Abstract：
:A mouse major histocompatibility antigen (H-2) gene, encoding a novel H-2Ld molecule lacking its intracytoplasmic domain, has been constructed and introduced into mouse L-cells. The novel H-2 molecule is found on the surface of the transfected cells at the same level as L-cells transfected with the native H-2Ld gene. Allo- and influenza-specific cytotoxic T lymphocytes can recognize the truncated H-2 gene product nearly as efficiently as the normal H-2Ld gene product. However, vesicular stomatitis virus-specific cytotoxic T lymphocytes recognize the truncated H-2Ld molecule less efficiently than the complete H-2Ld product. The rate of capping of the truncated H-2Ld molecule was investigated and found to be the same as that of the complete H-2Ld gene product.
journal_name
Naturejournal_title
Natureauthors
Murre C,Reiss CS,Bernabeu C,Chen LB,Burakoff SJ,Seidman JGdoi
10.1038/307432a0subject
Has Abstractpub_date
1984-02-02 00:00:00pages
432-6issue
5950eissn
0028-0836issn
1476-4687journal_volume
307pub_type
杂志文章相关文献
NATURE文献大全abstract：:Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antib...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/379346a0
更新日期：1996-01-25 00:00:00
abstract：:To cause diseases in plants, pathogenic microorganisms have evolved mechanisms to deliver proteins directly into plant cells, where they suppress plant defences and facilitate tissue invasion. How plant pathogenic fungi, which cause many of the world's most serious plant diseases, deliver proteins during plant infecti...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04567
更新日期：2006-03-23 00:00:00
abstract：:Complex-oxide materials exhibit a vast range of functional properties desirable for next-generation electronic, spintronic, magnetoelectric, neuromorphic, and energy conversion storage devices1-4. Their physical functionalities can be coupled by stacking layers of such materials to create heterostructures and can be f...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-1939-z
更新日期：2020-02-01 00:00:00
abstract：:Transforming growth factor-alpha (TGF-alpha) is a mitogenically active polypeptide hormone produced by acutely proliferating neoplastic and embryonic tissues. Molecular cloning of TGF-alpha cDNA from human and rat has indicated that this factor is synthesized as part of a larger precursor, proTGF-alpha. An intriguing ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/326883a0
更新日期：1987-04-30 00:00:00
abstract：:Satellite observations have transformed our understanding of the Antarctic cryosphere. The continent holds the vast majority of Earth's fresh water, and blankets swathes of the Southern Hemisphere in ice. Reductions in the thickness and extent of floating ice shelves have disturbed inland ice, triggering retreat, acce...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/s41586-018-0171-6
更新日期：2018-06-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signallin...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11208
更新日期：2012-06-13 00:00:00
abstract：:Direct dating of ductile shear zones and calculation of uplift/exhumation rates can be done using various radiometric dating techniques. But radiometric dating of shallow crustal faulting, which occurs in the crust's brittle regime, has remained difficult because the low temperatures typical of shallow crusted faults ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35084053
更新日期：2001-07-12 00:00:00
abstract：:Hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both heart and brain. All four family members contain both a core transmembrane segment domain, homologous to the S1-S6 regions of voltage-gated K+ channels, and a carboxy-terminal 120 amino-acid cyclic nu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35081088
更新日期：2001-06-14 00:00:00
abstract：:The yeast [PSI+] element represents a new type of genetic inheritance, in which changes in phenotype are transmitted by a 'protein only' mechanism reminiscent of the 'protein-only' transmission of mammalian prion diseases. The underlying molecular mechanisms for both are poorly understood and it is not clear how simil...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/23048
更新日期：1999-08-05 00:00:00
abstract：:Because their molecular signatures are often prominent in extracts of sediments, bacteria are thought to be important contributors to petroleum source beds. It has been shown recently, however, that abundances of biomarkers do not always reflect relative contributions to sedimentary organic carbon (Corg). The contrib...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/369224a0
更新日期：1994-05-19 00:00:00
abstract：:The structure of foot-and-mouth disease virus has been determined at close to atomic resolution by X-ray diffraction without experimental phase information. The virus shows similarities with other picornaviruses but also several unique features. The canyon or pit found in other picornaviruses is absent; this has impor...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/337709a0
更新日期：1989-02-23 00:00:00
abstract：:Muscle actin genes are the earliest yet described to show cell type-specific activation in amphibian embryos. Gene-specific probes show that alpha-skeletal and alpha-cardiac actin genes start to be transcribed simultaneously at the end of gastrulation, but only in those regions of the mesoderm that subsequently form e...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/311716a0
更新日期：1984-10-25 00:00:00
abstract：:Excision of introns from nuclear precursors to messenger RNAs (pre-mRNAs) by the spliceosome requires two distinct phosphodiester transfer (transesterification) reactions: exchange of a 3'-5' for a 2'-5' bond in the first step (lariat formation) and exchange of one 3'-5' phosphodiester for another in the second step (...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/365364a0
