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NATURE文献大全abstract::Transforming growth factor-alpha (TGF-alpha) is a mitogenically active polypeptide hormone produced by acutely proliferating neoplastic and embryonic tissues. Molecular cloning of TGF-alpha cDNA from human and rat has indicated that this factor is synthesized as part of a larger precursor, proTGF-alpha. An intriguing ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326883a0
更新日期:1987-04-30 00:00:00
abstract::The enzyme Cu, Zn superoxide dismutase (SOD) protects against oxidative damage by dismuting the superoxide radical O2-. to molecular oxygen and hydrogen peroxide at the active-site Cu ion in a reaction that is rate-limited by diffusion and enhanced by electrostatic guidance. SOD has evolved to be one of the fastest en...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/358347a0
更新日期:1992-07-23 00:00:00
abstract::Many physiological events require transient increases in cytosolic Ca(2+) concentrations. Ryanodine receptors (RyRs) are ion channels that govern the release of Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Mutations in RyRs can lead to severe genetic conditions that affect both cardiac and skeletal muscle, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09471
更新日期:2010-11-25 00:00:00
abstract::The activation of innate immune responses by nucleic acids is crucial to protective and pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and cytosolic receptors. However, it remains unknown whether a mechanism exists that integrates these nucleic-acid-sensing systems. Here we sho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08512
更新日期:2009-11-05 00:00:00
abstract::Mineralocorticoid secretion is predominantly controlled by the octapeptide angiotensin II, which exerts trophic actions on the adrenal glomerulosa and acute regulatory effects on aldosterone biosynthesis. The trophic actions include stimulation of angiotensin II receptors and enzymes of the aldosterone biosynthetic pa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289507a0
更新日期:1981-02-05 00:00:00
abstract::A report adopted by the Council of Europe lists eight recommendations on the legal, ethical, and social issues raised by recombinant DNA research. The legislators stressed that the right to a "genetic inheritance free from any form of engineering" should be included in the European Human Rights Convention, and that s...
journal_title:Nature
pub_type: 新闻
doi:10.1038/295545a0
更新日期:1982-02-18 00:00:00
abstract::The hot streak-loosely defined as 'winning begets more winnings'-highlights a specific period during which an individual's performance is substantially better than his or her typical performance. Although hot streaks have been widely debated in sports1,2, gambling3-5 and financial markets6,7 over the past several deca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0315-8
更新日期:2018-07-01 00:00:00
abstract::It is thought that neutron stars in low-mass binary systems can accrete matter and angular momentum from the companion star and be spun-up to millisecond rotational periods. During the accretion stage, the system is called a low-mass X-ray binary, and bright X-ray emission is observed. When the rate of mass transfer d...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12470
更新日期:2013-09-26 00:00:00
abstract::Change history: In this Letter, the final two pages of the Supplementary Information, which included two tables listing primer and antibodies, respectively, were missing; see accompanying Amendment for the missing Supplementary Tables. This Letter has not been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1328-7
更新日期:2019-07-01 00:00:00
abstract::RNase P is the only endonuclease responsible for processing the 5' end of transfer RNA by cleaving a precursor and leading to tRNA maturation. It contains an RNA component and a protein component and has been identified in all organisms. It was one of the first catalytic RNAs identified and the first that acts as a mu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01386
更新日期:2003-02-13 00:00:00
abstract::Although directed migration is a feature of both individual cells and cell groups, guided migration has been studied most extensively for single cells in simple environments. Collective guidance of cell groups remains poorly understood, despite its relevance for development and metastasis. Neural crest cells and neuro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature05965
更新日期:2007-07-19 00:00:00
abstract::The sensitivity of soil carbon to warming is a major uncertainty in projections of carbon dioxide concentration and climate. Experimental studies overwhelmingly indicate increased soil organic carbon (SOC) decomposition at higher temperatures, resulting in increased carbon dioxide emissions from soils. However, recent...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03226
更新日期:2005-01-20 00:00:00
abstract::Thyroglobulin (TG) is the protein precursor of thyroid hormones, which are essential for growth, development and the control of metabolism in vertebrates1,2. Hormone synthesis from TG occurs in the thyroid gland via the iodination and coupling of pairs of tyrosines, and is completed by TG proteolysis3. Tyrosine proxim...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1995-4
更新日期:2020-02-01 00:00:00
