Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma.

abstract：:The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research. However, little evidence exists that the viral reservoir can be sufficiently targeted to improve virologic control following discontinuation of antiretroviral therapy. Here ...

journal_title：Nature

authors： Borducchi EN,Cabral C,Stephenson KE,Liu J,Abbink P,Ng'ang'a D,Nkolola JP,Brinkman AL,Peter L,Lee BC,Jimenez J,Jetton D,Mondesir J,Mojta S,Chandrashekar A,Molloy K,Alter G,Gerold JM,Hill AL,Lewis MG,Pau MG,Schuit

更新日期：2016-12-08 00:00:00

abstract：:Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in pr...

journal_title：Nature

authors： Walsh C

更新日期：2001-01-11 00:00:00

abstract：:The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion channels conduct long-range electrical signals within bacterial biofilm communities through spatially ...

journal_title：Nature

authors： Prindle A,Liu J,Asally M,Ly S,Garcia-Ojalvo J,Süel GM

更新日期：2015-11-05 00:00:00

abstract：:Large-scale systematic sequencing has generally depended on the availability of an ordered library of large-insert bacterial or viral genomic clones for the organism under study. The generation of these large insert libraries, and the location of each clone on a genome map, is a laborious and time-consuming process. I...

journal_title：Nature

authors： Churcher C,Bowman S,Badcock K,Bankier A,Brown D,Chillingworth T,Connor R,Devlin K,Gentles S,Hamlin N,Harris D,Horsnell T,Hunt S,Jagels K,Jones M,Lye G,Moule S,Odell C,Pearson D,Rajandream M,Rice P,Rowley N,Ske

更新日期：1997-05-29 00:00:00

abstract：:Long-term reconstitution of the lymphohaematopoietic cells of a mouse after lethal irradiation requires the transplantation of at least (5-10) x 10(3) bone marrow cells. Several cell-separation techniques based on cell-surface characteristics have been used in attempts to identify the pluripotent haematopoietic stem c...

journal_title：Nature

authors： Jones RJ,Wagner JE,Celano P,Zicha MS,Sharkis SJ

更新日期：1990-09-13 00:00:00

abstract：:The normal cellular form of prion protein (PrPC) is a precursor to the pathogenic protease-resistant forms (PrPSc) believed to cause scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease. Its amino terminus contains the octapeptide PHGGGWGQ, which is repeated four times and is among the best-pr...

journal_title：Nature

authors： Brown DR,Qin K,Herms JW,Madlung A,Manson J,Strome R,Fraser PE,Kruck T,von Bohlen A,Schulz-Schaeffer W,Giese A,Westaway D,Kretzschmar H

更新日期：1997-12-18 00:00:00

abstract：:Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2. The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban ...

journal_title：Nature

authors： Merckx T,Souffreau C,Kaiser A,Baardsen LF,Backeljau T,Bonte D,Brans KI,Cours M,Dahirel M,Debortoli N,De Wolf K,Engelen JMT,Fontaneto D,Gianuca AT,Govaert L,Hendrickx F,Higuti J,Lens L,Martens K,Matheve H,Matthysen

更新日期：2018-06-01 00:00:00

abstract：:Retinal nerve fibres form an orderly map of visual space in several centres in the vertebrate brain. Such topographic maps are a common feature of central nervous system organization, yet the way in which they develop is poorly understood. Early nerve projections in the fetal and neonatal mammalian brain have been fou...

journal_title：Nature

authors： Holt CE,Harris WA

更新日期：1983-01-13 00:00:00

abstract：:Landscapes modified by glacial erosion show a distinct distribution of surface area with elevation (hypsometry). In particular, the height of these regions is influenced by climatic gradients controlling the altitude where glacial and periglacial processes are the most active, and as a result, surface area is focused ...

journal_title：Nature

authors： Pedersen VK,Egholm DL

更新日期：2013-01-10 00:00:00

abstract：:Neural mechanisms that mediate the ability to make value-guided decisions have received substantial attention in humans and animals1-6. Experiments in animals typically involve long training periods. By contrast, choices in the real world often need to be made between new options spontaneously. It is therefore possibl...

