Abstract:
:The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent work has highlighted its remarkable mode of synthesis by the ribonucleoprotein reverse transcriptase, telomerase, as well as its ability to form unusual structures in vitro. Moreover, telomere synthesis by telomerase has been shown to be essential for telomere maintenance and long-term viability.
journal_name
Naturejournal_title
Natureauthors
Blackburn EHdoi
10.1038/350569a0subject
Has Abstractpub_date
1991-04-18 00:00:00pages
569-73issue
6319eissn
0028-0836issn
1476-4687journal_volume
350pub_type
杂志文章,评审相关文献
NATURE文献大全abstract::The snowball Earth hypothesis postulates that the planet was entirely covered by ice for millions of years in the Neoproterozoic era, in a self-enhanced glaciation caused by the high albedo of the ice-covered planet. In a hard-snowball picture, the subsequent rapid unfreezing resulted from an ultra-greenhouse event at...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10499
更新日期:2011-10-05 00:00:00
abstract::Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lnc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12943
更新日期:2014-01-30 00:00:00
abstract::The four-chambered mammalian heart develops from two fields of cardiac progenitor cells distinguished by their spatiotemporal patterns of differentiation and contributions to the definitive heart. The first heart field differentiates earlier in lateral plate mesoderm, generates the linear heart tube and ultimately giv...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10094
更新日期:2011-05-29 00:00:00
abstract::A fundamental tenet of cerebellar learning theories asserts that climbing fibre afferents from the inferior olive provide a teaching signal that promotes the gradual adaptation of movements. Data from several forms of motor learning provide support for this tenet. In pavlovian eyelid conditioning, for example, where a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416330a
更新日期:2002-03-21 00:00:00
abstract::Recent work has defined a class of transcriptional activators, members of which activate transcription in yeast, plant, insect and mammalian cells. These proteins contain two parts: one directs DNA binding and the other, called the activating region, presumably interacts with some component of the transcriptional mach...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335563a0
更新日期:1988-10-06 00:00:00
abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09058
更新日期:2010-07-22 00:00:00
abstract::Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14495
更新日期:2015-07-16 00:00:00
abstract::Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC after androgen ablation therapy is predominantly driven by deregulated androgen receptor (AR) signalling. Despite the success of recently approved therapies targeting AR signalling, such as abi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13229
更新日期:2014-06-12 00:00:00
abstract::Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature ageing disease, characterized by premature arteriosclerosis and degeneration of vascular smooth muscle cells (SMCs). HGPS is caused by a single point mutation in the lamin A (LMNA) gene, resulting in the generation of progerin, a truncated...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09879
更新日期:2011-04-14 00:00:00
abstract::Devices that convert information from one form into another according to a definite procedure are known as automata. One such hypothetical device is the universal Turing machine, which stimulated work leading to the development of modern computers. The Turing machine and its special cases, including finite automata, o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35106533
更新日期:2001-11-22 00:00:00
abstract::High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein. In the cell nucleus it acts as an architectural chromatin-binding factor that bends DNA and promotes protein assembly on specific DNA targets. Outside the cell, it binds with high affinity to RAGE (the receptor for advanced glycatio...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature00858
更新日期:2002-07-11 00:00:00
abstract::Double-stranded RNAs (dsRNAs) induce post-transcriptional gene silencing in several species of animal and plant. In plants, dsRNAs targeted to CpG islands within a promoter can also induce RNA-directed DNA methylation; however, it remains unclear whether gene silencing mediated by DNA methylation can be induced by dsR...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/nature02889
更新日期:2004-09-09 00:00:00
abstract::The dehydration of subducting oceanic crust and upper mantle has been inferred both to promote the partial melting leading to arc magmatism and to induce intraslab intermediate-depth earthquakes, at depths of 50-300 km. Yet there is still no consensus about how slab hydration occurs or where and how much chemically bo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01961
更新日期:2003-09-25 00:00:00
abstract::The main asteroid belt lies between the orbits of Mars and Jupiter, but the region is not uniformly filled with asteroids. There are gaps, known as the Kirkwood gaps, in distinct locations that are associated with orbital resonances with the giant planets; asteroids placed in these locations will follow chaotic orbits...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07778
更新日期:2009-02-26 00:00:00
abstract::In a very short time the scanning tunnelling microscope has become an important tool in surface science, and physics in general. Its primary use has been to obtain atomic-resolution images of surfaces, but recently, efforts have been made to use it to manipulate materials as well as image them. One may now reasonably ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/331324a0
更新日期:1988-01-28 00:00:00
abstract::Cell signalling through Frizzled receptors has evolved to considerable complexity within the metazoans. The Frizzled-dependent signalling cascade comprises several branches, whose differential activation depends on specific Wnt ligands, Frizzled receptor isoforms and the cellular context. In Xenopus laevis embryos, th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35101621
更新日期:2001-10-25 00:00:00
abstract::Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues. The phosphatase(s) involved in p34cdc2 dephosphorylation is unknown, but the product of the fission yeast...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/351242a0
更新日期:1991-05-16 00:00:00
abstract::The uranyl ion (UO22+; U(VI) oxidation state) is the most common form of uranium found in terrestrial and aquatic environments and is a central component in nuclear fuel processing and waste remediation efforts. Uranyl capture from either seawater or nuclear waste has been well studied and typically relies on extremel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1926-4
更新日期:2020-01-01 00:00:00
abstract::An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...
