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Regulation of the bacterial cell cycle by an integrated genetic circuit.

Abstract：

:How bacteria regulate cell cycle progression at a molecular level is a fundamental but poorly understood problem. In Caulobacter crescentus, two-component signal transduction proteins are crucial for cell cycle regulation, but the connectivity of regulators involved has remained elusive and key factors are unidentified. Here we identify ChpT, an essential histidine phosphotransferase that controls the activity of CtrA, the master cell cycle regulator. We show that the essential histidine kinase CckA initiates two phosphorelays, each requiring ChpT, which lead to the phosphorylation and stabilization of CtrA. Downregulation of CckA activity therefore results in the dephosphorylation and degradation of CtrA, which in turn allow the initiation of DNA replication. Furthermore, we show that CtrA triggers its own destruction by promoting cell division and inducing synthesis of the essential regulator DivK, which feeds back to downregulate CckA immediately before S phase. Our results define a single integrated circuit whose components and connectivity can account for the cell cycle oscillations of CtrA in Caulobacter.

journal_name

Nature

journal_title

Nature

authors

Biondi EG,Reisinger SJ,Skerker JM,Arif M,Perchuk BS,Ryan KR,Laub MT

doi

10.1038/nature05321

subject

Has Abstract

pub_date

2006-12-14 00:00:00

pages

899-904

issue

7121

eissn

0028-0836

issn

1476-4687

pii

nature05321

journal_volume

444

pub_type

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