journal_title：Nature

authors： Bongioanni A,Folloni D,Verhagen L,Sallet J,Klein-Flügge MC,Rushworth MFS

更新日期：2021-01-06 00:00:00

abstract：:Bilingual individuals need effective mechanisms to prevent interference from one language while processing material in the other. Here we show, using event-related brain potentials and functional magnetic resonance imaging (fMRI), that words from the non-target language are rejected at an early stage before semantic a...

journal_title：Nature

authors： Rodriguez-Fornells A,Rotte M,Heinze HJ,Nösselt T,Münte TF

更新日期：2002-02-28 00:00:00

abstract：:Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10-15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (brea...

journal_title：Nature

authors： Dilley RL,Verma P,Cho NW,Winters HD,Wondisford AR,Greenberg RA

更新日期：2016-11-03 00:00:00

abstract：:On being heated, ice melts into liquid water. Although in practice this process tends to be heterogeneous, it can occur homogeneously inside bulk ice. The thermally induced homogeneous melting of solids is fairly well understood, and involves the formation and growth of melting nuclei. But in the case of water, resili...

journal_title：Nature

authors： Mochizuki K,Matsumoto M,Ohmine I

更新日期：2013-06-20 00:00:00

abstract：:Angiogenesis, the formation of new capillaries from pre-existing vessels, is essential for tumour progression. Angiostatin, a proteolytic fragment of plasminogen that was first isolated from the serum and urine of tumour-bearing mice, inhibits angiogenesis and thereby growth of primary and metastatic tumours. Radiothe...

journal_title：Nature

authors： Mauceri HJ,Hanna NN,Beckett MA,Gorski DH,Staba MJ,Stellato KA,Bigelow K,Heimann R,Gately S,Dhanabal M,Soff GA,Sukhatme VP,Kufe DW,Weichselbaum RR

更新日期：1998-07-16 00:00:00

abstract：:De novo engineering of gene circuits inside cells is extremely difficult, and efforts to realize predictable and robust performance must deal with noise in gene expression and variation in phenotypes between cells. Here we demonstrate that by coupling gene expression to cell survival and death using cell-cell communic...

journal_title：Nature

authors： You L,Cox RS 3rd,Weiss R,Arnold FH

更新日期：2004-04-22 00:00:00

abstract：:All forms of locomotion are repetitive motor activities that require coordinated bilateral activation of muscles. The executive elements of locomotor control are networks of spinal neurons that determine gait pattern through the sequential activation of motor-neuron pools on either side of the body axis. However, litt...

journal_title：Nature

authors： Talpalar AE,Bouvier J,Borgius L,Fortin G,Pierani A,Kiehn O

更新日期：2013-08-01 00:00:00

abstract：:Particle acceleration based on high intensity laser systems (a process known as laser-plasma acceleration) has achieved high quality particle beams that compare favourably with conventional acceleration techniques in terms of emittance, brightness and pulse duration. A long-term difficulty associated with laser-plasma...

journal_title：Nature

authors： Schwoerer H,Pfotenhauer S,Jäckel O,Amthor KU,Liesfeld B,Ziegler W,Sauerbrey R,Ledingham KW,Esirkepov T

更新日期：2006-01-26 00:00:00

abstract：:Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...

journal_title：Nature

authors： Mróz P,Udalski A,Skowron J,Poleski R,Kozłowski S,Szymański MK,Soszyński I,Wyrzykowski Ł,Pietrukowicz P,Ulaczyk K,Skowron D,Pawlak M

更新日期：2017-08-10 00:00:00

abstract：:Photoreceptors of the vertebrate retina hyperpolarize in response to light. The hyperpolarization elicited by a brief flash is approximately ten times slower in rods than in cones of the same retina. We have examined the amplification and temporal properties of synaptic transfer of rod and cone signals to a common pos...

journal_title：Nature

authors： Schnapf JL,Copenhagen DR

更新日期：1982-04-29 00:00:00

abstract：:The kinesin superfamily is a class of microtubule-based mechano-enzymes involved in intracellular transport and chromosome movements. Molecules that move towards either the plus end or the minus end of microtubules are represented within the family. The motor domains of these molecules exhibit considerable sequence ho...

