Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates.

abstract：:7SL RNA is an abundant cytoplasmic RNA which functions in protein secretion as a component of the signal recognition particle. Alu sequences are the most abundant family of human and rodent middle repetitive DNA sequences (reviewed in ref. 2). The primary structure of human 7SL RNA consists of an Alu sequence interrup...

journal_title：Nature

authors： Ullu E,Tschudi C

更新日期：1984-11-08 00:00:00

abstract：:Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppre...

journal_title：Nature

authors： Png KJ,Halberg N,Yoshida M,Tavazoie SF

更新日期：2011-12-14 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:The Ndc80 complex is a key site of regulated kinetochore-microtubule attachment (a process required for cell division), but the molecular mechanism underlying its function remains unknown. Here we present a subnanometre-resolution cryo-electron microscopy reconstruction of the human Ndc80 complex bound to microtubules...

journal_title：Nature

authors： Alushin GM,Ramey VH,Pasqualato S,Ball DA,Grigorieff N,Musacchio A,Nogales E

更新日期：2010-10-14 00:00:00

abstract：:The primary action of a family of mitogens including bombesin, bradykinin, vasopressin and alpha-thrombin is to activate the hydrolysis of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phospholipase C is mediated through coupling of surface receptors to a GTP-binding pro...

journal_title：Nature

authors： Chambard JC,Paris S,L'Allemain G,Pouysségur J

更新日期：1987-04-23 00:00:00

abstract：:The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation ...

journal_title：Nature

authors： Marmottant P,Hilgenfeldt S

更新日期：2003-05-08 00:00:00

abstract：:Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a compl...

journal_title：Nature

authors： Perry JR,Day F,Elks CE,Sulem P,Thompson DJ,Ferreira T,He C,Chasman DI,Esko T,Thorleifsson G,Albrecht E,Ang WQ,Corre T,Cousminer DL,Feenstra B,Franceschini N,Ganna A,Johnson AD,Kjellqvist S,Lunetta KL,McMahon G,N

更新日期：2014-10-02 00:00:00

abstract：:The surfaces of Earth and Mars contain large bedrock canyons that were carved by catastrophic outburst floods. Reconstructing the magnitude of these canyon-forming floods is essential for understanding the ways in which floods modify planetary surfaces, the hydrology of early Mars and abrupt changes in climate. Flood ...

journal_title：Nature

authors： Larsen IJ,Lamb MP

更新日期：2016-10-13 00:00:00

abstract：:Genetic models predict that genomic rearrangement in hybrids can facilitate reproductive isolation and the formation of new species by preventing gene flow between the parent species and hybrid (sunflowers are an example). The mechanism underlying hybridization-induced chromosome remodelling is as yet unknown, althoug...

journal_title：Nature

authors： O'Neill RJ,O'Neill MJ,Graves JA

更新日期：1998-05-07 00:00:00

abstract：:Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross...

journal_title：Nature

authors： Maser RS,Choudhury B,Campbell PJ,Feng B,Wong KK,Protopopov A,O'Neil J,Gutierrez A,Ivanova E,Perna I,Lin E,Mani V,Jiang S,McNamara K,Zaghlul S,Edkins S,Stevens C,Brennan C,Martin ES,Wiedemeyer R,Kabbarah O,Noguei

更新日期：2007-06-21 00:00:00

abstract：:The increasing ability to control light-matter interactions at the nanometre scale has improved the performance of semiconductor lasers in the past decade. The ultimate optimization is realized in semiconductor microcavities, in which strong coupling between quantum-well excitons and cavity photons gives rise to hybri...

journal_title：Nature

authors： Tsintzos SI,Pelekanos NT,Konstantinidis G,Hatzopoulos Z,Savvidis PG

更新日期：2008-05-15 00:00:00

abstract：:With the world's focus on reducing our dependency on fossil-fuel energy, the scientific community can investigate new plastic materials that are much less dependent on petroleum than are conventional plastics. Given increasing environmental issues, the idea of replacing plastics with water-based gels, so-called hydrog...

journal_title：Nature

authors： Wang Q,Mynar JL,Yoshida M,Lee E,Lee M,Okuro K,Kinbara K,Aida T

更新日期：2010-01-21 00:00:00

abstract：:Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues. The phosphatase(s) involved in p34cdc2 dephosphorylation is unknown, but the product of the fission yeast...

journal_title：Nature

authors： Strausfeld U,Labbé JC,Fesquet D,Cavadore JC,Picard A,Sadhu K,Russell P,Dorée M

更新日期：1991-05-16 00:00:00

abstract：:Recent computational and psychological theories of human texture vision assert that texture discrimination is based on first-order differences in geometric and luminance attributes of texture elements, called 'textons'. Significant differences in the density, orientation, size, or contrast of line segments or other sm...

journal_title：Nature

authors： Voorhees H,Poggio T

更新日期：1988-05-26 00:00:00

abstract：:Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...

journal_title：Nature

authors： Ueda HR,Chen W,Adachi A,Wakamatsu H,Hayashi S,Takasugi T,Nagano M,Nakahama K,Suzuki Y,Sugano S,Iino M,Shigeyoshi Y,Hashimoto S

更新日期：2002-08-01 00:00:00

abstract：:In nature, organisms are exposed to chronic low-dose ultraviolet light (CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA repair by the nucleotide excision repair pathway and for checkpoin...

journal_title：Nature

authors： Hishida T,Kubota Y,Carr AM,Iwasaki H

更新日期：2009-01-29 00:00:00

abstract：:Living cells regulate the activity of their ion channels through a process known as gating. To open the pore, protein conformational changes must occur within a channel's membrane-spanning ion pathway. KcsA and MthK, closed and opened K(+) channels, respectively, reveal how such gating transitions occur. Pore-lining '...

