Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.

abstract：:Sex in mammals is determined in the fetal gonad by the presence or absence of the Y chromosome gene Sry, which controls whether bipotential precursor cells differentiate into testicular Sertoli cells or ovarian granulosa cells. This pivotal decision in a single gonadal cell type ultimately controls sexual differentiat...

journal_title：Nature

authors： Matson CK,Murphy MW,Sarver AL,Griswold MD,Bardwell VJ,Zarkower D

更新日期：2011-07-20 00:00:00

abstract：:Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...

journal_title：Nature

authors： Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

更新日期：2010-11-11 00:00:00

abstract：:Microsomes prepared from rabbit or pig aortas transformed endoperoxides (PGG2 or PGH2) to an unstable substance (PGX) that inhibited human platelet aggregation. PGX was 30 times more potent in this respect than prostaglandin E1. PGX contracted some gastrointestinal smooth muscle and relaxed certain isolated blood vess...

journal_title：Nature

authors： Moncada S,Gryglewski R,Bunting S,Vane JR

更新日期：1976-10-21 00:00:00

abstract：:In mammals, the emergence of totipotency after fertilization involves extensive rearrangements of the spatial positioning of the genome1,2. However, the contribution of spatial genome organization to the regulation of developmental programs is unclear3. Here we generate high-resolution maps of genomic interactions wit...

journal_title：Nature

authors： Borsos M,Perricone SM,Schauer T,Pontabry J,de Luca KL,de Vries SS,Ruiz-Morales ER,Torres-Padilla ME,Kind J

更新日期：2019-05-01 00:00:00

abstract：:A first step towards somatic hybridization in plants has been achieved. Protoplasts have been isolated and seen to fuse. ...

journal_title：Nature

authors： Power JB,Cummins SE,Cocking EC

更新日期：1970-03-14 00:00:00

abstract：:Although parasite-host co-speciation is a long-held hypothesis, convincing evidence for long-term co-speciation remains elusive, largely because of small numbers of hosts and parasites studied and uncertainty over rates of evolutionary change. Co-speciation is especially rare in RNA viruses, in which cross-species tra...

journal_title：Nature

authors： Switzer WM,Salemi M,Shanmugam V,Gao F,Cong ME,Kuiken C,Bhullar V,Beer BE,Vallet D,Gautier-Hion A,Tooze Z,Villinger F,Holmes EC,Heneine W

更新日期：2005-03-17 00:00:00

abstract：:DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases as intermediates of several important physiological processes. The cellular response to genotoxic DNA breaks includes the activation of transcriptional programs known primarily to regulate cell-cycle checkpoints and cell survival....

journal_title：Nature

authors： Bredemeyer AL,Helmink BA,Innes CL,Calderon B,McGinnis LM,Mahowald GK,Gapud EJ,Walker LM,Collins JB,Weaver BK,Mandik-Nayak L,Schreiber RD,Allen PM,May MJ,Paules RS,Bassing CH,Sleckman BP

更新日期：2008-12-11 00:00:00

abstract：:The current outbreak of coronavirus disease-2019 (COVID-19) poses unprecedented challenges to global health1. The new coronavirus responsible for this outbreak-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-shares high sequence identity to SARS-CoV and a bat coronavirus, RaTG132. Although bats may be the...

journal_title：Nature

authors： Xiao K,Zhai J,Feng Y,Zhou N,Zhang X,Zou JJ,Li N,Guo Y,Li X,Shen X,Zhang Z,Shu F,Huang W,Li Y,Zhang Z,Chen RA,Wu YJ,Peng SM,Huang M,Xie WJ,Cai QH,Hou FH,Chen W,Xiao L,Shen Y

更新日期：2020-07-01 00:00:00

abstract：:Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression...

journal_title：Nature

authors： Heinzel T,Lavinsky RM,Mullen TM,Söderstrom M,Laherty CD,Torchia J,Yang WM,Brard G,Ngo SD,Davie JR,Seto E,Eisenman RN,Rose DW,Glass CK,Rosenfeld MG

更新日期：1997-05-01 00:00:00

abstract：:Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic perturbations are required to elaborate full malignant transformation. To...

journal_title：Nature

authors： Firestein R,Bass AJ,Kim SY,Dunn IF,Silver SJ,Guney I,Freed E,Ligon AH,Vena N,Ogino S,Chheda MG,Tamayo P,Finn S,Shrestha Y,Boehm JS,Jain S,Bojarski E,Mermel C,Barretina J,Chan JA,Baselga J,Tabernero J,Root DE,

