Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.

abstract：:The species diversity of natural communities is often strongly related to their productivity. The pattern of this relationship seems to vary: diversity is known to increase monotonically with productivity, to decrease monotonically with productivity, and to be unimodally related to productivity, with maximum diversity...

journal_title：Nature

authors： Kassen R,Buckling A,Bell G,Rainey PB

更新日期：2000-08-03 00:00:00

abstract：:Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show that presenilin-1 forms a complex with beta-catenin in vivo that incr...

journal_title：Nature

authors： Zhang Z,Hartmann H,Do VM,Abramowski D,Sturchler-Pierrat C,Staufenbiel M,Sommer B,van de Wetering M,Clevers H,Saftig P,De Strooper B,He X,Yankner BA

更新日期：1998-10-15 00:00:00

abstract：:The Indian Ocean dipole is a prominent mode of coupled ocean-atmosphere variability, affecting the lives of millions of people in Indian Ocean rim countries. In its positive phase, sea surface temperatures are lower than normal off the Sumatra-Java coast, but higher in the western tropical Indian Ocean. During the ext...

journal_title：Nature

authors： Cai W,Santoso A,Wang G,Weller E,Wu L,Ashok K,Masumoto Y,Yamagata T

更新日期：2014-06-12 00:00:00

abstract：: ...

journal_title：Nature

authors： Díaz RF

更新日期：2018-11-01 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiation and maintenance of several inflammatory respons...

journal_title：Nature

authors： Carvelli J,Demaria O,Vély F,Batista L,Chouaki Benmansour N,Fares J,Carpentier S,Thibult ML,Morel A,Remark R,André P,Represa A,Piperoglou C,Explore COVID-19 IPH group.,Explore COVID-19 Marseille Immunopole group.,Cordier PY

更新日期：2020-12-01 00:00:00

abstract：:In the era of precision cosmology, it is essential to determine the Hubble constant empirically with an accuracy of one per cent or better1. At present, the uncertainty on this constant is dominated by the uncertainty in the calibration of the Cepheid period-luminosity relationship2,3 (also known as the Leavitt law). ...

journal_title：Nature

authors： Pietrzyński G,Graczyk D,Gallenne A,Gieren W,Thompson IB,Pilecki B,Karczmarek P,Górski M,Suchomska K,Taormina M,Zgirski B,Wielgórski P,Kołaczkowski Z,Konorski P,Villanova S,Nardetto N,Kervella P,Bresolin F,Kudritzki RP

更新日期：2019-03-01 00:00:00

abstract：:Insulin is the primary hormone involved in glucose homeostasis, and impairment of insulin action and/or secretion has a critical role in the pathogenesis of diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or 'SHIP2', is a member of the inositol polyphosphate 5-phosphatase family. In vitro stud...

journal_title：Nature

authors： Clément S,Krause U,Desmedt F,Tanti JF,Behrends J,Pesesse X,Sasaki T,Penninger J,Doherty M,Malaisse W,Dumont JE,Le Marchand-Brustel Y,Erneux C,Hue L,Schurmans S

更新日期：2001-01-04 00:00:00

abstract：:The age of dense interstellar cloud cores, where stars and planets form, is a crucial parameter in star formation and difficult to measure. Some models predict rapid collapse, whereas others predict timescales of more than one million years (ref. 3). One possible approach to determining the age is through chemical cha...

journal_title：Nature

authors： Brünken S,Sipilä O,Chambers ET,Harju J,Caselli P,Asvany O,Honingh CE,Kamiński T,Menten KM,Stutzki J,Schlemmer S

更新日期：2014-12-11 00:00:00

abstract：:Suppressor of cytokine signalling-2 (SOCS-2) is a member of the suppressor of cytokine signalling family, a group of related proteins implicated in the negative regulation of cytokine action through inhibition of the Janus kinase (JAK) signal transducers and activators of transcription (STAT) signal-transduction pathw...

journal_title：Nature

authors： Metcalf D,Greenhalgh CJ,Viney E,Willson TA,Starr R,Nicola NA,Hilton DJ,Alexander WS

