Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.

abstract：:RNA polymerase (Pol) II produces messenger RNA during transcription of protein-coding genes in all eukaryotic cells. The Pol II structure is known at high resolution from X-ray crystallography for two yeast species. Structural studies of mammalian Pol II, however, remain limited to low-resolution electron microscopy a...

journal_title：Nature

authors： Bernecky C,Herzog F,Baumeister W,Plitzko JM,Cramer P

更新日期：2016-01-28 00:00:00

abstract：: ...

journal_title：Nature

authors： Larrimore KE,Rancati G

更新日期：2019-02-01 00:00:00

abstract：:Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gati...

journal_title：Nature

authors： Seo MD,Velamakanni S,Ishiyama N,Stathopulos PB,Rossi AM,Khan SA,Dale P,Li C,Ames JB,Ikura M,Taylor CW

更新日期：2012-01-29 00:00:00

abstract：:Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene variants that individually have minimal effect sizes. As environmental factors that perturb neurodevelopment also underlie idiopathic ASD, it is crucial to identify altered regulators that can orchestrate multiple ASD risk genes during ...

journal_title：Nature

authors： Parras A,Anta H,Santos-Galindo M,Swarup V,Elorza A,Nieto-González JL,Picó S,Hernández IH,Díaz-Hernández JI,Belloc E,Rodolosse A,Parikshak NN,Peñagarikano O,Fernández-Chacón R,Irimia M,Navarro P,Geschwind DH,Méndez R,L

更新日期：2018-08-01 00:00:00

abstract：:Graphene, or single-layered graphite, with its high crystallinity and interesting semimetal electronic properties, has emerged as an exciting two-dimensional material showing great promise for the fabrication of nanoscale devices. Thin, elongated strips of graphene that possess straight edges, termed graphene ribbons,...

journal_title：Nature

authors： Kosynkin DV,Higginbotham AL,Sinitskii A,Lomeda JR,Dimiev A,Price BK,Tour JM

更新日期：2009-04-16 00:00:00

abstract：:The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...

journal_title：Nature

authors： Vidal-Madjar A,Des Etangs AL,Désert JM,Ballester GE,Ferlet R,Hébrard G,Mayor M

更新日期：2003-03-13 00:00:00

abstract：:Binocular coordination of eye movements is essential for stereopsis (depth perception) and to prevent double vision. More than a century ago, Hering and Helmholtz debated the neural basis of binocular coordination. Helmholtz believed that each eye is controlled independently and that binocular coordination is learned....

journal_title：Nature

authors： Zhou W,King WM

更新日期：1998-06-18 00:00:00

abstract：:DNA methylation is an important epigenetic modification that is essential for various developmental processes through regulating gene expression, genomic imprinting, and epigenetic inheritance. Mammalian genomic DNA methylation is established during embryogenesis by de novo DNA methyltransferases, DNMT3A and DNMT3B, a...

journal_title：Nature

authors： Guo X,Wang L,Li J,Ding Z,Xiao J,Yin X,He S,Shi P,Dong L,Li G,Tian C,Wang J,Cong Y,Xu Y

更新日期：2015-01-29 00:00:00

abstract：:Solitons are large-amplitude, spatially confined wave packets in nonlinear media. They occur in a wide range of physical systems, such as water surfaces, optical fibres, plasmas, Bose-Einstein condensates and magnetically ordered media. A distinguishing feature of soliton behaviour that is common to all systems, is th...

journal_title：Nature

authors： Demokritov SO,Serga AA,Demidov VE,Hillebrands B,Kostylev MP,Kalinikos BA

更新日期：2003-11-13 00:00:00

abstract：:The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake,...

journal_title：Nature

authors： Galagan JE,Calvo SE,Cuomo C,Ma LJ,Wortman JR,Batzoglou S,Lee SI,Baştürkmen M,Spevak CC,Clutterbuck J,Kapitonov V,Jurka J,Scazzocchio C,Farman M,Butler J,Purcell S,Harris S,Braus GH,Draht O,Busch S,D'Enfert C,Bou