更新日期：2008-09-25 00:00:00

abstract：:At fertilization, an increase of cytosolic calcium ions (Ca2+) triggers various activation responses in animal eggs. In vertebrates, these responses include exit from metaphase arrest in meiosis II (MII exit) and cortical remodelling initiated by cortical granule exocytosis. Although the essential requirement of Ca2+/...

journal_title：Nature

authors： Nishiyama T,Yoshizaki N,Kishimoto T,Ohsumi K

更新日期：2007-09-20 00:00:00

abstract：:Evolution of the earliest mammals shows successive episodes of diversification. Lineage-splitting in Mesozoic mammals is coupled with many independent evolutionary experiments and ecological specializations. Classic scenarios of mammalian morphological evolution tend to posit an orderly acquisition of key evolutionary...

journal_title：Nature

authors： Luo ZX

更新日期：2007-12-13 00:00:00

abstract：:In mammalian somatic-cell cycles, progression through the G1-phase restriction point and initiation of DNA replication are controlled by the ability of the retinoblastoma tumour-suppressor protein (pRb) family to regulate the E2F/DP transcription factors. Continuing transcription of E2F target genes beyond the G1/S tr...

journal_title：Nature

authors： Lukas C,Sørensen CS,Kramer E,Santoni-Rugiu E,Lindeneg C,Peters JM,Bartek J,Lukas J

更新日期：1999-10-21 00:00:00

abstract：:Early co-transcriptional events during eukaryotic ribosome assembly result in the formation of precursors of the small (40S) and large (60S) ribosomal subunits. A multitude of transient assembly factors regulate and chaperone the systematic folding of pre-ribosomal RNA subdomains. However, owing to a lack of structura...

journal_title：Nature

authors： Sanghai ZA,Miller L,Molloy KR,Barandun J,Hunziker M,Chaker-Margot M,Wang J,Chait BT,Klinge S

更新日期：2018-04-05 00:00:00

abstract：:Natural composite materials are renowned for their mechanical strength and toughness: despite being highly mineralized, with the organic component constituting not more than a few per cent of the composite material, the fracture toughness exceeds that of single crystals of the pure mineral by two to three orders of ma...

journal_title：Nature

authors： Kamat S,Su X,Ballarini R,Heuer AH

更新日期：2000-06-29 00:00:00

abstract：:Non-coding apurinic/apyrimidinic (AP) sites in DNA are continually created in cells both spontaneously and by damage-specific DNA glycosylases. The biologically critical human base excision repair enzyme APE1 cleaves the DNA sugar-phosphate backbone at a position 5' of AP sites to prime DNA repair synthesis. Here we r...

journal_title：Nature

authors： Mol CD,Izumi T,Mitra S,Tainer JA

更新日期：2000-01-27 00:00:00

abstract：:Deep chlorophyll maxima (DCMs) are widespread in large parts of the world's oceans. These deep layers of high chlorophyll concentration reflect a compromise of phytoplankton growth exposed to two opposing resource gradients: light supplied from above and nutrients supplied from below. It is often argued that DCMs are ...

journal_title：Nature

authors： Huisman J,Pham Thi NN,Karl DM,Sommeijer B

更新日期：2006-01-19 00:00:00

abstract：:Transition-metal complexes are widely used in the physical and biological sciences. They have essential roles in catalysis, synthesis, materials science, photophysics and bioinorganic chemistry. Our understanding of transition-metal complexes originates from Alfred Werner's realization that their three-dimensional sha...

journal_title：Nature

authors： Garçon M,Bakewell C,Sackman GA,White AJP,Cooper RI,Edwards AJ,Crimmin MR

更新日期：2019-10-01 00:00:00

abstract：:Gram-negative bacteria, such as Escherichia coli, expel toxic chemicals through tripartite efflux pumps that span both the inner and outer membrane. The three parts are an inner membrane, substrate-binding transporter; a membrane fusion protein; and an outer-membrane-anchored channel. The fusion protein connects the t...

journal_title：Nature

authors： Su CC,Long F,Zimmermann MT,Rajashankar KR,Jernigan RL,Yu EW

更新日期：2011-02-24 00:00:00

abstract：:Biodiversity is rapidly declining, and this may negatively affect ecosystem processes, including economically important ecosystem services. Previous studies have shown that biodiversity has positive effects on organisms and processes across trophic levels. However, only a few studies have so far incorporated an explic...

