Circulating angiotensin II and adrenal receptors after nephrectomy.

abstract：:The atmospheric partial pressure of carbon dioxide (p(CO(2))) will almost certainly be double that of pre-industrial levels by 2100 and will be considerably higher than at any time during the past few million years. The oceans are a principal sink for anthropogenic CO(2) where it is estimated to have caused a 30% incr...

journal_title：Nature

authors： Hall-Spencer JM,Rodolfo-Metalpa R,Martin S,Ransome E,Fine M,Turner SM,Rowley SJ,Tedesco D,Buia MC

更新日期：2008-07-03 00:00:00

abstract：:Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas (TCGA) pilot project aims to assess the value of large-scale multi-dimensional analysis of these molecular characteristics in human c...

journal_title：Nature

authors： Cancer Genome Atlas Research Network.

更新日期：2008-10-23 00:00:00

abstract：:The immunoglobulin superfamily is a group of proteins, each made of one or several domains sharing key structural features with either the variable (V) or the constant (C) immunoglobulin domains. It includes such functionally important members as the immunoglobulins themselves, major histocompatibility complex (MHC) c...

journal_title：Nature

authors： Brunet JF,Denizot F,Luciani MF,Roux-Dosseto M,Suzan M,Mattei MG,Golstein P

更新日期：1987-07-16 00:00:00

abstract：:A kinase distinct from the MEK activator Raf, termed MEK kinase-1 (MEKK), was originally identified by virtue of its homology to kinases involved in yeast mating signal cascades. Like Raf, MEKK is capable of activating MEK in vitro. High-level expression of MEKK in COS-7 cells or using vaccinia virus vectors also acti...

journal_title：Nature

authors： Yan M,Dai T,Deak JC,Kyriakis JM,Zon LI,Woodgett JR,Templeton DJ

更新日期：1994-12-22 00:00:00

abstract：:'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo...

journal_title：Nature

authors： Sutcliffe JG,Milner RJ,Gottesfeld JM,Lerner RA

更新日期：1984-03-15 00:00:00

abstract：:Diatoms are one of the most ecologically successful classes of photosynthetic marine eukaryotes in the contemporary oceans. Over the past 30 million years, they have helped to moderate Earth's climate by absorbing carbon dioxide from the atmosphere, sequestering it via the biological carbon pump and ultimately burying...

journal_title：Nature

authors： Bailleul B,Berne N,Murik O,Petroutsos D,Prihoda J,Tanaka A,Villanova V,Bligny R,Flori S,Falconet D,Krieger-Liszkay A,Santabarbara S,Rappaport F,Joliot P,Tirichine L,Falkowski PG,Cardol P,Bowler C,Finazzi G

更新日期：2015-08-20 00:00:00

abstract：:The GAL4 protein activates transcription of the genes required for galactose utilization in Saccharomyces cerevisiae. The protein, consisting of 881 amino acids, is dimeric when bound to one of the approximately twofold symmetrical DNA sites present in the galactose upstream activating sequence (UASG). Here we use two...

journal_title：Nature

authors： Baleja JD,Marmorstein R,Harrison SC,Wagner G

更新日期：1992-04-02 00:00:00

abstract：:The retinotectal projection has long been studied experimentally and theoretically, as a model for the formation of topographic brain maps. Neighbouring retinal ganglion cells (RGCs) project their axons to neighbouring positions in the optic tectum, thus re-establishing a continuous neural representation of visual spa...

journal_title：Nature

authors： Gosse NJ,Nevin LM,Baier H

更新日期：2008-04-17 00:00:00

abstract：:Ten eleven translocation (TET) enzymes, including TET1, TET2 and TET3, convert 5-methylcytosine to 5-hydroxymethylcytosine and regulate gene transcription. However, the molecular mechanism by which TET family enzymes regulate gene transcription remains elusive. Using protein affinity purification, here we search for f...

journal_title：Nature

authors： Chen Q,Chen Y,Bian C,Fujiki R,Yu X

更新日期：2013-01-24 00:00:00

abstract：:During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalli...

journal_title：Nature

authors： Lee JS,Hnilova M,Maes M,Lin YC,Putarjunan A,Han SK,Avila J,Torii KU

更新日期：2015-06-25 00:00:00

abstract：:High-temperature superconductivity is achieved by doping copper oxide insulators with charge carriers. The density of carriers in conducting materials can be determined from measurements of the Hall voltage--the voltage transverse to the flow of the electrical current that is proportional to an applied magnetic field....

journal_title：Nature

authors： Balakirev FF,Betts JB,Migliori A,Ono S,Ando Y,Boebinger GS

更新日期：2003-08-21 00:00:00

abstract：:The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution struct...

