Driven coherent oscillations of a single electron spin in a quantum dot.

abstract：:Many proteins are expressed in distinct embryonic and adult forms. However, in most cases we do not know why the embryonic form of proteins is required. This question can be readily addressed for the acetylcholine receptor (AChR) because developmentally specified modifications of this ligand-gated ion channel can be d...

journal_title：Nature

authors： Jaramillo F,Vicini S,Schuetze SM

更新日期：1988-09-01 00:00:00

abstract：:Because monoclonal antibodies can recognize and bind to specific groups of atoms such as tumour antigens, they have promise for use in vivo as carriers of radionuclides, drugs or other appended molecules for diagnosis and treatment of disease. Attachment of metal ions to antibodies by means of bifunctional chelating a...

journal_title：Nature

authors： Reardan DT,Meares CF,Goodwin DA,McTigue M,David GS,Stone MR,Leung JP,Bartholomew RM,Frincke JM

更新日期：1985-07-18 00:00:00

abstract：:The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse...

journal_title：Nature

authors： van Lohuizen M,Frasch M,Wientjens E,Berns A

更新日期：1991-09-26 00:00:00

abstract：:The RNA polymerase II general transcription factor TFIIH is composed of several polypeptides. The observation that the largest subunit of TFIIH is the excision-repair protein XPB/ERCC3 (ref. 1), a helicase implicated in the human DNA-repair disorders xeroderma pigmentosum (XP) and Cockayne's syndrome, suggests a funct...

journal_title：Nature

authors： Drapkin R,Reardon JT,Ansari A,Huang JC,Zawel L,Ahn K,Sancar A,Reinberg D

更新日期：1994-04-21 00:00:00

abstract：:There is increasing evidence for the process of sympatric speciation, in which reproductive isolation of species occurs without physical isolation. Theoretical models have focused on disruptive natural selection as the crucial pressure for splitting a species. Here we report the theoretical finding that sympatric spec...

journal_title：Nature

authors： Higashi M,Takimoto G,Yamamura N

更新日期：1999-12-02 00:00:00

abstract：:B lymphocytes originate from pluripotential haematopoietic stem cells and differentiate into immunoglobulin (Ig)-producing cells. B-cell lineage differentiation is accompanied by two types of immunoglobulin gene rearrangements--rearrangement of V, D and J gene segments to create a functional V gene and rearrangement o...

journal_title：Nature

authors： Sugiyama H,Akira S,Kikutani H,Kishimoto S,Yamamura Y,Kishimoto T

更新日期：1983-06-30 00:00:00

abstract：:Is the big-bang hot, warm or cold? And are galactic masses determined by the interplay of gravitational and strong interactions in the very early universe? ...

journal_title：Nature

authors： Harrison ER

更新日期：1970-10-17 00:00:00

abstract：:The mechanism of action of antisteroids is not understood and explanations of their antagonistic activity have been sought at all levels of hormone action. It has been proposed that antisteroids, after binding to receptor, trap it into a non-activated (non DNA-binding) form possibly through interaction with a heat-sho...

journal_title：Nature

authors： Guiochon-Mantel A,Loosfelt H,Ragot T,Bailly A,Atger M,Misrahi M,Perricaudet M,Milgrom E

更新日期：1988-12-15 00:00:00

abstract：:Graphene oxide membranes-partially oxidized, stacked sheets of graphene-can provide ultrathin, high-flux and energy-efficient membranes for precise ionic and molecular sieving in aqueous solution. These materials have shown potential in a variety of applications, including water desalination and purification, gas and ...

journal_title：Nature

authors： Chen L,Shi G,Shen J,Peng B,Zhang B,Wang Y,Bian F,Wang J,Li D,Qian Z,Xu G,Liu G,Zeng J,Zhang L,Yang Y,Zhou G,Wu M,Jin W,Li J,Fang H

更新日期：2017-10-19 00:00:00

abstract：:Transparent electronic devices formed on flexible substrates are expected to meet emerging technological demands where silicon-based electronics cannot provide a solution. Examples of active flexible applications include paper displays and wearable computers. So far, mainly flexible devices based on hydrogenated amorp...

journal_title：Nature

authors： Nomura K,Ohta H,Takagi A,Kamiya T,Hirano M,Hosono H

更新日期：2004-11-25 00:00:00

abstract：:The 37-amino-acid calcitonin gene-related peptide (CGRP) occurs as a result of alternative processing of mRNA from the calcitonin gene. The potency of CGRP as a vasodilator and the occurrence of the peptide in nerves associated with blood vessels suggest an important role for CGRP in the regulation of blood flow. The ...

