Abstract：
:The assembly of microtubules has been investigated by time-resolved X-ray diffraction using synchrotron radiation. The small-angle scattering becomes visible within seconds and thus enables study of the structural transitions of the protein aggregates during assembly from their subunits in solution. The X-ray pattern at 4 degrees C arises from a mixture of tubulin rings, dimers and some other species. Raising the temperature to 36 degrees C induces the breakdown of rings, followed by the growth of microtubules. The results suggest that microtubules may be formed from tubulin oligomers smaller than rings.
journal_name
Naturejournal_title
Natureauthors
Mandelkow EM,Harmsen A,Mandelkow E,Bordas Jdoi
10.1038/287595a0subject
Has Abstractpub_date
1980-10-16 00:00:00pages
595-9issue
5783eissn
0028-0836issn
1476-4687journal_volume
287pub_type
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