Structure of the TRPV1 ion channel determined by electron cryo-microscopy.

abstract：:There have been many reports that eukaryotic cells contain ring-shaped 19S or 20S particles which are composed of numerous polypeptide subunits ranging in size between 25 and 35 kilodaltons. Because these particles seemed to copurify with inactive mRNA, they were assumed to function in regulating mRNA translation and ...

journal_title：Nature

authors： Arrigo AP,Tanaka K,Goldberg AL,Welch WJ

更新日期：1988-01-14 00:00:00

abstract：:Accurate chromosome segregation requires timely dissolution of chromosome cohesion after chromosomes are properly attached to the mitotic spindle. Separase is absolutely essential for cohesion dissolution in organisms from yeast to man. It cleaves the kleisin subunit of cohesin and opens the cohesin ring to allow chro...

journal_title：Nature

authors： Lin Z,Luo X,Yu H

更新日期：2016-04-07 00:00:00

abstract：:The inhibitory activity associated with myelin is a major obstacle for successful axon regeneration in the adult mammalian central nervous system (CNS). In addition to myelin-associated glycoprotein (MAG) and Nogo-A, available evidence suggests the existence of additional inhibitors in CNS myelin. We show here that a ...

journal_title：Nature

authors： Wang KC,Koprivica V,Kim JA,Sivasankaran R,Guo Y,Neve RL,He Z

更新日期：2002-06-27 00:00:00

abstract：:Sex is expensive. A population of females that reproduce asexually should prima facie have twice the growth rate of an otherwise equivalent anisogamous sexual population lacking paternal care, or a population with modes of paternal care that can be co-opted by parthenogenetic females. The two leading theories for the ...

journal_title：Nature

authors： Siller S,Department of Zoology, University of Oxford, UK. steven.siller@zoo.ox.ac.uk.

更新日期：2001-06-07 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder which affects approximately 1 in 3,300 males, making it the most common of the neuromuscular dystrophies. The biochemical basis of the disease is unknown and as yet no effective treatment is available. A small number of females are also affected with ...

journal_title：Nature

authors： Ray PN,Belfall B,Duff C,Logan C,Kean V,Thompson MW,Sylvester JE,Gorski JL,Schmickel RD,Worton RG

更新日期：1985-12-19 00:00:00

abstract：:The Milankovitch theory states that global climate variability on orbital timescales from tens to hundreds of thousands of years is dominated by the summer insolation at high northern latitudes. The supporting evidence includes reconstructed air temperatures in Antarctica that are nearly in phase with boreal summer in...

journal_title：Nature

authors： Laepple T,Werner M,Lohmann G

更新日期：2011-03-03 00:00:00

abstract：:One of the earliest computational principles attributed to the cerebellum was the measurement of time. This idea was originally suggested on anatomical grounds, and was taken up again to explain some of the deficits in cerebellar patients. The contribution of the cerebellum to eye movements, in contrast, has tradition...

journal_title：Nature

authors： Thier P,Dicke PW,Haas R,Barash S

更新日期：2000-05-04 00:00:00

abstract：:The crab Xenograpsus testudinatus lives at enormously high densities around the sulphur-rich hydrothermal vents found in shallow waters off Taiwan, even though this acidic environment is low in nutrients. Here we show that these crabs swarm out of their crevices at slack water and feed on the vast numbers of zooplankt...

journal_title：Nature

authors： Jeng MS,Ng NK,Ng PK

更新日期：2004-12-23 00:00:00

abstract：:More than 99 per cent of the roughly 58,000 living vertebrate species have jaws. This major clade, whose members are collectively known as gnathostomes ('jawed mouths'), made its earliest definitive appearance in the Silurian period, 444-416 million years (Myr) ago, with both the origin of the modern (crown-group) rad...

journal_title：Nature

authors： Anderson PS,Friedman M,Brazeau MD,Rayfield EJ

更新日期：2011-07-06 00:00:00

abstract：:In the fasted state, increases in circulating glucagon promote hepatic glucose production through induction of the gluconeogenic program. Triggering of the cyclic AMP pathway increases gluconeogenic gene expression via the de-phosphorylation of the CREB co-activator CRTC2 (ref. 1). Glucagon promotes CRTC2 dephosphoryl...

