Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli.

abstract：:Phosphatidylinositol 4,5-bisphosphate (PIP2), which comprises only about 1% of the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three second messengers, activates many ion channels and enzymes, is involved in both endocytosis and exocytosis, anchors proteins to the membrane through...

journal_title：Nature

authors： McLaughlin S,Murray D

更新日期：2005-12-01 00:00:00

abstract：:The metabolic basis of the autosomal recessive disease cystic fibrosis (CF) remains unidentified. Elevated levels of a serum protein in CF homozygotes and obligate heterozygotes have been described. As heterozygotes are clinically unaffected, any consistently observed abnormality in these individuals is a likely point...

journal_title：Nature

authors： Dorin JR,Novak M,Hill RE,Brock DJ,Secher DS,van Heyningen V

更新日期：1987-04-09 00:00:00

abstract：:Time is divided by geologists according to marked shifts in Earth's state. Recent global environmental changes suggest that Earth may have entered a new human-dominated geological epoch, the Anthropocene. Here we review the historical genesis of the idea and assess anthropogenic signatures in the geological record aga...

journal_title：Nature

authors： Lewis SL,Maslin MA

更新日期：2015-03-12 00:00:00

abstract：:The ubiquity of tertiary alkylamines in pharmaceutical and agrochemical agents, natural products and small-molecule biological probes1,2 has stimulated efforts towards their streamlined synthesis3-9. Arguably the most robust method for the synthesis of tertiary alkylamines is carbonyl reductive amination3, which compr...

journal_title：Nature

authors： Kumar R,Flodén NJ,Whitehurst WG,Gaunt MJ

更新日期：2020-05-01 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00

abstract：:Hunger is a hard-wired motivational state essential for survival. Agouti-related peptide (AgRP)-expressing neurons in the arcuate nucleus (ARC) at the base of the hypothalamus are crucial to the control of hunger. They are activated by caloric deficiency and, when naturally or artificially stimulated, they potently in...

journal_title：Nature

authors： Krashes MJ,Shah BP,Madara JC,Olson DP,Strochlic DE,Garfield AS,Vong L,Pei H,Watabe-Uchida M,Uchida N,Liberles SD,Lowell BB

更新日期：2014-03-13 00:00:00

abstract：:Functional studies seem now to confirm, as first suggested by E. Geoffroy Saint-Hilaire in 1822, that there was an inversion of the dorsoventral axis during animal evolution. A conserved system of extracellular signals provides positional information for the allocation of embryonic cells to specific tissue types both ...

journal_title：Nature

authors： De Robertis EM,Sasai Y

更新日期：1996-03-07 00:00:00

abstract：:A temperature sensitive mutant has been isolated for the first time from a replication defective acute leukaemia virus, AEV. In vivo, at 41 degrees C, the mutant shows a reduced leukaemogenic potential. In vitro, in erythroblasts transformed at 35 degrees C, haemoglobin synthesis can be induced by a shift to 41 degree...

journal_title：Nature

authors： Graf T,Ade N,Beug H

更新日期：1978-10-12 00:00:00

abstract：:The pathways that control insulin secretion and regulate pancreatic beta-cell mass are crucial in the development of diabetes mellitus. Maturity-onset diabetes of the young comprises a number of single-gene disorders affecting pancreatic beta-cell function, and the consequences of mutations in these genes are so serio...

journal_title：Nature

authors： Bell GI,Polonsky KS

更新日期：2001-12-13 00:00:00

abstract：:Lymphocyte function-associated antigen-1 (LFA-1) is a heterodimer composed of an alpha and beta chain that is expressed on the surface of most leukocytes and is an essential molecule for adhesion reactions between cells participating in the immune response. A putative ligand for LFA-1 is the intercellular adhesion mol...

journal_title：Nature

authors： van Noesel C,Miedema F,Brouwer M,de Rie MA,Aarden LA,van Lier RA

更新日期：1988-06-30 00:00:00

abstract：:With only a few exceptions that are well understood, conventional superconductivity does not coexist with long-range magnetic order (for example, ref. 1). Unconventional superconductivity, on the other hand, develops near a phase boundary separating magnetically ordered and magnetically disordered phases. A maximum in...

