当前位置： SCI文献检索 > NATURE期刊下所有文献 > OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

Abstract：

:OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain assembly complex) and is critical for preventing auto-inflammatory disease1,2 and embryonic lethality during mouse development3. Here we show that OTULIN promotes rather than counteracts LUBAC activity by preventing its auto-ubiquitination with linear polyubiquitin. Thus, knock-in mice that express catalytically inactive OTULIN, either constitutively or selectively in endothelial cells, resembled LUBAC-deficient mice4 and died midgestation as a result of cell death mediated by TNFR1 (tumour necrosis factor receptor 1) and the kinase activity of RIPK1 (receptor-interacting protein kinase 1). Inactivation of OTULIN in adult mice also caused pro-inflammatory cell death. Accordingly, embryonic lethality and adult auto-inflammation were prevented by the combined loss of cell death mediators: caspase 8 for apoptosis and RIPK3 for necroptosis. Unexpectedly, OTULIN mutant mice that lacked caspase 8 and RIPK3 died in the perinatal period, exhibiting enhanced production of type I interferon that was dependent on RIPK1. Collectively, our results indicate that OTULIN and LUBAC function in a linear pathway, and highlight a previously unrecognized interaction between linear ubiquitination, regulators of cell death, and induction of type I interferon.

journal_name

Nature

journal_title

Nature

authors

Heger K,Wickliffe KE,Ndoja A,Zhang J,Murthy A,Dugger DL,Maltzman A,de Sousa E Melo F,Hung J,Zeng Y,Verschueren E,Kirkpatrick DS,Vucic D,Lee WP,Roose-Girma M,Newman RJ,Warming S,Hsiao YC,Kőműves LG,Webster JD,Newto

doi

10.1038/s41586-018-0256-2

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

120-124

issue

7712

eissn

0028-0836

issn

1476-4687

pii

10.1038/s41586-018-0256-2

journal_volume

559

pub_type

杂志文章

相关文献

NATURE文献大全
  • The accessible surface area and stability of oligomeric proteins.

    abstract：:Protein structures are stabilized by hydrophobic and van der Waals forces, and by hydrogen bonds. The relation between these thermodynamic quantities and the actual three-dimensional structure of proteins can not be calculated precisely. However, certain empirical relations have been discovered. Hydrophobic energy is ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/328834a0

    authors： Miller S,Lesk AM,Janin J,Chothia C

    更新日期：1987-08-27 00:00:00

  • Tumour maintenance is mediated by eNOS.

    abstract：:Tumour cells become addicted to the expression of initiating oncogenes like Ras, such that loss of oncogene expression in established tumours leads to tumour regression. HRas, NRas or KRas are mutated to remain in the active GTP-bound oncogenic state in many cancers. Although Ras activates several proteins to initiate...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature06778

    authors： Lim KH,Ancrile BB,Kashatus DF,Counter CM

    更新日期：2008-04-03 00:00:00

  • Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies.

    abstract：:In vitro studies of muscle mitochondrial metabolism in patients with mitochondrial myopathy have identified a variety of functional defects of the mitochondrial respiratory chain, predominantly affecting complex I (NADH-CoQ reductase) or complex III (ubiquinol-cytochrome c reductase) in adult cases. These two enzymes ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/331717a0

    authors： Holt IJ,Harding AE,Morgan-Hughes JA

    更新日期：1988-02-25 00:00:00

  • Sisyphus cooling of electrically trapped polyatomic molecules.

    abstract：:Polar molecules have a rich internal structure and long-range dipole-dipole interactions, making them useful for quantum-controlled applications and fundamental investigations. Their potential fully unfolds at ultracold temperatures, where various effects are predicted in many-body physics, quantum information science...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature11595

    authors： Zeppenfeld M,Englert BG,Glöckner R,Prehn A,Mielenz M,Sommer C,van Buuren LD,Motsch M,Rempe G

    更新日期：2012-11-22 00:00:00

  • Reconstitution of the tubular endoplasmic reticulum network with purified components.

    abstract：:Organelles display characteristic morphologies that are intimately tied to their cellular function, but how organelles are shaped is poorly understood. The endoplasmic reticulum is particularly intriguing, as it comprises morphologically distinct domains, including a dynamic network of interconnected membrane tubules....

