Decreased stability of methane hydrates in marine sediments owing to phase-boundary roughness.

abstract：:Circadian rhythms have evolved to anticipate and adapt animals to the constraints of the earth's 24-hour light cycle. Although the molecular processes that establish periodicity in clock neurons of the suprachiasmatic nucleus (SCN) are well understood, the mechanisms by which axonal projections from the central clock ...

journal_title：Nature

authors： Gizowski C,Zaelzer C,Bourque CW

更新日期：2016-09-29 00:00:00

abstract：:The U6 small nuclear (sn)RNA gene (SNR6) from the yeast Saccharomyces cerevisiae is transcribed by RNA polymerase III in vivo. This gene is unusual in having a TATA box at position -30, and an essential B-block element located downstream of the T-rich termination signal. The B block is one of the two intragenic promot...

journal_title：Nature

authors： Burnol AF,Margottin F,Huet J,Almouzni G,Prioleau MN,Méchali M,Sentenac A

更新日期：1993-04-01 00:00:00

abstract：:Neuromorphic computing draws inspiration from the brain to provide computing technology and architecture with the potential to drive the next wave of computer engineering1-13. Such brain-inspired computing also provides a promising platform for the development of artificial general intelligence14,15. However, unlike c...

journal_title：Nature

authors： Zhang Y,Qu P,Ji Y,Zhang W,Gao G,Wang G,Song S,Li G,Chen W,Zheng W,Chen F,Pei J,Zhao R,Zhao M,Shi L

更新日期：2020-10-01 00:00:00

abstract：:The way in which proteins attain and maintain their final form is of fundamental importance. Recent work has focused on the role of a set of ubiquitous proteins, termed chaperonins, in the assembly of phage and multisubunit proteins. The range of chaperonin action is unknown; they could interact with most cellular pol...

journal_title：Nature

authors： Van Dyk TK,Gatenby AA,LaRossa RA

更新日期：1989-11-23 00:00:00

abstract：:The tropics have been suggested as the drivers of global ocean and atmosphere circulation and biogeochemical cycling during the extreme warmth of the Cretaceous period; but the links between orbital forcing, freshwater runoff and the biogeochemistry of continental margins in extreme greenhouse conditions are not fully...

journal_title：Nature

authors： Beckmann B,Flögel S,Hofmann P,Schulz M,Wagner T

更新日期：2005-09-08 00:00:00

abstract：:Accurate measurement of the lifetime of the neutron (which is unstable to beta decay) is important for understanding the weak nuclear force and the creation of matter during the Big Bang. Previous measurements of the neutron lifetime have mainly been limited by certain systematic errors; however, these could in princi...

journal_title：Nature

authors： Huffman PR,Brome CR,Butterworth JS,Coakley KJ,Dewey MS,Dzhosyuk SN,Golub R,Greene GL,Habicht K,Lamoreaux SK,Mattoni CE,McKinsey DN,Wietfeldt FE,Doyle JM

更新日期：2000-01-06 00:00:00

abstract：:The study of language origin and divergence is important for understanding the history of human populations and their cultures. The Sino-Tibetan language family is the second largest in the world after Indo-European, and there is a long-running debate about its phylogeny and the time depth of its original divergence1....

journal_title：Nature

authors： Zhang M,Yan S,Pan W,Jin L

更新日期：2019-05-01 00:00:00

abstract：:In Fig. 1b of this Article, a U was inadvertently inserted after G15 in the D loop. The original Article has not been corrected. ...

journal_title：Nature

authors： Naganuma M,Sekine SI,Chong YE,Guo M,Yang XL,Gamper H,Hou YM,Schimmel P,Yokoyama S

更新日期：2018-12-01 00:00:00

abstract：:A thermal light-emitting source, such as a black body or the incandescent filament of a light bulb, is often presented as a typical example of an incoherent source and is in marked contrast to a laser. Whereas a laser is highly monochromatic and very directional, a thermal source has a broad spectrum and is usually qu...