journal_title：Nature

authors： Scherber C,Eisenhauer N,Weisser WW,Schmid B,Voigt W,Fischer M,Schulze ED,Roscher C,Weigelt A,Allan E,Bessler H,Bonkowski M,Buchmann N,Buscot F,Clement LW,Ebeling A,Engels C,Halle S,Kertscher I,Klein AM,Koller R,

更新日期：2010-11-25 00:00:00

abstract：:Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer patients and are probably the origin of intractable metastatic disease. Although extremely rare, CTCs represent a potential alternative to invasive biopsies as a source of tumour tissue for th...

journal_title：Nature

authors： Nagrath S,Sequist LV,Maheswaran S,Bell DW,Irimia D,Ulkus L,Smith MR,Kwak EL,Digumarthy S,Muzikansky A,Ryan P,Balis UJ,Tompkins RG,Haber DA,Toner M

更新日期：2007-12-20 00:00:00

abstract：:When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...

journal_title：Nature

authors： Trinh TQ,Sinden RR

更新日期：1991-08-08 00:00:00

abstract：:It has been established that many eukaryotic mRNAs contain poly(adenylic acid) tracts at their 3'-termini. The polyadenylation of mRNA occurs post-transcriptionally in the nucleus as a rapid, initial addition of 100-200 adenylate residues to the pre-mRNA (ref. 1). Subsequently, a slower chain extension (6-8 bases) of ...

journal_title：Nature

authors： Rose KM,Bell LE,Jacob ST

更新日期：1977-05-12 00:00:00

abstract：:Felsenstein's application of the bootstrap method to evolutionary trees is one of the most cited scientific papers of all time. The bootstrap method, which is based on resampling and replications, is used extensively to assess the robustness of phylogenetic inferences. However, increasing numbers of sequences are now ...

journal_title：Nature

authors： Lemoine F,Domelevo Entfellner JB,Wilkinson E,Correia D,Dávila Felipe M,De Oliveira T,Gascuel O

更新日期：2018-04-01 00:00:00

abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

journal_title：Nature

authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

更新日期：2021-01-27 00:00:00

abstract：:Differentiation of bone marrow derived precursors into mature T cells takes place in the thymus. During differentiation, T cells develop the receptor repertoire which allows them to recognize antigen in the context of self major histocompatibility complex (MHC) molecules. Mature T helper cells (mostly CD4+ CD8-) recog...

journal_title：Nature

authors： Maruŝić-Galesić S,Stephany DA,Longo DL,Kruisbeek AM

更新日期：1988-05-12 00:00:00

abstract：:The existence of so great a diversity of species on Earth remains a mystery, the solution to which may also explain why and how biodiversity influences the functioning of ecosystems. The answer may lie in quantifying the trade-offs that organisms face in dealing with the constraints of their environment. Societal resp...

journal_title：Nature

authors： Tilman D

更新日期：2000-05-11 00:00:00

abstract：:Conjugate (or 1,4-) additions of carbanionic species to α,β-unsaturated carbonyl compounds are vital to research in organic and medicinal chemistry, and there are several chiral catalysts that facilitate the catalytic enantioselective additions of nucleophiles to enoates. Nonetheless, catalytic enantioselective 1,6-co...

journal_title：Nature

authors： Meng F,Li X,Torker S,Shi Y,Shen X,Hoveyda AH

更新日期：2016-09-15 00:00:00

abstract：:CD95 (also called Fas and APO-1) is a prototypical death receptor that regulates tissue homeostasis mainly in the immune system through the induction of apoptosis. During cancer progression CD95 is frequently downregulated or cells are rendered apoptosis resistant, raising the possibility that loss of CD95 is part of ...

journal_title：Nature

authors： Chen L,Park SM,Tumanov AV,Hau A,Sawada K,Feig C,Turner JR,Fu YX,Romero IL,Lengyel E,Peter ME

更新日期：2010-05-27 00:00:00

abstract：:IN 1969, Murozumi et al.1 demonstrated that the concentration of lead in Greenland snow had increased by a factor of 200 since ancient times, and concluded that most of this increase was a result of the use of alkyl-leaded petrol. Partly because of these findings, the United States and other western countries limited ...

journal_title：Nature

authors： Rosman KJR,Chisholm W,Boutron CF,Candelone JP,Görlach U

更新日期：1993-03-25 00:00:00