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature21387

    authors： Powers RE,Wang S,Liu TY,Rapoport TA

    更新日期：2017-03-09 00:00:00

  • Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques.

    abstract：:The CD4 molecule is a high-affinity cell-surface receptor for the human immunodeficiency virus (HIV-1) and a soluble truncated form of CD4 produced by recombinant DNA technology is a potent inhibitor of HIV-1 replication and HIV-1-induced cell fusion in vitro. Rhesus monkeys infected with the simian immunodeficiency v...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/337267a0

    authors： Watanabe M,Reimann KA,DeLong PA,Liu T,Fisher RA,Letvin NL

    更新日期：1989-01-19 00:00:00

  • Wave-particle duality of C(60) molecules.

    abstract：:Quantum superposition lies at the heart of quantum mechanics and gives rise to many of its paradoxes. Superposition of de Broglie matter waves' has been observed for massive particles such as electrons, atoms and dimers, small van der Waals clusters, and neutrons. But matter wave interferometry with larger objects has...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/44348

    authors： Arndt M,Nairz O,Vos-Andreae J,Keller C,van der Zouw G,Zeilinger A

    更新日期：1999-10-14 00:00:00

  • Anisotropic spinodal dewetting as a route to self-assembly of patterned surfaces

    abstract：:The ability to pattern surfaces on a microscopic length scale is of importance for technological applications such as the fabrication of microelectronic circuits and digital storage media. Devices fabricated entirely from polymers are now available, opening up the possibility of adapting polymer processing technologie...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35006597

    authors： Higgins AM,Jones RA

    更新日期：2000-03-30 00:00:00

  • How snuggling close affects bats' microbiome.

    abstract：: ...

    journal_title：Nature

    pub_type： 新闻

    doi：10.1038/d41586-018-07706-1

    authors：

    更新日期：2018-12-01 00:00:00

  • The GTP-binding protein Ran/TC4 is required for protein import into the nucleus.

    abstract：:Two cytosolic fractions (A and B) from Xenopus oocytes are sufficient to support protein import into the nuclei of digitonin-permeabilized cells. Fraction A recognizes the nuclear localization sequence (NLS) and binds the import substrate to the nuclear envelope, whereas fraction B mediates the subsequent passage of t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/365661a0

    authors： Moore MS,Blobel G

    更新日期：1993-10-14 00:00:00

  • The Drosophila claret segregation protein is a minus-end directed motor molecule.

    abstract：:A product encoded at the claret locus in Drosophila is needed for normal chromosome segregation in meiosis in females and in early mitotic divisions of the embryo. The predicted amino-acid sequence of the segregation protein was shown recently to be strikingly similar to Drosophila kinesin heavy chain. We have express...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/347780a0

    authors： Walker RA,Salmon ED,Endow SA

    更新日期：1990-10-25 00:00:00

  • Stress changes from the 2008 Wenchuan earthquake and increased hazard in the Sichuan basin.

    abstract：:On 12 May 2008, the devastating magnitude 7.9 (Wenchuan) earthquake struck the eastern edge of the Tibetan plateau, collapsing buildings and killing thousands in major cities aligned along the western Sichuan basin in China. After such a large-magnitude earthquake, rearrangement of stresses in the crust commonly leads...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature07177

    authors： Parsons T,Ji C,Kirby E

    更新日期：2008-07-24 00:00:00

  • Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma.

    abstract：:The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online. ...

    journal_title：Nature

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41586-019-0959-z

    authors： Hilf N,Kuttruff-Coqui S,Frenzel K,Bukur V,Stevanović S,Gouttefangeas C,Platten M,Tabatabai G,Dutoit V,van der Burg SH,Straten PT,Martinez-Ricarte F,Ponsati B,Okada H,Lassen U,Admon A,Ottensmeier CH,Ulges A,Kreiter S,

    更新日期：2019-02-01 00:00:00

  • Substantial reservoirs of molecular hydrogen in the debris disks around young stars.

    abstract：:Circumstellar accretion disks transfer matter from molecular clouds to young stars and to the sites of planet formation. The disks observed around pre-main-sequence stars have properties consistent with those expected for the pre-solar nebula from which our own Solar System formed 4.5 Gyr ago. But the 'debris' disks t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35051033

    authors： Thi WF,Blake GA,van Dishoeck EF,van Zadelhoff GJ,Horn JM,Becklin EE,Mannings V,Sargent AI,van Den Ancker ME,Natta A

