The role of neuronal identity in synaptic competition.

abstract：:During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...

journal_title：Nature

authors： Lee JS,Hnilova M,Maes M,Lin YC,Putarjunan A,Han SK,Avila J,Torii KU

更新日期：2015-06-25 00:00:00

abstract：:Two large-scale yeast two-hybrid screens were undertaken to identify protein-protein interactions between full-length open reading frames predicted from the Saccharomyces cerevisiae genome sequence. In one approach, we constructed a protein array of about 6,000 yeast transformants, with each transformant expressing on...

journal_title：Nature

authors： Uetz P,Giot L,Cagney G,Mansfield TA,Judson RS,Knight JR,Lockshon D,Narayan V,Srinivasan M,Pochart P,Qureshi-Emili A,Li Y,Godwin B,Conover D,Kalbfleisch T,Vijayadamodar G,Yang M,Johnston M,Fields S,Rothberg JM

更新日期：2000-02-10 00:00:00

abstract：:Locomotion relies on neural networks called central pattern generators (CPGs) that generate periodic motor commands for rhythmic movements. In vertebrates, the excitatory synaptic drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identi...

journal_title：Nature

authors： Wyart C,Del Bene F,Warp E,Scott EK,Trauner D,Baier H,Isacoff EY

更新日期：2009-09-17 00:00:00

abstract：:The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucl...

journal_title：Nature

authors： Zheng Y,Wong ML,Alberts B,Mitchison T

更新日期：1995-12-07 00:00:00

abstract：:A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. ...

journal_title：Nature

authors： Murre C,Reiss CS,Bernabeu C,Chen LB,Burakoff SJ,Seidman JG

更新日期：1984-02-02 00:00:00

abstract：:Mitogen-activated protein kinases, MAP kinases or ERKs (extracellular signal-regulated kinases) are rapidly stimulated by growth-promoting factors acting on a variety of cell-surface receptors. In turn, ERKs phosphorylate and regulate key intracellular enzymes and transcription factors involved in the control of cellu...

journal_title：Nature

authors： Crespo P,Xu N,Simonds WF,Gutkind JS

更新日期：1994-06-02 00:00:00

abstract：:Human lymphocytes have been shown to lyse in vitro a large variety of target cells derived from tumour as well as normal tissues. The effector cells involved in this spontaneous cell-mediated cytotoxicity (SCMC) have generally been characterised as lymphocytes which lack surface membrane immunoglobulin (sIg) and lack ...

journal_title：Nature

authors： de Vries JE,Mendelsohn J,Bont WS

更新日期：1980-02-07 00:00:00

abstract：:Gamma-ray bursts (GRBs) are most probably powered by collimated relativistic outflows (jets) from accreting black holes at cosmological distances. Bright afterglows are produced when the outflow collides with the ambient medium. Afterglow polarization directly probes the magnetic properties of the jet when measured mi...

journal_title：Nature

authors： Wiersema K,Covino S,Toma K,van der Horst AJ,Varela K,Min M,Greiner J,Starling RL,Tanvir NR,Wijers RA,Campana S,Curran PA,Fan Y,Fynbo JP,Gorosabel J,Gomboc A,Götz D,Hjorth J,Jin ZP,Kobayashi S,Kouveliotou C,Munde

更新日期：2014-05-08 00:00:00

abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...

journal_title：Nature

authors： Agarwal J,Jewitt D,Mutchler M,Weaver H,Larson S

更新日期：2017-09-20 00:00:00

abstract：:Quantum computers are expected to outperform conventional computers in several important applications, from molecular simulation to search algorithms, once they can be scaled up to large numbers-typically millions-of quantum bits (qubits)1-3. For most solid-state qubit technologies-for example, those using superconduc...

journal_title：Nature

authors： Yang CH,Leon RCC,Hwang JCC,Saraiva A,Tanttu T,Huang W,Camirand Lemyre J,Chan KW,Tan KY,Hudson FE,Itoh KM,Morello A,Pioro-Ladrière M,Laucht A,Dzurak AS