journal_title：Nature

authors： Hoenger A,Sablin EP,Vale RD,Fletterick RJ,Milligan RA

更新日期：1995-07-20 00:00:00

abstract：:Strong interactions between electrons in a solid material can lead to surprising properties. A prime example is the Mott insulator, in which suppression of conductivity occurs as a result of interactions rather than a filled Bloch band. Proximity to the Mott insulating phase in fermionic systems is the origin of many ...

journal_title：Nature

authors： Jördens R,Strohmaier N,Günter K,Moritz H,Esslinger T

更新日期：2008-09-11 00:00:00

abstract：:It is possible to infer aspects of an organism's lifestyle from its gene content. Can the reverse also be done? Here we consider this issue by modelling evolution of the reduced genomes of endosymbiotic bacteria. The diversity of gene content in these bacteria may reflect both variation in selective forces and conting...

journal_title：Nature

authors： Pál C,Papp B,Lercher MJ,Csermely P,Oliver SG,Hurst LD

更新日期：2006-03-30 00:00:00

abstract：:Extremely intense and ultrafast X-ray pulses from free-electron lasers offer unique opportunities to study fundamental aspects of complex transient phenomena in materials. Ultrafast time-resolved methods usually require highly synchronized pulses to initiate a transition and then probe it after a precisely defined tim...

journal_title：Nature

authors： Chapman HN,Hau-Riege SP,Bogan MJ,Bajt S,Barty A,Boutet S,Marchesini S,Frank M,Woods BW,Benner WH,London RA,Rohner U,Szöke A,Spiller E,Möller T,Bostedt C,Shapiro DA,Kuhlmann M,Treusch R,Plönjes E,Burmeister F,Ber

更新日期：2007-08-09 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:During embryonic development, orderly patterns of gene expression eventually assign each cell in the embryo its particular fate. For the anteroposterior axis of the Drosophila embryo, the first step in this process depends on a spatial gradient of the maternal morphogen Bicoid (Bcd). Positional information of this gra...

journal_title：Nature

authors： Houchmandzadeh B,Wieschaus E,Leibler S

更新日期：2002-02-14 00:00:00

abstract：:Runs of adenines (adenine tracts) have been implicated as the main determinant of sequence-directed DNA bending. The most widely used experimental test for bending relies on the observation that bent DNA migrates more slowly than straight DNA on a polyacrylamide electrophoresis gel. It was shown recently that the poly...

journal_title：Nature

authors： Burkhoff AM,Tullius TD

更新日期：1988-02-04 00:00:00

abstract：:Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast. However, the function or occurrence of this specific histone mark has not been studied in multicellular e...

journal_title：Nature

authors： Das C,Lucia MS,Hansen KC,Tyler JK

更新日期：2009-05-07 00:00:00

abstract：:Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...

journal_title：Nature

authors： Zhang XK,Hoffmann B,Tran PB,Graupner G,Pfahl M

更新日期：1992-01-30 00:00:00

abstract：:Earth's climate history is often understood by breaking it down into constituent climatic epochs1. Over the Common Era (the past 2,000 years) these epochs, such as the Little Ice Age2-4, have been characterized as having occurred at the same time across extensive spatial scales5. Although the rapid global warming seen...

journal_title：Nature

authors： Neukom R,Steiger N,Gómez-Navarro JJ,Wang J,Werner JP

更新日期：2019-07-01 00:00:00

abstract：:Understanding ice sheet behaviour in the geological past is essential for evaluating the role of the cryosphere in the climate system and for projecting rates and magnitudes of sea level rise in future warming scenarios1-4. Although both geological data5-7 and ice sheet models3,8 indicate that marine-based sectors of ...

journal_title：Nature

authors： Wilson DJ,Bertram RA,Needham EF,van de Flierdt T,Welsh KJ,McKay RM,Mazumder A,Riesselman CR,Jimenez-Espejo FJ,Escutia C

更新日期：2018-09-01 00:00:00