journal_title：Nature

authors： Brain SD,Williams TJ

更新日期：1988-09-01 00:00:00

abstract：:Sea ice and dust flux increased greatly in the Southern Ocean during the last glacial period. Palaeorecords provide contradictory evidence about marine productivity in this region, but beyond one glacial cycle, data were sparse. Here we present continuous chemical proxy data spanning the last eight glacial cycles (740...

journal_title：Nature

authors： Wolff EW,Fischer H,Fundel F,Ruth U,Twarloh B,Littot GC,Mulvaney R,Röthlisberger R,de Angelis M,Boutron CF,Hansson M,Jonsell U,Hutterli MA,Lambert F,Kaufmann P,Stauffer B,Stocker TF,Steffensen JP,Bigler M,Siggaard-An

更新日期：2006-03-23 00:00:00

abstract：:Establishing the age at death of individuals is an important step in their identification and can be done with high precision up to adolescence by analysis of dentition, but it is more difficult in adults. Here we show that the amount of radiocarbon present in tooth enamel as a result of nuclear bomb testing during 19...

journal_title：Nature

authors： Spalding KL,Buchholz BA,Bergman LE,Druid H,Frisén J

更新日期：2005-09-15 00:00:00

abstract：:A pathological hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the brain. The principal component of amyloid fibrils is beta/A4 amyloid protein, which can be generated by the aberrant processing of a large membrane-bound glycoprotein, the beta/A4 amyloid protein precursor (APP)3. To test whethe...

journal_title：Nature

authors： Yoshikawa K,Aizawa T,Hayashi Y

更新日期：1992-09-03 00:00:00

abstract：:In developing mammalian muscle, axon branches of several motor neurons co-innervate the same muscle fibre. Competition among them results in the strengthening of one and the withdrawal of the rest. It is not known why one particular axon branch survives or why some competitions resolve sooner than others. Here we show...

journal_title：Nature

authors： Kasthuri N,Lichtman JW

更新日期：2003-07-24 00:00:00

abstract：:Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...

journal_title：Nature

authors： Goud B,Zahraoui A,Tavitian A,Saraste J

更新日期：1990-06-07 00:00:00

abstract：:It is well established that muscle contraction results from the relative sliding of actin and myosin filaments. Both filaments have definite polarities and well-ordered structures. Thick filaments, however, are not vital for supporting movement in vitro. Previously we have demonstrated that actin filaments can move co...

journal_title：Nature

authors： Toyoshima YY,Toyoshima C,Spudich JA

更新日期：1989-09-14 00:00:00

abstract：:Haem is essential for living organisms, functioning as a crucial element in the redox-sensitive reaction centre in haemproteins. During the biogenesis of these proteins, the haem cofactor is typically incorporated enzymatically into the haem pockets of the apo-haemprotein as the functionally indispensable prosthetic g...

journal_title：Nature

authors： Tang XD,Xu R,Reynolds MF,Garcia ML,Heinemann SH,Hoshi T

更新日期：2003-10-02 00:00:00

abstract：:Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cell...

journal_title：Nature

authors： Israel MA,Yuan SH,Bardy C,Reyna SM,Mu Y,Herrera C,Hefferan MP,Van Gorp S,Nazor KL,Boscolo FS,Carson CT,Laurent LC,Marsala M,Gage FH,Remes AM,Koo EH,Goldstein LS

更新日期：2012-01-25 00:00:00

abstract：:Human T-cell leukaemias and lymphomas associated with the human T-cell leukaemia viruses (HTLV) are invariably neoplasms of cells with mature T-lymphocyte phenotype. Epstein-Barr virus-transformed B- lymphoycte lines which are productively infected with HTLV may be isolated from patients with HTLV malignancies, but no...

journal_title：Nature

authors： Chen IS,McLaughlin J,Golde DW

更新日期：1984-05-17 00:00:00

abstract：:Glandular epithelia, including the mammary and prostate glands, are composed of basal cells (BCs) and luminal cells (LCs)1,2. Many glandular epithelia develop from multipotent basal stem cells (BSCs) that are replaced in adult life by distinct pools of unipotent stem cells1,3-8. However, adult unipotent BSCs can react...

