Abstract:
:A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylation but is required for the cleavage step preceding polyadenylation to occur efficiently.
journal_name
Naturejournal_title
Natureauthors
Montell C,Fisher EF,Caruthers MH,Berk AJdoi
10.1038/305600a0subject
Has Abstractpub_date
1983-10-13 00:00:00pages
600-5issue
5935eissn
0028-0836issn
1476-4687journal_volume
305pub_type
杂志文章相关文献
NATURE文献大全abstract::During early mammalian development, as the pluripotent cells that give rise to all of the tissues of the body proliferate and expand in number, they pass through transition states marked by a stepwise restriction in developmental potential and by changes in the expression of key regulatory genes. Recent findings show ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature09228
更新日期:2010-06-10 00:00:00
abstract::Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease. Although its precise mechanism of action is unclear, osteocalcin influences bone mineralization, in part th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02079
更新日期:2003-10-30 00:00:00
abstract::The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381127a0
更新日期:1996-05-09 00:00:00
abstract::Phosphatidylinositol 4,5-bisphosphate (PIP2), which comprises only about 1% of the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three second messengers, activates many ion channels and enzymes, is involved in both endocytosis and exocytosis, anchors proteins to the membrane through...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature04398
更新日期:2005-12-01 00:00:00
abstract::Conjugate (or 1,4-) additions of carbanionic species to α,β-unsaturated carbonyl compounds are vital to research in organic and medicinal chemistry, and there are several chiral catalysts that facilitate the catalytic enantioselective additions of nucleophiles to enoates. Nonetheless, catalytic enantioselective 1,6-co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature19063
更新日期:2016-09-15 00:00:00
abstract::To communicate, spacecraft and satellites rely on microwave devices, which at present are based on relatively inefficient thermionic electron sources that require heating and cannot be switched on instantaneously. Here we describe a microwave diode that uses a cold-cathode electron source consisting of carbon nanotube...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/437968a
更新日期:2005-10-13 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-019-00087-z
更新日期:2019-01-01 00:00:00
abstract::Published data from X-ray telescopes are not adequate to reveal the fluctuations in the surface brightness of the background radiation caused by clustering or superclustering of the sources giving rise to the background. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/238020a0
更新日期:1972-07-07 00:00:00
abstract::The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated through the intracellular effectors SMAD2 and SMAD3 (hereafter SMAD2/3), whose canonical function is to control the activity of target genes by interacting with transcriptiona...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25784
更新日期:2018-03-08 00:00:00
abstract::Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial cells line the cerebral ventricles and generate intermediate progenitor cells that migrate into the subventricular zone (SVZ) and proliferate to increase neuronal number. The developing hu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08845
更新日期:2010-03-25 00:00:00
abstract::The neural crest, a source of many different cell types in vertebrate embryos, has not been identified in other chordates. Current opinion therefore holds that neural crest cells were a vertebrate innovation. Here we describe a migratory cell population resembling neural crest cells in the ascidian urochordate Ecteina...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02975
更新日期:2004-10-07 00:00:00
abstract::Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells. However, the genes contributing to this stability remain obscure. We previously identified Zscan4 as a specific marker for two-cell embryo and ES cells. Here we show that Zscan4 is involved in telomere maintenance and long-term g...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08882
更新日期:2010-04-08 00:00:00
abstract::Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues. The phosphatase(s) involved in p34cdc2 dephosphorylation is unknown, but the product of the fission yeast...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351242a0
更新日期:1991-05-16 00:00:00
abstract::The discovery of the basis of genetic variation has opened inroads to understanding our history as a species. It has revealed the remarkable genetic similarity we share with other individuals as well as with our closest primate relatives. To understand what make us unique, both as individuals and as a species, we need...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature01400
更新日期:2003-01-23 00:00:00
