hall E,Kalinda A,Brun YV,VanNieuwenhze M,Maurelli AT

更新日期：2014-02-27 00:00:00