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NATURE文献大全abstract::RNA is involved in many biological functions, ranging from information storage and transfer to the catalysis of reactions involving both nucleic acids and proteins. Previous crystallographic studies on RNA oligomeric chains provide only averaged structures or information limited in resolution. The oligomer [U(U-A)6A]2...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335375a0
更新日期:1988-09-22 00:00:00
abstract::Large seasonal and hemispheric asymmetries in the martian climate system are generally ascribed to variations in solar heating associated with orbital eccentricity. As the orbital elements slowly change (over a period of >104 years), characteristics of the climate such as dustiness and the vigour of atmospheric circul...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416298a
更新日期:2002-03-21 00:00:00
abstract::It is of fundamental importance to establish whether there is a limit to how thin a superconducting wire can be, while retaining its superconducting character--and if there is a limit, to determine what sets it. This issue may also be of practical importance in defining the limit to miniaturization of superconducting ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35010060
更新日期:2000-04-27 00:00:00
abstract::The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, ma...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/298443a0
更新日期:1982-07-29 00:00:00
abstract::Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic contacts) and bloc...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/nature09217
更新日期:2010-08-12 00:00:00
abstract::Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tumours with massive chromosome loss. Recent success in establishing ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11435
更新日期:2012-10-18 00:00:00
abstract::Owing to their scientific and technological importance, inorganic single crystals with highly reactive surfaces have long been studied. Unfortunately, surfaces with high reactivity usually diminish rapidly during the crystal growth process as a result of the minimization of surface energy. A typical example is titaniu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06964
更新日期:2008-05-29 00:00:00
abstract::A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2228-6
更新日期:2020-06-01 00:00:00
abstract::Establishment and maintenance of proper architecture is essential for endoplasmic reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and maintenance, and has been shown to depend on GTP hydrolysis. Here we demonstrate that Drosophila Atlastin--the fly homologue of the mammalian GTPase atl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08280
更新日期:2009-08-20 00:00:00
abstract::Many corals bleach as a result of increased seawater temperature, which causes them to lose their vital symbiotic algae (Symbiodinium spp.) - unless these symbioses are able to adapt to global warming, bleaching threatens coral reefs worldwide. Here I show that some corals have adapted to higher temperatures, at least...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/430742a
更新日期:2004-08-12 00:00:00
abstract::Gut commensal microbes shape the mucosal immune system by regulating the differentiation and expansion of several types of T cell. Clostridia, a dominant class of commensal microbe, can induce colonic regulatory T (Treg) cells, which have a central role in the suppression of inflammatory and allergic responses. Howeve...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12721
更新日期:2013-12-19 00:00:00
abstract::A paramutation is an epigenetic interaction between two alleles of a locus, through which one allele induces a heritable modification in the other allele without modifying the DNA sequence. The paramutated allele itself becomes paramutagenic, that is, capable of epigenetically converting a new paramutable allele. Here...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11416
更新日期:2012-10-04 00:00:00
abstract::Multiple endocrine neoplasia type 1 (MEN-1) is a predisposition to hyperplasia of the parathyroid glands, and to hyperplasia or tumours of the anterior pituitary and the endocrine pancreas, and is inherited as an autosomal dominant trait. Here we map the MEN-1 locus to chromosome 11 by family studies, and demonstrate ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/332085a0
更新日期:1988-03-03 00:00:00
abstract::In this Letter, in Fig. 3c and f the Saccharomyces cerevisiae and Escherichia coli networks were subject to both weight loss and node deletion, a combination of two types of perturbation, as opposed to weight loss only (as the labelling incorrectly indicated). The collapse in Fig. 3h was also obtained from this combin...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1091-9
更新日期:2019-04-01 00:00:00
abstract::The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376490a0
更新日期:1995-08-10 00:00:00
abstract::Bacterial adhesion pili are designed to bind specifically and maintain attachment of bacteria to target cells. Uropathogenic P-pili are sufficiently mechanically resilient to resist the cleansing action of urine flow that removes most other bacteria. P-pili are 68 A in diameter and approximately 1 micron long, and are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373164a0
