The genome of Tetranychus urticae reveals herbivorous pest adaptations.

abstract：: ...

journal_title：Nature

authors： Liao SE

更新日期：2018-11-01 00:00:00

abstract：:Haem is essential for living organisms, functioning as a crucial element in the redox-sensitive reaction centre in haemproteins. During the biogenesis of these proteins, the haem cofactor is typically incorporated enzymatically into the haem pockets of the apo-haemprotein as the functionally indispensable prosthetic g...

journal_title：Nature

authors： Tang XD,Xu R,Reynolds MF,Garcia ML,Heinemann SH,Hoshi T

更新日期：2003-10-02 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:HIV-1 protease processes the Gag and Gag-Pol polyproteins into mature structural and functional proteins, including itself, and is therefore indispensable for viral maturation. The mature protease is active only as a dimer with each subunit contributing catalytic residues. The full-length transframe region protease pr...

journal_title：Nature

authors： Tang C,Louis JM,Aniana A,Suh JY,Clore GM

更新日期：2008-10-02 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:Tumour suppressor genes (TSGs) inhibiting normal cellular growth are frequently silenced epigenetically in cancer. DNA methylation is commonly associated with TSG silencing, yet mutations in the DNA methylation initiation and recognition machinery in carcinogenesis are unknown. An intriguing possible mechanism for gen...

journal_title：Nature

authors： Yu W,Gius D,Onyango P,Muldoon-Jacobs K,Karp J,Feinberg AP,Cui H

更新日期：2008-01-10 00:00:00

abstract：:Extremely intense and ultrafast X-ray pulses from free-electron lasers offer unique opportunities to study fundamental aspects of complex transient phenomena in materials. Ultrafast time-resolved methods usually require highly synchronized pulses to initiate a transition and then probe it after a precisely defined tim...

journal_title：Nature

authors： Chapman HN,Hau-Riege SP,Bogan MJ,Bajt S,Barty A,Boutet S,Marchesini S,Frank M,Woods BW,Benner WH,London RA,Rohner U,Szöke A,Spiller E,Möller T,Bostedt C,Shapiro DA,Kuhlmann M,Treusch R,Plönjes E,Burmeister F,Ber

更新日期：2007-08-09 00:00:00

abstract：:To understand the complex physics of a system with strong electron-electron interactions, the ideal is to control and monitor its properties while tuning an external electric field applied to the system (the electric-field effect). Indeed, complete electric-field control of many-body states in strongly correlated elec...

journal_title：Nature

authors： Li LJ,O'Farrell EC,Loh KP,Eda G,Özyilmaz B,Castro Neto AH

更新日期：2016-01-14 00:00:00

abstract：:Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence between taxa at neutrally evolving sites in the genome is proportional to the per nucleotide mutation rate, u (ref. 1), and this ...

journal_title：Nature

authors： Haag-Liautard C,Dorris M,Maside X,Macaskill S,Halligan DL,Houle D,Charlesworth B,Keightley PD

更新日期：2007-01-04 00:00:00

abstract：:Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by inducing degradation of target messenger RNAs. It is unknown how much translational control is exerted by miRNAs on a genome-wide scale. We used a new proteomic approach to measure changes in synthesis of several thousand proteins i...

journal_title：Nature

authors： Selbach M,Schwanhäusser B,Thierfelder N,Fang Z,Khanin R,Rajewsky N

更新日期：2008-09-04 00:00:00

abstract：:The observed number counts of high-redshift galaxy candidates have been used to build up a statistical description of star-forming activity at redshift z ≳ 7, when galaxies reionized the Universe. Standard models predict that a high incidence of gravitational lensing will probably distort measurements of flux and numb...

journal_title：Nature

authors： Wyithe JS,Yan H,Windhorst RA,Mao S

更新日期：2011-01-13 00:00:00

abstract：:Proteomics, the large-scale analysis of proteins, will contribute greatly to our understanding of gene function in the post-genomic era. Proteomics can be divided into three main areas: (1) protein micro-characterization for large-scale identification of proteins and their post-translational modifications; (2) 'differ...

