I-POU: a POU-domain protein that inhibits neuron-specific gene activation.

abstract：:The high-resolution seismic imaging of subducted oceanic slabs has become a powerful tool for reconstructing palaeogeography. The images can now be interpreted quantitatively by comparison with models of the general circulation of the Earth's mantle. Here we use a three-dimensional spherical computer model of mantle c...

journal_title：Nature

authors： Bunge HP,Grand SP

更新日期：2000-05-18 00:00:00

abstract：:Chondrules are millimetre-sized spherules (mostly silicate) that dominate the texture of primitive meteorites. Their formation mechanism is debated, but their sheer abundance suggests that the mechanism was both energetic and ubiquitous in the early inner Solar System. The processes suggested--such as shock waves, sol...

journal_title：Nature

authors： Cuzzi JN,Alexander CM

更新日期：2006-05-25 00:00:00

abstract：:Vitreoscilla, a filamentous bacterium in the Beggiatoa family, synthesizes a soluble haem-protein which has two identical subunits of relative molecular mass 15,775 and two b haems per molecule. It is synthesized in relatively large quantities when the organism, a strict aerobe, is grown under hypoxic conditions. It f...

journal_title：Nature

authors： Wakabayashi S,Matsubara H,Webster DA

更新日期：1986-07-31 00:00:00

abstract：:Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...

journal_title：Nature

authors： Shim W,Braunschweig AB,Liao X,Chai J,Lim JK,Zheng G,Mirkin CA

更新日期：2011-01-27 00:00:00

abstract：:Precipitation and atmospheric circulation are the coupled processes through which tropical ocean surface temperatures drive global weather and climate1-5. Local sea surface warming tends to increase precipitation, but this local control is difficult to disentangle from remote effects of conditions elsewhere. As an exa...

journal_title：Nature

authors： Good P,Chadwick R,Holloway CE,Kennedy J,Lowe JA,Roehrig R,Rushley SS

更新日期：2021-01-01 00:00:00

abstract：:Substrates of the proteasome are recognized and unfolded by the regulatory particle, and then translocated into the core particle (CP) to be degraded. A hetero-hexameric ATPase ring, containing subunits Rpt1-6, is situated within the base subassembly of the regulatory particle. The ATPase ring sits atop the CP, with t...

journal_title：Nature

authors： Park S,Roelofs J,Kim W,Robert J,Schmidt M,Gygi SP,Finley D

更新日期：2009-06-11 00:00:00

abstract：:Numerous reports have emphasized the need for major changes in the global food system: agriculture must meet the twin challenge of feeding a growing population, with rising demand for meat and high-calorie diets, while simultaneously minimizing its global environmental impacts. Organic farming—a system aimed at produc...

journal_title：Nature

authors： Seufert V,Ramankutty N,Foley JA

更新日期：2012-05-10 00:00:00

abstract：:Nuclear import of the NF-AT transcription factors during T-cell activation requires the calcium-activated phosphatase calcineurin, which unmasks nuclear-location signals on NF-AT. We show here that the nuclear import of NF-ATs is not sufficient to activate NF-AT target genes, as NF-ATs are subject to a futile cycling ...

journal_title：Nature

authors： Zhu J,McKeon F

更新日期：1999-03-18 00:00:00

abstract：:The CD4 subset of cells displays helper/inducer activity and recognizes class II antigens of the major histocompatibility complex (MHC), while the CD8 subset recognizes class I MHC antigens and exhibits cytotoxic or suppressor function. Considerable functional as well as corresponding phenotypic heterogeneity exists w...

journal_title：Nature

authors： Morimoto C,Rudd CE,Letvin NL,Schlossman SF

更新日期：1987-12-03 00:00:00

abstract：:The internal organization of eukaryotic cells into functionally specialized, membrane-delimited organelles of unique composition implies a need for active, regulated lipid transport. Phosphatidylserine (PS), for example, is synthesized in the endoplasmic reticulum and then preferentially associates--through mechanisms...

journal_title：Nature

authors： Maeda K,Anand K,Chiapparino A,Kumar A,Poletto M,Kaksonen M,Gavin AC

更新日期：2013-09-12 00:00:00

abstract：:During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...

journal_title：Nature

authors： Forchhammer K,Leinfelder W,Böck A

更新日期：1989-11-23 00:00:00

abstract：:The dominant forcing factors for past large-scale changes in vegetation are widely debated. Changes in the distribution of C4 plants--adapted to warm, dry conditions and low atmospheric CO2 concentrations--have been attributed to marked changes in environmental conditions, but the relative impacts of changes in aridit...

journal_title：Nature

authors： Schefuss E,Schouten S,Jansen JH,Sinninghe Damsté JS

更新日期：2003-03-27 00:00:00

abstract：:The commitment of non-dividing cells (in G0) to enter division can be studied using primary cultures of lymphocytes. The cells are stable in G0 unless stimulated by mitogen such as concanavalin A (Con A). Commitment to enter the division cycle depends on the expression of gene(s) induced by Con A and the synthesis of ...

journal_title：Nature

authors： Milner J

更新日期：1984-07-12 00:00:00

abstract：:Since Bridgman's discovery of five solid water (H2O) ice phases1 in 1912, studies on the extraordinary polymorphism of H2O have documented more than seventeen crystalline and several amorphous ice structures2,3, as well as rich metastability and kinetic effects4,5. This unique behaviour is due in part to the geometric...

journal_title：Nature

authors： Millot M,Coppari F,Rygg JR,Correa Barrios A,Hamel S,Swift DC,Eggert JH

更新日期：2019-05-01 00:00:00

abstract：:It has been proposed that the trans-sarcolemmal influx of Ca2+ occurring during the plateau of the mammalian cardiac action potentials is insufficient in itself to activate the myofilaments, but can trigger a release of Ca2+ from the sarcoplasmic reticulum (SR) which is sufficient for activation. The demonstration of ...

