Abstract:
:Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.
journal_name
Naturejournal_title
Natureauthors
Adams JM,Harris AW,Pinkert CA,Corcoran LM,Alexander WS,Cory S,Palmiter RD,Brinster RLdoi
10.1038/318533a0subject
Has Abstractpub_date
1985-12-12 00:00:00pages
533-8issue
6046eissn
0028-0836issn
1476-4687journal_volume
318pub_type
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