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NATURE文献大全abstract::Retinoic acid may be the natural morphogen used to generate digit pattern in the chick limb bud. It has been proposed that retinoic acid acts by binding to a cellular retinoic acid-binding protein (CRABP) and then entering the nucleus to alter the pattern of gene activity. High-affinity receptors that bind both retino...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335733a0
更新日期:1988-10-20 00:00:00
abstract::Optical irradiation accompanied by spontaneous anti-Stokes emission can lead to cooling of matter, in a phenomenon known as laser cooling, or optical refrigeration, which was proposed by Pringsheim in 1929. In gaseous matter, an extremely low temperature can be obtained in diluted atomic gases by Doppler cooling, and ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11721
更新日期:2013-01-24 00:00:00
abstract::Pathogenesis in sickle cell disease depends on the polymerization of deoxyhaemoglobin S into long fibres followed by 'gel' formation. The 'gelation' renders the affected erythrocytes less deformable than normal so that they obstruct the microvasculature and the 'gelation' process has been one of the targets for the de...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/288622a0
更新日期:1980-12-11 00:00:00
abstract::The maintenance of genome stability during mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an inhibitor of the anaphase-promoting complex (APC/C, also known as the cyclosome)1,2. Unattached kinetochores control MCC assembly by catalysing a chan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0281-1
更新日期:2018-07-01 00:00:00
abstract::The colonization of a new habitat is a fundamental process in metapopulation biology, but it is difficult to study. The emigration of colonists from established populations might be induced by resource competition owing to high local population density. Migration distances are also important because they determine the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/416424a
更新日期:2002-03-28 00:00:00
abstract::The direct functionalization of unactivated sp(3) C-H bonds is still one of the most challenging problems facing synthetic organic chemists. The appeal of such transformations derives from their capacity to facilitate the construction of complex organic molecules via the coupling of simple and otherwise inert building...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14255
更新日期:2015-03-05 00:00:00
abstract::Adsorption-based phenomena are important in gas separations, such as the treatment of greenhouse-gas and toxic-gas pollutants, and in water-adsorption-based heat pumps for solar cooling systems. The ability to tune the pore size, shape and functionality of crystalline porous coordination polymers--or metal-organic fra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17430
更新日期:2016-04-21 00:00:00
abstract::A key step in the elimination of pathogens from the body is the covalent binding of complement proteins C3 and C4 to their surfaces. Proteolytic activation of these proteins results in a conformational change, and an internal thioester is exposed which reacts with amino or hydroxyl groups on the target surface to form...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/379177a0
更新日期:1996-01-11 00:00:00
abstract::DNA-binding repressor proteins mediate regulation of yeast genes by cell type (Mcm1/alpha 2 and a1/alpha 2), glucose (Mig1) and oxygen (Rox1) (refs 1-4 respectively). An unusual feature of all these regulatory pathways is that transcriptional repression requires two physically associated proteins that do not bind DNA ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369758a0
更新日期:1994-06-30 00:00:00
abstract::Time-of-flight mass spectrometry-most notably matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) spectrometry-is an important class of techniques for the study of proteins and other biomolecules. Although these techniques provide excellent performance for masses up to about 20,000 daltons, there ha...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35582
更新日期:1998-02-12 00:00:00
abstract::The plasma membrane-bound mammalian ras proteins of relative molecular mass 21,000 (ras p21) share biochemical and structural properties with other guanine nucleotide-binding regulatory proteins (G-proteins). Oncogenic ras p21 variants result from amino acid substitutions at specific positions that cause p21 to occur ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335090a0
更新日期:1988-09-01 00:00:00
abstract::Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-03160-0
更新日期:2021-01-20 00:00:00
abstract::Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2071-9
更新日期:2020-03-01 00:00:00
abstract::Cyclosporin A (CSA) is a fungal metabolite which exerts profound effects on the immune system and has potential as a selective immuno-suppressive agent. Clinical trials with human renal allograft recipients have confirmed this potential but there have been disturbing reports of lymphoma in a significant number of pati...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289300a0
更新日期:1981-01-22 00:00:00
abstract::In sexually reproducing animals, a crucial step in zygote formation is the decondensation of the fertilizing sperm nucleus into a DNA replication-competent male pronucleus. Genome-wide nucleosome assembly on paternal DNA implies the replacement of sperm chromosomal proteins, such as protamines, by maternally provided ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04059