    更新日期：2001-01-04 00:00:00

  • Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases.

    abstract：:Holliday junctions (HJs) are key intermediates in homologous recombination and are especially important for the production of crossover recombinants. Bacterial RecA family proteins promote the formation and branch migration of HJs in vitro by catalysing a reciprocal DNA-strand exchange reaction between two duplex DNA ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature06609

    authors： Murayama Y,Kurokawa Y,Mayanagi K,Iwasaki H

    更新日期：2008-02-21 00:00:00

  • Total synthesis and isolation of citrinalin and cyclopiamine congeners.

    abstract：:Many natural products that contain basic nitrogen atoms--for example alkaloids like morphine and quinine-have the potential to treat a broad range of human diseases. However, the presence of a nitrogen atom in a target molecule can complicate its chemical synthesis because of the basicity of nitrogen atoms and their s...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature13273

    authors： Mercado-Marin EV,Garcia-Reynaga P,Romminger S,Pimenta EF,Romney DK,Lodewyk MW,Williams DE,Andersen RJ,Miller SJ,Tantillo DJ,Berlinck RGS,Sarpong R

    更新日期：2014-05-15 00:00:00

  • Neural circuitry linking mating and egg laying in Drosophila females.

    abstract：:Mating and egg laying are tightly cooordinated events in the reproductive life of all oviparous females. Oviposition is typically rare in virgin females but is initiated after copulation. Here we identify the neural circuitry that links egg laying to mating status in Drosophila melanogaster. Activation of female-speci...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2055-9

    authors： Wang F,Wang K,Forknall N,Patrick C,Yang T,Parekh R,Bock D,Dickson BJ

    更新日期：2020-03-01 00:00:00

  • Structural basis for the final steps of human 40S ribosome maturation.

    abstract：:Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2. Small subunit maturation ends in the cytosol, when the...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-020-2929-x

    authors： Ameismeier M,Zemp I,van den Heuvel J,Thoms M,Berninghausen O,Kutay U,Beckmann R

    更新日期：2020-11-01 00:00:00

  • Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.

    abstract：:Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/349388a0

    authors： Broek D,Bartlett R,Crawford K,Nurse P

    更新日期：1991-01-31 00:00:00

  • The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S.

    abstract：:The 2.2 A crystal structure of activated rod transducin, Gt alpha.GTP gamma S, shows the bound GTP gamma S molecule occluded deep in a cleft between a domain structurally homologous to small GTPases and a helical domain unique to heterotrimeric G proteins. The structure, when combined with biochemical and genetic stud...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/366654a0

    authors： Noel JP,Hamm HE,Sigler PB

    更新日期：1993-12-16 00:00:00

  • Fast heating of ultrahigh-density plasma as a step towards laser fusion ignition.

    abstract：:Modern high-power lasers can generate extreme states of matter that are relevant to astrophysics, equation-of-state studies and fusion energy research. Laser-driven implosions of spherical polymer shells have, for example, achieved an increase in density of 1,000 times relative to the solid state. These densities are ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/35090525

    authors： Kodama R,Norreys PA,Mima K,Dangor AE,Evans RG,Fujita H,Kitagawa Y,Krushelnick K,Miyakoshi T,Miyanaga N,Norimatsu T,Rose SJ,Shozaki T,Shigemori K,Sunahara A,Tampo M,Tanaka KA,Toyama Y,Yamanaka T,Zepf M

    更新日期：2001-08-23 00:00:00

  • New Miocene locality in Turkey with evidence on the origin of Ramapithecus and Sivapithecus.

    abstract：:Collections in early Middle Miocene deposits at Pasalar in Turkey have yielded a very rich fauna. Included in this are two hominoid species referred here to Sivapithecus darwini (Abel) 1902 and Ramapithecus wickeri (Leakey) 1962. These are both more primitive morphologically and earlier in time than other species of t...

    journal_title：Nature

    pub_type： 历史文章,杂志文章

    doi：10.1038/268699a0

    authors： Andrews P,Tobien H

    更新日期：1977-08-25 00:00:00

  • The contribution of China's emissions to global climate forcing.

