Plasma membrane phosphoinositide organization by protein electrostatics.

Abstract:

:Phosphatidylinositol 4,5-bisphosphate (PIP2), which comprises only about 1% of the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three second messengers, activates many ion channels and enzymes, is involved in both endocytosis and exocytosis, anchors proteins to the membrane through several structured domains and has other roles. How can a single lipid in a fluid bilayer regulate so many distinct physiological processes? Spatial organization might be the key to this. Recent studies suggest that membrane proteins concentrate PIP2 and, in response to local increases in intracellular calcium concentration, release it to interact with other biologically important molecules.

journal_name

Nature

journal_title

Nature

authors

McLaughlin S,Murray D

doi

10.1038/nature04398

keywords:

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

605-11

issue

7068

eissn

0028-0836

issn

1476-4687

pii

nature04398

journal_volume

438

pub_type

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