Plasma membrane phosphoinositide organization by protein electrostatics.


:Phosphatidylinositol 4,5-bisphosphate (PIP2), which comprises only about 1% of the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three second messengers, activates many ion channels and enzymes, is involved in both endocytosis and exocytosis, anchors proteins to the membrane through several structured domains and has other roles. How can a single lipid in a fluid bilayer regulate so many distinct physiological processes? Spatial organization might be the key to this. Recent studies suggest that membrane proteins concentrate PIP2 and, in response to local increases in intracellular calcium concentration, release it to interact with other biologically important molecules.






McLaughlin S,Murray D





Has Abstract


2005-12-01 00:00:00
















  • Novel clonal strains from adult rat anterior pituitary producing S-100 protein.

    abstract::S-100 protein, one of the unique proteins found in the nervous system, has recently been discovered unexpectedly in the rat anterior pituitary. Immunocytochemistry reveals that stellate, follicular and folliculostellate cells, and marginal cells of the rat anterior pituitary contain this protein; however, as far as we...


    pub_type: 杂志文章


    authors: Ishikawa H,Nogami H,Shirasawa N

    更新日期:1983-06-23 00:00:00

  • Rapid gating and anion permeability of an intracellular aquaporin.

    abstract::Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...


    pub_type: 杂志文章


    authors: Yasui M,Hazama A,Kwon TH,Nielsen S,Guggino WB,Agre P

    更新日期:1999-11-11 00:00:00

  • HER2 expression identifies dynamic functional states within circulating breast cancer cells.

    abstract::Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...


    pub_type: 杂志文章


    authors: Jordan NV,Bardia A,Wittner BS,Benes C,Ligorio M,Zheng Y,Yu M,Sundaresan TK,Licausi JA,Desai R,O'Keefe RM,Ebright RY,Boukhali M,Sil S,Onozato ML,Iafrate AJ,Kapur R,Sgroi D,Ting DT,Toner M,Ramaswamy S,Haas W,Mah

    更新日期:2016-09-01 00:00:00

  • Downregulation of enkephalin-mediated inflammatory responses by CD10/neutral endopeptidase 24.11.

    abstract::The antigen CD10 (common acute lymphoblastic leukaemia antigen), which is the zinc metalloprotease, neutral endopeptidase 24.11 (also known as NEP or 'enkephalinase'), is expressed by acute lymphoblastic leukaemias, normal lymphoid progenitors, mature polymorphonuclear leukocytes and certain nonhaematopoietic cells. C...


    pub_type: 杂志文章


    authors: Shipp MA,Stefano GB,D'Adamio L,Switzer SN,Howard FD,Sinisterra J,Scharrer B,Reinherz EL

    更新日期:1990-09-27 00:00:00

  • A route to high surface area, porosity and inclusion of large molecules in crystals.

    abstract::One of the outstanding challenges in the field of porous materials is the design and synthesis of chemical structures with exceptionally high surface areas. Such materials are of critical importance to many applications involving catalysis, separation and gas storage. The claim for the highest surface area of a disord...


    pub_type: 杂志文章


    authors: Chae HK,Siberio-Pérez DY,Kim J,Go Y,Eddaoudi M,Matzger AJ,O'Keeffe M,Yaghi OM

    更新日期:2004-02-05 00:00:00

  • Regulation of receptor-mediated endocytosis by Rho and Rac.

    abstract::Pinocytosis and membrane ruffling are among the earliest and most dramatic cellular responses to stimulation by growth factors or other mitogens. The small Ras-related G proteins Rho and Rac have a regulatory role in membrane ruffling and activated Rho has been shown to stimulate pinocytosis when microinjected into Xe...


    pub_type: 杂志文章


    authors: Lamaze C,Chuang TH,Terlecky LJ,Bokoch GM,Schmid SL

    更新日期:1996-07-11 00:00:00

  • Symbolic arithmetic knowledge without instruction.

    abstract::Symbolic arithmetic is fundamental to science, technology and economics, but its acquisition by children typically requires years of effort, instruction and drill. When adults perform mental arithmetic, they activate nonsymbolic, approximate number representations, and their performance suffers if this nonsymbolic sys...


    pub_type: 杂志文章


    authors: Gilmore CK,McCarthy SE,Spelke ES

    更新日期:2007-05-31 00:00:00

  • Identification of proliferative and mature β-cells in the islets of Langerhans.

    abstract::Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential; understanding the mechanisms that underlie this functional heterogeneity might make it possible to ...


    pub_type: 杂志文章


    authors: Bader E,Migliorini A,Gegg M,Moruzzi N,Gerdes J,Roscioni SS,Bakhti M,Brandl E,Irmler M,Beckers J,Aichler M,Feuchtinger A,Leitzinger C,Zischka H,Wang-Sattler R,Jastroch M,Tschöp M,Machicao F,Staiger H,Häring HU,Chme

    更新日期:2016-07-21 00:00:00

  • A global resource allocation strategy governs growth transition kinetics of Escherichia coli.

