Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes.

Abstract:

:The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of p53 protein correlates with this commitment step. I show here that in unstimulated cells, a second form of p53 is synthesized and is restricted to G0.

journal_name

Nature

journal_title

Nature

authors

Milner J

doi

10.1038/310143a0

subject

Has Abstract

pub_date

1984-07-12 00:00:00

pages

143-5

issue

5973

eissn

0028-0836

issn

1476-4687

journal_volume

310

pub_type

杂志文章

相关文献

NATURE文献大全
  • ovo/svb integrates Wingless and DER pathways to control epidermis differentiation.

    abstract::In Drosophila, as in mammals, epidermal differentiation is controlled by signalling cascades that include Wnt proteins and the ovo/shavenbaby (svb) family of zinc-finger transcription factors. Ovo/svb is a complex gene with two genetic functions corresponding to separate control regions: ovo is required for female ger...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/22330

    authors: Payre F,Vincent A,Carreno S

    更新日期:1999-07-15 00:00:00

  • A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens.

    abstract::Soybean (Glycine max (L.) Merr.) is an important crop that provides a sustainable source of protein and oil worldwide. Soybean cyst nematode (Heterodera glycines Ichinohe) is a microscopic roundworm that feeds on the roots of soybean and is a major constraint to soybean production. This nematode causes more than US$1 ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11651

    authors: Liu S,Kandoth PK,Warren SD,Yeckel G,Heinz R,Alden J,Yang C,Jamai A,El-Mellouki T,Juvale PS,Hill J,Baum TJ,Cianzio S,Whitham SA,Korkin D,Mitchum MG,Meksem K

    更新日期:2012-12-13 00:00:00

  • Direct addition of insulin inhibits a high affinity Ca2+-ATPase in isolated adipocyte plasma membranes.

    abstract::The mechanism by which insulin regulates cellular metabolism remains unknown although indirect evidence suggests that alterations in intracellular calcium are important. More specifically, it has been proposed that insulin triggers an increase in intracellular calcium which is responsible for the subsequent modificati...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/281495a0

    authors: Pershadsingh HA,McDonald JM

    更新日期:1979-10-11 00:00:00

  • Accessory cell-dependent selection of specific T-cell functions.

    abstract::Activation of many T-cell functions depends on their interaction with antigen-presenting accessory cells which express I region associated (Ia) products. Cells expressing accessory cell function include those of the monocyte/macrophage lineage and dendritic cells. More recently, B cells and a number of tumour cell lin...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/304442a0

    authors: Ramila G,Erb P

    更新日期:1983-08-04 00:00:00

  • Involvement of an ICE-like protease in Fas-mediated apoptosis.

    abstract::Fas is a type-I membrane protein that transduces an apoptotic signal. Binding of Fas ligand or agonistic anti-Fas antibody to Fas kills the cells by apoptosis. Studies in the nematode Caenorhabditis elegans have suggested that proteases such as interleukin-1 beta-converting enzyme (ICE) or the product of the C. elegan...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/375078a0

    authors: Enari M,Hug H,Nagata S

    更新日期:1995-05-04 00:00:00

  • X-ray structure of a mammalian stearoyl-CoA desaturase.

    abstract::Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first double bond into saturated fatty acyl-CoAs. Because the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters and triglycerides, SCD is pivotal in fatty acid metabolism. Humans have two SCD ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature14549

    authors: Bai Y,McCoy JG,Levin EJ,Sobrado P,Rajashankar KR,Fox BG,Zhou M

    更新日期:2015-08-13 00:00:00

  • BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

    abstract::Genome instability is central to ageing, cancer and other diseases. It is not only proteins involved in DNA replication or the DNA damage response (DDR) that are important for maintaining genome integrity: from yeast to higher eukaryotes, mutations in genes involved in pre-mRNA splicing and in the biogenesis and expor...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13374

    authors: Bhatia V,Barroso SI,García-Rubio ML,Tumini E,Herrera-Moyano E,Aguilera A

    更新日期:2014-07-17 00:00:00

  • A cryo-electron microscopic study of ribosome-bound termination factor RF2.

    abstract::Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01224

    authors: Rawat UB,Zavialov AV,Sengupta J,Valle M,Grassucci RA,Linde J,Vestergaard B,Ehrenberg M,Frank J

    更新日期:2003-01-02 00:00:00

  • Germline Elongator mutations in Sonic Hedgehog medulloblastoma.

    abstract::Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children1,2, and genetic events that cooperate with known somatic dri...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-020-2164-5

    authors: Waszak SM,Robinson GW,Gudenas BL,Smith KS,Forget A,Kojic M,Garcia-Lopez J,Hadley J,Hamilton KV,Indersie E,Buchhalter I,Kerssemakers J,Jäger N,Sharma T,Rausch T,Kool M,Sturm D,Jones DTW,Vasilyeva A,Tatevossian RG,N

