Noise to order.

abstract：:The spider mite Tetranychus urticae is a cosmopolitan agricultural pest with an extensive host plant range and an extreme record of pesticide resistance. Here we present the completely sequenced and annotated spider mite genome, representing the first complete chelicerate genome. At 90 megabases T. urticae has the sma...

journal_title：Nature

authors： Grbić M,Van Leeuwen T,Clark RM,Rombauts S,Rouzé P,Grbić V,Osborne EJ,Dermauw W,Ngoc PC,Ortego F,Hernández-Crespo P,Diaz I,Martinez M,Navajas M,Sucena É,Magalhães S,Nagy L,Pace RM,Djuranović S,Smagghe G,Iga M,Chr

更新日期：2011-11-23 00:00:00

abstract：:Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bon...

journal_title：Nature

authors： Woychik RP,Maas RL,Zeller R,Vogt TF,Leder P

更新日期：1990-08-30 00:00:00

abstract：:Growing concern about how loss of biodiversity will affect ecosystems has stimulated numerous studies. Although most studies have assumed that species go extinct randomly, species often go extinct in order of their sensitivity to a stress that intensifies through time (such as climate change). Here we show that the co...

journal_title：Nature

authors： Ives AR,Cardinale BJ

更新日期：2004-05-13 00:00:00

abstract：:Cancer cells hijack and remodel existing metabolic pathways for their benefit. Argininosuccinate synthase (ASS1) is a urea cycle enzyme that is essential in the conversion of nitrogen from ammonia and aspartate to urea. A decrease in nitrogen flux through ASS1 in the liver causes the urea cycle disorder citrullinaemia...

journal_title：Nature

authors： Rabinovich S,Adler L,Yizhak K,Sarver A,Silberman A,Agron S,Stettner N,Sun Q,Brandis A,Helbling D,Korman S,Itzkovitz S,Dimmock D,Ulitsky I,Nagamani SC,Ruppin E,Erez A

更新日期：2015-11-19 00:00:00

abstract：:Inflammasomes are intracellular protein complexes that drive the activation of inflammatory caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have been described that recruit the common adaptor protein ASC to activate caspase-1, leading to the secretion of mature IL-1β and IL-18 proteins. The...

journal_title：Nature

authors： He Y,Zeng MY,Yang D,Motro B,Núñez G

更新日期：2016-02-18 00:00:00

abstract：: ...

journal_title：Nature

authors： Glausiusz J

更新日期：2019-01-01 00:00:00

abstract：:The evolutionary divergence of a single species into two has never been directly observed in nature, primarily because speciation can take a long time to occur. A ring species, in which a chain of intergrading populations encircles a barrier and the terminal forms coexist without interbreeding, provides a situation in...

journal_title：Nature

authors： Irwin DE,Bensch S,Price TD

更新日期：2001-01-18 00:00:00

abstract：:The site of action of the antispastic drug baclofen has long been considered to reside in the spinal cord although supraspinal effects have also been reported. This beta-chlorophenyl derivative of the neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission in the cord ...

journal_title：Nature

authors： Price GW,Wilkin GP,Turnbull MJ,Bowery NG

更新日期：1984-01-05 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration. Antibody-based immunotherapy against Aβ to trigger its clearance or mitigate its neurotoxicity has so far been unsuccessful. Here we rep...

journal_title：Nature

authors： Sevigny J,Chiao P,Bussière T,Weinreb PH,Williams L,Maier M,Dunstan R,Salloway S,Chen T,Ling Y,O'Gorman J,Qian F,Arastu M,Li M,Chollate S,Brennan MS,Quintero-Monzon O,Scannevin RH,Arnold HM,Engber T,Rhodes K,Ferr

更新日期：2016-09-01 00:00:00

abstract：:Type II topoisomerases help regulate DNA topology during transcription, replication and recombination by catalysing DNA strand transfer through transient double-stranded breaks. All type II topoisomerases described so far are members of a single protein family. We have cloned and sequenced the genes encoding the A and...