    abstract：:Knowledge of the contribution that individual countries have made to global radiative forcing is important to the implementation of the agreement on "common but differentiated responsibilities" reached by the United Nations Framework Convention on Climate Change. Over the past three decades, China has experienced rapi...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature17165

    authors： Li B,Gasser T,Ciais P,Piao S,Tao S,Balkanski Y,Hauglustaine D,Boisier JP,Chen Z,Huang M,Li LZ,Li Y,Liu H,Liu J,Peng S,Shen Z,Sun Z,Wang R,Wang T,Yin G,Yin Y,Zeng H,Zeng Z,Zhou F

    更新日期：2016-03-17 00:00:00

  • Anaerobic microbial metabolism can proceed close to thermodynamic limits.

    abstract：:Many fermentative bacteria obtain energy for growth by reactions in which the change in free energy (DeltaG') is less than that needed to synthesize ATP. These bacteria couple substrate metabolism directly to ATP synthesis, however, by classical phosphoryl transfer reactions. An explanation for the energy economy of t...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/415454a

    authors： Jackson BE,McInerney MJ

    更新日期：2002-01-24 00:00:00

  • HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

    abstract：:Endochondral ossification, an important process in vertebrate bone formation, is highly dependent on correct functioning of growth plate chondrocytes1. Proliferation of these cells determines longitudinal bone growth and the matrix deposited provides a scaffold for future bone formation. However, these two energy-depe...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-0874-3

    authors： Stegen S,Laperre K,Eelen G,Rinaldi G,Fraisl P,Torrekens S,Van Looveren R,Loopmans S,Bultynck G,Vinckier S,Meersman F,Maxwell PH,Rai J,Weis M,Eyre DR,Ghesquière B,Fendt SM,Carmeliet P,Carmeliet G

    更新日期：2019-01-01 00:00:00

  • Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.

    abstract：:The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical ...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature07763

    authors： Taufiq-Ur-Rahman,Skupin A,Falcke M,Taylor CW

    更新日期：2009-04-02 00:00:00

  • Anatase TiO2 single crystals with a large percentage of reactive facets.

    abstract：:Owing to their scientific and technological importance, inorganic single crystals with highly reactive surfaces have long been studied. Unfortunately, surfaces with high reactivity usually diminish rapidly during the crystal growth process as a result of the minimization of surface energy. A typical example is titaniu...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature06964

    authors： Yang HG,Sun CH,Qiao SZ,Zou J,Liu G,Smith SC,Cheng HM,Lu GQ

    更新日期：2008-05-29 00:00:00

  • A 3.8-million-year-old hominin cranium from Woranso-Mille, Ethiopia.

    abstract：:The cranial morphology of the earliest known hominins in the genus Australopithecus remains unclear. The oldest species in this genus (Australopithecus anamensis, specimens of which have been dated to 4.2-3.9 million years ago) is known primarily from jaws and teeth, whereas younger species (dated to 3.5-2.0 million y...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/s41586-019-1513-8

    authors： Haile-Selassie Y,Melillo SM,Vazzana A,Benazzi S,Ryan TM

    更新日期：2019-09-01 00:00:00

  • Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels.

    abstract：:Haem is essential for living organisms, functioning as a crucial element in the redox-sensitive reaction centre in haemproteins. During the biogenesis of these proteins, the haem cofactor is typically incorporated enzymatically into the haem pockets of the apo-haemprotein as the functionally indispensable prosthetic g...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/nature02003

    authors： Tang XD,Xu R,Reynolds MF,Garcia ML,Heinemann SH,Hoshi T

    更新日期：2003-10-02 00:00:00

  • Structure of the cro repressor from bacteriophage lambda and its interaction with DNA.

    abstract：:The three-dimensional structure of the 66-amino acid cro repressor protein of bacteriophage lambda suggests how it binds to its operator DNA. We propose that a dimer of cro protein is bound to the B-form of DNA with the 2-fold axis of the dimer coincident with the 2-fold axis of DNA. A pair of 2-fold-related alpha-hel...

    journal_title：Nature

    pub_type： 杂志文章

    doi：10.1038/290754a0

    authors： Anderson WF,Ohlendorf DH,Takeda Y,Matthews BW

    更新日期：1981-04-30 00:00:00