    更新日期:2020-04-01 00:00:00

  • S-Nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons.

    abstract::Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse nervous system by influencing the expression of many specific genes that promote differentiation, cell survival, synapse formation and, later, synaptic plasticity. Although nitric oxide (NO) is kn...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature07238

    authors: Nott A,Watson PM,Robinson JD,Crepaldi L,Riccio A

    更新日期:2008-09-18 00:00:00

  • Asymmetric neurotransmitter release enables rapid odour lateralization in Drosophila.

    abstract::In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to both sides of the brain. Having bilateral rather than unilateral projections may represent a useful redundancy. However, bilateral ORN projections to the brain should also compromise the ability to lateralize odours. Nevertheless, ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature11747

    authors: Gaudry Q,Hong EJ,Kain J,de Bivort BL,Wilson RI

    更新日期:2013-01-17 00:00:00

  • An integrated physical map of human chromosome 16.

    abstract::We describe an integrated physical, genetic and cytogenetic map of human chromosome 16 comprising both a low-resolution megaYAC map and a high-resolution cosmid contig/miniYAC map, which provides nearly complete coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytog...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/377335a0

    authors: Doggett NA,Goodwin LA,Tesmer JG,Meincke LJ,Bruce DC,Clark LM,Altherr MR,Ford AA,Chi HC,Marrone BL

    更新日期:1995-09-28 00:00:00

  • Information causality as a physical principle.

    abstract::Quantum physics has remarkable distinguishing characteristics. For example, it gives only probabilistic predictions (non-determinism) and does not allow copying of unknown states (no-cloning). Quantum correlations may be stronger than any classical ones, but information cannot be transmitted faster than light (no-sign...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature08400

    authors: Pawłowski M,Paterek T,Kaszlikowski D,Scarani V,Winter A,Zukowski M

    更新日期:2009-10-22 00:00:00

  • Mechanisms of extensive spatiotemporal chaos in Rayleigh-Benard convection

    abstract::Spatially extended dynamical systems exhibit complex behaviour in both space and time--spatiotemporal chaos. Analysis of dynamical quantities (such as fractal dimensions and Lyapunov exponents) has provided insights into low-dimensional systems; but it has proven more difficult to understand spatiotemporal chaos in hi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/35008013

    authors: Egolf DA,Melnikov IV IV,Pesch W,Ecke RE

    更新日期:2000-04-13 00:00:00

  • Backtracking by single RNA polymerase molecules observed at near-base-pair resolution.

    abstract::Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo. Its low error rate may be achieved by means of a 'proofreading' mechanism comprised of two sequential events. The first event (backtracking) involves a transcriptionally upstream motion of RNAP through several base pairs, which ca...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02191

    authors: Shaevitz JW,Abbondanzieri EA,Landick R,Block SM

    更新日期:2003-12-11 00:00:00

  • Damage to the shallow Landers fault from the nearby Hector Mine earthquake.

    abstract::Crustal faults have long been identified as sites where localized sliding motion occurs during earthquakes, which allows for the relative motion between adjacent crustal blocks. Although there is a growing awareness that we must understand the evolution of fault systems on many timescales to relate present-day crustal...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01354

    authors: Vidale JE,Li YG

    更新日期:2003-01-30 00:00:00

  • Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum.

    abstract::Shiga toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans-Golgi network. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication, but it is not known whether the enzymatically active part of the toxins ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/358510a0

    authors: Sandvig K,Garred O,Prydz K,Kozlov JV,Hansen SH,van Deurs B

    更新日期:1992-08-06 00:00:00

  • Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.

    abstract::To ensure cell survival, it is essential that the ubiquitous pro-apoptotic machinery is kept quiescent. As death is irreversible, cells must continually integrate developmental information with regulatory inputs to control the switch between repressing and activating apoptosis. Inappropriate activation or suppression ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature01920

    authors: Bloss TA,Witze ES,Rothman JH

    更新日期:2003-08-28 00:00:00

  • A palaeotemperature curve for the Precambrian oceans based on silicon isotopes in cherts.

    abstract::The terrestrial sediment record indicates that the Earth's climate varied drastically in the Precambrian era (before 550 million years ago), ranging from surface temperatures similar to or higher than today's to global glaciation events. The most continuous record of sea surface temperatures of that time has been deri...

    journal_title:Nature

    pub_type: 历史文章,杂志文章

    doi:10.1038/nature05239

    authors: Robert F,Chaussidon M

    更新日期:2006-10-26 00:00:00

  • Structure of tumour necrosis factor.

    abstract::Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/338225a0

    authors: Jones EY,Stuart DI,Walker NP

    更新日期:1989-03-16 00:00:00

  • Substrate twinning activates the signal recognition particle and its receptor.

