Immunisation against heterologous type II collagen induces arthritis in mice.

abstract：:Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and experimental studies have demonstrated a causal relationship between neutr...

journal_title：Nature

authors： Wellenstein MD,Coffelt SB,Duits DEM,van Miltenburg MH,Slagter M,de Rink I,Henneman L,Kas SM,Prekovic S,Hau CS,Vrijland K,Drenth AP,de Korte-Grimmerink R,Schut E,van der Heijden I,Zwart W,Wessels LFA,Schumacher TN,Jonk

更新日期：2019-08-01 00:00:00

abstract：:In animals, maternal gene products deposited into eggs regulate embryonic development before activation of the zygotic genome. In plants, an analogous period of prolonged maternal control over embryogenesis is thought to occur based on some gene-expression studies. However, other gene-expression studies and genetic an...

journal_title：Nature

authors： Nodine MD,Bartel DP

更新日期：2012-01-22 00:00:00

abstract：:The UK Farm-Scale Evaluations (FSE) compared the effects on biodiversity of management of genetically modified herbicide-tolerant (GMHT) spring-sown crops with conventional crop management. The FSE reported larger weed abundance under GMHT management for fodder maize, one of three crops studied. Increased seed product...

journal_title：Nature

authors： Perry JN,Firbank LG,Champion GT,Clark SJ,Heard MS,May MJ,Hawes C,Squire GR,Rothery P,Woiwod IP,Pidgeon JD

更新日期：2004-03-18 00:00:00

abstract：:At early stages of the mammalian visual cortex, neurons with similar stimulus selectivities are vertically arrayed through the thickness of the cortical sheet and clustered in patches or bands across the surface. This organization, referred to as a 'column', has been found with respect to one-dimensional stimulus para...

journal_title：Nature

authors： Fujita I,Tanaka K,Ito M,Cheng K

更新日期：1992-11-26 00:00:00

abstract：:Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons. Several groups have attributed this apparent plasticity to 'transdifferentiation'. Others, however, have suggested that cell fusion could explain these results...

journal_title：Nature

authors： Alvarez-Dolado M,Pardal R,Garcia-Verdugo JM,Fike JR,Lee HO,Pfeffer K,Lois C,Morrison SJ,Alvarez-Buylla A

更新日期：2003-10-30 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:NMDA (N-methyl-d-aspartate) receptors (NMDARs) are a principal subtype of excitatory ligand-gated ion channel with prominent roles in physiological and disease processes in the central nervous system. Recognition that glycine potentiates NMDAR-mediated currents as well as being a requisite co-agonist of the NMDAR subt...

journal_title：Nature

authors： Nong Y,Huang YQ,Ju W,Kalia LV,Ahmadian G,Wang YT,Salter MW

更新日期：2003-03-20 00:00:00

abstract：:D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...

journal_title：Nature

authors： Lukas J,Parry D,Aagaard L,Mann DJ,Bartkova J,Strauss M,Peters G,Bartek J

更新日期：1995-06-08 00:00:00

abstract：:The modern giant sperm whale Physeter macrocephalus, one of the largest known predators, preys upon cephalopods at great depths. Lacking a functional upper dentition, it relies on suction for catching its prey; in contrast, several smaller Miocene sperm whales (Physeteroidea) have been interpreted as raptorial (versus...

journal_title：Nature

authors： Lambert O,Bianucci G,Post K,de Muizon C,Salas-Gismondi R,Urbina M,Reumer J

更新日期：2010-07-01 00:00:00

abstract：:Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetim...

journal_title：Nature

authors： Berry MP,Graham CM,McNab FW,Xu Z,Bloch SA,Oni T,Wilkinson KA,Banchereau R,Skinner J,Wilkinson RJ,Quinn C,Blankenship D,Dhawan R,Cush JJ,Mejias A,Ramilo O,Kon OM,Pascual V,Banchereau J,Chaussabel D,O'Garra A

更新日期：2010-08-19 00:00:00

abstract：:How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentifie...

