Abstract：
:Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade.
journal_name
Naturejournal_title
Natureauthors
Wrana JL,Attisano L,Wieser R,Ventura F,Massagué Jdoi
10.1038/370341a0subject
Has Abstractpub_date
1994-08-04 00:00:00pages
341-7issue
6488eissn
0028-0836issn
1476-4687journal_volume
370pub_type
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