更新日期：2005-12-22 00:00:00

abstract：:Close inbreeding is known for a variety of small mammal species for which a high probability of mortality during dispersal makes helping and delayed maturation a relatively secure fitness option. Prolonged inbreeding, however, is usually associated with lowered fitness, and it has been shown that most highly inbred sm...

journal_title：Nature

authors： O'Riain MJ,Jarvis JU,Faulkes CG

更新日期：1996-04-18 00:00:00

abstract：:The question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs suc...

journal_title：Nature

authors： Pontieri FE,Tanda G,Orzi F,Di Chiara G

更新日期：1996-07-18 00:00:00

abstract：:B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that these tumours are dependent on the RAF/MEK/ERK pathway, offered hope that inhibition of B-RAF kinase activity could benefit melanoma patients. He...

journal_title：Nature

authors： Bollag G,Hirth P,Tsai J,Zhang J,Ibrahim PN,Cho H,Spevak W,Zhang C,Zhang Y,Habets G,Burton EA,Wong B,Tsang G,West BL,Powell B,Shellooe R,Marimuthu A,Nguyen H,Zhang KY,Artis DR,Schlessinger J,Su F,Higgins B,Iy

更新日期：2010-09-30 00:00:00

abstract：:The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress1,2. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promote...

journal_title：Nature

authors： Shakeel S,Rajendra E,Alcón P,O'Reilly F,Chorev DS,Maslen S,Degliesposti G,Russo CJ,He S,Hill CH,Skehel JM,Scheres SHW,Patel KJ,Rappsilber J,Robinson CV,Passmore LA

更新日期：2019-11-01 00:00:00

abstract：:Malignancy is a common and dreaded complication following organ transplantation. The high incidence of neoplasm and its aggressive progression, which are associated with immunosuppressive therapy, are thought to be due to the resulting impairment of the organ recipient's immune-surveillance system. Here we report a me...

journal_title：Nature

authors： Hojo M,Morimoto T,Maluccio M,Asano T,Morimoto K,Lagman M,Shimbo T,Suthanthiran M

更新日期：1999-02-11 00:00:00

abstract：:Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial cells line the cerebral ventricles and generate intermediate progenitor cells that migrate into the subventricular zone (SVZ) and proliferate to increase neuronal number. The developing hu...

journal_title：Nature

authors： Hansen DV,Lui JH,Parker PR,Kriegstein AR

更新日期：2010-03-25 00:00:00

abstract：:Perfusion chromatography is a technique based on fluid dynamics for reducing stagnant mobile phase mass transfer in liquid chromatography. This is achieved by using supports with large pores that allow mobile phase to flow through particles. ...

journal_title：Nature

authors： Regnier FE

更新日期：1991-04-18 00:00:00

abstract：:Highly correlated electronic systems--such as transition-metal oxides that are doped Mott insulators--are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies suggest that in such systems collective electronic phenomena are impor...

journal_title：Nature

authors： Yoo YK,Duewer F,Yang H,Yi D,Li JW,Xiang XD

更新日期：2000-08-17 00:00:00

abstract：:Saturn's largest moon, Titan, remains an enigma, explored only by remote sensing from Earth, and by the Voyager and Cassini spacecraft. The most puzzling aspects include the origin of the molecular nitrogen and methane in its atmosphere, and the mechanism(s) by which methane is maintained in the face of rapid destruct...

journal_title：Nature

authors： Niemann HB,Atreya SK,Bauer SJ,Carignan GR,Demick JE,Frost RL,Gautier D,Haberman JA,Harpold DN,Hunten DM,Israel G,Lunine JI,Kasprzak WT,Owen TC,Paulkovich M,Raulin F,Raaen E,Way SH

更新日期：2005-12-08 00:00:00

abstract：:A detailed description of the interactions between an antibody and its epitope is necessary to allow an understanding of the way in which antibodies bind to antigenic surfaces presented by foreign molecules. Ideally this should be done by analysis of crystal structures of antibody-antigen complexes, but so far only tw...