journal_title：Nature

authors： Biondi EG,Reisinger SJ,Skerker JM,Arif M,Perchuk BS,Ryan KR,Laub MT

更新日期：2006-12-14 00:00:00

abstract：:Zooxanthellae, endosymbiotic algae of reef-building corals, substantially contribute to the high gross primary production of coral reefs, but corals exude up to half of the carbon assimilated by their zooxanthellae as mucus. Here we show that released coral mucus efficiently traps organic matter from the water column ...

journal_title：Nature

authors： Wild C,Huettel M,Klueter A,Kremb SG,Rasheed MY,Jørgensen BB

更新日期：2004-03-04 00:00:00

abstract：:Plant respiration results in an annual flux of carbon dioxide (CO2) to the atmosphere that is six times as large as that due to the emissions from fossil fuel burning, so changes in either will impact future climate. As plant respiration responds positively to temperature, a warming world may result in additional resp...

journal_title：Nature

authors： Reich PB,Sendall KM,Stefanski A,Wei X,Rich RL,Montgomery RA

更新日期：2016-03-31 00:00:00

abstract：:AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system. Gated by the neurotransmitter glutamate, AMPA receptors are critical for synaptic strength, and dysregulation of AMPA receptor-mediated si...

journal_title：Nature

authors： Twomey EC,Yelshanskaya MV,Grassucci RA,Frank J,Sobolevsky AI

更新日期：2017-09-07 00:00:00

abstract：:In vertebrates, unfertilized eggs (or mature oocytes) are arrested at metaphase of meiosis II by a cytoplasmic activity called cytostatic factor (CSF). The classical Mos-MAPK pathway has long been implicated in CSF arrest of vertebrate eggs, but exactly how it exerts CSF activity remains unclear. Recently, Erp1 (also ...

journal_title：Nature

authors： Inoue D,Ohe M,Kanemori Y,Nobui T,Sagata N

更新日期：2007-04-26 00:00:00

abstract：:Only 17% of 111 reef-building coral genera and none of the 18 coral families with reef-builders are considered endemic to the Atlantic, whereas the corresponding percentages for the Indo-west Pacific are 76% and 39%. These figures depend on the assumption that genera and families spanning the two provinces belong to t...

journal_title：Nature

authors： Fukami H,Budd AF,Paulay G,Solé-Cava A,Allen Chen C,Iwao K,Knowlton N

更新日期：2004-02-26 00:00:00

abstract：:Individual mammals have the capacity to express at least one million distinct antigen binding specificities, implying a high degree of structural heterogeneity in the variable heavy and light chain (VH and VL) portions of the antibody molecules. Studies of higher vertebrate species suggest that this heterogeneity is c...

journal_title：Nature

authors： Mäkelä O,Litman GW

更新日期：1980-10-16 00:00:00

abstract：:The annotated genomes of organisms define a 'blueprint' of their possible gene products. Post-genome analyses attempt to confirm and modify the annotation and impose a sense of the spatial, temporal and developmental usage of genetic information by the organism. Here we describe a large-scale, high-accuracy (average d...

journal_title：Nature

authors： Lasonder E,Ishihama Y,Andersen JS,Vermunt AM,Pain A,Sauerwein RW,Eling WM,Hall N,Waters AP,Stunnenberg HG,Mann M

更新日期：2002-10-03 00:00:00

abstract：:The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and signal through the mitochondrial antiviral signalling adaptor MAVS (also known as Cardif, VISA and IPS-1) during a viral infection. MAVS activation leads to the rapid production of antiviral cytokines, including type 1 interfer...

journal_title：Nature

authors： Moore CB,Bergstralh DT,Duncan JA,Lei Y,Morrison TE,Zimmermann AG,Accavitti-Loper MA,Madden VJ,Sun L,Ye Z,Lich JD,Heise MT,Chen Z,Ting JP

更新日期：2008-01-31 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Luteijn RD,Zaver SA,Gowen BG,Wyman SK,Garelis NE,Onia L,McWhirter SM,Katibah GE,Corn JE,Woodward JJ,Raulet DH

