Abstract:
:Support-free high-speed countercurrent liquid chromatography provides a rich domain of applications, some beyond reach of conventional liquid chromatography.
journal_name
Naturejournal_title
Natureauthors
Ito Ydoi
10.1038/326419a0subject
Has Abstractpub_date
1987-03-26 00:00:00pages
419-20issue
6111eissn
0028-0836issn
1476-4687journal_volume
326pub_type
杂志文章相关文献
NATURE文献大全abstract::Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/329451a0
更新日期:1987-10-01 00:00:00
abstract::The axial relationship between the collagen and mineral componetns in calcified turkey leg tendon was investigated using low-angle X-ray and neutron diffraction. The results indicate that the mineral is arranged with the same axial periodicity as the collagen and occupies the gap region of the collagen structure. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/266421a0
更新日期:1977-03-31 00:00:00
abstract::The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416763a
更新日期:2002-04-18 00:00:00
abstract::All living organisms use ion channels to regulate the transport of ions across cellular membranes. Certain ion channels are classed as voltage-dependent because they have a voltage-sensing structure that induces their pores to open in response to changes in the cell membrane voltage. Until recently, the voltage-depend...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01473
更新日期:2003-03-13 00:00:00
abstract::Blood production is ensured by rare, self-renewing haematopoietic stem cells (HSCs). How HSCs accommodate the diverse cellular stresses associated with their life-long activity remains elusive. Here we identify autophagy as an essential mechanism protecting HSCs from metabolic stress. We show that mouse HSCs, in contr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11895
更新日期:2013-02-21 00:00:00
abstract::Tumour necrosis factor (TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75). Most TNF-mediated biological responses, such as cell death, gene induction, antiviral activity and cytokine production, have been attributed to TNF-R1 (refs 1-5). Gene targeting ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/372560a0
更新日期:1994-12-08 00:00:00
abstract::So far, two genes associated with familial melanoma have been identified, accounting for a minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of familial cases, and predisposing mutations in CDK4 have been reported in a very small number of melanoma kindreds. Here we report the who...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10630
更新日期:2011-11-13 00:00:00
abstract::Mutations in the transcription factor FOXA1 define a unique subset of prostate cancers but the functional consequences of these mutations and whether they confer gain or loss of function is unknown1-9. Here, by annotating the landscape of FOXA1 mutations from 3,086 human prostate cancers, we define two hotspots in the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1318-9
更新日期:2019-07-01 00:00:00
abstract::The polarized architecture of epithelial cells depends on the highly stereotypic distribution of cellular junctions and other membrane-associated protein complexes. In epithelial cells of the Drosophila embryo, three distinct domains subdivide the lateral plasma membrane. The most apical one comprises the subapical co...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/414638a
更新日期:2001-12-06 00:00:00
abstract::Modern chitons (Mollusca: Polyplacophora) possess a highly conserved skeleton of eight shell plates (valves) surrounded by spicules or scales, and fossil evidence suggests that the chiton skeleton has changed little since the first appearance of the class in the Late Cambrian period (about 500 million years before pre...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02548
更新日期:2004-05-20 00:00:00
abstract::We have shown previously that chromosome VI of Saccharomyces cerevisiae contains nine origins of DNA replication that differ in initiation frequency and replicate sequentially during the S phase of the cell cycle. Here we show that there are links between activation of these multiple origins and regulation of S-phase ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/27007
更新日期:1998-10-08 00:00:00
abstract::The widely occurring tetradecapeptide somatostatin (SRIF-14) has been variously implicated as a neurotransmitter, a neurohormone, a cybernin (local regulatory factor) and a hormone. In the first isolation of SRIF-14 from hypothalamic extracts and subsequent extracts of other tissues, peptides of higher molecular weigh...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/291076a0
更新日期:1981-05-07 00:00:00
abstract::Cancer control by adaptive immunity involves a number of defined death and clearance mechanisms. However, efficient inhibition of exponential cancer growth by T cells and interferon-γ (IFN-γ) requires additional undefined mechanisms that arrest cancer cell proliferation. Here we show that the combined action of the T-...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11824
更新日期:2013-02-21 00:00:00
abstract::During the biosynthesis of selenoproteins in both prokaryotes and eukaryotes, selenocysteine is cotranslationally incorporated into the nascent polypeptide chain through a process directed by a UGA codon that normally functions as a stop codon. Recently, four genes have been identified whose products are required for ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/342453a0