    abstract::Signal sequences target proteins for secretion from cells or for integration into cell membranes. As nascent proteins emerge from the ribosome, signal sequences are recognized by the signal recognition particle (SRP), which subsequently associates with its receptor (SR). In this complex, the SRP and SR stimulate each ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature02250

    authors: Egea PF,Shan SO,Napetschnig J,Savage DF,Walter P,Stroud RM

    更新日期:2004-01-15 00:00:00

  • Long-term phenotypic evolution of bacteria.

    abstract::For many decades comparative analyses of protein sequences and structures have been used to investigate fundamental principles of molecular evolution. In contrast, relatively little is known about the long-term evolution of species' phenotypic and genetic properties. This represents an important gap in our understandi...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13827

    authors: Plata G,Henry CS,Vitkup D

    更新日期:2015-01-15 00:00:00

  • GAL4-VP16 is an unusually potent transcriptional activator.

    abstract::Recent work has defined a class of transcriptional activators, members of which activate transcription in yeast, plant, insect and mammalian cells. These proteins contain two parts: one directs DNA binding and the other, called the activating region, presumably interacts with some component of the transcriptional mach...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/335563a0

    authors: Sadowski I,Ma J,Triezenberg S,Ptashne M

    更新日期:1988-10-06 00:00:00

  • Demasculinization of X chromosomes in the Drosophila genus.

    abstract::X chromosomes evolve differently from autosomes, but general governing principles have not emerged. For example, genes with male-biased expression are under-represented on the X chromosome of D. melanogaster, but are randomly distributed in the genome of Anopheles gambiae. In direct global profiling experiments using ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature06330

    authors: Sturgill D,Zhang Y,Parisi M,Oliver B

    更新日期:2007-11-08 00:00:00

  • Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice.

    abstract::Expression of Ets2, a proto-oncogene and transcription factor, occurs in a variety of cell types. During murine development it is highly expressed in newly forming cartilage, including in the skull precursor cells and vertebral primordia. Ets2 is located on human chromosome 21 (ref. 8) and is overexpressed in Down's s...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/379534a0

    authors: Sumarsono SH,Wilson TJ,Tymms MJ,Venter DJ,Corrick CM,Kola R,Lahoud MH,Papas TS,Seth A,Kola I

    更新日期:1996-02-08 00:00:00

  • A supermassive black hole in an ultra-compact dwarf galaxy.

    abstract::Ultra-compact dwarf galaxies are among the densest stellar systems in the Universe. These systems have masses of up to 2 × 10(8) solar masses, but half-light radii of just 3-50 parsecs. Dynamical mass estimates show that many such dwarfs are more massive than expected from their luminosity. It remains unclear whether ...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/nature13762

    authors: Seth AC,van den Bosch R,Mieske S,Baumgardt H,den Brok M,Strader J,Neumayer N,Chilingarian I,Hilker M,McDermid R,Spitler L,Brodie J,Frank MJ,Walsh JL

    更新日期:2014-09-18 00:00:00

  • Occluded bound calcium on the phosphorylated sarcoplasmic transport ATPase.

    abstract::The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/290271a0

    authors: Takisawa H,Makinose M

    更新日期:1981-03-19 00:00:00

  • Do female hyaenas choose mates based on tenure?

    abstract::In their investigation into whether female mate-choice drives male dispersal, Höner et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are...

    journal_title:Nature

    pub_type: 评论,杂志文章

    doi:10.1038/nature07122

    authors: Van Horn RC,Watts HE,Holekamp KE

    更新日期:2008-07-10 00:00:00

  • Observation of room-temperature polar skyrmions.

    abstract::Complex topological configurations are fertile ground for exploring emergent phenomena and exotic phases in condensed-matter physics. For example, the recent discovery of polarization vortices and their associated complex-phase coexistence and response under applied electric fields in superlattices of (PbTiO3)n/(SrTiO...

    journal_title:Nature

    pub_type: 杂志文章

    doi:10.1038/s41586-019-1092-8

    authors: Das S,Tang YL,Hong Z,Gonçalves MAP,McCarter MR,Klewe C,Nguyen KX,Gómez-Ortiz F,Shafer P,Arenholz E,Stoica VA,Hsu SL,Wang B,Ophus C,Liu JF,Nelson CT,Saremi S,Prasad B,Mei AB,Schlom DG,Íñiguez J,García-Fernández P

    更新日期:2019-04-01 00:00:00

  • Molecular machines governing exocytosis of synaptic vesicles.

    abstract::Calcium-dependent exocytosis of synaptic vesicles mediates the release of neurotransmitters. Important proteins in this process have been identified such as the SNAREs, synaptotagmins, complexins, Munc18 and Munc13. Structural and functional studies have yielded a wealth of information about the physiological role of ...

    journal_title:Nature

    pub_type: 杂志文章,评审

    doi:10.1038/nature11320

    authors: Jahn R,Fasshauer D

    更新日期:2012-10-11 00:00:00