    abstract::A grand challenge of systems biology is to predict the kinetic responses of living systems to perturbations starting from the underlying molecular interactions. Changes in the nutrient environment have long been used to study regulation and adaptation phenomena in microorganisms and they remain a topic of active inves...


    pub_type: 杂志文章


    authors: Erickson DW,Schink SJ,Patsalo V,Williamson JR,Gerland U,Hwa T

    更新日期:2017-11-02 00:00:00

  • Selective amplification by auto- and cross-catalysis in a replicating peptide system.

    abstract::Self-replication has been demonstrated in synthetic chemical systems based on oligonucleotides, peptides and complementary molecules without natural analogues. However, within a living cell virtually no molecule catalyses its own formation, and the search for chemical systems in which both auto- and cross-catalysis ca...


    pub_type: 杂志文章


    authors: Yao S,Ghosh I,Zutshi R,Chmielewski J

    更新日期:1998-12-03 00:00:00

  • Half-metallic graphene nanoribbons.

    abstract::Electrical current can be completely spin polarized in a class of materials known as half-metals, as a result of the coexistence of metallic nature for electrons with one spin orientation and insulating nature for electrons with the other. Such asymmetric electronic states for the different spins have been predicted f...


    pub_type: 杂志文章


    authors: Son YW,Cohen ML,Louie SG

    更新日期:2006-11-16 00:00:00

  • G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.

    abstract::The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Ka...


    pub_type: 杂志文章


    authors: Bais C,Santomasso B,Coso O,Arvanitakis L,Raaka EG,Gutkind JS,Asch AS,Cesarman E,Gershengorn MC,Mesri EA

    更新日期:1998-01-01 00:00:00

  • Organization and functions of mGlu and GABAB receptor complexes.

    abstract::The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...


    pub_type: 杂志文章,评审


    authors: Pin JP,Bettler B

    更新日期:2016-12-01 00:00:00

  • Potential sea-level rise from Antarctic ice-sheet instability constrained by observations.

    abstract::Large parts of the Antarctic ice sheet lying on bedrock below sea level may be vulnerable to marine-ice-sheet instability (MISI), a self-sustaining retreat of the grounding line triggered by oceanic or atmospheric changes. There is growing evidence that MISI may be underway throughout the Amundsen Sea embayment (ASE),...


    pub_type: 杂志文章


    authors: Ritz C,Edwards TL,Durand G,Payne AJ,Peyaud V,Hindmarsh RC

    更新日期:2015-12-03 00:00:00

  • A molecular timescale for vertebrate evolution.

    abstract::A timescale is necessary for estimating rates of molecular and morphological change in organisms and for interpreting patterns of macroevolution and biogeography. Traditionally, these times have been obtained from the fossil record, where the earliest representatives of two lineages establish a minimum time of diverge...


    pub_type: 杂志文章


    authors: Kumar S,Hedges SB

    更新日期:1998-04-30 00:00:00

  • Krox-20 controls myelination in the peripheral nervous system.

    abstract::The molecular mechanisms controlling the process of myelination by Schwann cells remain elusive, despite recent progress in the identification and characterization of genes encoding myelin components (reviewed in ref. 1). We have created a null allele in the mouse Krox-20 gene, which encodes a zinc-finger transcriptio...


    pub_type: 杂志文章


    authors: Topilko P,Schneider-Maunoury S,Levi G,Baron-Van Evercooren A,Chennoufi AB,Seitanidou T,Babinet C,Charnay P

    更新日期:1994-10-27 00:00:00

  • Genetics and the public interest.

    abstract::The seemingly endless studies of the ethical connotations of genetics serve a valuable role in general understanding even if the ethical problems involved are often insubstantial. ...


    pub_type: 社论



    更新日期:1992-04-02 00:00:00

  • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction.

    abstract::A serine/threonine kinase, named protein kinase B (PKB) for its sequence homology to both protein kinase A and C, has previously been isolated. PKB, which is identical to the kinase Rac, was later found to be the cellular homologue of the transforming v-Akt. Here we show that PKB is activated by stimuli such as insuli...


    pub_type: 杂志文章


    authors: Burgering BM,Coffer PJ

    更新日期:1995-08-17 00:00:00

  • The impacts of climate change on water resources and agriculture in China.

    abstract::China is the world's most populous country and a major emitter of greenhouse gases. Consequently, much research has focused on China's influence on climate change but somewhat less has been written about the impact of climate change on China. China experienced explosive economic growth in recent decades, but with only...


    pub_type: 杂志文章


    authors: Piao S,Ciais P,Huang Y,Shen Z,Peng S,Li J,Zhou L,Liu H,Ma Y,Ding Y,Friedlingstein P,Liu C,Tan K,Yu Y,Zhang T,Fang J

    更新日期:2010-09-02 00:00:00

  • T-cell recognition of antigen and the Ia molecule as a ternary complex.