更新日期：1993-09-23 00:00:00
abstract：:Throughout the latter half of this century, the development and spread of resistance to most front-line antimalarial compounds used in the prevention and treatment of the most severe form of human malaria has given cause for grave clinical concern. Polymorphisms in pfmdr1, the gene encoding the P-glycoprotein homologu...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/35002615
更新日期：2000-02-24 00:00:00
abstract：:Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/21202
更新日期：1999-06-10 00:00:00
abstract：:The best spectrographs are limited in stability by their calibration light source. Laser frequency combs are the ideal calibrators for astronomical spectrographs. They emit a spectrum of lines that are equally spaced in frequency and that are as accurate and stable as the atomic clock relative to which the comb is sta...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature11092
更新日期：2012-05-30 00:00:00
abstract：:When mountains form through the collision of lithospheric plates, uplift of the Earth's surface is accompanied by thickening of the crust, and the buoyancy of these deep crustal roots (relative to the surrounding mantle) is thought to contribute to the support of mountain topography. Once active tectonism ceases, cont...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature00855
更新日期：2002-06-27 00:00:00
abstract：:A model catalyst is described which has properties in common with carbonic anhydrase. The model demonstrates the availability of a mechanism, previously only hypothetical, for the action of the enzyme. It also shows, however, that this mechanism alone is not adequate to produce the high activity of the enzyme. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/258677a0
更新日期：1975-12-25 00:00:00
abstract：:Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature13374
更新日期：2014-07-17 00:00:00
abstract：:The battle for survival between bacteria and the viruses that infect them (phages) has led to the evolution of many bacterial defence systems and phage-encoded antagonists of these systems. Clustered regularly interspaced short palindromic repeats (CRISPR) and the CRISPR-associated (cas) genes comprise an adaptive imm...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature15254
更新日期：2015-10-01 00:00:00
abstract：:AFTER exposure to secretagogues the small intestine changes from a tissue that absorbs fluid and electrolyte from lumen to blood into a tissue that secretes electrolyte and fluid into the lumen(1-4). It has been shown that this secretion results from an increase in the passive Cl(-) permeability of the mucosal border,...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/279446a0
更新日期：1979-05-31 00:00:00
abstract：:Although the link between long gamma-ray bursts (GRBs) and supernovae has been established, hitherto there have been no observations of the beginning of a supernova explosion and its intimate link to a GRB. In particular, we do not know how the jet that defines a gamma-ray burst emerges from the star's surface, nor ho...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature04892
更新日期：2006-08-31 00:00:00
abstract：:Constructing agents with planning capabilities has long been one of the main challenges in the pursuit of artificial intelligence. Tree-based planning methods have enjoyed huge success in challenging domains, such as chess1 and Go2, where a perfect simulator is available. However, in real-world problems, the dynamics ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/s41586-020-03051-4
更新日期：2020-12-01 00:00:00
abstract：:Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cytotoxic activities against virus-infected cells and produce various cytokin...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature08636
更新日期：2010-01-28 00:00:00
abstract：:Ongoing efforts within synthetic and systems biology have been directed towards the building of artificial computational devices using engineered biological units as basic building blocks. Such efforts, inspired in the standard design of electronic circuits, are limited by the difficulties arising from wiring the basi...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature09679
更新日期：2011-01-13 00:00:00
abstract：:Deaf children whose access to usable conventional linguistic input, signed or spoken, is severely limited nevertheless use gesture to communicate. These gestures resemble natural language in that they are structured at the level both of sentence and of word. Although the inclination to use gesture may be traceable to ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/34646
更新日期：1998-01-15 00:00:00
abstract：:Monoclonal antibodies can now be genetically engineered and endowed with new properties. In the future, gene technology could enable antigen-binding fragments to be made by exploiting repertoires of variable domain genes derived from immunized animals and expressed in bacteria. How readily can this approach be extende...
journal_title：Nature
pub_type： 杂志文章,评审
doi：10.1038/349293a0
更新日期：1991-01-24 00:00:00
abstract：:The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/310143a0
更新日期：1984-07-12 00:00:00
abstract：:Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporid...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/nature02977
更新日期：2004-10-28 00:00:00
abstract：:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements. ...
journal_title：Nature
pub_type： 杂志文章
doi：10.1038/302587a0
更新日期：1983-04-14 00:00:00