更新日期:1995-01-12 00:00:00
abstract::Aerobic methanotrophic bacteria consume methane as it diffuses away from methanogenic zones of soil and sediment. They act as a biofilter to reduce methane emissions to the atmosphere, and they are therefore targets in strategies to combat global climate change. No cultured methanotroph grows optimally below pH 5, but...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06411
更新日期:2007-12-06 00:00:00
abstract::Guard cells are located in the epidermis of plant leaves, and in pairs surround stomatal pores. These control both the influx of CO2 as a raw material for photosynthesis and water loss from plants through transpiration to the atmosphere. Guard cells have become a highly developed system for dissecting early signal tra...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/35066500
更新日期:2001-03-15 00:00:00
abstract::In plants, the small GTP-binding proteins called Rops work as signalling switches that control growth, development and plant responses to various environmental stimuli. Rop proteins (Rho of plants, Rac-like and AtRac in Arabidopsis thaliana) belong to the Rho family of Ras-related GTP-binding proteins that turn on sig...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03883
更新日期:2005-08-25 00:00:00
abstract::The travelling salesman problem is a classical problem in the field of combinatorial optimization, concerned with efficient methods for maximizing or minimizing a function of many independent variables. Given the positions of N cities, which in the simplest case lie in the plane, what is the shortest closed tour in wh...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326689a0
更新日期:1987-04-16 00:00:00
abstract::We have investigated age-related reactivation of the X chromosome by devising a model in which reactivation of a single gene in one cell among many can be identified. We have used mice with an X-autosomal translocation giving consistent non-random inactivation of the normal X (as judged by biochemical and cytogenetic ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/327725a0
更新日期:1987-06-25 00:00:00
abstract::The intestinal tract maintains proper function by replacing aged cells with freshly produced cells that arise from a population of self-renewing intestinal stem cells (ISCs). In the mammalian intestine, ISC self renewal, amplification and differentiation take place along the crypt-villus axis, and are controlled by th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07156
更新日期:2008-07-31 00:00:00
abstract::Because it is so tall, the giraffe, Giraffa camelopardalis, provides an important animal model for investigating adaptive mechanisms to orthostatic (gravitational) pressure changes. Previous physiological studies of the giraffe have concentrated on arterial blood pressures in the heart and neck. Briefly, these investi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329059a0
更新日期:1987-09-03 00:00:00
abstract::Electric-field-induced charge separation (polarization) is the most fundamental manifestation of the interaction of light with matter and a phenomenon of great technological relevance. Nonlinear optical polarization produces coherent radiation in spectral ranges inaccessible by lasers and constitutes the key to ultima...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17650
更新日期:2016-06-02 00:00:00
abstract::The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35018500
更新日期:2000-07-20 00:00:00
abstract::Non-ribosomal peptide synthetase (NRPS) mega-enzyme complexes are modular assembly lines that are involved in the biosynthesis of numerous peptide metabolites independently of the ribosome. The multiple interactions between catalytic domains within the NRPS machinery are further complemented by additional interactions...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14141
更新日期:2015-05-07 00:00:00
abstract::The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03469
更新日期:2005-04-21 00:00:00
abstract::Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and form the basis of some of the world's most productive marine food webs. The diatom nuclear genome contains genes with bacterial and plastid origins as well as genes of the secondary endosymbiotic host (the exosymbiont), yet little is known a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10074
更新日期:2011-05-12 00:00:00
abstract::Cell competition-the sensing and elimination of less fit 'loser' cells by neighbouring 'winner' cells-was first described in Drosophila. Although cell competition has been proposed as a selection mechanism to optimize tissue and organ development, its evolutionary generality remains unclear. Here, by using live imagin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1199-y
更新日期:2019-05-01 00:00:00
abstract::DNA methylation is an important epigenetic modification that is essential for various developmental processes through regulating gene expression, genomic imprinting, and epigenetic inheritance. Mammalian genomic DNA methylation is established during embryogenesis by de novo DNA methyltransferases, DNMT3A and DNMT3B, a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13899
更新日期:2015-01-29 00:00:00