journal_title：Nature

authors： Bergerat A,de Massy B,Gadelle D,Varoutas PC,Nicolas A,Forterre P

更新日期：1997-03-27 00:00:00

abstract：:A major aim in immunology has been to understand how the immune system evokes characteristic responses to infection, foreign tissue grafts and tumours. The current view of immunoregulation is based mainly on studies of lymphocyte subsets, either in vitro or by adoptive transfer to irradiated recipients. Many reagents ...

journal_title：Nature

authors： Cobbold SP,Jayasuriya A,Nash A,Prospero TD,Waldmann H

更新日期：1984-12-06 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have been generated by enforced expression of defined sets of transcription factors in somatic cells. It remains controversial whether iPSCs are molecularly and functionally equivalent to blastocyst-derived embryonic stem (ES) cells. By comparing genetically identical mouse ES ce...

journal_title：Nature

authors： Stadtfeld M,Apostolou E,Akutsu H,Fukuda A,Follett P,Natesan S,Kono T,Shioda T,Hochedlinger K

更新日期：2010-05-13 00:00:00

abstract：:Bilingual individuals need effective mechanisms to prevent interference from one language while processing material in the other. Here we show, using event-related brain potentials and functional magnetic resonance imaging (fMRI), that words from the non-target language are rejected at an early stage before semantic a...

journal_title：Nature

authors： Rodriguez-Fornells A,Rotte M,Heinze HJ,Nösselt T,Münte TF

更新日期：2002-02-28 00:00:00

abstract：:Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative analyses. Here we present a large-scale evolutionary study of lnc...

journal_title：Nature

authors： Necsulea A,Soumillon M,Warnefors M,Liechti A,Daish T,Zeller U,Baker JC,Grützner F,Kaessmann H

更新日期：2014-01-30 00:00:00

abstract：:Rous sarcoma virus (RSV) is an acutely oncogenic avian retrovirus which induces sarcomas in animals and transforms fibroblasts in cell culture. Genetic analysis indicates that the viral src gene (v-src) mediates neoplastic transformation. The product of v-src is a 60,000 molecular weight (MW) phosphoprotein (pp60v-src...

journal_title：Nature

authors： Simon MA,Kornberg TB,Bishop JM

更新日期：1983-04-28 00:00:00

abstract：:Multistranded DNA structures based upon guanine association have been proposed to be important in the structure of chromosome telomeres and in immunoglobulin class switching. Nucleic acids containing runs of guanine bases form a number of structures in vitro, including fold-back structures (Fig. 1a) and parallel-stran...

journal_title：Nature

authors： Aboul-ela F,Murchie AI,Lilley DM

更新日期：1992-11-19 00:00:00

abstract：:In magnetic memory devices, logical bits are recorded by selectively setting the magnetization vector of individual magnetic domains either 'up' or 'down'. In such devices, the fastest and most efficient recording method involves precessional switching: when a magnetic field B(p) is applied as a write pulse over a per...

journal_title：Nature

authors： Tudosa I,Stamm C,Kashuba AB,King F,Siegmann HC,Stöhr J,Ju G,Lu B,Weller D

更新日期：2004-04-22 00:00:00

abstract：:A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes1,2 and that Meis1, a three am...

journal_title：Nature

authors： Nguyen NUN,Canseco DC,Xiao F,Nakada Y,Li S,Lam NT,Muralidhar SA,Savla JJ,Hill JA,Le V,Zidan KA,El-Feky HW,Wang Z,Ahmed MS,Hubbi ME,Menendez-Montes I,Moon J,Ali SR,Le V,Villalobos E,Mohamed MS,Elhelaly WM,Thet

更新日期：2020-06-01 00:00:00

abstract：:Transient receptor potential (TRP) channels are sensors for a wide range of cellular and environmental signals, but elucidating how these channels respond to physical and chemical stimuli has been hampered by a lack of detailed structural information. Here we exploit advances in electron cryo-microscopy to determine t...

journal_title：Nature

authors： Liao M,Cao E,Julius D,Cheng Y

更新日期：2013-12-05 00:00:00

abstract：:The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...

journal_title：Nature

authors： Vidal-Madjar A,Des Etangs AL,Désert JM,Ballester GE,Ferlet R,Hébrard G,Mayor M

