GAL4-VP16 is an unusually potent transcriptional activator.

abstract：:Viruses are the most abundant biological organisms of the world's oceans. Viral infections are a substantial source of mortality in a range of organisms-including autotrophic and heterotrophic plankton-but their impact on the deep ocean and benthic biosphere is completely unknown. Here we report that viral production ...

journal_title：Nature

authors： Danovaro R,Dell'Anno A,Corinaldesi C,Magagnini M,Noble R,Tamburini C,Weinbauer M

更新日期：2008-08-28 00:00:00

abstract：:Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its mai...

journal_title：Nature

authors： Scita G,Di Fiore PP

更新日期：2010-01-28 00:00:00

abstract：:Uptake of glutamate into glial cells in the CNS maintains the extracellular glutamate concentration below neurotoxic levels and helps terminate its action as a neurotransmitter. The co-transport of two sodium ions on the glutamate carrier is thought to provide the energy needed to transport glutamate into cells. We ha...

journal_title：Nature

authors： Barbour B,Brew H,Attwell D

更新日期：1988-09-29 00:00:00

abstract：:Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma. We have used zebrafish...

journal_title：Nature

authors： White RM,Cech J,Ratanasirintrawoot S,Lin CY,Rahl PB,Burke CJ,Langdon E,Tomlinson ML,Mosher J,Kaufman C,Chen F,Long HK,Kramer M,Datta S,Neuberg D,Granter S,Young RA,Morrison S,Wheeler GN,Zon LI

更新日期：2011-03-24 00:00:00

abstract：:Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 s...

journal_title：Nature

authors： Kawano M,Hirano T,Matsuda T,Taga T,Horii Y,Iwato K,Asaoku H,Tang B,Tanabe O,Tanaka H

更新日期：1988-03-03 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha) is a mitogenically active polypeptide hormone produced by acutely proliferating neoplastic and embryonic tissues. Molecular cloning of TGF-alpha cDNA from human and rat has indicated that this factor is synthesized as part of a larger precursor, proTGF-alpha. An intriguing ...

journal_title：Nature

authors： Teixidó J,Gilmore R,Lee DC,Massagué J

更新日期：1987-04-30 00:00:00

abstract：:RNA ligases have essential roles in many cellular processes in eukaryotes, archaea and bacteria, including in RNA repair and stress-induced splicing of messenger RNA. In archaea and eukaryotes, RNA ligases also have a role in transfer RNA splicing to generate functional tRNAs required for protein synthesis. We recentl...

journal_title：Nature

authors： Popow J,Jurkin J,Schleiffer A,Martinez J

更新日期：2014-07-03 00:00:00

abstract：:THE mouse H19 gene encodes one of the most abundant RNAs in the developing mouse embryo. It is expressed at the blastocyst stage of development, and accumulates to high levels in tissues of endodermal and mesodermal origin (H. Kim, unpublished result). After birth the gene is expressed in all tissues except skeletal m...

journal_title：Nature

authors： Bartolomei MS,Zemel S,Tilghman SM

更新日期：1991-05-09 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Seafloor spreading is largely unobserved because 98 per cent of the global mid-ocean-ridge system is below the ocean surface. Our understanding of the dynamic processes that control seafloor spreading is thus inferred largely from geophysical observations of spreading events on land at Afar in East Africa and Iceland....

journal_title：Nature

authors： Tan YJ,Tolstoy M,Waldhauser F,Wilcock WS

更新日期：2016-12-08 00:00:00

abstract：: ...

journal_title：Nature

authors： Payne D

更新日期：2018-11-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutralizing activity that can protect against infection in animal models1,2. Antibody ...

journal_title：Nature

authors： Gaebler C,Wang Z,Lorenzi JCC,Muecksch F,Finkin S,Tokuyama M,Cho A,Jankovic M,Schaefer-Babajew D,Oliveira TY,Cipolla M,Viant C,Barnes CO,Bram Y,Breton G,Hägglöf T,Mendoza P,Hurley A,Turroja M,Gordon K,Millard KG,

更新日期：2021-01-18 00:00:00

abstract：:The c-myc gene product is a nuclear protein expressed in a wide variety of cell types. It has been implicated in the control of normal cell growth as well as transformation, but its exact function is unknown. When the human promyelocytic leukaemia cell line HL60 is treated with retinoic acid, the cells differentiate i...

journal_title：Nature

authors： Bentley DL,Groudine M

更新日期：1986-06-12 00:00:00

abstract：:The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...

journal_title：Nature

authors： Vogel US,Dixon RA,Schaber MD,Diehl RE,Marshall MS,Scolnick EM,Sigal IS,Gibbs JB

更新日期：1988-09-01 00:00:00

abstract：:Most species live in species-rich food webs; yet, for a century, most mathematical models for population dynamics have included only one or two species. We ask whether such models are relevant to the real world. Two-species population models of an interacting consumer and resource collapse to one-species dynamics when...

journal_title：Nature

authors： Murdoch WW,Kendall BE,Nisbet RM,Briggs CJ,McCauley E,Bolser R

更新日期：2002-05-30 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:The growth and differentiation of cytolytic T lymphocytes (CTL) is regulated by soluble growth hormones, of which interleukin-2 (IL-2) is considered to be of prime importance. Here we report that the lymphokine B-cell stimulatory factor (BSF-1 or interleukin-4) also has profound effects on the generation of these func...

journal_title：Nature

authors： Widmer MB,Grabstein KH

更新日期：1987-04-23 00:00:00

abstract：:The rapid development of the silk glands of Bombyx mori during the last larval instar shows two phases. During the first 4 days, in both the middle and posterior parts of the silk glands, the ribosomal machinery is assembled and the synthesis of housekeeping proteins starts. During the second phase (the last 4 days), ...