abstract::The radio sky is relatively unexplored for transient signals, although the potential of radio-transient searches is high. This was demonstrated recently by the discovery of a previously unknown type of source, varying on timescales of minutes to hours. Here we report a search for radio sources that vary on much shorte...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04440
更新日期:2006-02-16 00:00:00
abstract::Supramolecular soft crystals are periodic structures that are formed by the hierarchical assembly of complex constituents, and occur in a broad variety of 'soft-matter' systems1. Such soft crystals exhibit many of the basic features (such as three-dimensional lattices and space groups) and properties (such as band str...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1706-1
更新日期:2019-11-01 00:00:00
abstract::The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06423
更新日期:2007-12-13 00:00:00
abstract::The actin cytoskeleton is regulated by GTP-hydrolysing proteins, the Rho GTPases, which act as molecular switches in diverse signal-transduction processes. Various bacterial toxins can inactivate Rho GTPases by ADP-ribosylation or glucosylation. Previous research has identified Rho proteins as putative targets for Esc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/42735
更新日期:1997-06-12 00:00:00
abstract::The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/340521a0
更新日期:1989-08-17 00:00:00
abstract::In the Caenorhabditis elegans hermaphrodite germ line, sperm and then oocytes are made from a common pool of germ-cell precursors. The decision to differentiate as a sperm or an oocyte is regulated by the sex-determining gene, fem-3. Expression of fem-3 in the hermaphrodite germ line directs spermatogenesis and must b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/349346a0
更新日期:1991-01-24 00:00:00
abstract::The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/432969a
更新日期:2004-12-23 00:00:00
abstract::A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project Consortium has established a population-scale framework to develop metagenomic protocols, resu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11209
更新日期:2012-06-13 00:00:00
abstract::Temperature is a primary driver of the distribution of biodiversity as well as of ecosystem boundaries. Declining temperature with increasing elevation in montane systems has long been recognized as a major factor shaping plant community biodiversity, metabolic processes, and ecosystem dynamics. Elevational gradients,...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21027
更新日期:2017-02-02 00:00:00
abstract::Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function. In the periphery, ATP mediates nociception, mechanosensitivity, thermal sensitivity and O2 chemosensitivity. These processes share a common mechanism that involves the release of ATP to excite afferent fibres via acti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03690
更新日期:2005-07-07 00:00:00
abstract::Cell and lipid membranes are able to bend, as manifested during membrane fusion and the formation of non-lamellar lyotropic mesophases in water. But there is an energy cost to bending of lipid layers, called the curvature elastic energy. Although the functional form of this energy is known, a complete quantitative kno...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/368224a0
更新日期:1994-03-17 00:00:00
abstract::When present in single-stranded DNA, palindromic or quasi-palindromic sequences have the potential to form complex secondary structures, including hairpins, which may facilitate interstrand misalignment of direct repeats and be responsible for diverse types of replication-based mutations, including deletions, addition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/352544a0
更新日期:1991-08-08 00:00:00
abstract::The class II region of the human major histocompatibility complex (MHC) encodes a polymorphic set of cell surface glycoproteins involved in the regulation of the immune response. Each glycoprotein is a heterodimer composed of a alpha-chain of relative molecular mass (Mr) 34,000 (34 K) and a beta-chain of Mr = 28K. The...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323453a0
更新日期:1986-10-02 00:00:00
abstract::Gut microbes supply the human body with energy from dietary polysaccharides through carbohydrate active enzymes, or CAZymes, which are absent in the human genome. These enzymes target polysaccharides from terrestrial plants that dominated diet throughout human evolution. The array of CAZymes in gut microbes is highly ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08937
更新日期:2010-04-08 00:00:00
abstract::Evolution of the earliest mammals shows successive episodes of diversification. Lineage-splitting in Mesozoic mammals is coupled with many independent evolutionary experiments and ecological specializations. Classic scenarios of mammalian morphological evolution tend to posit an orderly acquisition of key evolutionary...
journal_title:Nature
pub_type: 历史文章,杂志文章,评审
doi:10.1038/nature06277
更新日期:2007-12-13 00:00:00
abstract::The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types as part of the TCGA Pan-Cancer effort. We...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12634
更新日期:2013-10-17 00:00:00
abstract::Recently, several groups have initiated studies on cytosolic proteins that bind to isolated secretory vesicle membranes in the presence of Ca2+ in order to identify proteins that may regulate exocytosis. Two major chromaffin granule binding proteins, of molecular weights 32,000 (32K) and 34,000 (34K), were reported to...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/308208a0
更新日期:1984-03-08 00:00:00