Abstract:
:Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.
journal_name
Naturejournal_title
Natureauthors
Cuskin F,Lowe EC,Temple MJ,Zhu Y,Cameron E,Pudlo NA,Porter NT,Urs K,Thompson AJ,Cartmell A,Rogowski A,Hamilton BS,Chen R,Tolbert TJ,Piens K,Bracke D,Vervecken W,Hakki Z,Speciale G,Munōz-Munōz JL,Day A,Peña MJ,doi
10.1038/nature13995subject
Has Abstractpub_date
2015-01-08 00:00:00pages
165-169issue
7533eissn
0028-0836issn
1476-4687journal_volume
517pub_type
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