Abstract：
:The structure of the operator-binding domain of the lambda repressor has been determined at 3.2 A resolution. This domain contains an extended N-terminal arm and five alpha-helices. Model-building studies of the repressor-operator complex suggest that alpha-helices, especially the N-terminal parts of these helices, may provide a useful surface for protein-DNA interactions.
journal_name
Naturejournal_title
Natureauthors
Pabo CO,Lewis Mdoi
10.1038/298443a0subject
Has Abstractpub_date
1982-07-29 00:00:00pages
443-7issue
5873eissn
0028-0836issn
1476-4687journal_volume
298pub_type
杂志文章相关文献
NATURE文献大全abstract：:Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07341
更新日期：2008-10-30 00:00:00
abstract：:The mariner transposable element is a small member of the short inverted terminal repeat class thought to transpose through a DNA intermediate. Originally described in Drosophila mauritiana, it is now known in several species of the family Drosophilidae, and in a moth Hyalophora cecropia. Here I use primers designed t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/362241a0
更新日期：1993-03-18 00:00:00
abstract：:Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature22078
更新日期：2017-05-04 00:00:00
abstract：:Serine proteases are present in virtually all organisms and function both inside and outside the cell; they exist as two families, the 'trypsin-like' and the 'subtilisin-like', that have independently evolved a similar catalytic device characterized by the Ser, His, Asp triad, an oxyanion binding site, and possibly ot...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/332564a0
更新日期：1988-04-07 00:00:00
abstract：:Chondrules and Ca-Al-rich inclusions (CAIs) are high-temperature components of meteorites that formed during transient heating events in the early Solar System. A major unresolved issue is the relative timing of CAI and chondrule formation. From the presence of chondrule fragments in an igneous CAI, it was concluded t...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03470
更新日期：2005-04-21 00:00:00
abstract：:The T-cell receptor (TCR) repertoire is selected in the thymus after rearrangement of genes encoding TCR alpha and beta chains. Selection is based on the recognition by newly emergent T cells of self-ligands associated with molecules of the major histocompatibility complex: some combinations result in positive selecti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/349531a0
更新日期：1991-02-07 00:00:00
abstract：:The complete knowledge of a quantum state allows the prediction of the probability of all possible measurement outcomes, a crucial step in quantum mechanics. It can be provided by tomographic methods which have been applied to atomic, molecular, spin and photonic states. For optical or microwave photons, standard tomo...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13821
更新日期：2014-10-30 00:00:00
abstract：:Protein aggregates are the hallmark of stressed and ageing cells, and characterize several pathophysiological states. Healthy metazoan cells effectively eliminate intracellular protein aggregates, indicating that efficient disaggregation and/or degradation mechanisms exist. However, metazoans lack the key heat-shock p...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14884
更新日期：2015-08-13 00:00:00
abstract：:Peptidoglycan is the major structural constituent of the bacterial cell wall, forming a meshwork outside the cytoplasmic membrane that maintains cell shape and prevents lysis. In Gram-negative bacteria, peptidoglycan is located in the periplasm, where it is protected from exogenous lytic enzymes by the outer membrane....