更新日期：2020-04-01 00:00:00

abstract：:The murine cardioviruses, such as the Mengo and encephalomyocarditis viruses, and the bovine aphthoviruses, such as foot-and-mouth disease virus, are distinguished among positive-strand RNA viruses by the presence of long homopolymeric poly(C) tracts within their 5' noncoding sequences. Although the specific lengths (...

journal_title：Nature

authors： Duke GM,Osorio JE,Palmenberg AC

更新日期：1990-02-01 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00

abstract：:The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour development. This raises the hypothesis that pharmacological modulation o...

journal_title：Nature

authors： Sulli G,Rommel A,Wang X,Kolar MJ,Puca F,Saghatelian A,Plikus MV,Verma IM,Panda S

更新日期：2018-01-18 00:00:00

abstract：:Magnetic surveys of the martian surface have revealed significantly lower magnetic field intensities over the gigantic impact craters Hellas and Argyre than over surrounding regions. The reduced fields are commonly attributed to pressure demagnetization caused by shock waves generated during meteorite impact, in the a...

journal_title：Nature

authors： Carporzen L,Gilder SA,Hart RJ

更新日期：2005-05-12 00:00:00

abstract：:Pluto's tenuous nitrogen atmosphere was first detected by the imprint left on the light curve of a star that was occulted by the planet in 1985 (ref. 1), and studied more extensively during a second occultation event in 1988 (refs 2-6). These events are, however, quite rare and Pluto's atmosphere remains poorly unders...

journal_title：Nature

authors： Sicardy B,Widemann T,Lellouch E,Veillet C,Cuillandre JC,Colas F,Roques F,Beisker W,Kretlow M,Lagrange AM,Gendron E,Lacombe F,Lecacheux J,Birnbaum C,Fienga A,Leyrat C,Maury A,Raynaud E,Renner S,Schultheis M,Brooks

更新日期：2003-07-10 00:00:00

abstract：:gamma-Aminobutyric acid (GABA), a major inhibitory neurotransmitter in the mammalian nervous system, is known to operate bicuculline-sensitive Cl- channels through GABAA receptors and bicuculline-insensitive cation channels through GABAB receptors. Recent observations indicate that the retina may contain GABA receptor...

journal_title：Nature

authors： Feigenspan A,Wässle H,Bormann J

更新日期：1993-01-14 00:00:00

abstract：:A long-standing hypothesis posits that natural selection can favour two female strategies when density cycles. At low density, females producing many smaller progeny are favoured when the intrinsic rate of increase, r, governs population growth. At peak density, females producing fewer, high-quality, progeny are favou...

journal_title：Nature

authors： Sinervo B,Svensson E,Comendant T

更新日期：2000-08-31 00:00:00

abstract：:Dynamin is a mechanochemical GTPase that oligomerizes around the neck of clathrin-coated pits and catalyses vesicle scission in a GTP-hydrolysis-dependent manner. The molecular details of oligomerization and the mechanism of the mechanochemical coupling are currently unknown. Here we present the crystal structure of h...

journal_title：Nature

authors： Faelber K,Posor Y,Gao S,Held M,Roske Y,Schulze D,Haucke V,Noé F,Daumke O

更新日期：2011-09-18 00:00:00

abstract：:Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by environmental influences, and functionally implicated in behavioural responses to stress and antidepressants1-4. However, how adult-born neurons regulate dentate gyrus information processing to protect from stress-induced anxiety-like be...

journal_title：Nature

authors： Anacker C,Luna VM,Stevens GS,Millette A,Shores R,Jimenez JC,Chen B,Hen R

更新日期：2018-07-01 00:00:00

abstract：:Alternative splicing of pre-messenger RNAs diversifies gene products in eukaryotes and is guided by factors that enable spliceosomes to recognize particular splice sites. Here we report that alternative splicing of Saccharomyces cerevisiae SRC1 pre-mRNA is promoted by the conserved ubiquitin-like protein Hub1. Structu...

journal_title：Nature

authors： Mishra SK,Ammon T,Popowicz GM,Krajewski M,Nagel RJ,Ares M Jr,Holak TA,Jentsch S

更新日期：2011-05-25 00:00:00

abstract：:Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...