更新日期：2000-06-29 00:00:00

abstract：:The study of planarian regeneration may help us to understand how we can rebuild organs and tissues after injury, disease or ageing. The robust regenerative abilities of planarians are based upon a population of totipotent stem cells (neoblasts), and among the organs regenerated by these animals is a well-organized ce...

journal_title：Nature

authors： Cebrià F,Kobayashi C,Umesono Y,Nakazawa M,Mineta K,Ikeo K,Gojobori T,Itoh M,Taira M,Sánchez Alvarado A,Agata K

更新日期：2002-10-10 00:00:00

abstract：:The behaviour of electrons in solids is well described by Landau's Fermi-liquid theory, which predicts that although electrons in a metal interact, they can still be treated as well defined fermions, which are called 'quasiparticles'. At low temperatures, the ability of quasiparticles to transport heat is given strict...

journal_title：Nature

authors： Hill RW,Proust C,Taillefer L,Fournier P,Greene RL

更新日期：2001-12-13 00:00:00

abstract：:Tuberculosis is the leading cause of death in the world resulting from a single bacterial infection. Despite its enormous burden on world health, little is known about the molecular mechanisms of pathogenesis of Mycobacterium tuberculosis. Bacterial multiplication and concomitant tissue damage within an infected host,...

journal_title：Nature

authors： Cox JS,Chen B,McNeil M,Jacobs WR Jr

更新日期：1999-11-04 00:00:00

abstract：:Long before infants reach, crawl or walk, they explore the world by looking: they look to learn and to engage, giving preferential attention to social stimuli, including faces, face-like stimuli and biological motion. This capacity-social visual engagement-shapes typical infant development from birth and is pathognomo...

journal_title：Nature

authors： Constantino JN,Kennon-McGill S,Weichselbaum C,Marrus N,Haider A,Glowinski AL,Gillespie S,Klaiman C,Klin A,Jones W

更新日期：2017-07-20 00:00:00

abstract：:In platelets, agonists that stimulate phosphoinositide turnover cause the rapid phosphorylation of a protein of apparent relative molecular mass (Mr) 40-47,000, called P47, by protein kinase C (PKC). Diverse identities have been ascribed to P47 including lipocortin, inositol 1,4,5-trisphosphate 5-phosphomonoesterase, ...

journal_title：Nature

authors： Tyers M,Rachubinski RA,Stewart MI,Varrichio AM,Shorr RG,Haslam RJ,Harley CB

更新日期：1988-06-02 00:00:00

abstract：:Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which encodes a vital negative regulatory molecule of the immune system--as can...

journal_title：Nature

authors： Ueda H,Howson JM,Esposito L,Heward J,Snook H,Chamberlain G,Rainbow DB,Hunter KM,Smith AN,Di Genova G,Herr MH,Dahlman I,Payne F,Smyth D,Lowe C,Twells RC,Howlett S,Healy B,Nutland S,Rance HE,Everett V,Smink LJ,L

更新日期：2003-05-29 00:00:00

abstract：:Deoxygenated sickle haemoglobin polymerizes into long 210-A diameter fibres that distort and decrease the deformability of red blood cells, and cause sickle cell disease. The fibres consist of seven intertwined double strands. They can form birefringent nematic liquid crystals (tactoids) and spherulites. Rheologically...

journal_title：Nature

authors： Samuel RE,Salmon ED,Briehl RW

更新日期：1990-06-28 00:00:00

abstract：:During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...

journal_title：Nature

authors： Forchhammer K,Leinfelder W,Böck A

更新日期：1989-11-23 00:00:00

abstract：:Fullerenes are graphitic cage structures incorporating exactly twelve pentagons. The smallest possible fullerene is thus C20, which consists solely of pentagons. But the extreme curvature and reactivity of this structure have led to doubts about its existence and stability. Although theoretical calculations have ident...

journal_title：Nature

authors： Prinzbach H,Weiler A,Landenberger P,Wahl F,Worth J,Scott LT,Gelmont M,Olevano D,v. Issendorff B