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature10244
更新日期：2011-07-20 00:00:00
abstract：:A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/379177a0
更新日期：1996-01-11 00:00:00
abstract：:A kinase distinct from the MEK activator Raf, termed MEK kinase-1 (MEKK), was originally identified by virtue of its homology to kinases involved in yeast mating signal cascades. Like Raf, MEKK is capable of activating MEK in vitro. High-level expression of MEKK in COS-7 cells or using vaccinia virus vectors also acti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/372798a0
更新日期：1994-12-22 00:00:00
abstract：:In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent male pronucleus. Genome-wide nucleosome assembly on paternal DNA implies the replacement of sperm chromosomal proteins, such as protamines, by maternally provided ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04059
更新日期：2005-10-27 00:00:00
abstract：:We are in the enviable position of having two distinct drafts of the human genome sequence. Although gaps, errors, redundancy and incomplete annotation mean that individually each falls short of the ideal, many of these problems can be assessed by comparison. Here we present some comparative analyses of these drafts. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35057055
更新日期：2001-02-15 00:00:00
abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35007061
更新日期：2000-04-06 00:00:00
abstract：:The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature07763
更新日期：2009-04-02 00:00:00
abstract：:Ribosomes are translational machineries that catalyse protein synthesis. Ribosome structures from various species are known at the atomic level, but obtaining the structure of the human ribosome has remained a challenge; efforts to address this would be highly relevant with regard to human diseases. Here we report the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature14427
更新日期：2015-04-30 00:00:00
abstract：:The type 1 human immunodeficiency virus (HIV-1) contains a conical capsid comprising approximately 1,500 CA protein subunits, which organizes the viral RNA genome for uncoating and replication in a new host cell. In vitro, CA spontaneously assembles into helical tubes and cones that resemble authentic viral capsids. H...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35030177
更新日期：2000-09-21 00:00:00
abstract：:In somatic cells, entry into mitosis depends on the completion of DNA synthesis. This dependency is established by S-phase feedback controls that arrest cell division when damaged or unreplicated DNA is present. In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/355365a0
更新日期：1992-01-23 00:00:00
abstract：:The M13 coat protein spans the Escherichia coli plasma membrane with its amino-terminus facing the periplasm. It is made as a precursor--the procoat--with a typical leader peptide. Mutations which destroy the basic character of the carboxy-terminal domain of procoat, a domain which is oriented towards the cytoplasm, b...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/322335a0
更新日期：1986-07-24 00:00:00
abstract：:Dusty disks around young stars are formed out of interstellar dust that consists of amorphous, submicrometre grains. Yet the grains found in comets and meteorites, and traced in the spectra of young stars, include large crystalline grains that must have undergone annealing or condensation at temperatures in excess of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08032
更新日期：2009-05-14 00:00:00
abstract：:Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at severa...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/318533a0
更新日期：1985-12-12 00:00:00
abstract：:The Amazon rainforest plays a crucial role in the climate system, helping to drive atmospheric circulations in the tropics by absorbing energy and recycling about half of the rainfall that falls on it. This region (Amazonia) is also estimated to contain about one-tenth of the total carbon stored in land ecosystems, an...
journal_title：Nature
pub_type： 历史文章,杂志文章
doi：10.1038/nature06960
更新日期：2008-05-08 00:00:00
abstract：:Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called diphthamide, which is the target of diphtheria toxin. The biosynthesis of diphthamide was proposed to involve three steps, with the first being the formation of a C-C bond between the histidi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09138
更新日期：2010-06-17 00:00:00
abstract：: ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/d41586-018-07501-y
更新日期：2018-11-01 00:00:00
abstract：:Resistance to infection and clearance of cell debris in mammals depend on the activation of the complement system, which is an important component of innate and adaptive immunity. Central to the complement system is the activated form of C3, called C3b, which attaches covalently to target surfaces to amplify complemen...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature05172
更新日期：2006-11-09 00:00:00
abstract：:Most sensory information destined for the neocortex is relayed through the thalamus, where considerable transformation occurs1,2. One means of transformation involves interactions between excitatory thalamocortical neurons that carry data to the cortex and inhibitory neurons of the thalamic reticular nucleus (TRN) tha...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-2512-5
更新日期：2020-07-01 00:00:00
abstract：:Acute stress suppresses pain by activating brain pathways that engage opioid or non-opioid mechanisms. Here we show that an opioid-independent form of this phenomenon, termed stress-induced analgesia, is mediated by the release of endogenous marijuana-like (cannabinoid) compounds in the brain. Blockade of cannabinoid ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature03658
更新日期：2005-06-23 00:00:00
abstract：:Although a few cancer genes are mutated in a high proportion of tumours of a given type (>20%), most are mutated at intermediate frequencies (2-20%). To explore the feasibility of creating a comprehensive catalogue of cancer genes, we analysed somatic point mutations in exome sequences from 4,742 human cancers and the...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature12912
更新日期：2014-01-23 00:00:00
abstract：:During embryogenesis, body pattern is established in a stepwise process. After specification of the body axis, the embryo is subdivided into smaller units. Within these units, a diverse array of cell types is then generated. The subdivisions of the Drosophila embryo, called parasegments, are defined by the interface b...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/360347a0
更新日期：1992-11-26 00:00:00
abstract：:There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and reduce the number and severity of adverse drug reactions. However, such personalization of drug treatments requires the ability to predict how different individuals will ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04648
更新日期：2006-04-20 00:00:00