更新日期:2005-10-27 00:00:00
abstract::Deep neural networks have achieved impressive successes in fields ranging from object recognition to complex games such as Go1,2. Navigation, however, remains a substantial challenge for artificial agents, with deep neural networks trained by reinforcement learning3-5 failing to rival the proficiency of mammalian spat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0102-6
更新日期:2018-05-01 00:00:00
abstract::Long-term potentiation (LTP) and long-term depression (LTD) are activity-dependent changes in synaptic strength that may serve as the cellular mechanisms of information storage in the vertebrate brain. The mossy fibre-CA3 synapse displays NMDA (M-methyl-D-aspartate) receptor-independent forms of LTP and LTD that were ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381429a0
更新日期:1996-05-30 00:00:00
abstract::Homopyrimidine oligonucleotides bind to homopurine-homopyrimidine sequences of duplex DNA forming a local triple helix. This binding can be demonstrated either directly by a footprinting technique, gel assays, or indirectly by inducing irreversible reactions in the target sequence, such as photocrosslinking or cleavag...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/344358a0
更新日期:1990-03-22 00:00:00
abstract::Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this distinct tumour type. We found that patients with tumours in which t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-1815-x
更新日期:2019-12-01 00:00:00
abstract::Some Pacific island societies, such as those of Easter Island and Mangareva, inadvertently contributed to their own collapse by causing massive deforestation. Others retained forest cover and survived. How can those fateful differences be explained? Although the answers undoubtedly involve both different cultural resp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02801
更新日期:2004-09-23 00:00:00
abstract::Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated not only with loss-of-function mutations of tumour suppressor genes, but also with gain-of-function mutations of proto-oncogenes. Here we show unique gain-of-function mutations of the C-CBL (...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08240
更新日期:2009-08-13 00:00:00
abstract::The vasopressor angiotensin II regulates vascular contractility and blood pressure through binding to type 1 angiotensin II receptors (AT1; refs 1, 2). Bradykinin, a vasodepressor, is a functional antagonist of angiotensin II (ref. 3). The two hormone systems are interconnected by the angiotensin-converting enzyme, wh...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35024095
更新日期:2000-09-07 00:00:00
abstract::Following the introduction of hydrochlorofluorocarbon (HCFCs) and hydrofluorocarbon (HFCs) gases as replacements for the ozone-destroying chlorofluorocarbons (CFCs), it has been discovered that HCFCs/HFCs can degrade in the atmosphere to produce trifluoroacetic acid, a compound with no known loss mechanisms in the env...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35085548
更新日期:2001-07-19 00:00:00
abstract::The HLA-D region of the human major histocompatibility complex (MHC) has been shown to be homologous to the murine I region in terms of both structure and function. Both regions encode class II MHC molecules which restrict T-lymphocyte interactions with antigen-presenting cells. We have recently described the MHC rest...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/301716a0
更新日期:1983-02-24 00:00:00
abstract::What limits the rate at which sensory information can be transmitted across synaptic connections in the brain? High-frequency signalling is restricted to brief bursts at many central excitatory synapses, whereas graded ribbon-type synapses can sustain release and transmit information at high rates. Here we investigate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04509
更新日期:2006-02-23 00:00:00
abstract::There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322552a0
更新日期:1986-08-07 00:00:00
abstract::In contrast to activated CD4+ T cells, resting human CD4+ T cells circulating in blood are highly resistant to infection with human immunodeficiency virus (HIV). Whether the inability of HIV to infect these resting CD4+ T cells is due to the lack of a key factor, or alternatively reflects the presence of an efficient ...
journal_title:Nature
pub_type: 杂志文章,收录出版
doi:10.1038/nature03493
更新日期:2005-05-05 00:00:00
abstract::Skeletal muscles consist of motor units which may differ considerably in contractile properties and types of usage. Some units participate mainly in relatively rare, quick movements and contract rapidly and are easily fatigued (type FF); others contribute to the maintenance of posture and hence contract slowly and are...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/314164a0
更新日期:1985-03-14 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 新闻
doi:10.1038/d41586-018-07283-3
更新日期:2018-11-01 00:00:00
abstract::Exoplanet detections have revolutionized astronomy, offering new insights into solar system architecture and planet demographics. While nearly 1,900 exoplanets have now been discovered and confirmed, none are still in the process of formation. Transition disks, protoplanetary disks with inner clearings best explained ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature15761
更新日期:2015-11-19 00:00:00