更新日期：2020-03-01 00:00:00

abstract：:The mechanism of action of antisteroids is not understood and explanations of their antagonistic activity have been sought at all levels of hormone action. It has been proposed that antisteroids, after binding to receptor, trap it into a non-activated (non DNA-binding) form possibly through interaction with a heat-sho...

journal_title：Nature

authors： Guiochon-Mantel A,Loosfelt H,Ragot T,Bailly A,Atger M,Misrahi M,Perricaudet M,Milgrom E

更新日期：1988-12-15 00:00:00

abstract：:Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting increase in synaptic transmission called long-term potentiation (LTP). It is generally believed that this synaptic plasticity may underlie certain forms of learning and memory. LTP at most synapses involves the activat...

journal_title：Nature

authors： Castillo PE,Janz R,Südhof TC,Tzounopoulos T,Malenka RC,Nicoll RA

更新日期：1997-08-07 00:00:00

abstract：:An inhomogeneous superconducting state, not yet conclusively identified, was predicted by Fulde and Ferrell and Larkin and Ovchinnikov (FFLO) to arise in superconductors with strong Pauli limiting, a consequence of the electrons' Zeeman (spin) energy in a magnetic field. Radovan et al. propose that the observed cascad...

journal_title：Nature

authors： Movshovich R,Bianchi A,Capan C,Jaime M,Goodrich RG

更新日期：2004-02-26 00:00:00

abstract：:Laboratory measurements of sound velocities of high-pressure minerals provide crucial information on the composition and constitution of the deep mantle via comparisons with observed seismic velocities. Calcium silicate (CaSiO3) perovskite (CaPv) is a high-pressure phase that occurs at depths greater than about 560 ki...

journal_title：Nature

authors： Gréaux S,Irifune T,Higo Y,Tange Y,Arimoto T,Liu Z,Yamada A

更新日期：2019-01-01 00:00:00

abstract：:In Drosophila and mice, olfactory receptor neurons (ORNs) expressing the same receptors have convergent axonal projections to specific glomerular targets in the antennal lobe/olfactory bulb, creating an odour map in this first olfactory structure of the central nervous system. Projection neurons of the Drosophila ante...

journal_title：Nature

authors： Jefferis GS,Marin EC,Stocker RF,Luo L

更新日期：2001-11-08 00:00:00

abstract：:Mature cortical pyramidal neurons receive excitatory inputs onto small protrusions emanating from their dendrites called spines. Spines undergo activity-dependent remodelling, stabilization and pruning during development, and similar structural changes can be triggered by learning and changes in sensory experiences. H...

journal_title：Nature

authors： Kwon HB,Sabatini BL

更新日期：2011-06-02 00:00:00

abstract：:The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 tran...

journal_title：Nature

authors： Glöckner G,Eichinger L,Szafranski K,Pachebat JA,Bankier AT,Dear PH,Lehmann R,Baumgart C,Parra G,Abril JF,Guigó R,Kumpf K,Tunggal B,Cox E,Quail MA,Platzer M,Rosenthal A,Noegel AA,Dictyostelium Genome Sequencing Consort

更新日期：2002-07-04 00:00:00

abstract：:In somatic cells, entry into mitosis depends on the completion of DNA synthesis. This dependency is established by S-phase feedback controls that arrest cell division when damaged or unreplicated DNA is present. In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosi...

journal_title：Nature

authors： Sorger PK,Murray AW

更新日期：1992-01-23 00:00:00

abstract：:The repressor of phage 434 binds to six operator sites on the phage chromosome. A comparison of the sequences of these 14-base-pair (bp) operator sites reveals a striking pattern: at five of the six sites, the symmetrically arrayed outer eight base pairs (four in each half-site) are identical and the remaining site di...

journal_title：Nature

authors： Koudelka GB,Harrison SC,Ptashne M

更新日期：1987-04-30 00:00:00

abstract：:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...

journal_title：Nature

authors： Garcia R,Vouimba RM,Baudry M,Thompson RF

更新日期：1999-11-18 00:00:00