journal_title:Nature
pub_type: 评论,杂志文章
doi:10.1038/427802a
更新日期:2004-02-26 00:00:00
abstract::The battle for survival between bacteria and the viruses that infect them (phages) has led to the evolution of many bacterial defence systems and phage-encoded antagonists of these systems. Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated (cas) genes comprise an adaptive imm...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15254
更新日期:2015-10-01 00:00:00
abstract::Embryonic stem (ES) cells are pluripotent and characterized by open chromatin and high transcription levels, achieved through auto-regulatory and feed-forward transcription factor loops. ES-cell identity is maintained by a core of factors including Oct4 (also known as Pou5f1), Sox2, Klf4, c-Myc (OSKM) and Nanog, and f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11970
更新日期:2013-03-28 00:00:00
abstract::The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06423
更新日期:2007-12-13 00:00:00
abstract::One of the main unanswered questions in solar physics is why the Sun's outer atmosphere is hotter than its surface. Theory predicts abundant production of high-frequency (10-50 mHz) acoustic waves in subsurface layers of the Sun, and such waves are believed by many to constitute the dominant heating mechanism of the c...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03695
更新日期:2005-06-16 00:00:00
abstract::Polar molecules have a rich internal structure and long-range dipole-dipole interactions, making them useful for quantum-controlled applications and fundamental investigations. Their potential fully unfolds at ultracold temperatures, where various effects are predicted in many-body physics, quantum information science...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11595
更新日期:2012-11-22 00:00:00
abstract::Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivors of the acute event, larger non-functional scars adversely affect lo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04672
更新日期:2006-04-27 00:00:00
abstract::OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain assembly complex) and is critical for preventing auto-inflammatory disease1,2 and embryonic lethality during mouse development3. Here we show that OTULIN promo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0256-2
更新日期:2018-07-01 00:00:00
abstract::Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...
journal_title:Nature
pub_type: 信件
doi:10.1038/nature05732
更新日期:2007-04-19 00:00:00
abstract::Transfer RNA nucleotidyltransferases (CCA-adding enzymes) are responsible for the maturation or repair of the functional 3' end of tRNAs by means of the addition of the essential nucleotides CCA. However, it is unclear how tRNA nucleotidyltransferases polymerize CCA onto the 3' terminus of immature tRNAs without using...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02711
更新日期:2004-08-05 00:00:00
abstract::Diminishing fossil fuel reserves and growing concerns about global warming indicate that sustainable sources of energy are needed in the near future. For fuels to be useful in the transportation sector, they must have specific physical properties that allow for efficient distribution, storage and combustion; these pro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05923
更新日期:2007-06-21 00:00:00
abstract::The optimal water transport system in plants should maximize hydraulic conductance (which is proportional to photosynthesis) for a given investment in transport tissue. To investigate how this optimum may be achieved, we have performed computer simulations of the hydraulic conductance of a branched transport system. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01444
更新日期:2003-02-27 00:00:00