更新日期：2003-03-13 00:00:00

abstract：:Excitatory amino acids mediate fast synaptic transmission in the central nervous system through the activation of at least three distinct ionotropic receptors: N-methyl-D-aspartate (NMDA), the alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/quisqualate (QUIS) and the kainate subtypes (for reviews, see ref...

journal_title：Nature

authors： Charpak S,Gähwiler BH,Do KQ,Knöpfel T

更新日期：1990-10-25 00:00:00

abstract：:Established infections with the human and simian immunodeficiency viruses (HIV and SIV, respectively) are thought to be permanent with even the most effective immune responses and antiretroviral therapies only able to control, but not clear, these infections. Whether the residual virus that maintains these infections ...

journal_title：Nature

authors： Hansen SG,Piatak M Jr,Ventura AB,Hughes CM,Gilbride RM,Ford JC,Oswald K,Shoemaker R,Li Y,Lewis MS,Gilliam AN,Xu G,Whizin N,Burwitz BJ,Planer SL,Turner JM,Legasse AW,Axthelm MK,Nelson JA,Früh K,Sacha JB,Estes JD

更新日期：2013-10-03 00:00:00

abstract：:Normal cellular function requires that organelles be positioned in specific locations. The direction in which molecular motors move organelles is based in part on the polarity of microtubules and actin filaments. However, this alone does not determine the intracellular destination of organelles. For example, the yeast...

journal_title：Nature

authors： Tang F,Kauffman EJ,Novak JL,Nau JJ,Catlett NL,Weisman LS

更新日期：2003-03-06 00:00:00

abstract：:Intestinal parasites are common in man and animals and can cause severe disease. Knowledge of immunity to such infections is limited and comes largely from studies using laboratory host-parasite systems. Understanding how immunity can operate, and why it often does not, is not only of intrinsic interest but necessary ...

journal_title：Nature

authors： Wakelin D

更新日期：1978-06-22 00:00:00

abstract：:The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiolo...

journal_title：Nature

authors： Karsenty G,Ferron M

更新日期：2012-01-18 00:00:00

abstract：:The paired helical filament (PHF) is the major component of the neurofibrillary deposits that form a defining neuropathological characteristic of Alzheimer's disease. PHFs are composed of microtubule-associated protein tau, in a hyperphosphorylated state. Hyperphosphorylation of tau results in its inability to bind to...

journal_title：Nature

authors： Goedert M,Jakes R,Spillantini MG,Hasegawa M,Smith MJ,Crowther RA

更新日期：1996-10-10 00:00:00

abstract：:Progress in the fabrication of nanometre-scale electronic devices is opening new opportunities to uncover deeper aspects of the Kondo effect--a characteristic phenomenon in the physics of strongly correlated electrons. Artificial single-impurity Kondo systems have been realized in various nanostructures, including sem...

journal_title：Nature

authors： Jarillo-Herrero P,Kong J,van der Zant HS,Dekker C,Kouwenhoven LP,De Franceschi S

更新日期：2005-03-24 00:00:00

abstract：:Recent work demonstrates that stochastic fluctuations in molecular populations have consequences for gene regulation. Previous experiments focused on noise sources or noise propagation through gene networks by measuring noise magnitudes. However, in theoretical analysis, we showed that noise frequency content is deter...

journal_title：Nature

authors： Austin DW,Allen MS,McCollum JM,Dar RD,Wilgus JR,Sayler GS,Samatova NF,Cox CD,Simpson ML

更新日期：2006-02-02 00:00:00

abstract：:Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...

journal_title：Nature

authors： Cooper DM,Mons N,Karpen JW

更新日期：1995-03-30 00:00:00

abstract：:Gram-negative bacteria, such as Escherichia coli, expel toxic chemicals through tripartite efflux pumps that span both the inner and outer membrane. The three parts are an inner membrane, substrate-binding transporter; a membrane fusion protein; and an outer-membrane-anchored channel. The fusion protein connects the t...

journal_title：Nature

authors： Su CC,Long F,Zimmermann MT,Rajashankar KR,Jernigan RL,Yu EW

更新日期：2011-02-24 00:00:00