journal_title：Nature

authors： Vassylyev DG,Vassylyeva MN,Perederina A,Tahirov TH,Artsimovitch I

更新日期：2007-07-12 00:00:00

abstract：:SAMHD1, an analogue of the murine interferon (IFN)-γ-induced gene Mg11 (ref. 1), has recently been identified as a human immunodeficiency virus-1 (HIV-1) restriction factor that blocks early-stage virus replication in dendritic and other myeloid cells and is the target of the lentiviral protein Vpx, which can relieve ...

journal_title：Nature

authors： Goldstone DC,Ennis-Adeniran V,Hedden JJ,Groom HC,Rice GI,Christodoulou E,Walker PA,Kelly G,Haire LF,Yap MW,de Carvalho LP,Stoye JP,Crow YJ,Taylor IA,Webb M

更新日期：2011-11-06 00:00:00

abstract：:The verification of nuclear warheads for arms control involves a paradox: international inspectors will have to gain high confidence in the authenticity of submitted items while learning nothing about them. Proposed inspection systems featuring 'information barriers', designed to hide measurements stored in electronic...

journal_title：Nature

authors： Glaser A,Barak B,Goldston RJ

更新日期：2014-06-26 00:00:00

abstract：:Established infections with the human and simian immunodeficiency viruses (HIV and SIV, respectively) are thought to be permanent with even the most effective immune responses and antiretroviral therapies only able to control, but not clear, these infections. Whether the residual virus that maintains these infections ...

journal_title：Nature

authors： Hansen SG,Piatak M Jr,Ventura AB,Hughes CM,Gilbride RM,Ford JC,Oswald K,Shoemaker R,Li Y,Lewis MS,Gilliam AN,Xu G,Whizin N,Burwitz BJ,Planer SL,Turner JM,Legasse AW,Axthelm MK,Nelson JA,Früh K,Sacha JB,Estes JD

更新日期：2013-10-03 00:00:00

abstract：:Botulinum neurotoxin A (BoNT/A) belongs to the most dangerous class of bioweapons. Despite this, BoNT/A is used to treat a wide range of common medical conditions such as migraines and a variety of ocular motility and movement disorders. BoNT/A is probably best known for its use as an antiwrinkle agent in cosmetic app...

journal_title：Nature

authors： Benoit RM,Frey D,Hilbert M,Kevenaar JT,Wieser MM,Stirnimann CU,McMillan D,Ceska T,Lebon F,Jaussi R,Steinmetz MO,Schertler GF,Hoogenraad CC,Capitani G,Kammerer RA

更新日期：2014-01-02 00:00:00

abstract：:Although there are substantial differences between the magnetospheres of Jupiter and Saturn, it has been suggested that cryovolcanic activity at Enceladus could lead to electrodynamic coupling between Enceladus and Saturn like that which links Jupiter with Io, Europa and Ganymede. Powerful field-aligned electron beams...

journal_title：Nature

authors： Pryor WR,Rymer AM,Mitchell DG,Hill TW,Young DT,Saur J,Jones GH,Jacobsen S,Cowley SW,Mauk BH,Coates AJ,Gustin J,Grodent D,Gérard JC,Lamy L,Nichols JD,Krimigis SM,Esposito LW,Dougherty MK,Jouchoux AJ,Stewart AI,Mc

更新日期：2011-04-21 00:00:00

abstract：:The induction of polyarthritis in rats by intradermal immunisation with homologous or heterologous type II collagen incomplete or incomplete Freund's adjuvant was reported recently by Trentham et al. We have now produced a similar disease in certain strains of mice. ...

journal_title：Nature

authors： Courtenay JS,Dallman MJ,Dayan AD,Martin A,Mosedale B

更新日期：1980-02-14 00:00:00

abstract：:This corrects the article DOI: 10.1038/nature24295. ...

journal_title：Nature

authors： Waldron A,Miller DC,Redding D,Mooers A,Kuhn TS,Nibbelink N,Roberts JT,Tobias JA,Gittleman JL

更新日期：2018-01-25 00:00:00

abstract：:Recognition and removal of apoptotic cells by professional phagocytes, including dendritic cells and macrophages, preserves immune self-tolerance and prevents chronic inflammation and autoimmune pathologies. The diverse array of phagocytes that reside within different tissues, combined with the necessarily prompt natu...

journal_title：Nature

authors： Cummings RJ,Barbet G,Bongers G,Hartmann BM,Gettler K,Muniz L,Furtado GC,Cho J,Lira SA,Blander JM