journal_title：Nature

authors： Jiang Y,Lee A,Chen J,Cadene M,Chait BT,MacKinnon R

更新日期：2002-05-30 00:00:00

abstract：:Chronic myeloid leukaemia (CML) is caused by a defined genetic abnormality that generates BCR-ABL, a constitutively active tyrosine kinase. It is widely believed that BCR-ABL activates Akt signalling that suppresses the forkhead O transcription factors (FOXO), supporting the proliferation or inhibiting the apoptosis o...

journal_title：Nature

authors： Naka K,Hoshii T,Muraguchi T,Tadokoro Y,Ooshio T,Kondo Y,Nakao S,Motoyama N,Hirao A

更新日期：2010-02-04 00:00:00

abstract：:De novo-designed proteins1-3 hold great promise as building blocks for synthetic circuits, and can complement the use of engineered variants of natural proteins4-7. One such designer protein-degronLOCKR, which is based on 'latching orthogonal cage-key proteins' (LOCKR) technology8-is a switch that degrades a protein o...

journal_title：Nature

authors： Ng AH,Nguyen TH,Gómez-Schiavon M,Dods G,Langan RA,Boyken SE,Samson JA,Waldburger LM,Dueber JE,Baker D,El-Samad H

更新日期：2019-08-01 00:00:00

abstract：:Experimental realization of a universal set of quantum logic gates is the central requirement for the implementation of a quantum computer. In an 'all-geometric' approach to quantum computation, the quantum gates are implemented using Berry phases and their non-Abelian extensions, holonomies, from geometric transforma...

journal_title：Nature

authors： Zu C,Wang WB,He L,Zhang WG,Dai CY,Wang F,Duan LM

更新日期：2014-10-02 00:00:00

abstract：:In a very short time the scanning tunnelling microscope has become an important tool in surface science, and physics in general. Its primary use has been to obtain atomic-resolution images of surfaces, but recently, efforts have been made to use it to manipulate materials as well as image them. One may now reasonably ...

journal_title：Nature

authors： Foster JS,Frommer JE,Arnett PC

更新日期：1988-01-28 00:00:00

abstract：:A cholecystokinin (CCK)-inactivating peptidase was purified and identified as a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10), a cytosolic subtilisin-like peptidase of previously unknown functions. The peptidase was found in neurons responding to cholecystokinin, as well as in non-neuronal cells. B...

journal_title：Nature

authors： Rose C,Vargas F,Facchinetti P,Bourgeat P,Bambal RB,Bishop PB,Chan SM,Moore AN,Ganellin CR,Schwartz JC

更新日期：1996-04-04 00:00:00

abstract：:Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has recently been shown to have a critical role in packaging DNA into chromatin following DNA replication and repair in budding yeast. However, the function or occurrence of this specific histone mark has not been studied in multicellular e...

journal_title：Nature

authors： Das C,Lucia MS,Hansen KC,Tyler JK

更新日期：2009-05-07 00:00:00

abstract：:Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine confers an additio...

journal_title：Nature

authors： Corder R,Douthwaite JA,Lees DM,Khan NQ,Viseu Dos Santos AC,Wood EG,Carrier MJ

更新日期：2001-12-20 00:00:00

abstract：:Oxygen, one of the most abundant elements on Earth, often forms an undesired interstitial impurity or ceramic phase (such as an oxide particle) in metallic materials. Even when it adds strength, oxygen doping renders metals brittle1-3. Here we show that oxygen can take the form of ordered oxygen complexes, a state in ...

journal_title：Nature

authors： Lei Z,Liu X,Wu Y,Wang H,Jiang S,Wang S,Hui X,Wu Y,Gault B,Kontis P,Raabe D,Gu L,Zhang Q,Chen H,Wang H,Liu J,An K,Zeng Q,Nieh TG,Lu Z

更新日期：2018-11-01 00:00:00

abstract：:The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average d...

journal_title：Nature

authors： Lasonder E,Ishihama Y,Andersen JS,Vermunt AM,Pain A,Sauerwein RW,Eling WM,Hall N,Waters AP,Stunnenberg HG,Mann M

更新日期：2002-10-03 00:00:00

abstract：:Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. In p...

journal_title：Nature

authors： Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR

更新日期：2017-09-28 00:00:00

abstract：:Muscle force is generated by myosin crossbridges interacting with actin. As estimated from stiffness and equatorial X-ray diffraction of muscle and muscle fibres, most myosin crossbridges are attached to actin during isometric contraction, but a much smaller fraction is bound stereospecifically. To determine the fract...

journal_title：Nature

authors： Bershitsky SY,Tsaturyan AK,Bershitskaya ON,Mashanov GI,Brown P,Burns R,Ferenczi MA

更新日期：1997-07-10 00:00:00

abstract：:The species diversity of natural communities is often strongly related to their productivity. The pattern of this relationship seems to vary: diversity is known to increase monotonically with productivity, to decrease monotonically with productivity, and to be unimodally related to productivity, with maximum diversity...

journal_title：Nature

authors： Kassen R,Buckling A,Bell G,Rainey PB

更新日期：2000-08-03 00:00:00

abstract：:More than 30 years ago, human beings looked back from the Moon to see the magnificent spectacle of Earth-rise. The technology that put us into space has since been used to assess the damage we are doing to our natural environment and is now being harnessed to monitor and predict diseases through space and time. Satell...

journal_title：Nature

authors： Rogers DJ,Randolph SE,Snow RW,Hay SI

更新日期：2002-02-07 00:00:00