journal_title：Nature

authors： Wang Y,Li G,Goode J,Paz JC,Ouyang K,Screaton R,Fischer WH,Chen J,Tabas I,Montminy M

更新日期：2012-04-08 00:00:00

abstract：:The electronic properties of heterostructures of atomically thin van der Waals crystals can be modified substantially by moiré superlattice potentials from an interlayer twist between crystals1,2. Moiré tuning of the band structure has led to the recent discovery of superconductivity3,4 and correlated insulating phase...

journal_title：Nature

authors： Kerelsky A,McGilly LJ,Kennes DM,Xian L,Yankowitz M,Chen S,Watanabe K,Taniguchi T,Hone J,Dean C,Rubio A,Pasupathy AN

更新日期：2019-08-01 00:00:00

abstract：:Magnetic reconnection is the process by which magnetic field lines of opposite polarity reconfigure to a lower-energy state, with the release of magnetic energy to the surroundings. Reconnection at the Earth's dayside magnetopause and in the magnetotail allows the solar wind into the magnetosphere. It begins in a smal...

journal_title：Nature

authors： Oieroset M,Phan TD,Fujimoto M,Lin RP,Lepping RP

更新日期：2001-07-26 00:00:00

abstract：:Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after multiple courses of therapy. In contrast to HER2-amplified primary breast cancer, which is highly sensitive to HER2-targete...

journal_title：Nature

authors： Jordan NV,Bardia A,Wittner BS,Benes C,Ligorio M,Zheng Y,Yu M,Sundaresan TK,Licausi JA,Desai R,O'Keefe RM,Ebright RY,Boukhali M,Sil S,Onozato ML,Iafrate AJ,Kapur R,Sgroi D,Ting DT,Toner M,Ramaswamy S,Haas W,Mah

更新日期：2016-09-01 00:00:00

abstract：:Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellula...

journal_title：Nature

authors： Dustin ML,Springer TA

更新日期：1989-10-19 00:00:00

abstract：:Nanofabrication strategies are becoming increasingly expensive and equipment-intensive, and consequently less accessible to researchers. As an alternative, scanning probe lithography has become a popular means of preparing nanoscale structures, in part owing to its relatively low cost and high resolution, and a regist...

journal_title：Nature

authors： Shim W,Braunschweig AB,Liao X,Chai J,Lim JK,Zheng G,Mirkin CA

更新日期：2011-01-27 00:00:00

abstract：:Autism spectrum disorder (ASD) is an early-onset developmental disorder characterized by deficits in communication and social interaction and restrictive or repetitive behaviours1,2. Family studies demonstrate that ASD has a substantial genetic basis with contributions both from inherited and de novo variants3,4. It h...

journal_title：Nature

authors： Mitra I,Huang B,Mousavi N,Ma N,Lamkin M,Yanicky R,Shleizer-Burko S,Lohmueller KE,Gymrek M

更新日期：2021-01-01 00:00:00

abstract：:Magnetic fields play a part in almost all stages of stellar evolution. Most low-mass stars, including the Sun, show surface fields that are generated by dynamo processes in their convective envelopes. Intermediate-mass stars do not have deep convective envelopes, although 10 per cent exhibit strong surface fields that...

journal_title：Nature

authors： Stello D,Cantiello M,Fuller J,Huber D,García RA,Bedding TR,Bildsten L,Aguirre VS

更新日期：2016-01-21 00:00:00

abstract：:Magnetic interactions and magnetic impurities are destructive to superconductivity in conventional superconductors. By contrast, in some unconventional macroscopic quantum systems (such as superfluid 3He and superconducting UGe2), the superconductivity (or superfluidity) is actually mediated by magnetic interactions. ...

journal_title：Nature

authors： Hudson EW,Lang KM,Madhavan V,Pan SH,Eisaki H,Uchida S,Davis JC

更新日期：2001-06-21 00:00:00

abstract：:Patterns in natural systems abound, from the stripes on a zebra to ripples in a riverbed. In many of these systems, the appearance of an ordered state is not unexpected as the outcome of an underlying ordered process. Thus crystal growth, honeycomb manufacture and floret evolution generate regular and predictable patt...

