Dissemination, divergence and establishment of H7N9 influenza viruses in China.

abstract：:Eukaryotic cells seem to use GTP hydrolysis to regulate vesicular traffic in exocytosis and endocytosis. The best evidence for this comes from studies on the yeast Saccharomyces cerevisiae that have identified two small Ras-related GTP-binding proteins, Sec4p and Ypt1p, which control distinct stages of the secretory p...

journal_title：Nature

authors： Goud B,Zahraoui A,Tavitian A,Saraste J

更新日期：1990-06-07 00:00:00

abstract：:In mammalian tissues the C-terminal amide structure has been found to occur only in neuroactive or hormonally-active peptides. About half known neuropeptide and peptide hormones have this unique chemical feature. Using a chemical detection method, a search for previously unknown peptides that possess the C-terminal am...

journal_title：Nature

authors： Tatemoto K,Efendić S,Mutt V,Makk G,Feistner GJ,Barchas JD

更新日期：1986-12-04 00:00:00

abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...

journal_title：Nature

authors： Agarwal J,Jewitt D,Mutchler M,Weaver H,Larson S

更新日期：2017-09-20 00:00:00

abstract：:To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...

journal_title：Nature

authors： Ganeshram RS,Pedersen TF,Calvert S,François R

更新日期：2002-01-10 00:00:00

abstract：:Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome b...

journal_title：Nature

authors： Chailangkarn T,Trujillo CA,Freitas BC,Hrvoj-Mihic B,Herai RH,Yu DX,Brown TT,Marchetto MC,Bardy C,McHenry L,Stefanacci L,Järvinen A,Searcy YM,DeWitt M,Wong W,Lai P,Ard MC,Hanson KL,Romero S,Jacobs B,Dale AM,Dai L

更新日期：2016-08-18 00:00:00

abstract：:Novel biochemical processes using magnetic particles have been automated to provide a robotic system to perform processes for large-scale shotgun sequencing. ...

journal_title：Nature

authors： Watson A,Smaldon N,Lucke R,Hawkins T

更新日期：1993-04-08 00:00:00

abstract：:It is thought that in skeletal muscle excitation-contraction (EC) coupling, the release of Ca2+ from the sarcoplasmic reticulum is controlled by the dihydropyridine (DHP) receptor in the transverse tubular membrane, where it serves as the voltage sensor. We have shown previously that injection of an expression plasmid...

journal_title：Nature

authors： Tanabe T,Beam KG,Adams BA,Niidome T,Numa S

更新日期：1990-08-09 00:00:00

abstract：:Titan, the largest moon of Saturn, is the only satellite in the Solar System with a substantial atmosphere. The atmosphere is poorly understood and obscures the surface, leading to intense speculation about Titan's nature. Here we present observations of Titan from the imaging science experiment onboard the Cassini sp...

journal_title：Nature

authors： Porco CC,Baker E,Barbara J,Beurle K,Brahic A,Burns JA,Charnoz S,Cooper N,Dawson DD,Del Genio AD,Denk T,Dones L,Dyudina U,Evans MW,Fussner S,Giese B,Grazier K,Helfenstein P,Ingersoll AP,Jacobson RA,Johnson TV,McE

更新日期：2005-03-10 00:00:00

abstract：:Most tetrapods have retained terrestrial locomotion since it evolved in the Palaeozoic era, but bats have become so specialized for flight that they have almost lost the ability to manoeuvre on land at all. Vampire bats, which sneak up on their prey along the ground, are an important exception. Here we show that commo...

journal_title：Nature

authors： Riskin DK,Hermanson JW

更新日期：2005-03-17 00:00:00

abstract：:Double-stranded DNA copies of the RNA gene coding for the haemagglutinin glycoproteins from human H2 and H3 pandemic strains of influenza virus have been cloned. DNA sequence analysis provides the first reported complete nucleotide sequence of an H2 haemagglutinin gene and a partial sequence (45%) of the H3 gene. The ...

journal_title：Nature

authors： Gething MJ,Bye J,Skehel J,Waterfield M

更新日期：1980-09-25 00:00:00

abstract：:Protein synthesis takes place on the ribosome, where genetic information carried by messenger RNA is translated into a sequence of amino acids. This process is terminated when a stop codon moves into the ribosomal decoding centre (DC) and is recognized by a class-1 release factor (RF). RFs have a conserved GGQ amino-a...

