Abstract：
:In mice gamma delta T-cell populations with distinct T-cell receptor (TCR) repertoires and homing properties have been identified. Diversified populations are found in lymphoid organs and intestinal epithelia. By contrast, the gamma delta T-cells that have been found in the murine skin are homogeneous. They express a TCR consisting of one particular V gamma 5 and one particular V delta 1 chain and seem to originate from early fetal thymocytes. We have now systematically analysed many tissues by immunohistochemistry and TCR gene sequencing aided by the polymerase chain reaction. These studies revealed a second homogeneous gamma delta T-cell subset in epithelia not of the intestine and skin, but of the vagina, uterus and tongue. The TCR expressed by this gamma delta T-cell subset consists of the same V delta 1 chain. Cells that express this particular TCR have previously been shown to be positively selected in the late fetal thymus.
journal_name
Naturejournal_title
Natureauthors
Itohara S,Farr AG,Lafaille JJ,Bonneville M,Takagaki Y,Haas W,Tonegawa Sdoi
10.1038/343754a0subject
Has Abstractpub_date
1990-02-22 00:00:00pages
754-7issue
6260eissn
0028-0836issn
1476-4687journal_volume
343pub_type
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