Abstract:
:Haem is essential for living organisms, functioning as a crucial element in the redox-sensitive reaction centre in haemproteins. During the biogenesis of these proteins, the haem cofactor is typically incorporated enzymatically into the haem pockets of the apo-haemprotein as the functionally indispensable prosthetic group. A class of ion channel, the large-conductance calcium-dependent Slo1 BK channels, possesses a conserved haem-binding sequence motif. Here we present electrophysiological and structural evidence showing that haem directly regulates cloned human Slo1 channels and wild-type BK channels in rat brain. Both oxidized and reduced haem binds to the hSlo1 channel protein and profoundly inhibits transmembrane K+ currents by decreasing the frequency of channel opening. This direct regulation of the BK channel identifies a previously unknown role of haem as an acute signalling molecule.
journal_name
Naturejournal_title
Natureauthors
Tang XD,Xu R,Reynolds MF,Garcia ML,Heinemann SH,Hoshi Tdoi
10.1038/nature02003keywords:
subject
Has Abstractpub_date
2003-10-02 00:00:00pages
531-5issue
6957eissn
0028-0836issn
1476-4687pii
nature02003journal_volume
425pub_type
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