journal_title：Nature

authors： Pandey A,Mann M

更新日期：2000-06-15 00:00:00

abstract：:Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (Treg) cells4-8, and the use of low doses of IL-2 has emerged as a potential therapeutic strat...

journal_title：Nature

authors： Zhou L,Chu C,Teng F,Bessman NJ,Goc J,Santosa EK,Putzel GG,Kabata H,Kelsen JR,Baldassano RN,Shah MA,Sockolow RE,Vivier E,Eberl G,Smith KA,Sonnenberg GF

更新日期：2019-04-01 00:00:00

abstract：:The Gram-negative bacterium Myxococcus xanthus has a complex life cycle during which large amounts of a protein of relative molecular mass (Mr) 19,000, known as protein S, are assembled into a spore surface coat by a process that specifically requires calcium ions. The gene for protein S has been cloned and the DNA se...

journal_title：Nature

authors： Wistow G,Summers L,Blundell T

更新日期：1985-06-27 00:00:00

abstract：:Pollinators are declining worldwide and this has raised concerns for a parallel decline in the essential pollination service they provide to both crops and wild plants. Anthropogenic drivers linked to this decline include habitat changes, intensive agriculture, pesticides, invasive alien species, spread of pathogens a...

journal_title：Nature

authors： Knop E,Zoller L,Ryser R,Gerpe C,Hörler M,Fontaine C

更新日期：2017-08-10 00:00:00

abstract：:Temperature is a primary driver of the distribution of biodiversity as well as of ecosystem boundaries. Declining temperature with increasing elevation in montane systems has long been recognized as a major factor shaping plant community biodiversity, metabolic processes, and ecosystem dynamics. Elevational gradients,...

journal_title：Nature

authors： Mayor JR,Sanders NJ,Classen AT,Bardgett RD,Clément JC,Fajardo A,Lavorel S,Sundqvist MK,Bahn M,Chisholm C,Cieraad E,Gedalof Z,Grigulis K,Kudo G,Oberski DL,Wardle DA

更新日期：2017-02-02 00:00:00

abstract：:All of the DNA synthesis genes of budding yeast examined so far are periodically expressed and hence under cell-cycle control (Table 1). Expression occurs near the G1/S phase boundary and the genes seem to be coordinately regulated (reviewed in ref. 4). The upstream promoter sequences of these genes have only a hexame...

journal_title：Nature

authors： Lowndes NF,Johnson AL,Johnston LH

更新日期：1991-03-21 00:00:00

abstract：:The establishment and maintenance of epigenetic gene silencing is fundamental to cell determination and function. The essential epigenetic systems involved in heritable repression of gene activity are the Polycomb group (PcG) proteins and the DNA methylation systems. Here we show that the corresponding silencing pathw...

journal_title：Nature

authors： Viré E,Brenner C,Deplus R,Blanchon L,Fraga M,Didelot C,Morey L,Van Eynde A,Bernard D,Vanderwinden JM,Bollen M,Esteller M,Di Croce L,de Launoit Y,Fuks F

更新日期：2006-02-16 00:00:00

abstract：:Coherent light sources can be used to manipulate the outcome of light-matter interactions by exploiting interference phenomena in the time and frequency domain. A powerful tool in this emerging field of 'quantum control' is the adaptive shaping of femtosecond laser pulses, resulting, for instance, in selective molecul...

journal_title：Nature

authors： Brixner T,Damrauer NH,Niklaus P,Gerber G

更新日期：2001-11-01 00:00:00

abstract：:Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex. Here we ...

journal_title：Nature

authors： Jiang L,Liu X,Xiong G,Liu H,Chen F,Wang L,Meng X,Liu G,Yu H,Yuan Y,Yi W,Zhao L,Ma H,He Y,Wu Z,Melcher K,Qian Q,Xu HE,Wang Y,Li J

更新日期：2013-12-19 00:00:00

abstract：:The Gamburtsev Subglacial Mountains are the least understood tectonic feature on Earth, because they are completely hidden beneath the East Antarctic Ice Sheet. Their high elevation and youthful Alpine topography, combined with their location on the East Antarctic craton, creates a paradox that has puzzled researchers...