更新日期：2016-11-24 00:00:00

abstract：:The ice-rich surface of the jovian satellite Europa is sparsely cratered, suggesting that this moon might be geologically active today. Moreover, models of the satellite's interior indicate that tidal interactions with Jupiter might produce enough heat to maintain a subsurface liquid water layer. But the mechanisms of...

journal_title：Nature

authors： Pappalardo RT,Head JW,Greeley R,Sullivan RJ,Pilcher C,Schubert G,Moore WB,Carr MH,Moore JM,Belton MJ,Goldsby DL

更新日期：1998-01-22 00:00:00

abstract：:Efficient long-distance quantum teleportation is crucial for quantum communication and quantum networking schemes. Here we describe the high-fidelity teleportation of photons over a distance of 600 metres across the River Danube in Vienna, with the optimal efficiency that can be achieved using linear optics. Our resul...

journal_title：Nature

authors： Ursin R,Jennewein T,Aspelmeyer M,Kaltenbaek R,Lindenthal M,Walther P,Zeilinger A

更新日期：2004-08-19 00:00:00

abstract：:A DNA probe from a human Y chromosome-derived cosmid detects a single-copy genomic DNA fragment which can appear in different allelic forms shared by both sex chromosomes. Variants at this DNA locus show an autosomal pattern of inheritance, undergo recombination with sexual phenotype and can therefore be described as ...

journal_title：Nature

authors： Simmler MC,Rouyer F,Vergnaud G,Nyström-Lahti M,Ngo KY,de la Chapelle A,Weissenbach J

更新日期：1985-10-24 00:00:00

abstract：:Cyclosporin A, a cyclic undecapeptide, is a potent immunosuppressant that binds to a peptidyl-prolyl cis-trans isomerase of 165 amino acids, cyclophilin. The cyclosporin A/cyclophilin complex inhibits the calcium- and calmodulin-dependent phosphatase, calcineurin, resulting in a failure to activate genes encoding inte...

journal_title：Nature

authors： Thériault Y,Logan TM,Meadows R,Yu L,Olejniczak ET,Holzman TF,Simmer RL,Fesik SW

更新日期：1993-01-07 00:00:00

abstract：:Regulation of transcription initiation by proteins binding at DNA sequences some distance from the promoter region itself seems to be a general phenomenon in both eukaryotes and prokaryotes. Proteins bound to an enhancer site in eukaryotes can turn on a distant gene, whereas efficient repression of some prokaryotic ge...

journal_title：Nature

authors： Dandanell G,Valentin-Hansen P,Larsen JE,Hammer K

更新日期：1987-02-26 00:00:00

abstract：:Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...

journal_title：Nature

authors： Witkowski FX,Leon LJ,Penkoske PA,Giles WR,Spano ML,Ditto WL,Winfree AT

更新日期：1998-03-05 00:00:00

abstract：:The axial coupling of the nucleon, gA, is the strength of its coupling to the weak axial current of the standard model of particle physics, in much the same way as the electric charge is the strength of the coupling to the electromagnetic current. This axial coupling dictates the rate at which neutrons decay to proton...

journal_title：Nature

authors： Chang CC,Nicholson AN,Rinaldi E,Berkowitz E,Garron N,Brantley DA,Monge-Camacho H,Monahan CJ,Bouchard C,Clark MA,Joó B,Kurth T,Orginos K,Vranas P,Walker-Loud A

更新日期：2018-06-01 00:00:00

abstract：:Gigantopithecus blacki was a giant hominid that inhabited densely forested environments of Southeast Asia during the Pleistocene epoch1. Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear2,3....

journal_title：Nature

authors： Welker F,Ramos-Madrigal J,Kuhlwilm M,Liao W,Gutenbrunner P,de Manuel M,Samodova D,Mackie M,Allentoft ME,Bacon AM,Collins MJ,Cox J,Lalueza-Fox C,Olsen JV,Demeter F,Wang W,Marques-Bonet T,Cappellini E

更新日期：2019-12-01 00:00:00

abstract：:Reorganizations of the Atlantic meridional overturning circulation were associated with large and abrupt climatic changes in the North Atlantic region during the last glacial period. Projections with climate models suggest that similar reorganizations may also occur in response to anthropogenic global warming. Here I ...

journal_title：Nature

authors： Schmittner A

更新日期：2005-03-31 00:00:00

abstract：:The fossil record of the living great apes is poor. New fossils from undocumented areas, particularly the equatorial forested habitats of extant hominoids, are therefore crucial for understanding their origins and evolution. Two main competing hypotheses have been proposed for orang-utan origins: dental similarities s...

journal_title：Nature

authors： Chaimanee Y,Suteethorn V,Jintasakul P,Vidthayanon C,Marandat B,Jaeger JJ

更新日期：2004-01-29 00:00:00