journal_title：Nature

authors： Shinbrot T,Muzzio FJ

更新日期：2001-03-08 00:00:00

abstract：:Cryptochromes are blue/ultraviolet-A light receptors that mediate various light responses in plants and animals. But the initial photochemical reaction of cryptochrome is still unclear. For example, although most photoreceptors are known to undergo light-dependent protein modification such as phosphorylation, no blue-...

journal_title：Nature

authors： Shalitin D,Yang H,Mockler TC,Maymon M,Guo H,Whitelam GC,Lin C

更新日期：2002-06-13 00:00:00

abstract：:The cellular response to hypoxia is critical for cell survival and is fine-tuned to allow cells to recover from hypoxic stress and adapt to heterogeneous or fluctuating oxygen levels. The hypoxic response is mediated by the α-subunit of the transcription factor HIF-1 (HIF-1α), which interacts through its intrinsically...

journal_title：Nature

authors： Berlow RB,Dyson HJ,Wright PE

更新日期：2017-03-16 00:00:00

abstract：:Data collected at approximately 60 Global Positioning System (GPS) sites in southeast Asia show the crustal deformation caused by the 26 December 2004 Sumatra-Andaman earthquake at an unprecedented large scale. Small but significant co-seismic jumps are clearly detected more than 3,000 km from the earthquake epicentre...

journal_title：Nature

authors： Vigny C,Simons WJ,Abu S,Bamphenyu R,Satirapod C,Choosakul N,Subarya C,Socquet A,Omar K,Abidin HZ,Ambrosius BA

更新日期：2005-07-14 00:00:00

abstract：:The ability to differentiate stimuli predicting positive or negative outcomes is critical for survival, and perturbations of emotional processing underlie many psychiatric disease states. Synaptic plasticity in the basolateral amygdala complex (BLA) mediates the acquisition of associative memories, both positive and n...

journal_title：Nature

authors： Namburi P,Beyeler A,Yorozu S,Calhoon GG,Halbert SA,Wichmann R,Holden SS,Mertens KL,Anahtar M,Felix-Ortiz AC,Wickersham IR,Gray JM,Tye KM

更新日期：2015-04-30 00:00:00

abstract：:The X-ray structure of a pentameric ligand-gated ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution. The structure shows a homo-pentameric protein with a barrel-stave architecture that defines an ion-conduction pore located on the f...

journal_title：Nature

authors： Hilf RJ,Dutzler R

更新日期：2009-01-01 00:00:00

abstract：:When an individual molecule, nanocrystal, nanotube or lithographically defined quantum dot is attached to metallic electrodes via tunnel barriers, electron transport is dominated by single-electron charging and energy-level quantization. As the coupling to the electrodes increases, higher-order tunnelling and correlat...

journal_title：Nature

authors： Liang W,Shores MP,Bockrath M,Long JR,Park H

更新日期：2002-06-13 00:00:00

abstract：:A novel, structurally distinct POU-domain protein has been identified that inhibits activation by another positive POU-domain regulator of neuron-specific transcription units. Two Drosophila POU-domain proteins, I-POU and Cf1-a, are coexpressed in overlapping subsets of neurons during development. Because I-POU lacks ...

journal_title：Nature

authors： Treacy MN,He X,Rosenfeld MG

更新日期：1991-04-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature

authors： Apffel B,Novkoski F,Eddi A,Fort E

更新日期：2020-10-01 00:00:00

abstract：:The protein HLA-E is a non-classical major histocompatibility complex (MHC) molecule of limited sequence variability. Its expression on the cell surface is regulated by the binding of peptides derived from the signal sequence of some other MHC class I molecules. Here we report the identification of ligands for HLA-E. ...

journal_title：Nature

authors： Braud VM,Allan DS,O'Callaghan CA,Söderström K,D'Andrea A,Ogg GS,Lazetic S,Young NT,Bell JI,Phillips JH,Lanier LL,McMichael AJ

更新日期：1998-02-19 00:00:00

abstract：:Ligand-induced allosteric changes in proteins are important in their cellular functions and regulation, and both concerted and sequential examples are known. The distinction has entailed elaborate analysis, however, and only a few systems have been unequivocally analysed. We have investigated the coupling between ATP ...

journal_title：Nature

authors： Lindsley JE,Wang JC

更新日期：1993-02-25 00:00:00

abstract：:Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite ...

journal_title：Nature

authors： Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg V

更新日期：1985-11-07 00:00:00