journal_title：Nature

authors： Rawat UB,Zavialov AV,Sengupta J,Valle M,Grassucci RA,Linde J,Vestergaard B,Ehrenberg M,Frank J

更新日期：2003-01-02 00:00:00

abstract：:There seems a real prospect that one of the infectious scourges of the past half century will not persist much beyond the present century, but polio will be only the second infection of human beings to be eradicated. Many more remain. ...

journal_title：Nature

authors：

更新日期：1995-04-20 00:00:00

abstract：:Transcriptional activator proteins (activators) function, at least in part, by increasing preinitiation complex assembly (for reviews see refs 1-4). Previous studies have shown that an acidic activator forms a contact with the general transcription factor TFIIB (refs 5-7) and recruits it into the preinitiation complex...

journal_title：Nature

authors： Roberts SG,Green MR

更新日期：1994-10-20 00:00:00

abstract：:A single U leads to G transversion in the 3' consensus sequence AAUAAA of the adenovirus early region 1A gene was constructed and the effect of this mutation on processing of the 3' end of the nuclear early region 1A RNAs was analysed. The results demonstrate that the intact AAUAAA is not required for RNA polyadenylat...

journal_title：Nature

authors： Montell C,Fisher EF,Caruthers MH,Berk AJ

更新日期：1983-10-13 00:00:00

abstract：:Astrophysical observations indicate that there is roughly five times more dark matter in the Universe than ordinary baryonic matter1, and an even larger amount of the Universe's energy content is attributed to dark energy2. However, the microscopic properties of these dark components remain unknown. Moreover, even ord...

journal_title：Nature

authors： Smorra C,Stadnik YV,Blessing PE,Bohman M,Borchert MJ,Devlin JA,Erlewein S,Harrington JA,Higuchi T,Mooser A,Schneider G,Wiesinger M,Wursten E,Blaum K,Matsuda Y,Ospelkaus C,Quint W,Walz J,Yamazaki Y,Budker D,Ulmer S

更新日期：2019-11-01 00:00:00

abstract：:The homotypic fusion of yeast vacuoles includes a 'docking' step, which we show here to consist of two sequential reactions: a reversible 'tethering' mediated by the GTPase Ypt7, and 'SNARE pairing', in which SNARE proteins from opposite membranes form a complex in trans. The function of this trans-SNARE complex must ...

journal_title：Nature

authors： Ungermann C,Sato K,Wickner W

更新日期：1998-12-10 00:00:00

abstract：:Multiple sclerosis is commonly associated with a local humoral immune response within the central nervous system. A hallmark of this intrathecal response is the presence of electrophoretically demonstrable oligoclonal bands of IgG in the cerebrospinal fluid (CSF) of up to 95% of patients. Observations indicating that ...

journal_title：Nature

authors： Vandvik B,Norrby E

更新日期：1989-04-27 00:00:00

abstract：:The ventral tegmental area (VTA) and nucleus accumbens (NAc) are essential for learning about environmental stimuli associated with motivationally relevant outcomes. The task of signalling such events, both rewarding and aversive, from the VTA to the NAc has largely been ascribed to dopamine neurons. The VTA also cont...

journal_title：Nature

authors： Brown MT,Tan KR,O'Connor EC,Nikonenko I,Muller D,Lüscher C

更新日期：2012-12-20 00:00:00

abstract：:Hypermethylation is associated with the silencing of tumour susceptibility genes in several forms of cancer; however, the mechanisms responsible for this aberrant methylation are poorly understood. The prototypic DNA methyltransferase, DNMT1, has been widely assumed to be responsible for most of the methylation of the...

journal_title：Nature

authors： Rhee I,Jair KW,Yen RW,Lengauer C,Herman JG,Kinzler KW,Vogelstein B,Baylin SB,Schuebel KE

更新日期：2000-04-27 00:00:00

abstract：:Recent seismological discoveries have indicated that the Earth's core-mantle boundary is far more complex than a simple boundary between the molten outer core and the silicate mantle. Instead, its structural complexities probably rival those of the Earth's crust. Some regions of the lowermost mantle have been observed...