journal_title：Nature

authors： Roberts S,Cheetham JC,Rees AR

更新日期：1987-08-20 00:00:00

abstract：:The Gamburtsev Subglacial Mountains are the least understood tectonic feature on Earth, because they are completely hidden beneath the East Antarctic Ice Sheet. Their high elevation and youthful Alpine topography, combined with their location on the East Antarctic craton, creates a paradox that has puzzled researchers...

journal_title：Nature

authors： Ferraccioli F,Finn CA,Jordan TA,Bell RE,Anderson LM,Damaske D

更新日期：2011-11-16 00:00:00

abstract：:Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about resistance to infection and silencing or tolerance to self. In the settings of infection and cancer, microbes and tumours can exploit DCs to evade immunity, but DCs also can generate resistance, a capacity that is readily enhanced with...

journal_title：Nature

authors： Steinman RM,Banchereau J

更新日期：2007-09-27 00:00:00

abstract：:As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the...

journal_title：Nature

authors： Hagai T,Chen X,Miragaia RJ,Rostom R,Gomes T,Kunowska N,Henriksson J,Park JE,Proserpio V,Donati G,Bossini-Castillo L,Vieira Braga FA,Naamati G,Fletcher J,Stephenson E,Vegh P,Trynka G,Kondova I,Dennis M,Haniffa M,No

更新日期：2018-11-01 00:00:00

abstract：:Co-evolution between plants and their natural enemies is generally believed to have generated much of the Earth's biological diversity. A process analogous to co-evolution occurs in agricultural systems, in which natural enemies adapt to crop resistance introduced by breeding or genetic engineering. Because of this si...

journal_title：Nature

authors： Rausher MD

更新日期：2001-06-14 00:00:00

abstract：:Asteroids are primitive Solar System bodies that evolve both collisionally and through disruptions arising from rapid rotation. These processes can lead to the formation of binary asteroids and to the release of dust, both directly and, in some cases, through uncovering frozen volatiles. In a subset of the asteroids c...

journal_title：Nature

authors： Agarwal J,Jewitt D,Mutchler M,Weaver H,Larson S

更新日期：2017-09-20 00:00:00

abstract：:Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring abou...

journal_title：Nature

authors： Pavelka N,Rancati G,Zhu J,Bradford WD,Saraf A,Florens L,Sanderson BW,Hattem GL,Li R

更新日期：2010-11-11 00:00:00

abstract：:Fluorescence polarization (FP) equilibrium binding assays differ from other types of binding studies in one important regard: they require no steps to separate free from bound tracer and are therefore fast, simple and accurate. ...

journal_title：Nature

authors： Checovich WJ,Bolger RE,Burke T

更新日期：1995-05-18 00:00:00

abstract：:Alzheimer's disease (AD) affects more than 30% of people over 80 years of age. The aetiology and pathogenesis of this progressive dementia is poorly understood, but symptomatic disease is associated histopathologically with amyloid plaques, neurofibrillary tangles and neuronal loss primarily in the temporal lobe and n...

journal_title：Nature

authors： Kawabata S,Higgins GA,Gordon JW

更新日期：1991-12-12 00:00:00

abstract：:Introduction of DNA fragments, hundreds of kilobases in size, into mouse embryonic stem (ES) cells would greatly advance the ability to manipulate the mouse genome. Mice generated from such modified cells would permit investigation of the function and expression of very large or crudely mapped genes. Large DNA molecul...

journal_title：Nature

authors： Jakobovits A,Moore AL,Green LL,Vergara GJ,Maynard-Currie CE,Austin HA,Klapholz S

更新日期：1993-03-18 00:00:00

abstract：:Mature cortical pyramidal neurons receive excitatory inputs onto small protrusions emanating from their dendrites called spines. Spines undergo activity-dependent remodelling, stabilization and pruning during development, and similar structural changes can be triggered by learning and changes in sensory experiences. H...

journal_title：Nature

authors： Kwon HB,Sabatini BL

更新日期：2011-06-02 00:00:00