    abstract::T-lymphocyte co-recognition of antigen and major histocompatibility complex (MHC)-encoded molecules (such as murine Ia molecules) is thought to be mediated by a single cell-surface receptor, although the molecular mechanism by which this occurs is controversial (reviewed in ref. 1). One possibility is that the antigen...


    pub_type: 杂志文章


    authors: Ashwell JD,Schwartz RH

    更新日期:1986-03-13 00:00:00

  • Thalamic control of sensory selection in divided attention.

    abstract::How the brain selects appropriate sensory inputs and suppresses distractors is unknown. Given the well-established role of the prefrontal cortex (PFC) in executive function, its interactions with sensory cortical areas during attention have been hypothesized to control sensory selection. To test this idea and, more ge...


    pub_type: 杂志文章


    authors: Wimmer RD,Schmitt LI,Davidson TJ,Nakajima M,Deisseroth K,Halassa MM

    更新日期:2015-10-29 00:00:00

  • Dissociable neural mechanisms supporting visual short-term memory for objects.

    abstract::Using visual information to guide behaviour requires storage in a temporary buffer, known as visual short-term memory (VSTM), that sustains attended information across saccades and other visual interruptions. There is growing debate on whether VSTM capacity is limited to a fixed number of objects or whether it is vari...


    pub_type: 杂志文章


    authors: Xu Y,Chun MM

    更新日期:2006-03-02 00:00:00

  • West Nile virus emergence and large-scale declines of North American bird populations.

    abstract::Emerging infectious diseases present a formidable challenge to the conservation of native species in the twenty-first century. Diseases caused by introduced pathogens have had large impacts on species abundances, including the American chestnut, Hawaiian bird species and many amphibians. Changes in host population siz...


    pub_type: 杂志文章


    authors: LaDeau SL,Kilpatrick AM,Marra PP

    更新日期:2007-06-07 00:00:00

  • Adherens junction protein nectin-4 is the epithelial receptor for measles virus.

    abstract::Measles virus is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. Although it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to infect initially macrophages and dendritic cells of t...


    pub_type: 杂志文章


    authors: Mühlebach MD,Mateo M,Sinn PL,Prüfer S,Uhlig KM,Leonard VH,Navaratnarajah CK,Frenzke M,Wong XX,Sawatsky B,Ramachandran S,McCray PB Jr,Cichutek K,von Messling V,Lopez M,Cattaneo R

    更新日期:2011-11-02 00:00:00

  • Multiple spike-initiation zones in single neurons revealed by voltage-sensitive dyes.

    abstract::The primary function of the nerve cell is to process electrical signals. Over the past fifteen years there has been renewed interest in the detailed spatial analysis of signalling in individual neurons owing to experimental evidence that the regional electrical properties of neurons are complex. Thus the behaviour of ...


    pub_type: 杂志文章


    authors: Zecević D

    更新日期:1996-05-23 00:00:00

  • A unique regulatory phase of DNA methylation in the early mammalian embryo.

    abstract::DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so far no base-resoluti...


    pub_type: 杂志文章


    authors: Smith ZD,Chan MM,Mikkelsen TS,Gu H,Gnirke A,Regev A,Meissner A

    更新日期:2012-03-28 00:00:00

  • Evolution of antibody immunity to SARS-CoV-2.

    abstract::Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutralizing activity that can protect against infection in animal models1,2. Antibody ...


    pub_type: 杂志文章


    authors: Gaebler C,Wang Z,Lorenzi JCC,Muecksch F,Finkin S,Tokuyama M,Cho A,Jankovic M,Schaefer-Babajew D,Oliveira TY,Cipolla M,Viant C,Barnes CO,Bram Y,Breton G,Hägglöf T,Mendoza P,Hurley A,Turroja M,Gordon K,Millard KG,

    更新日期:2021-01-18 00:00:00

  • Social learning promotes institutions for governing the commons.

    abstract::Theoretical and empirical research highlights the role of punishment in promoting collaborative efforts. However, both the emergence and the stability of costly punishment are problematic issues. It is not clear how punishers can invade a society of defectors by social learning or natural selection, or how second-orde...


    pub_type: 杂志文章


    authors: Sigmund K,De Silva H,Traulsen A,Hauert C

    更新日期:2010-08-12 00:00:00

  • Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor.

    abstract::Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75. TrkA is a receptor with tyrosine kinase ac...


    pub_type: 杂志文章


    authors: Wiesmann C,Ultsch MH,Bass SH,de Vos AM

    更新日期:1999-09-09 00:00:00

  • Distinct functions for the two importin subunits in nuclear protein import.

    abstract::The import of nuclear proteins proceeds through the nuclear pore complex and requires nuclear localization signals (NLSs), energy and soluble factors, namely importin-alpha (M(r) 60K), importin-beta (90K) and Ran. Importin-alpha is primarily responsible for NLS recognition and is a member of a protein family that incl...


    pub_type: 杂志文章


    authors: Görlich D,Vogel F,Mills AD,Hartmann E,Laskey RA

    更新日期:1995-09-21 00:00:00