journal_title：Nature

authors： Park T,Ronning F,Yuan HQ,Salamon MB,Movshovich R,Sarrao JL,Thompson JD

更新日期：2006-03-02 00:00:00

abstract：:X-chromosome inactivation results in the strictly cis-limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females. One feature of virtually all models of X inactivation is the existence of an X-inactivation centre (XIC) required in cis f...

journal_title：Nature

authors： Brown CJ,Lafreniere RG,Powers VE,Sebastio G,Ballabio A,Pettigrew AL,Ledbetter DH,Levy E,Craig IW,Willard HF

更新日期：1991-01-03 00:00:00

abstract：:Hepatocellularcarcinoma (HCC) that occur in woodchucks chronically infected with woodchuck hepatitis virus (WHV) were screened for activation of cellular oncogenes. Enhanced expression and allelic alterations of the c-myc oncogene were found in three HCC out of nine. Variations in the size of the c-myc transcripts, ra...

journal_title：Nature

authors： Möröy T,Marchio A,Etiemble J,Trépo C,Tiollais P,Buendia MA

更新日期：1986-11-20 00:00:00

abstract：:The assembly of ribosomes in bacterial cells is a complex process that remains poorly characterized. The in vitro assembly of active ribosomal subunits from purified RNA and protein components indicates that all of the information for proper assembly resides in the primary sequences of these macromolecules. On the oth...

journal_title：Nature

authors： Nishi K,Morel-Deville F,Hershey JW,Leighton T,Schnier J

更新日期：1988-12-01 00:00:00

abstract：:Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens. Although the first outbreak wave that was centred on eastern China was seemingly averted, human infections recurred in October 2013 (refs 3-7). It is unclear ...

journal_title：Nature

authors： Lam TT,Zhou B,Wang J,Chai Y,Shen Y,Chen X,Ma C,Hong W,Chen Y,Zhang Y,Duan L,Chen P,Jiang J,Zhang Y,Li L,Poon LL,Webby RJ,Smith DK,Leung GM,Peiris JS,Holmes EC,Guan Y,Zhu H

更新日期：2015-06-04 00:00:00

abstract：:Retrotransposons, which proliferate by reverse transcription of RNA intermediates, comprise a major portion of plant genomes. Plants often change the genome size and organization during evolution by rapid proliferation and deletion of long terminal repeat (LTR) retrotransposons. Precise transposon sequences throughout...

journal_title：Nature

authors： Tsukahara S,Kobayashi A,Kawabe A,Mathieu O,Miura A,Kakutani T

更新日期：2009-09-17 00:00:00

abstract：:Processes such as the scattering of alpha particles ((4)He), the triple-alpha reaction, and alpha capture play a major role in stellar nucleosynthesis. In particular, alpha capture on carbon determines the ratio of carbon to oxygen during helium burning, and affects subsequent carbon, neon, oxygen, and silicon burning...

journal_title：Nature

authors： Elhatisari S,Lee D,Rupak G,Epelbaum E,Krebs H,Lähde TA,Luu T,Meißner UG

更新日期：2015-12-03 00:00:00

abstract：:The hypothesis that animal population dynamics may be synchronized by climate is highly relevant in the context of climate change because it suggests that several populations might respond simultaneously to climatic trends if their dynamics are entrained by environmental correlation. The dynamics of many species throu...

journal_title：Nature

authors： Post E,Forchhammer MC

更新日期：2002-11-14 00:00:00

abstract：:More than 50 copies of a phi X174 DNA template can be made in 60 min in an in vitro DNA replication system consisting of seven purfied replication proteins isolated from T4 bacteriophage-infected cells. By transfecting with the DNA products and assaying for the reversion of specific amber mutants, the high degree of b...

journal_title：Nature

authors： Hibner U,Alberts BM

更新日期：1980-05-29 00:00:00

abstract：:Attempts to inhibit the recognition of soluble antigens by T lymphocytes using antibodies specific for the antigen in question have been uniformally unsuccessful, in contrast to the observed specific inhibition of antibody generation by B cells. One exception is the unique situation whereby anti-hapten antisera inhibi...

journal_title：Nature

authors： Corradin G,Engers HD

更新日期：1984-04-05 00:00:00

abstract：:The inner ear is capable of highly selective frequency discrimination. This is achieved not only by the travelling wave of the basilar membrane in the cochlear partition, but also by the active participation of nonlinear and vulnerable elements that enhance frequency selectivity. It has been shown that isolated mammal...