journal_title：Nature

authors： Hentzen D,Chevallier A,Garel JP

更新日期：1981-03-19 00:00:00

abstract：:Over the past decade, ice loss from the Greenland Ice Sheet increased as a result of both increased surface melting and ice discharge to the ocean. The latter is controlled by the acceleration of ice flow and subsequent thinning of fast-flowing marine-terminating outlet glaciers. Quantifying the future dynamic contrib...

journal_title：Nature

authors： Nick FM,Vieli A,Andersen ML,Joughin I,Payne A,Edwards TL,Pattyn F,van de Wal RS

更新日期：2013-05-09 00:00:00

abstract：:Tissue-specific transcription factors regulate several important aspects of embryonic development. They must function in the context of DNA assembled into the higher-order structure of chromatin. Enzymatic complexes such as the Swi/Snf-like BAF complexes remodel chromatin to allow the transcriptional machinery access ...

journal_title：Nature

authors： Lickert H,Takeuchi JK,Von Both I,Walls JR,McAuliffe F,Adamson SL,Henkelman RM,Wrana JL,Rossant J,Bruneau BG

更新日期：2004-11-04 00:00:00

abstract：:The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-. to molecular oxygen and hydrogen peroxide at the active-site Cu ion in a reaction that is rate-limited by diffusion and enhanced by electrostatic guidance. SOD has evolved to be one of the fastest en...

journal_title：Nature

authors： Getzoff ED,Cabelli DE,Fisher CL,Parge HE,Viezzoli MS,Banci L,Hallewell RA

更新日期：1992-07-23 00:00:00

abstract：:The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...

journal_title：Nature

authors： Shakeel S,Rajendra E,Alcón P,O'Reilly F,Chorev DS,Maslen S,Degliesposti G,Russo CJ,He S,Hill CH,Skehel JM,Scheres SHW,Patel KJ,Rappsilber J,Robinson CV,Passmore LA

更新日期：2019-11-01 00:00:00

abstract：:A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The ge...

journal_title：Nature

authors： Kuro-o M,Matsumura Y,Aizawa H,Kawaguchi H,Suga T,Utsugi T,Ohyama Y,Kurabayashi M,Kaname T,Kume E,Iwasaki H,Iida A,Shiraki-Iida T,Nishikawa S,Nagai R,Nabeshima YI

更新日期：1997-11-06 00:00:00

abstract：:The mechanistic Target of Rapamycin Complex 1 (mTORC1) is a major regulator of eukaryotic growth that coordinates anabolic and catabolic cellular processes with inputs such as growth factors and nutrients, including amino acids. In mammals arginine is particularly important, promoting diverse physiological effects suc...

journal_title：Nature

authors： Saxton RA,Chantranupong L,Knockenhauer KE,Schwartz TU,Sabatini DM

更新日期：2016-08-11 00:00:00

abstract：:The homeobox is a 183-base-pair DNA sequence originally found in Drosophila segmentation and homeotic genes. In Drosophila, homeotic genes are clustered in the Antennapedia and Bithorax complexes, collectively called the homeotic gene complex (HOM-C). In the mouse genome, about 40 homeobox genes (Hox) are clustered in...

journal_title：Nature

authors： Tomotsune D,Shoji H,Wakamatsu Y,Kondoh H,Takahashi N

更新日期：1993-09-02 00:00:00

abstract：:Modern agriculture has accelerated biological methane and nitrogen cycling on a global scale. Freshwater sediments often receive increased downward fluxes of nitrate from agricultural runoff and upward fluxes of methane generated by anaerobic decomposition. In theory, prokaryotes should be capable of using nitrate to ...

journal_title：Nature

authors： Raghoebarsing AA,Pol A,van de Pas-Schoonen KT,Smolders AJ,Ettwig KF,Rijpstra WI,Schouten S,Damsté JS,Op den Camp HJ,Jetten MS,Strous M

更新日期：2006-04-13 00:00:00

abstract：:The specification of both the germ line and abdomen in Drosophila depends on the localization of oskar messenger RNA to the posterior of the oocyte. This localization requires several trans-acting factors, including Barentsz and the Mago-Y14 heterodimer, which assemble with oskar mRNA into ribonucleoprotein particles ...

journal_title：Nature

authors： Palacios IM,Gatfield D,St Johnston D,Izaurralde E

更新日期：2004-02-19 00:00:00

abstract：:The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would p...

journal_title：Nature

authors： Koppens FH,Buizert C,Tielrooij KJ,Vink IT,Nowack KC,Meunier T,Kouwenhoven LP,Vandersypen LM

更新日期：2006-08-17 00:00:00

abstract：:When a person walks through a rigid environment while holding eyes and head fixed, the pattern of retinal motion flows radially away from a point, the focus of expansion (Fig. 1a). Under such conditions of translation, heading corresponds to the focus of expansion and people identify it readily. But when making an eye...

journal_title：Nature

authors： Royden CS,Banks MS,Crowell JA

更新日期：1992-12-10 00:00:00

abstract：:The variable regions of mouse kappa (kappa) chains are coded for by multiple variable (V) gene segments and multiple joining (J) gene segments. The V kappa gene segments code for residues 1 to 95; the J kappa gene segments code for residues 96 to 108 (refs 1-3). This gene organisation is similar to that encoding the V...

journal_title：Nature

authors： Weigert M,Perry R,Kelley D,Hunkapiller T,Schilling J,Hood L

更新日期：1980-01-31 00:00:00