journal_title：Nature

authors： Greffet JJ,Carminati R,Joulain K,Mulet JP,Mainguy S,Chen Y

更新日期：2002-03-07 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Hsiang S,Allen D,Annan-Phan S,Bell K,Bolliger I,Chong T,Druckenmiller H,Huang LY,Hultgren A,Krasovich E,Lau P,Lee J,Rolf E,Tseng J,Wu T

更新日期：2020-09-01 00:00:00

abstract：:Predation can be intense, creating strong direct and indirect effects throughout food webs. In addition, ecologists increasingly recognize that fluxes of organisms across ecosystem boundaries can have major consequences for community dynamics. Species with complex life histories often shift habitats during their life ...

journal_title：Nature

authors： Knight TM,McCoy MW,Chase JM,McCoy KA,Holt RD

更新日期：2005-10-06 00:00:00

abstract：:It has been known for some 50 years that birds use photoreceptors in or near the hypothalamus to mediate the photoperiodic responses that control seasonal breeding. So far, however, attempts to identify the photopigment by determining an action spectrum have failed. The problems stem from the selective filtering of li...

journal_title：Nature

authors： Foster RG,Follett BK,Lythgoe JN

更新日期：1985-01-03 00:00:00

abstract：:Many chemical and physical systems can occur in two forms distinguished solely by being mirror images of each other. This phenomenon, known as chirality, is important in biochemistry, where reactions involving chiral molecules often require the participation of one specific enantiomer (mirror image) of the two possibl...

journal_title：Nature

authors： Rikken GL,Raupach E

更新日期：2000-06-22 00:00:00

abstract：:Quantum electrodynamics describes the interactions of electrons and photons. Electric charge (the gauge coupling constant) is energy dependent, and there is a previous claim that charge is affected by gravity (described by general relativity) with the implication that the charge is reduced at high energies. However, t...

journal_title：Nature

authors： Toms DJ

更新日期：2010-11-04 00:00:00

abstract：:Thewissen et al. describe new fossils from India that apparently support a phylogeny that places Cetacea (that is, whales, dolphins, porpoises) as the sister group to the extinct family Raoellidae, and Hippopotamidae as more closely related to pigs and peccaries (that is, Suina) than to cetaceans. However, our reanaly...

journal_title：Nature

authors： Geisler JH,Theodor JM

更新日期：2009-03-19 00:00:00

abstract：:CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism of tumour suppressi...

journal_title：Nature

authors： Krimpenfort P,Quon KC,Mooi WJ,Loonstra A,Berns A

更新日期：2001-09-06 00:00:00

abstract：:The structure-function relationship of the nicotinic acetylcholine receptor (AChR) has been effectively studied by the combination of complementary DNA manipulation and single-channel current analysis. Previous work with chimaeras between the Torpedo californica and bovine AChR delta-subunits has shown that the region...

journal_title：Nature

authors： Imoto K,Busch C,Sakmann B,Mishina M,Konno T,Nakai J,Bujo H,Mori Y,Fukuda K,Numa S

更新日期：1988-10-13 00:00:00

abstract：:A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates caspase-1 to process the proinflammatory cytokines interleukin (IL)-1beta and IL-18. The adaptor protein ASC is essential for inflammasome function, binding directly to caspase-1 (refs 3, 4)...

journal_title：Nature

authors： Mariathasan S,Weiss DS,Newton K,McBride J,O'Rourke K,Roose-Girma M,Lee WP,Weinrauch Y,Monack DM,Dixit VM

更新日期：2006-03-09 00:00:00

abstract：:The RNA polymerase II large subunit contains an essential carboxy-terminal domain (CTD) believed to be involved in the response to regulators during transcription initiation. The CTD is phosphorylated on a portion of RNA polymerase II molecules in vivo and it can be phosphorylated by the general transcription factor T...

journal_title：Nature

authors： Serizawa H,Mäkelä TP,Conaway JW,Conaway RC,Weinberg RA,Young RA

更新日期：1995-03-16 00:00:00

abstract：:The regular occurrence of a peak due to an unidentified substance (X) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. The biphasic excretion of X with maxima in the luteal phase of the ovulatory cycle and relatively high levels ...

journal_title：Nature

authors： Stitch SR,Toumba JK,Groen MB,Funke CW,Leemhuis J,Vink J,Woods GF

更新日期：1980-10-23 00:00:00

abstract：:Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron...