journal_title：Nature

authors： Rost S,Garnero EJ,Williams Q,Manga M

更新日期：2005-06-02 00:00:00

abstract：:Some plasmid DNAs, when maintained in wild-type Escherichia coli strains, form high levels of oligomeric species while others remain primarily monomers. One explanation of this observation is that the plasmids that do not form circular oligomers lack a DNA sequence necessary for the formation or maintenance of circula...

journal_title：Nature

authors： James AA,Morrison PT,Kolodner R

更新日期：1983-05-19 00:00:00

abstract：:Jupiter's atmosphere is rotating differentially, with zones and belts rotating at speeds that differ by up to 100 metres per second. Whether this is also true of the gas giant's interior has been unknown, limiting our ability to probe the structure and composition of the planet. The discovery by the Juno spacecraft th...

journal_title：Nature

authors： Guillot T,Miguel Y,Militzer B,Hubbard WB,Kaspi Y,Galanti E,Cao H,Helled R,Wahl SM,Iess L,Folkner WM,Stevenson DJ,Lunine JI,Reese DR,Biekman A,Parisi M,Durante D,Connerney JEP,Levin SM,Bolton SJ

更新日期：2018-03-07 00:00:00

abstract：:Chameleons are arboral lizards that spot their prey visually and catch it by highly precise shots with their long sticky tongue. They scan their environment by large-amplitude independent saccadic eye movements; once an insect is detected, the head axis is aligned towards the target ('head tracking', both eyes come fo...

journal_title：Nature

authors： Ott M,Schaeffel F

更新日期：1995-02-23 00:00:00

abstract：:Foreign protein antigens must be broken down within endosomes or lysosomes to generate suitable peptides that will form complexes with class II major histocompatibility complex molecules for presentation to T cells. However, it is not known which proteases are required for antigen processing. To investigate this, we e...

journal_title：Nature

authors： Manoury B,Hewitt EW,Morrice N,Dando PM,Barrett AJ,Watts C

更新日期：1998-12-17 00:00:00

abstract：:Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the...

journal_title：Nature

authors： Adams EJ,Karthaus WR,Hoover E,Liu D,Gruet A,Zhang Z,Cho H,DiLoreto R,Chhangawala S,Liu Y,Watson PA,Davicioni E,Sboner A,Barbieri CE,Bose R,Leslie CS,Sawyers CL

更新日期：2019-07-01 00:00:00

abstract：:Diatremes are carrot-shaped bodies forming the upper parts of very deep magmatic intrusions of kimberlite rock. These unusual, enigmatic and complex features are famous as the source of diamonds. Here we present a new model of kimberlite ascent and eruption, emphasizing the extremely unsteady nature of this process to...

journal_title：Nature

authors： Wilson L,Head Iii JW 3rd

更新日期：2007-05-03 00:00:00

abstract：:Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer. As the worldwide obesity epidemic has shown no signs of abating, better understanding of the mechanisms underlying obesity-associated cancer...

journal_title：Nature

authors： Yoshimoto S,Loo TM,Atarashi K,Kanda H,Sato S,Oyadomari S,Iwakura Y,Oshima K,Morita H,Hattori M,Honda K,Ishikawa Y,Hara E,Ohtani N

更新日期：2013-07-04 00:00:00

abstract：:In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of t...

journal_title：Nature

authors： Eulalio A,Mano M,Dal Ferro M,Zentilin L,Sinagra G,Zacchigna S,Giacca M

更新日期：2012-12-20 00:00:00

abstract：:A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The ge...

journal_title：Nature

authors： Kuro-o M,Matsumura Y,Aizawa H,Kawaguchi H,Suga T,Utsugi T,Ohyama Y,Kurabayashi M,Kaname T,Kume E,Iwasaki H,Iida A,Shiraki-Iida T,Nishikawa S,Nagai R,Nabeshima YI

更新日期：1997-11-06 00:00:00

abstract：:Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cyt...

journal_title：Nature

authors： Mok BY,de Moraes MH,Zeng J,Bosch DE,Kotrys AV,Raguram A,Hsu F,Radey MC,Peterson SB,Mootha VK,Mougous JD,Liu DR

更新日期：2020-07-01 00:00:00