abstract::Storing and retrieving a quantum state of light on demand, without corrupting the information it carries, is an important challenge in the field of quantum information processing. Classical measurement and reconstruction strategies for storing light must necessarily destroy quantum information as a consequence of the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09081
更新日期:2010-06-24 00:00:00
abstract::Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis, here we show that deletion of Dicer1 specifically in mouse osteoprogenitors, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08851
更新日期:2010-04-08 00:00:00
abstract::It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/415599b
更新日期:2002-02-07 00:00:00
abstract::Mistranslation arising from confusion of serine for alanine by alanyl-tRNA synthetases (AlaRSs) has profound functional consequences. Throughout evolution, two editing checkpoints prevent disease-causing mistranslation from confusing glycine or serine for alanine at the active site of AlaRS. In both bacteria and mice,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08612
更新日期:2009-12-10 00:00:00
abstract::Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23276
更新日期:2017-08-10 00:00:00
abstract::Retinoic acid is a vitamin A derivative with striking effects on development and cell differentiation. Several nuclear retinoic acid receptors (RARs), acting as ligand-inducible transcription factors, have been characterized and indirect evidence suggests that they have distinct roles. One of the most intriguing prope...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347558a0
更新日期:1990-10-11 00:00:00
abstract::The formation of disulphide bonds is essential to the structure and function of proteins. These bonds rapidly form either cotranslationally or immediately post-translationally in the lumen of the endoplasmic reticulum. Native disulphide pairing for such proteins has been achieved in vitro; however, the rates of reasse...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317267a0
更新日期:1985-09-19 00:00:00
abstract::Guard cells are located in the epidermis of plant leaves, and in pairs surround stomatal pores. These control both the influx of CO2 as a raw material for photosynthesis and water loss from plants through transpiration to the atmosphere. Guard cells have become a highly developed system for dissecting early signal tra...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35066500
更新日期:2001-03-15 00:00:00
abstract::How left/right functional asymmetry is layered on top of an anatomically symmetrical nervous system is poorly understood. In the nematode Caenorhabditis elegans, two morphologically bilateral taste receptor neurons, ASE left (ASEL) and ASE right (ASER), display a left/right asymmetrical expression pattern of putative ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02255
更新日期:2003-12-18 00:00:00
abstract::Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impa...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature02624
更新日期:2004-05-27 00:00:00
abstract::The observation of the superfluid to Mott insulator phase transition of ultracold atoms in optical lattices was an enabling discovery in experimental many-body physics, providing the first tangible example of a quantum phase transition (one that occurs even at zero temperature) in an ultracold atomic gas. For a trappe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08244
更新日期:2009-08-20 00:00:00
abstract::5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04130
更新日期:2005-11-10 00:00:00
abstract::alpha-Neurotoxins bind to cholinergic receptor, block transmission, and induce sprouting of retinal terminals in the toad tectum. New connections retain an orderliness that suggests a selective affinity between presynaptic terminals. The results suggest that postsynaptic cells exert a control, associated with receptor...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/269218a0
更新日期:1977-09-15 00:00:00
abstract::Complementary DNA cloning of the transcripts of the Drosophila clock gene period reveals three distinct transcripts. These result from unusual splicing pathways, one involving a CG 3' splice site and one resulting in the use of two different reading frames in one exon, and they predict three separate proteins. Two of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326042a0
更新日期:1987-03-05 00:00:00
abstract::Synaptic transmission of most vertebrate synapses is thought to be terminated by rapid transport of the neurotransmitter into presynaptic nerve terminals or neuroglia. L-Glutamate is the major excitatory transmitter in brain and its transport represents the mechanism by which it is removed from the synaptic cleft and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360464a0
更新日期:1992-12-03 00:00:00
abstract::Optical laser fields have been widely used to achieve quantum control over the motional and internal degrees of freedom of atoms and ions, molecules and atomic gases. A route to controlling the quantum states of macroscopic mechanical oscillators in a similar fashion is to exploit the parametric coupling between optic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10787
更新日期:2012-02-01 00:00:00