journal_title：Nature

authors： Brundin L,Flock A,Canlon B

更新日期：1989-12-14 00:00:00

abstract：:Tobacco smoking causes lung cancer1-3, a process that is driven by more than 60 carcinogens in cigarette smoke that directly damage and mutate DNA4,5. The profound effects of tobacco on the genome of lung cancer cells are well-documented6-10, but equivalent data for normal bronchial cells are lacking. Here we sequence...

journal_title：Nature

authors： Yoshida K,Gowers KHC,Lee-Six H,Chandrasekharan DP,Coorens T,Maughan EF,Beal K,Menzies A,Millar FR,Anderson E,Clarke SE,Pennycuick A,Thakrar RM,Butler CR,Kakiuchi N,Hirano T,Hynds RE,Stratton MR,Martincorena I,Janes

更新日期：2020-02-01 00:00:00

abstract：:Nanomachines of the future will require molecular-scale motors that can perform work and collectively induce controlled motion of much larger objects. We have designed a synthetic, light-driven molecular motor that is embedded in a liquid-crystal film and can rotate objects placed on the film that exceed the size of t...

journal_title：Nature

authors： Eelkema R,Pollard MM,Vicario J,Katsonis N,Ramon BS,Bastiaansen CW,Broer DJ,Feringa BL

更新日期：2006-03-09 00:00:00

abstract：:In mice gamma delta T-cell populations with distinct T-cell receptor (TCR) repertoires and homing properties have been identified. Diversified populations are found in lymphoid organs and intestinal epithelia. By contrast, the gamma delta T-cells that have been found in the murine skin are homogeneous. They express a ...

journal_title：Nature

authors： Itohara S,Farr AG,Lafaille JJ,Bonneville M,Takagaki Y,Haas W,Tonegawa S

更新日期：1990-02-22 00:00:00

abstract：:The assembly of microtubules has been investigated by time-resolved X-ray diffraction using synchrotron radiation. The small-angle scattering becomes visible within seconds and thus enables study of the structural transitions of the protein aggregates during assembly from their subunits in solution. The X-ray pattern ...

journal_title：Nature

authors： Mandelkow EM,Harmsen A,Mandelkow E,Bordas J

更新日期：1980-10-16 00:00:00

abstract：:Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...

journal_title：Nature

authors： Zhou L,Chu C,Teng F,Bessman NJ,Goc J,Santosa EK,Putzel GG,Kabata H,Kelsen JR,Baldassano RN,Shah MA,Sockolow RE,Vivier E,Eberl G,Smith KA,Sonnenberg GF

更新日期：2019-04-01 00:00:00

abstract：:A novel, structurally distinct POU-domain protein has been identified that inhibits activation by another positive POU-domain regulator of neuron-specific transcription units. Two Drosophila POU-domain proteins, I-POU and Cf1-a, are coexpressed in overlapping subsets of neurons during development. Because I-POU lacks ...

journal_title：Nature

authors： Treacy MN,He X,Rosenfeld MG

更新日期：1991-04-18 00:00:00

abstract：:A list of authors and their affiliations appears at the end of the paper New-particle formation is a major contributor to urban smog1,2, but how it occurs in cities is often puzzling3. If the growth rates of urban particles are similar to those found in cleaner environments (1-10 nanometres per hour), then existing un...

journal_title：Nature

authors： Wang M,Kong W,Marten R,He XC,Chen D,Pfeifer J,Heitto A,Kontkanen J,Dada L,Kürten A,Yli-Juuti T,Manninen HE,Amanatidis S,Amorim A,Baalbaki R,Baccarini A,Bell DM,Bertozzi B,Bräkling S,Brilke S,Murillo LC,Chiu R,

更新日期：2020-05-01 00:00:00

abstract：:Mr Clinton appears ready to compromise on health care reform despite previous denials. ...

journal_title：Nature

authors：

更新日期：1994-09-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that is important in adipocyte differentiation and glucose homeostasis and which depends on interactions with co-activators, including steroid receptor co-activating factor-1 (SRC-1). Here we present the X-ray ...

journal_title：Nature

authors： Nolte RT,Wisely GB,Westin S,Cobb JE,Lambert MH,Kurokawa R,Rosenfeld MG,Willson TM,Glass CK,Milburn MV

更新日期：1998-09-10 00:00:00