Adenylyl cyclases and the interaction between calcium and cAMP signalling.

Abstract:

:Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry into the cell. Oscillations in cellular cyclic AMP levels are predicted to arise because of feedback inhibition of adenylyl cyclase by Ca2+. Such findings inextricably intertwine cellular signalling by cAMP and internal Ca2+ and extend the known regulatory modes available to cAMP.

journal_name

Nature

journal_title

Nature

authors

Cooper DM,Mons N,Karpen JW

doi

10.1038/374421a0

subject

Has Abstract

pub_date

1995-03-30 00:00:00

pages

421-4

issue

6521

eissn

0028-0836

issn

1476-4687

journal_volume

374

pub_type

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