journal_title：Nature

authors： Cuskin F,Lowe EC,Temple MJ,Zhu Y,Cameron E,Pudlo NA,Porter NT,Urs K,Thompson AJ,Cartmell A,Rogowski A,Hamilton BS,Chen R,Tolbert TJ,Piens K,Bracke D,Vervecken W,Hakki Z,Speciale G,Munōz-Munōz JL,Day A,Peña MJ,

更新日期：2015-01-08 00:00:00

abstract：:The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCF(TIR1) and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the functio...

journal_title：Nature

authors： Gray WM,Kepinski S,Rouse D,Leyser O,Estelle M

更新日期：2001-11-15 00:00:00

abstract：:It is thought that immunity depends on naive CD4 T cells that proliferate in response to microbial antigens, differentiate into memory cells that produce anti-microbial lymphokines, and migrate to sites of infection. Here we use immunohistology to enumerate individual naive CD4 T cells, specific for a model antigen, i...

journal_title：Nature

authors： Reinhardt RL,Khoruts A,Merica R,Zell T,Jenkins MK

更新日期：2001-03-01 00:00:00

abstract：:Chondrules and Ca-Al-rich inclusions (CAIs) are high-temperature components of meteorites that formed during transient heating events in the early Solar System. A major unresolved issue is the relative timing of CAI and chondrule formation. From the presence of chondrule fragments in an igneous CAI, it was concluded t...

journal_title：Nature

authors： Krot AN,Yurimoto H,Hutcheon ID,MacPherson GJ

更新日期：2005-04-21 00:00:00

abstract：:A wide variety of systems, including granular media, colloidal suspensions and molecular systems, exhibit non-equilibrium transitions from a fluid-like to a solid-like state, characterized solely by the sudden arrest of their dynamics. Crowding or jamming of the constituent particles traps them kinetically, precluding...

journal_title：Nature

authors： Trappe V,Prasad V,Cipelletti L,Segre PN,Weitz DA

更新日期：2001-06-14 00:00:00

abstract：:Mammalian circadian clocks consist of complex integrated feedback loops that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological tec...

journal_title：Nature

authors： Ueda HR,Chen W,Adachi A,Wakamatsu H,Hayashi S,Takasugi T,Nagano M,Nakahama K,Suzuki Y,Sugano S,Iino M,Shigeyoshi Y,Hashimoto S

更新日期：2002-08-01 00:00:00

abstract：:Oxygen isotope analyses of Spondylus shells from neolithic sites suggest that the source for the shells used as ornaments in the Balkans and central Europe during the fourth millennium BC was the Aegean and not the Black Sea. The trade in Spondylus may have taken the form of an exchange of gifts. ...

journal_title：Nature

authors： Shackleton N,Renfrew C

更新日期：1970-12-12 00:00:00

abstract：:The kinesin superfamily is a class of microtubule-based mechano-enzymes involved in intracellular transport and chromosome movements. Molecules that move towards either the plus end or the minus end of microtubules are represented within the family. The motor domains of these molecules exhibit considerable sequence ho...

journal_title：Nature

authors： Hoenger A,Sablin EP,Vale RD,Fletterick RJ,Milligan RA

更新日期：1995-07-20 00:00:00

abstract：:Leprosy is a spectral disease in which immune responses to Mycobacterium leprae correlate with the clinical, bacteriological and histopathological manifestations of disease, so study of its pathology provides insights into immunoregulatory mechanisms in man. At the tuberculoid pole, patients have few lesions in the sk...

journal_title：Nature

authors： Modlin RL,Kato H,Mehra V,Nelson EE,Fan XD,Rea TH,Pattengale PK,Bloom BR

更新日期：1986-07-31 00:00:00

abstract：:Regulation of ion transport by phosphorylation and G proteins occurs in several epithelial and non-epithelial cell plasma membranes1-5. It is not known whether transporters on intracellular membranes are target sites for second messengers. Here we present direct evidence that a chloride conductance in endocytic vesicl...

journal_title：Nature

authors： Bae HR,Verkman AS

更新日期：1990-12-13 00:00:00