更新日期：2000-09-07 00:00:00

abstract：:Most Oryza sativa cultivars die within a week of complete submergence--a major constraint to rice production in south and southeast Asia that causes annual losses of over US 1 billion dollars and affects disproportionately the poorest farmers in the world. A few cultivars, such as the O. sativa ssp. indica cultivar FR...

journal_title：Nature

authors： Xu K,Xu X,Fukao T,Canlas P,Maghirang-Rodriguez R,Heuer S,Ismail AM,Bailey-Serres J,Ronald PC,Mackill DJ

更新日期：2006-08-10 00:00:00

abstract：:Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...

journal_title：Nature

authors： Pakmor R,Kromer M,Röpke FK,Sim SA,Ruiter AJ,Hillebrandt W

更新日期：2010-01-07 00:00:00

abstract：:First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biol...

journal_title：Nature

authors： Small EM,Olson EN

更新日期：2011-01-20 00:00:00

abstract：:Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...

journal_title：Nature

authors： Primakoff P,Lathrop W,Woolman L,Cowan A,Myles D

更新日期：1988-10-06 00:00:00

abstract：:During the fission yeast cell cycle, the rate of polyadenylated messenger RNA synthesis doubles when the cell reaches a critical size. This size-related control maintains average mRNA content in balance with total cell mass during exponential growth, even in cells growing at different absolute growth rates per cell. ...

journal_title：Nature

authors： Fraser RS,Nurse P

更新日期：1978-02-23 00:00:00

abstract：:Some Pacific island societies, such as those of Easter Island and Mangareva, inadvertently contributed to their own collapse by causing massive deforestation. Others retained forest cover and survived. How can those fateful differences be explained? Although the answers undoubtedly involve both different cultural resp...

journal_title：Nature

authors： Rolett B,Diamond J

更新日期：2004-09-23 00:00:00

abstract：:Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...

journal_title：Nature

authors： Toms DJ

更新日期：2010-11-04 00:00:00

abstract：:The biological importance of DNA methylation for gene expression in eukaryotes is becoming increasingly evident, and a direct role of methylation in gene expression has been suggested by an analysis of the infectivity of integrated retroviral genomes in a transfection assay. These studies, however, did not address whe...

journal_title：Nature

authors： Simon D,Stuhlmann H,Jähner D,Wagner H,Werner E,Jaenisch R

更新日期：1983-07-21 00:00:00

abstract：:In associative learning, the activated neurones undergo a variety of concomitant functional alterations--increases or decreases of firing activity and modifications of membrane potential or resistance and of synaptic responsiveness. Synaptic transmission which can be strengthened only when there is paired activity in ...

journal_title：Nature

authors： Baranyi A,Fehér O

更新日期：1981-04-02 00:00:00

abstract：:Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...

journal_title：Nature

authors： Yang CH,Leon RCC,Hwang JCC,Saraiva A,Tanttu T,Huang W,Camirand Lemyre J,Chan KW,Tan KY,Hudson FE,Itoh KM,Morello A,Pioro-Ladrière M,Laucht A,Dzurak AS

更新日期：2020-04-01 00:00:00

abstract：:High-energy cosmic-ray electrons and positrons (CREs), which lose energy quickly during their propagation, provide a probe of Galactic high-energy processes and may enable the observation of phenomena such as dark-matter particle annihilation or decay. The CRE spectrum has been measured directly up to approximately 2 ...

journal_title：Nature

authors： DAMPE Collaboration.

更新日期：2017-12-07 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeats (CRISPR)-associated enzyme Cas9 is an RNA-guided endonuclease that uses RNA-DNA base-pairing to target foreign DNA in bacteria. Cas9-guide RNA complexes are also effective genome engineering agents in animals and plants. Here we use single-molecule and bulk...

journal_title：Nature

authors： Sternberg SH,Redding S,Jinek M,Greene EC,Doudna JA

更新日期：2014-03-06 00:00:00