Abstract:
:Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite from splenic destruction and may play a role in the pathogenesis of cerebral malaria. Correlates of sequestration have been developed in vitro using cultured human endothelium and an amelanotic melanoma cell line. Knobless strains (K-) of P. falciparum fail to sequester in vivo and to bind to cells in vitro. We now present evidence that the receptor for cytoadherence is the glycoprotein, thrombospondin. Aotus monkey or human erythrocytes containing knobby (K+) but not Aotus erythrocytes containing knobless strains of P. falciparum bind to immobilized thrombospondin. Neither binds to the adhesive proteins laminin, fibronectin, factor VIII/von Willebrand factor or vitronectin. Both soluble thrombospondin and anti-thrombospondin antibodies inhibit binding of parasitized Aotus erythrocytes to immobilize thrombospondin and to melanoma cells which secrete thrombospondin.
journal_name
Naturejournal_title
Natureauthors
Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg Vdoi
10.1038/318064a0subject
Has Abstractpub_date
1985-11-07 00:00:00pages
64-6issue
6041eissn
0028-0836issn
1476-4687journal_volume
318pub_type
杂志文章相关文献
NATURE文献大全abstract::Post-translational modification (PTM) of proteins plays an important part in mediating protein interactions and/or the recruitment of specific protein targets. PTM can be mediated by the addition of functional groups (for example, acetylation or phosphorylation), peptides (for example, ubiquitylation or sumoylation), ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06420
更新日期:2008-01-03 00:00:00
abstract::Dopamine (DA) has largely been ignored in considering possible mechanisms underlying the therapeutic effects of tricyclic anti-depressants (TCA). Most previous work done has focused on the ability of some TCAs to block the in vitro re-uptake of DA--an effect which unfortunately requires very high doses. Recently, howe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287451a0
更新日期:1980-10-02 00:00:00
abstract::S-100 protein, one of the unique proteins found in the nervous system, has recently been discovered unexpectedly in the rat anterior pituitary. Immunocytochemistry reveals that stellate, follicular and folliculostellate cells, and marginal cells of the rat anterior pituitary contain this protein; however, as far as we...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/303711a0
更新日期:1983-06-23 00:00:00
abstract::Patterning matter on the nanometre scale is an important objective of current materials chemistry and physics. It is driven by both the need to further miniaturize electronic components and the fact that at the nanometre scale, materials properties are strongly size-dependent and thus can be tuned sensitively. In nano...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/382609a0
更新日期:1996-08-15 00:00:00
abstract::The induction of polyarthritis in rats by intradermal immunisation with homologous or heterologous type II collagen incomplete or incomplete Freund's adjuvant was reported recently by Trentham et al. We have now produced a similar disease in certain strains of mice. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/283666a0
更新日期:1980-02-14 00:00:00
abstract::The autosomal dominant hyper-IgE syndrome (HIES, 'Job's syndrome') is characterized by recurrent and often severe pulmonary infections, pneumatoceles, eczema, staphylococcal abscesses, mucocutaneous candidiasis, and abnormalities of bone and connective tissue. Mutations presumed to underlie HIES have recently been ide...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06764
更新日期:2008-04-10 00:00:00
abstract::Insulin stimulates the transport of glucose into fat and muscle cells. Although the precise molecular mechanisms involved in this process remain uncertain, insulin initiates its actions by binding to its tyrosine kinase receptor, leading to the phosphorylation of intracellular substrates. One such substrate is the Cbl...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35025089
更新日期:2000-09-14 00:00:00
abstract::Since the discovery of the first exoplanets, it has been known that other planetary systems can look quite unlike our own. Until fairly recently, we have been able to probe only the upper range of the planet size distribution, and, since last year, to detect planets that are the size of Earth or somewhat smaller. Hith...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11914
更新日期:2013-02-28 00:00:00
abstract::Adenylyl cyclase is the prototypical second messenger generator. Nearly all of the eight cloned adenylyl cyclases are regulated by one or other arm of the phospholipase C pathway. Functional and ultrastructural investigations have shown that adenylyl cyclases are intimately associated with sites of calcium ion entry i...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/374421a0
更新日期:1995-03-30 00:00:00
abstract::For cells of the innate immune system to mount a host defence response to infection, they must recognize products of microbial pathogens such as lipopolysaccharide (LPS), the endotoxin secreted by Gram-negative bacteria. These cellular responses require intracellular signalling pathways, such as the four MAP kinase (M...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/386296a0
更新日期:1997-03-20 00:00:00
abstract::There is ample evidence that the secretion of follicle stimulating hormone (FSH) by the pituitary gland is regulated by a nonsteroidal hormone of gonadal origin, termed inhibin. In several species, testicular extracts, gonadal lymph and seminal plasma have been shown to contain proteins which inhibit FSH release; lack...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/285246a0
更新日期:1980-05-22 00:00:00
abstract::Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, whic...
