A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.

abstract：:Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has bee...

journal_title：Nature

authors： Johannessen CM,Boehm JS,Kim SY,Thomas SR,Wardwell L,Johnson LA,Emery CM,Stransky N,Cogdill AP,Barretina J,Caponigro G,Hieronymus H,Murray RR,Salehi-Ashtiani K,Hill DE,Vidal M,Zhao JJ,Yang X,Alkan O,Kim S,Harris JL

更新日期：2010-12-16 00:00:00

abstract：:Classically, there is a direct correlation between the lipophilic nature of a molecule and its rate of permeation across a biological membrane, so cell membranes should be more permeable to small, neutral molecules than they are to charged molecular species of similar size. Consequently, the distribution of NH+4 in bi...

journal_title：Nature

authors： Kikeri D,Sun A,Zeidel ML,Hebert SC

更新日期：1989-06-08 00:00:00

abstract：:The alpha beta T-cell receptors (TCRs) react with complex ligands composed of peptides bound to major histocompatibility complex (MHC) proteins. In the absence of foreign antigens the peptides bound to MHC molecules come from the proteins of the host itself. Interactions between TCRs and these self-peptide-MHC ligands...

journal_title：Nature

authors： Kozono H,White J,Clements J,Marrack P,Kappler J

更新日期：1994-05-12 00:00:00

abstract：:In contrast to double-stranded DNA, there has so far been little evidence that double-stranded RNA can undergo major conformational transitions. We have investigated the conformation in different conditions of the double-stranded RNA molecule poly(G-C).poly(G-C), by NMR, circular dichroism and absorbance spectroscopy....

journal_title：Nature

authors： Hall K,Cruz P,Tinoco I Jr,Jovin TM,van de Sande JH

更新日期：1984-10-11 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Biodiversity is rapidly declining, and this may negatively affect ecosystem processes, including economically important ecosystem services. Previous studies have shown that biodiversity has positive effects on organisms and processes across trophic levels. However, only a few studies have so far incorporated an explic...

journal_title：Nature

authors： Scherber C,Eisenhauer N,Weisser WW,Schmid B,Voigt W,Fischer M,Schulze ED,Roscher C,Weigelt A,Allan E,Bessler H,Bonkowski M,Buchmann N,Buscot F,Clement LW,Ebeling A,Engels C,Halle S,Kertscher I,Klein AM,Koller R,

更新日期：2010-11-25 00:00:00

abstract：:To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...

journal_title：Nature

authors： Bloss TA,Witze ES,Rothman JH

更新日期：2003-08-28 00:00:00

abstract：:The spindle checkpoint prevents chromosome mis-segregation by delaying sister chromatid separation until all chromosomes have achieved bipolar attachment to the mitotic spindle. Its operation is essential for accurate chromosome segregation, whereas its dysregulation can contribute to birth defects and tumorigenesis. ...

journal_title：Nature

authors： Stegmeier F,Rape M,Draviam VM,Nalepa G,Sowa ME,Ang XL,McDonald ER 3rd,Li MZ,Hannon GJ,Sorger PK,Kirschner MW,Harper JW,Elledge SJ

更新日期：2007-04-19 00:00:00

abstract：:Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...

journal_title：Nature

authors： Ives AR,Cardinale BJ

更新日期：2004-05-13 00:00:00

abstract：:The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convert...

journal_title：Nature

authors： Wiesmann C,Katschke KJ,Yin J,Helmy KY,Steffek M,Fairbrother WJ,McCallum SA,Embuscado L,DeForge L,Hass PE,van Lookeren Campagne M

更新日期：2006-11-09 00:00:00

abstract：:It is of fundamental importance to establish whether there is a limit to how thin a superconducting wire can be, while retaining its superconducting character--and if there is a limit, to determine what sets it. This issue may also be of practical importance in defining the limit to miniaturization of superconducting ...