journal_title：Nature

authors： Ferraccioli F,Finn CA,Jordan TA,Bell RE,Anderson LM,Damaske D

更新日期：2011-11-16 00:00:00

abstract：:NADH oxidation in the respiratory chain is coupled to ion translocation across the membrane to build up an electrochemical gradient. The sodium-translocating NADH:quinone oxidoreductase (Na(+)-NQR), a membrane protein complex widespread among pathogenic bacteria, consists of six subunits, NqrA, B, C, D, E and F. To ou...

journal_title：Nature

authors： Steuber J,Vohl G,Casutt MS,Vorburger T,Diederichs K,Fritz G

更新日期：2014-12-04 00:00:00

abstract：:Cells subjected to a heat shock, or a variety of other stresses increase the synthesis of a set of proteins, known as heat shock proteins. This response is apparently universal, occurring in the entire range from bacterial to mammalian cells. In Escherichia coli heat shock protein synthesis transiently increases follo...

journal_title：Nature

authors： Straus DB,Walter WA,Gross CA

更新日期：1987-09-24 00:00:00

abstract：:Retinoic acid is a vitamin A derivative with striking effects on development and cell differentiation. Several nuclear retinoic acid receptors (RARs), acting as ligand-inducible transcription factors, have been characterized and indirect evidence suggests that they have distinct roles. One of the most intriguing prope...

journal_title：Nature

authors： de Thé H,Chomienne C,Lanotte M,Degos L,Dejean A

更新日期：1990-10-11 00:00:00

abstract：:Haematopoiesis is a developmental cascade that generates all blood cell lineages in health and disease. This process relies on quiescent haematopoietic stem cells capable of differentiating, self renewing and expanding upon physiological demand. However, the mechanisms that regulate haematopoietic stem cell homeostasi...

journal_title：Nature

authors： Fonseca-Pereira D,Arroz-Madeira S,Rodrigues-Campos M,Barbosa IA,Domingues RG,Bento T,Almeida AR,Ribeiro H,Potocnik AJ,Enomoto H,Veiga-Fernandes H

更新日期：2014-10-02 00:00:00

abstract：:Synapsin I is a neuron-specific phosphoprotein localized to the cytoplasmic surface of synaptic vesicles. This phosphoprotein is a major substrate for cyclic AMP-dependent and calcium/calmodulin-dependent protein kinases. Its state of phosphorylation can be altered both in vivo and in vitro by a variety of physiologic...

journal_title：Nature

authors： Bähler M,Greengard P

更新日期：1987-04-16 00:00:00

abstract：:Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various cancers. Commo...

journal_title：Nature

authors： Letessier A,Millot GA,Koundrioukoff S,Lachagès AM,Vogt N,Hansen RS,Malfoy B,Brison O,Debatisse M

更新日期：2011-02-03 00:00:00

abstract：:Although lunar crystalline rocks are essentially devoid of nitrogen, the same is not true of the lunar regolith. The nitrogen contents of individual regolith samples (which can be as high as 0.012% by mass) correlate strongly with abundances of noble gases known to be implanted in the lunar surface by solar radiation,...

journal_title：Nature

authors： Kim JS,Kim Y,Marti K,Kerridge JF

更新日期：1995-06-01 00:00:00

abstract：:Specific chromosomal deletions sometimes associated with tumours such as retinoblastoma (chromosome 13q14) and Wilm's tumour (chromosome 11p13) have led to the hypothesis that recessive genes may be involved in tumorigenesis. This hypothesis is supported by demonstration of allele loss specific for these regions using...

journal_title：Nature

authors： Naylor SL,Johnson BE,Minna JD,Sakaguchi AY

更新日期：1987-10-01 00:00:00

abstract：:A connection between thunderstorms and the ionosphere has been hypothesized since the mid-1920s. Several mechanisms have been proposed to explain this connection, and evidence from modelling as well as various types of measurements demonstrate that lightning can interact with the lower ionosphere. It has been proposed...

journal_title：Nature

authors： Davis CJ,Johnson CG

更新日期：2005-06-09 00:00:00