journal_title：Nature

authors： Centonze A,Lin S,Tika E,Sifrim A,Fioramonti M,Malfait M,Song Y,Wuidart A,Van Herck J,Dannau A,Bouvencourt G,Dubois C,Dedoncker N,Sahay A,de Maertelaer V,Siebel CW,Van Keymeulen A,Voet T,Blanpain C

更新日期：2020-08-01 00:00:00

abstract：:Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas). Genetic tumour profiling is used to classify disease and guide therapy1,2, but involves brain surgery for ti...

journal_title：Nature

authors： Miller AM,Shah RH,Pentsova EI,Pourmaleki M,Briggs S,Distefano N,Zheng Y,Skakodub A,Mehta SA,Campos C,Hsieh WY,Selcuklu SD,Ling L,Meng F,Jing X,Samoila A,Bale TA,Tsui DWY,Grommes C,Viale A,Souweidane MM,Tabar V,

更新日期：2019-01-01 00:00:00

abstract：:Memory formation is a multi-stage process that initially requires cellular consolidation in the hippocampus, after which memories are downloaded to the cortex for maintenance, in a process termed systems consolidation. Epigenetic mechanisms regulate both types of consolidation, but histone variant exchange, in which c...

journal_title：Nature

authors： Zovkic IB,Paulukaitis BS,Day JJ,Etikala DM,Sweatt JD

更新日期：2014-11-27 00:00:00

abstract：:G-protein-coupled receptors comprise the largest family of mammalian transmembrane receptors. They mediate numerous cellular pathways by coupling with downstream signalling transducers, including the hetrotrimeric G proteins Gs (stimulatory) and Gi (inhibitory) and several arrestin proteins. The structural mechanisms ...

journal_title：Nature

authors： Kang Y,Kuybeda O,de Waal PW,Mukherjee S,Van Eps N,Dutka P,Zhou XE,Bartesaghi A,Erramilli S,Morizumi T,Gu X,Yin Y,Liu P,Jiang Y,Meng X,Zhao G,Melcher K,Ernst OP,Kossiakoff AA,Subramaniam S,Xu HE

更新日期：2018-06-01 00:00:00

abstract：: ...

journal_title：Nature

authors： Dance A

更新日期：2018-11-01 00:00:00

abstract：:The genome of Aspergillus oryzae, a fungus important for the production of traditional fermented foods and beverages in Japan, has been sequenced. The ability to secrete large amounts of proteins and the development of a transformation system have facilitated the use of A. oryzae in modern biotechnology. Although both...

journal_title：Nature

authors： Machida M,Asai K,Sano M,Tanaka T,Kumagai T,Terai G,Kusumoto K,Arima T,Akita O,Kashiwagi Y,Abe K,Gomi K,Horiuchi H,Kitamoto K,Kobayashi T,Takeuchi M,Denning DW,Galagan JE,Nierman WC,Yu J,Archer DB,Bennett JW,Bh

更新日期：2005-12-22 00:00:00

abstract：:Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look...

journal_title：Nature

authors： Sicheri F,Yang DS

更新日期：1995-06-01 00:00:00

abstract：:The ability to design proteins with high affinity and selectivity for any given small molecule is a rigorous test of our understanding of the physiochemical principles that govern molecular recognition. Attempts to rationally design ligand-binding proteins have met with little success, however, and the computational d...

journal_title：Nature

authors： Tinberg CE,Khare SD,Dou J,Doyle L,Nelson JW,Schena A,Jankowski W,Kalodimos CG,Johnsson K,Stoddard BL,Baker D

更新日期：2013-09-12 00:00:00

abstract：:Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...

journal_title：Nature

authors： Reisz RR,Huang TD,Roberts EM,Peng S,Sullivan C,Stein K,LeBlanc AR,Shieh D,Chang R,Chiang C,Yang C,Zhong S

更新日期：2013-04-11 00:00:00

abstract：:Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, offering unrivalled accuracy in allele design and access to conditional mutagenesis. To bring these advantages to the wider research community, large-scale mouse knockout programmes are producing a permanen...

journal_title：Nature

authors： Skarnes WC,Rosen B,West AP,Koutsourakis M,Bushell W,Iyer V,Mujica AO,Thomas M,Harrow J,Cox T,Jackson D,Severin J,Biggs P,Fu J,Nefedov M,de Jong PJ,Stewart AF,Bradley A

更新日期：2011-06-15 00:00:00