journal_title：Nature

authors： Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

更新日期：2015-06-11 00:00:00

abstract：:Concentrating urine is mandatory for most mammals to prevent water loss from the body. Concentrated urine is produced in response to vasopressin by the transepithelial recovery of water from the lumen of the kidney collecting tubule through highly water-permeable membranes. In this nephron segment, vasopressin regulat...

journal_title：Nature

authors： Fushimi K,Uchida S,Hara Y,Hirata Y,Marumo F,Sasaki S

更新日期：1993-02-11 00:00:00

abstract：:The atmospheric partial pressure of carbon dioxide (p(CO(2))) will almost certainly be double that of pre-industrial levels by 2100 and will be considerably higher than at any time during the past few million years. The oceans are a principal sink for anthropogenic CO(2) where it is estimated to have caused a 30% incr...

journal_title：Nature

authors： Hall-Spencer JM,Rodolfo-Metalpa R,Martin S,Ransome E,Fine M,Turner SM,Rowley SJ,Tedesco D,Buia MC

更新日期：2008-07-03 00:00:00

abstract：:The development of immunologic interventions that can target the viral reservoir in HIV-1-infected individuals is a major goal of HIV-1 research. However, little evidence exists that the viral reservoir can be sufficiently targeted to improve virologic control following discontinuation of antiretroviral therapy. Here ...

journal_title：Nature

authors： Borducchi EN,Cabral C,Stephenson KE,Liu J,Abbink P,Ng'ang'a D,Nkolola JP,Brinkman AL,Peter L,Lee BC,Jimenez J,Jetton D,Mondesir J,Mojta S,Chandrashekar A,Molloy K,Alter G,Gerold JM,Hill AL,Lewis MG,Pau MG,Schuit

更新日期：2016-12-08 00:00:00

abstract：:Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells and extracellular matrix proteins. For example, the association of membrane proteins with proteins on different cells (trans-interactions) can drive the oligomerization of proteins on t...

journal_title：Nature

authors： Wu Y,Vendome J,Shapiro L,Ben-Shaul A,Honig B

更新日期：2011-07-27 00:00:00

abstract：:Change history: In this Letter, the received date should be 20 December 2017, instead of 27 April 2018. This has been corrected online. ...

journal_title：Nature

authors： Humphreys PC,Kalb N,Morits JPJ,Schouten RN,Vermeulen RFL,Twitchen DJ,Markham M,Hanson R

更新日期：2018-10-01 00:00:00

abstract：:Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogramming primary cells from patients into induced pluripotent stem cell...

journal_title：Nature

authors： Israel MA,Yuan SH,Bardy C,Reyna SM,Mu Y,Herrera C,Hefferan MP,Van Gorp S,Nazor KL,Boscolo FS,Carson CT,Laurent LC,Marsala M,Gage FH,Remes AM,Koo EH,Goldstein LS

更新日期：2012-01-25 00:00:00

abstract：:Cpdm (chronic proliferative dermatitis) mice develop chronic dermatitis and an immunodeficiency with increased serum IgM, symptoms that resemble those of patients with X-linked hyper-IgM syndrome and hypohydrotic ectodermal dysplasia (XHM-ED), which is caused by mutations in NEMO (NF-κB essential modulator; also known...

journal_title：Nature

authors： Tokunaga F,Nakagawa T,Nakahara M,Saeki Y,Taniguchi M,Sakata S,Tanaka K,Nakano H,Iwai K

更新日期：2011-03-31 00:00:00

abstract：:Experimental and simulation studies show that small monomeric proteins fold in one kinetic step, which entails overcoming the free-energy barrier between the unfolded and the native protein through a transition state. Two models of transition state formation have been proposed: a 'nonspecific' one in which it depends ...

journal_title：Nature

authors： Shakhnovich E,Abkevich V,Ptitsyn O

更新日期：1996-01-04 00:00:00

abstract：:Spontaneous type 1 diabetes occurs when the autoimmune destruction of pancreatic beta-islet cells prevents production of the hormone insulin. This causes an inability to regulate glucose metabolism, which results in dangerously raised blood glucose concentrations. It is generally accepted that thymus-derived lymphocyt...

journal_title：Nature

authors： Wilson DB

更新日期：2005-11-24 00:00:00