Abstract:
:The isolation of a mutant adenovirus carrying an insertion of cellular DNA has led to the identification of a new family of human repetitive sequences, which are found tandemly arranged in the genome. The sequence of the viral insert resembles that of eukaryotic transposable elements.
journal_name
Naturejournal_title
Natureauthors
Shimizu Y,Yoshida K,Ren CS,Fujinaga K,Rajagopalan S,Chinnadurai Gdoi
10.1038/302587a0subject
Has Abstractpub_date
1983-04-14 00:00:00pages
587-90issue
5909eissn
0028-0836issn
1476-4687journal_volume
302pub_type
杂志文章相关文献
NATURE文献大全abstract::Angiotensin-converting enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme. Experiments with hypertens...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375146a0
更新日期:1995-05-11 00:00:00
abstract::One goal of regenerative medicine, to use stem cells to replace cells lost by injury or disease, depends on producing an excess of the relevant cell for study or transplantation. To this end, the stepwise differentiation of stem cells into specialized derivatives has been successful for some cell types, but a major pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11463
更新日期:2012-11-29 00:00:00
abstract::Birds can perceive the reflectance of ultraviolet light by biological structures. Here we show that the skin of the mouth and body of starling nestlings substantially reflects light in the ultraviolet range and that young in which this reflectance is reduced will gain less mass than controls, despite low background le...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/431262a
更新日期:2004-09-16 00:00:00
abstract::Ordinarily, photons do not interact with one another. However, atoms can be used to mediate photonic interactions1,2, raising the prospect of forming synthetic materials3 and quantum information systems4-7 from photons. One promising approach combines highly excited Rydberg atoms8-12 with the enhanced light-matter cou...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1354-5
更新日期:2019-07-01 00:00:00
abstract::Hunter-Schreger bands (HSB) are seen in teeth that are composed of crossed sets of enamel prisms. They are present in the teeth of man and many other mammals, but absent in most insectivores and multituberculates. It has been suggested that the presence of HSB makes the tooth enamel less likely to split and is associa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328150a0
更新日期:1987-07-09 00:00:00
abstract::C-type (Ca(2+)-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 A resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360127a0
更新日期:1992-11-12 00:00:00
abstract::Long interspersed nuclear elements-1 (LINE-1 or L1s) are abundant retrotransposons that comprise approximately 20% of mammalian genomes. Active L1 retrotransposons can impact the genome in a variety of ways, creating insertions, deletions, new splice sites or gene expression fine-tuning. We have shown previously that ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09544
更新日期:2010-11-18 00:00:00
abstract::The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14366
更新日期:2015-04-30 00:00:00
abstract::Methane is a powerful greenhouse gas and is targeted for emissions mitigation by the US state of California and other jurisdictions worldwide1,2. Unique opportunities for mitigation are presented by point-source emitters-surface features or infrastructure components that are typically less than 10 metres in diameter a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1720-3
更新日期:2019-11-01 00:00:00
abstract::The dispersal of early humans from Africa by 1.75 Myr ago led to a marked expansion of their range, from the island of Flores in the east to the Iberian peninsula in the west. This range encompassed tropical forest, savannah and Mediterranean habitats, but has hitherto not been demonstrated beyond 45 degrees N. Until ...