journal_title:Nature
pub_type: 信件
doi:10.1038/nature05732
更新日期:2007-04-19 00:00:00
abstract::Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01209
更新日期:2002-11-28 00:00:00
abstract::A decade ago, Lovelock and Whitfield raised the question of how much longer the biosphere can survive on Earth. They pointed out that, despite the current fossil-fuel induced increase in the atmospheric CO2 concentration, the long-term trend should be in the opposite direction: as increased solar luminosity warms th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360721a0
更新日期:1992-12-24 00:00:00
abstract::Immunization of male and female animals with extracts of whole sperm cells is known to cause infertility. Also, men and women who spontaneously produce antisperm antibodies are infertile but otherwise healthy. Although the critical sperm antigens are unknown, these observations have led to the proposal that sperm prot...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/335543a0
更新日期:1988-10-06 00:00:00
abstract::Measurements of the cosmic microwave background (CMB) radiation can reveal with remarkable precision the conditions of the Universe when it was approximately 400,000 years old. The three most fundamental properties of the CMB are its frequency spectrum (which determines the temperature), and the fluctuations in both t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01271
更新日期:2002-12-19 00:00:00
abstract::Classically, there is a direct correlation between the lipophilic nature of a molecule and its rate of permeation across a biological membrane, so cell membranes should be more permeable to small, neutral molecules than they are to charged molecular species of similar size. Consequently, the distribution of NH+4 in bi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/339478a0
更新日期:1989-06-08 00:00:00
abstract::Many eukaryotic cellular and viral proteins have a covalently attached myristoyl group at the amino terminus. One such protein is recoverin, a calcium sensor in retinal rod cells, which controls the lifetime of photoexcited rhodopsin by inhibiting rhodopsin kinase. Recoverin has a relative molecular mass of 23,000 (M[...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/38310
更新日期:1997-09-11 00:00:00
abstract::The effect of ions on the light-sensitive current of retinal rods was studied by sucking the inner segment into a tightly fitting capillary with the outer segment projecting into a flowing solution. This new method showed that the light-sensitive pathway, in which Na+ is the normal carrier of current, has an ionic sel...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/292502a0
更新日期:1981-08-06 00:00:00
abstract::Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature22078
更新日期:2017-05-04 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not normally respond to self-DNA, but this restriction seems to break down in human autoimmune disease by an as yet poorly understood mechanism. Here we identify the antimicrob...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06116
更新日期:2007-10-04 00:00:00
abstract::Measles virus is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. Although it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to infect initially macrophages and dendritic cells of t...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10639
更新日期:2011-11-02 00:00:00
abstract::Traditionally, entanglement was considered to be a quirk of microscopic objects that defied a common-sense explanation. Now, however, entanglement is recognized to be ubiquitous and robust. With the realization that entanglement can occur in macroscopic systems - and with the development of experiments aimed at exploi...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07124
更新日期:2008-06-19 00:00:00
abstract::ATP is the dominant energy source in animals for mechanical and electrical work (for example, muscle contraction or neuronal firing). For chemical work, there is an equally important role for NADPH, which powers redox defence and reductive biosynthesis. The most direct route to produce NADPH from glucose is the oxidat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13236
更新日期:2014-06-12 00:00:00
abstract::5-hydroxytryptamine type 3 (5-HT3) receptors are members of the Cys-loop receptor superfamily. Neurotransmitter binding in these proteins triggers the opening (gating) of an ion channel by means of an as-yet-uncharacterized conformational change. Here we show that a specific proline (Pro 8*), located at the apex of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04130
更新日期:2005-11-10 00:00:00
abstract::Whereas short-term memory lasts from minutes to hours, long-term memory (LTM) can last for days or even an entire lifetime. LTM generally forms after spaced repeated training sessions and involves the regulation of gene expression, thereby implicating transcription factors in the initial steps of LTM establishment. Ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02726
更新日期:2004-07-22 00:00:00
abstract::Applications are emerging that require the creation of fine-scale structures in three dimensions--examples include scaffolds for tissue engineering, micro-fluidic devices and photonic materials that control light propagation over a range of frequencies. But writing methods such as dip-pen nanolithography and ink-jet p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/428386a
更新日期:2004-03-25 00:00:00
abstract::Dense plexuses of neurones containing immunoreactive vasoactive intestinal peptide (VIP) have been found in discrete areas of the central nervous system and in peripheral organs, including the gastrointestinal tract, pancreas and urogenital system. In many of these locations VIP is concentrated in nerve endings, where...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/281574a0
更新日期:1979-10-18 00:00:00
abstract::Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment of bone disease. Although its precise mechanism of action is unclear, osteocalcin influences bone mineralization, in part th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02079
更新日期:2003-10-30 00:00:00
abstract::The optimal water transport system in plants should maximize hydraulic conductance (which is proportional to photosynthesis) for a given investment in transport tissue. To investigate how this optimum may be achieved, we have performed computer simulations of the hydraulic conductance of a branched transport system. H...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01444
更新日期:2003-02-27 00:00:00