journal_title：Nature

authors： Bezryadin A,Lau CN,Tinkham M

更新日期：2000-04-27 00:00:00

abstract：:Macroscopic mechanical objects and electromagnetic degrees of freedom can couple to each other through radiation pressure. Optomechanical systems in which this coupling is sufficiently strong are predicted to show quantum effects and are a topic of considerable interest. Devices in this regime would offer new types of...

journal_title：Nature

authors： Thompson JD,Zwickl BM,Jayich AM,Marquardt F,Girvin SM,Harris JG

更新日期：2008-03-06 00:00:00

abstract：:Many planktonic organisms produce 'resting' stages when the environmental conditions deteriorate. Like seeds, resting stages can survive unfavourable conditions. The crustacean Daphnia normally reproduces by means of parthenogenetically produced normal, not resting, eggs-but occasionally switches to bisexual reproduct...

journal_title：Nature

authors： Alekseev V,Lampert W

更新日期：2001-12-20 00:00:00

abstract：:When simian virus 40 (SV40) infects host cells, the viral genes are expressed in two phases. Early in infection, the virus genome is transcribed and translated to yield two related proteins, 'large T' and 'small t' antigens. Later the rate of synthesis of the early messenger RNA falls and the viral genes coding for th...

journal_title：Nature

authors： McKay R,DiMaio D

更新日期：1981-02-26 00:00:00

abstract：:The wavefunction is the complex distribution used to completely describe a quantum system, and is central to quantum theory. But despite its fundamental role, it is typically introduced as an abstract element of the theory with no explicit definition. Rather, physicists come to a working understanding of the wavefunct...

journal_title：Nature

authors： Lundeen JS,Sutherland B,Patel A,Stewart C,Bamber C

更新日期：2011-06-08 00:00:00

abstract：:Fermi-liquid theory (the standard model of metals) has been challenged by the discovery of anomalous properties in an increasingly large number of metals. The anomalies often occur near a quantum critical point--a continuous phase transition in the limit of absolute zero, typically between magnetically ordered and par...

journal_title：Nature

authors： Doiron-Leyraud N,Walker IR,Taillefer L,Steiner MJ,Julian SR,Lonzarich GG

更新日期：2003-10-09 00:00:00

abstract：:X-linked spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of motorneuron disease which may be associated with signs of androgen insensitivity. We have now investigated whether the androgen receptor gene on the proximal long arm of the X chromosome is a candidate gene for this disease. In p...

journal_title：Nature

authors： La Spada AR,Wilson EM,Lubahn DB,Harding AE,Fischbeck KH

更新日期：1991-07-04 00:00:00

abstract：:Colorectal cancer results from mutations in components of the Wnt pathway that regulate beta-catenin levels. Dishevelled (Dvl or Dsh) signals downstream of Wnt receptors and stabilizes beta-catenin during cell proliferation and embryonic axis formation. Moreover, Dvl contributes to cytoskeletal reorganization during g...

journal_title：Nature

authors： Capelluto DG,Kutateladze TG,Habas R,Finkielstein CV,He X,Overduin M

更新日期：2002-10-17 00:00:00

abstract：:It is thought that immunity depends on naive CD4 T cells that proliferate in response to microbial antigens, differentiate into memory cells that produce anti-microbial lymphokines, and migrate to sites of infection. Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, i...

journal_title：Nature

authors： Reinhardt RL,Khoruts A,Merica R,Zell T,Jenkins MK

更新日期：2001-03-01 00:00:00

abstract：:The Duchenne muscular dystrophy (DMD) locus has been localized to the short arm of the human X chromosome (Xp21) by detection of structural abnormalities and by genetic linkage studies. A library highly enriched for human DNA from Xp21 was constructed using DNA isolated from a male patient who had a visible deletion a...

journal_title：Nature

authors： Monaco AP,Bertelson CJ,Middlesworth W,Colletti CA,Aldridge J,Fischbeck KH,Bartlett R,Pericak-Vance MA,Roses AD,Kunkel LM