journal_title:Nature
pub_type: 历史文章,杂志文章
doi:10.1038/nature09117
更新日期:2010-07-08 00:00:00
abstract::Speciation in many animal taxa is catalysed by the evolutionary diversification of mating signals. According to classical theories of speciation, mating signals diversify, in part, as an incidental byproduct of adaptation by natural selection to divergent ecologies, although empirical evidence in support of this hypot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35051570
更新日期:2001-01-11 00:00:00
abstract::Increasing human populations around the global coastline have caused extensive loss, degradation and fragmentation of coastal ecosystems, threatening the delivery of important ecosystem services1. As a result, alarming losses of mangrove, coral reef, seagrass, kelp forest and coastal marsh ecosystems have occurred1-6....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0805-8
更新日期:2019-01-01 00:00:00
abstract::Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02789
更新日期:2004-08-05 00:00:00
abstract::Dopamine D2 receptors (D2Rs) are densely expressed in the striatum and have been linked to neuropsychiatric disorders such as schizophrenia1,2. High-affinity binding of dopamine suggests that D2Rs detect transient reductions in dopamine concentration (the dopamine dip) during punishment learning3-5. However, the natur...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2115-1
更新日期:2020-03-01 00:00:00
abstract::Macrophages and dendritic cells have key roles in viral infections, providing virus reservoirs that frequently resist antiviral therapies and linking innate virus detection to antiviral adaptive immune responses. Human immunodeficiency virus 1 (HIV-1) fails to transduce dendritic cells and has a reduced ability to tra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10195
更新日期:2011-06-29 00:00:00
abstract::Hox genes are essential for growth and patterning of the tetrapod limb skeleton. Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/375678a0
更新日期:1995-06-22 00:00:00
abstract::The fossil record of the living great apes is poor. New fossils from undocumented areas, particularly the equatorial forested habitats of extant hominoids, are therefore crucial for understanding their origins and evolution. Two main competing hypotheses have been proposed for orang-utan origins: dental similarities s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02245
更新日期:2004-01-29 00:00:00
abstract::Erythroid differentiation entails the biogenesis of a membrane skeleton, a network of proteins underlying and interacting with the plasma membrane, whose major constituent is the heterodimeric protein spectrin, composed of two structurally similar but distinct subunits, alpha (relative molecular mass (Mr) 240,000) and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/321085a0
更新日期:1986-05-01 00:00:00
abstract::The DNA polymerase V (pol V) and RecA proteins are essential components of a mutagenic translesion synthesis pathway in Escherichia coli designed to cope with DNA damage. Previously, it has been assumed that RecA binds to the DNA template strand being copied. Here we show, however, that pol-V-catalysed translesion syn...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05042
更新日期:2006-08-24 00:00:00
abstract::We have used in vitro mutagenesis to identify a DNA sequence that is required for glucose regulation of the ADR2 locus of Saccharomyces cerevisiae. This region, located between 200 and 1,000 base pairs upstream of the structural gene for ADH II, has been identified by genetic and biochemical analysis as the site of AD...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/300724a0
更新日期:1982-12-23 00:00:00
abstract::The application of a sufficiently strong magnetic field to a superconductor will, in general, destroy the superconducting state. Two mechanisms are responsible for this. The first is the Zeeman effect, which breaks apart the paired electrons if they are in a spin-singlet (but not a spin-triplet) state. The second is t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35073531
更新日期:2001-04-19 00:00:00
abstract::A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/305600a0
更新日期:1983-10-13 00:00:00
abstract::The quest for higher data density in information storage is motivating investigations into approaches for manipulating magnetization by means other than magnetic fields. This is evidenced by the recent boom in magnetoelectronics and 'spintronics', where phenomena such as carrier effects in magnetic semiconductors and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02728
更新日期:2004-07-29 00:00:00
abstract::The src gene product, p60src, of Rous sarcoma virus (RSV) is a tyrosine-specific protein kinase which is associated with the plasma membrane of infected cells. Myristic acid is bound in an amide linkage to glycine 2 of p60src. Of the N-terminal 30 kilodaltons of p60src, only amino acids 1-14 are required for myristyla...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314374a0
更新日期:1985-03-28 00:00:00
abstract::Many animals are regarded as relatively sedentary and specialized in marginal parts of their geographical distributions. They are expected to be slow at colonizing new habitats. Despite this, the cool margins of many species' distributions have expanded rapidly in association with recent climate warming. We examined f...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35079066
更新日期:2001-05-31 00:00:00
abstract::Among the ten subtypes of mammalian voltage-gated calcium (Cav) channels, Cav3.1-Cav3.3 constitute the T-type, or the low-voltage-activated, subfamily, the abnormal activities of which are associated with epilepsy, psychiatric disorders and pain1-5. Here we report the cryo-electron microscopy structures of human Cav3....
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1801-3
更新日期:2019-12-01 00:00:00
abstract::The optics of the eye cause different wavelengths of light to be differentially focused at the retina. This phenomenon is due to longitudinal chromatic aberration, a wavelength-dependent change in refractive power. Retinal image quality may consequently vary for the different classes of cone photoreceptors, cells tune...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/417174a
更新日期:2002-05-09 00:00:00
abstract::Retinoic acid may be the natural morphogen used to generate digit pattern in the chick limb bud. It has been proposed that retinoic acid acts by binding to a cellular retinoic acid-binding protein (CRABP) and then entering the nucleus to alter the pattern of gene activity. High-affinity receptors that bind both retino...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335733a0
更新日期:1988-10-20 00:00:00
abstract::Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/295206a0
更新日期:1982-01-21 00:00:00
abstract::For many pathogens the availability of genome sequence, permitting genome-dependent methods of research, can partially substitute for powerful forward genetic methods (genome-independent) that have advanced model organism research for decades. In 2002 the genome sequence of Plasmodium falciparum, the parasite causing ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature07361
更新日期:2008-10-09 00:00:00