Abstract:
:The imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compartments. However, in most cases precise boundaries are formed between different cell types without early compartmentalization. One such boundary occurs between the wingless (wg)-expressing cells of the wing margin and the adjacent proneural cells, which give rise to margin sensory bristles. Here we show that this boundary arises in part by a mechanism of 'self-refinement', by which wingless protein (Wg) represses wg expression in adjacent cells. Cells unable to receive the Wg signal do not resolve the boundary between wg-expressing and proneural cells.
journal_name
Naturejournal_title
Natureauthors
Rulifson EJ,Micchelli CA,Axelrod JD,Perrimon N,Blair SSdoi
10.1038/384072a0subject
Has Abstractpub_date
1996-11-07 00:00:00pages
72-4issue
6604eissn
0028-0836issn
1476-4687journal_volume
384pub_type
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