更新日期:1989-11-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0796-5
更新日期:2018-12-01 00:00:00
abstract::Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. At the same time, augmentation ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/260582a0
更新日期:1976-04-15 00:00:00
abstract::Aquaporin (AQP) water-channel proteins are freely permeated by water but not by ions or charged solutes. Although mammalian aquaporins were believed to be located in plasma membranes, rat AQP6 is restricted to intracellular vesicles in renal epithelia. Here we show that AQP6 is functionally distinct from other known a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/46045
更新日期:1999-11-11 00:00:00
abstract::Insulin resistance occurs in a variety of conditions, including diabetes, obesity and essential hypertension, but its underlying molecular mechanisms are unclear. In type 2 (non-insulin-dependent) diabetes mellitus, it is insulin-resistance in skeletal muscle, the chief site of insulin-mediated glucose disposal in hum...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335632a0
更新日期:1988-10-13 00:00:00
abstract::Astrocyte proliferation and perivascular lymphocyte infiltration are conspicuous among the cellular changes in the active brain lesions of multiple sclerosis patients. Recent observations have indicated that most of the perivascular lymphocytes are T cells which may be actively involved in the generation of the brain ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307273a0
更新日期:1984-01-19 00:00:00
abstract::Many intracellular targets of protein-tyrosine kinases possess Src homology 2 (SH2) domains that directly recognize phosphotyrosine-containing sites on autophosphorylated growth factor receptors and cytoplasmic proteins, and thereby mediate the activation of biochemical signalling pathways. SH2 domains possess relativ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369502a0
更新日期:1994-06-09 00:00:00
abstract::Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35079578
更新日期:2001-06-07 00:00:00
abstract::Thyroid hormones and retinoic acid function through nuclear receptors that belong to the steroid/thyroid-hormone receptor superfamily. Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) require auxiliary nuclear proteins for efficient DNA binding. Here we report that retinoid X receptors RXR alpha is o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/355441a0
更新日期:1992-01-30 00:00:00
abstract::A plume of water vapour escapes from fissures crossing the south polar region of the Saturnian moon Enceladus. Tidal deformation of a thin surface crust above an internal ocean could result in tensile and compressive stresses that would affect the width of the fissures; therefore, the quantity of water vapour released...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07542
更新日期:2008-11-27 00:00:00
abstract::Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson's disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a poten...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2388-4
更新日期:2020-06-01 00:00:00
abstract::Despite its widespread distribution on both lymphoid and myeloid cells, the biological role of the low-affinity immunoglobulin-G receptor, Fc gamma RII, is not fully understood. Defects in this receptor or its signalling pathway in B cells result in perturbations in immune-complex-mediated feedback inhibition of antib...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379346a0
更新日期:1996-01-25 00:00:00
abstract::In the era of precision cosmology, it is essential to determine the Hubble constant empirically with an accuracy of one per cent or better1. At present, the uncertainty on this constant is dominated by the uncertainty in the calibration of the Cepheid period-luminosity relationship2,3 (also known as the Leavitt law). ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0999-4
更新日期:2019-03-01 00:00:00
abstract::Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1-2% of the world's population and is characterized by widespread joint inflammation. Interleukin-1 is an important mediator of cartilage destruction in rheumatic diseases, but our understanding of the upstream mechanisms leading to production of ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13322
更新日期:2014-08-07 00:00:00
abstract::The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03469
更新日期:2005-04-21 00:00:00
abstract::Grid cells provide a neural representation of space, by discharging when an animal traverses through the vertices of a periodic hexagonal grid spanning the environment. Although grid cells have been characterized in detail in rats, the fundamental question of what neural dynamics give rise to the grid structure remain...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10583
更新日期:2011-11-02 00:00:00
abstract::Bacterial cell division ends with septation, the constriction of the cell wall and cell membranes that leads to the formation of two daughter cells. During septation, FtsZ, a protein of relative molecular mass 40,000 which is ubiquitous in eubacteria and is also found in archaea and chloroplasts, localizes early at th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/34472
更新日期:1998-01-08 00:00:00