更新日期：1985-08-29 00:00:00

abstract：:The recognition and localization of sound signals is fundamental to acoustic communication. Complex neural mechanisms are thought to underlie the processing of species-specific sound patterns even in animals with simple auditory pathways. In female crickets, which orient towards the male's calling song, current models...

journal_title：Nature

authors： Hedwig B,Poulet JF

更新日期：2004-08-12 00:00:00

abstract：:Calcium (Ca(2+))-activated chloride channels are fundamental mediators in numerous physiological processes including transepithelial secretion, cardiac and neuronal excitation, sensory transduction, smooth muscle contraction and fertilization. Despite their physiological importance, their molecular identity has remain...

journal_title：Nature

authors： Yang YD,Cho H,Koo JY,Tak MH,Cho Y,Shim WS,Park SP,Lee J,Lee B,Kim BM,Raouf R,Shin YK,Oh U

更新日期：2008-10-30 00:00:00

abstract：:When we reach towards an object that suddenly appears in our peripheral visual field, not only does our arm extend towards the object, but our eyes, head and body also move in such a way that the image of the object falls on the fovea. Popular models of how reaching movements are programmed have argued that while the ...

journal_title：Nature

authors： Goodale MA,Pelisson D,Prablanc C

更新日期：1986-04-24 00:00:00

abstract：:Since the original work on Bose-Einstein condensation1,2, the use of quantum degenerate gases of atoms has enabled the quantum emulation of important systems in condensed matter and nuclear physics, as well as the study of many-body states that have no analogue in other fields of physics3. Ultracold molecules in the m...

journal_title：Nature

authors： Son H,Park JJ,Ketterle W,Jamison AO

更新日期：2020-04-01 00:00:00

abstract：:Tectal polarity for retinal connections remains reversible long after the anatomical pattern of neural structures has been determined. Cells in the diencephalon seem to control this polarity. Following certain embryonic operations, the diencephalon developed behind the tectum. In such cases, the polarity of the retino...

journal_title：Nature

authors： Chung SH,Cooke J

更新日期：1975-11-13 00:00:00

abstract：:The maternal messenger RNA An3 was originally identified localized to the animal hemisphere of Xenopus laevis oocytes, eggs and early embryos. Xenopus embryos depend on mRNA and protein present in the egg before fertilization (maternal molecules) to provide the information needed for early development. Localization of...

journal_title：Nature

authors： Gururajan R,Perry-O'Keefe H,Melton DA,Weeks DL

更新日期：1991-02-21 00:00:00

abstract：:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...

journal_title：Nature

authors： Garcia R,Vouimba RM,Baudry M,Thompson RF

更新日期：1999-11-18 00:00:00

abstract：:Heterotrimeric G-proteins bind to cell-surface receptors and are integral in transmission of signals from outside the cell. Upon activation of the Galpha subunit by binding of GTP, the Galpha and Gbetagamma subunits dissociate and interact with effector proteins for signal transduction. Regulatory proteins with the 19...

journal_title：Nature

authors： Kimple RJ,Kimple ME,Betts L,Sondek J,Siderovski DP

更新日期：2002-04-25 00:00:00

abstract：:The study of planarian regeneration may help us to understand how we can rebuild organs and tissues after injury, disease or ageing. The robust regenerative abilities of planarians are based upon a population of totipotent stem cells (neoblasts), and among the organs regenerated by these animals is a well-organized ce...

journal_title：Nature

authors： Cebrià F,Kobayashi C,Umesono Y,Nakazawa M,Mineta K,Ikeo K,Gojobori T,Itoh M,Taira M,Sánchez Alvarado A,Agata K

更新日期：2002-10-10 00:00:00

abstract：:For more than three-quarters of a century it has been assumed that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7),...

journal_title：Nature

authors： Kolokotrones T,Van Savage,Deeds EJ,Fontana W

更新日期：2010-04-01 00:00:00