journal_title：Nature

authors： Fabiato A,Fabiato F

更新日期：1979-09-13 00:00:00

abstract：:The beta, gamma-crystallins form a class of homologous proteins in the eye lens. Each gamma-crystallin comprises four topologically equivalent, Greek key motifs; pairs of motifs are organized around a local dyad to give domains and two similar domains are in turn related by a further local dyad. Sequence comparisons a...

journal_title：Nature

authors： Bax B,Lapatto R,Nalini V,Driessen H,Lindley PF,Mahadevan D,Blundell TL,Slingsby C

更新日期：1990-10-25 00:00:00

abstract：:In many cell types, receptor-mediated Ca2+ release from internal stores is followed by Ca2+ influx across the plasma membrane. The sustained entry of Ca2+ is thought to result partly from the depletion of intracellular Ca2+ pools. Most investigations have characterized Ca2+ influx indirectly by measuring Ca(2+)-activa...

journal_title：Nature

authors： Hoth M,Penner R

更新日期：1992-01-23 00:00:00

abstract：:ELLIPTICAL galaxies acting as gravitational lenses occasionally produce spectacular images-Einstein rings-of distant objects. Giant arcs(1) and radio rings(2) have been observed. A wide variety of image morphologies is possible, the generation of which is qualitatively understood in terms of large magnifications at ca...

journal_title：Nature

authors： Langston GI,Conner SR,Lehar J,Burke BF,Weiler KW

更新日期：1990-03-01 00:00:00

abstract：:'Pioneer' transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming1,2. Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-re...

journal_title：Nature

authors： Dodonova SO,Zhu F,Dienemann C,Taipale J,Cramer P

更新日期：2020-04-01 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:Streptococcus pneumoniae, the pneumococcus, is the most common cause of sepsis and meningitis. Multiple-antibiotic-resistant strains are widespread, and vancomycin is the antibiotic of last resort. Emergence of vancomycin resistance in this community-acquired bacterium would be catastrophic. Antibiotic tolerance, the ...

journal_title：Nature

authors： Novak R,Henriques B,Charpentier E,Normark S,Tuomanen E

更新日期：1999-06-10 00:00:00

abstract：:During the last glacial period, the Laurentide Ice Sheet sporadically discharged huge numbers of icebergs through the Hudson Strait into the North Atlantic Ocean, leaving behind distinct layers of ice-rafted debris in the ocean sediments. Perplexingly, these massive discharge events-Heinrich events-occurred during the...

journal_title：Nature

authors： Bassis JN,Petersen SV,Mac Cathles L

更新日期：2017-02-15 00:00:00

abstract：:Mitochondrial genomes (mitochondrial DNA, mtDNA) encode essential oxidative phosphorylation (OXPHOS) components. Because hundreds of mtDNAs exist per cell, a deletion in a single mtDNA has little impact. However, if the deletion genome is enriched, OXPHOS declines, resulting in cellular dysfunction. For example, Kearn...

journal_title：Nature

authors： Lin YF,Schulz AM,Pellegrino MW,Lu Y,Shaham S,Haynes CM

更新日期：2016-05-19 00:00:00

abstract：:All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-depend...

journal_title：Nature

authors： Ruta V,Jiang Y,Lee A,Chen J,MacKinnon R

更新日期：2003-03-13 00:00:00

abstract：:Neutralizing antibody function provides a foundation for the efficacy of vaccines and therapies1-3. Here, using a robust in vitro Ebola virus (EBOV) pseudo-particle infection assay and a well-defined set of solid-phase assays, we describe a wide spectrum of antibody responses in a cohort of healthy survivors of the Si...

journal_title：Nature

authors： Adaken C,Scott JT,Sharma R,Gopal R,Dicks S,Niazi S,Ijaz S,Edwards T,Smith CC,Cole CP,Kamara P,Kargbo O,Doughty HA,van Griensven J,Horby PW,Gevao SM,Sahr F,Ebola-CP Consortium.,Dimelow RJ,Tedder RS,Semple MG,Paxt

更新日期：2021-01-27 00:00:00

abstract：: ...

journal_title：Nature

authors： Ainsworth C

更新日期：2018-11-01 00:00:00

abstract：:Polar molecules have a rich internal structure and long-range dipole-dipole interactions, making them useful for quantum-controlled applications and fundamental investigations. Their potential fully unfolds at ultracold temperatures, where various effects are predicted in many-body physics, quantum information science...

journal_title：Nature

authors： Zeppenfeld M,Englert BG,Glöckner R,Prehn A,Mielenz M,Sommer C,van Buuren LD,Motsch M,Rempe G

更新日期：2012-11-22 00:00:00

abstract：:Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease, there is no clear evidence that red wine confers an additio...

journal_title：Nature

authors： Corder R,Douthwaite JA,Lees DM,Khan NQ,Viseu Dos Santos AC,Wood EG,Carrier MJ

更新日期：2001-12-20 00:00:00

abstract：:A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...

journal_title：Nature

authors： Human Microbiome Project Consortium.

更新日期：2012-06-13 00:00:00

abstract：:Lantibiotics are a class of peptide antibiotics that contain one or more thioether bonds. The lantibiotic nisin is an antimicrobial peptide that is widely used as a food preservative to combat food-borne pathogens. Nisin contains dehydroalanine and dehydrobutyrine residues that are formed by the dehydration of Ser/Thr...

journal_title：Nature

authors： Ortega MA,Hao Y,Zhang Q,Walker MC,van der Donk WA,Nair SK

更新日期：2015-01-22 00:00:00