CAP defines a second signalling pathway required for insulin-stimulated glucose transport.

abstract：:Patterns in natural systems abound, from the stripes on a zebra to ripples in a riverbed. In many of these systems, the appearance of an ordered state is not unexpected as the outcome of an underlying ordered process. Thus crystal growth, honeycomb manufacture and floret evolution generate regular and predictable patt...

journal_title：Nature

authors： Shinbrot T,Muzzio FJ

更新日期：2001-03-08 00:00:00

abstract：:RecBCD enzyme is a processive DNA helicase and nuclease that participates in the repair of chromosomal DNA through homologous recombination. We have visualized directly the movement of individual RecBCD enzymes on single molecules of double-stranded DNA (dsDNA). Detection involves the optical trapping of solitary, flu...

journal_title：Nature

authors： Bianco PR,Brewer LR,Corzett M,Balhorn R,Yeh Y,Kowalczykowski SC,Baskin RJ

更新日期：2001-01-18 00:00:00

abstract：:Dopamine (DA) has largely been ignored in considering possible mechanisms underlying the therapeutic effects of tricyclic anti-depressants (TCA). Most previous work done has focused on the ability of some TCAs to block the in vitro re-uptake of DA--an effect which unfortunately requires very high doses. Recently, howe...

journal_title：Nature

authors： Chiodo LA,Antelman SM

更新日期：1980-10-02 00:00:00

abstract：:Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by extensive genomic rearrangements and an oscillating pattern of DNA copy number levels, all curiously restricted to one or a few chromosomes. The mechanism for chromot...

journal_title：Nature

authors： Zhang CZ,Spektor A,Cornils H,Francis JM,Jackson EK,Liu S,Meyerson M,Pellman D

更新日期：2015-06-11 00:00:00

abstract：:Overfishing of large-bodied benthic fishes and their subsequent population collapses on the Scotian Shelf of Canada's east coast and elsewhere resulted in restructuring of entire food webs now dominated by planktivorous, forage fish species and macroinvertebrates. Despite the imposition of strict management measures i...

journal_title：Nature

authors： Frank KT,Petrie B,Fisher JA,Leggett WC

更新日期：2011-07-27 00:00:00

abstract：:The modern giant sperm whale Physeter macrocephalus, one of the largest known predators, preys upon cephalopods at great depths. Lacking a functional upper dentition, it relies on suction for catching its prey; in contrast, several smaller Miocene sperm whales (Physeteroidea) have been interpreted as raptorial (versus...

journal_title：Nature

authors： Lambert O,Bianucci G,Post K,de Muizon C,Salas-Gismondi R,Urbina M,Reumer J

更新日期：2010-07-01 00:00:00

abstract：:Transformation of the well-studied maize transposable elements into other plant species should enable transposon tagging methodology to be used for the isolation of interesting genes in the heterologous host. Here we describe the isolation of a transposon-tagged male sterile mutant in Arabidopsis thaliana using the ma...

journal_title：Nature

authors： Aarts MG,Dirkse WG,Stiekema WJ,Pereira A

更新日期：1993-06-24 00:00:00

abstract：:The initiation of plate tectonics on Earth is a critical event in our planet's history. The time lag between the first proto-subduction (about 4 billion years ago) and global tectonics (approximately 3 billion years ago) suggests that plates and plate boundaries became widespread over a period of 1 billion years. The ...

journal_title：Nature

authors： Bercovici D,Ricard Y

更新日期：2014-04-24 00:00:00

abstract：:Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. If the field is to move beyond correlations and beg...

journal_title：Nature

authors： Surana NK,Kasper DL

更新日期：2017-12-14 00:00:00

abstract：:Statistical dependencies in the responses of sensory neurons govern both the amount of stimulus information conveyed and the means by which downstream neurons can extract it. Although a variety of measurements indicate the existence of such dependencies, their origin and importance for neural coding are poorly underst...

journal_title：Nature

authors： Pillow JW,Shlens J,Paninski L,Sher A,Litke AM,Chichilnisky EJ,Simoncelli EP

更新日期：2008-08-21 00:00:00

abstract：:An unusual feature of the cerebellar cortex is that its output neurons, Purkinje cells, release GABA (γ-aminobutyric acid). Their high intrinsic firing rates (50 Hz) and extensive convergence predict that their target neurons in the cerebellar nuclei would be largely inhibited unless Purkinje cells pause their spiking...

journal_title：Nature

authors： Person AL,Raman IM

更新日期：2011-12-25 00:00:00

abstract：:The mec-2 gene is required for the function of a set of six touch receptor neurons in the nematode Caenorhabditis elegans; mec-2 mutants, which are touch-insensitive, have touch cells that appear morphologically normal. Gene interaction studies suggest that mec-2 positively regulates the activity of the putative mecha...

journal_title：Nature

authors： Huang M,Gu G,Ferguson EL,Chalfie M

更新日期：1995-11-16 00:00:00

abstract：:Variations in atmospheric radiocarbon (14C) concentrations can be attributed either to changes in the carbon cycle--through the rate of radiocarbon removal from the atmosphere--or to variations in the production rate of 14C due to changes in solar activity or the Earth's magnetic field. The production rates of 10Be an...

journal_title：Nature

authors： Muscheler R,Beer J,Wagner G,Finkel RC

更新日期：2000-11-30 00:00:00

abstract：:Global patterns of species richness and their structuring forces have fascinated biologists since Darwin and provide critical context for contemporary studies in ecology, evolution and conservation. Anthropogenic impacts and the need for systematic conservation planning have further motivated the analysis of diversity...

journal_title：Nature

authors： Tittensor DP,Mora C,Jetz W,Lotze HK,Ricard D,Berghe EV,Worm B

更新日期：2010-08-26 00:00:00

abstract：:Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have...

journal_title：Nature

authors： Lee KY,Peters MC,Anderson KW,Mooney DJ

更新日期：2000-12-21 00:00:00

abstract：:Cryptosporidium species cause acute gastroenteritis and diarrhoea worldwide. They are members of the Apicomplexa--protozoan pathogens that invade host cells by using a specialized apical complex and are usually transmitted by an invertebrate vector or intermediate host. In contrast to other Apicomplexans, Cryptosporid...

journal_title：Nature

authors： Xu P,Widmer G,Wang Y,Ozaki LS,Alves JM,Serrano MG,Puiu D,Manque P,Akiyoshi D,Mackey AJ,Pearson WR,Dear PH,Bankier AT,Peterson DL,Abrahamsen MS,Kapur V,Tzipori S,Buck GA

更新日期：2004-10-28 00:00:00

abstract：:The discovery that atrial extracts have potent diuretic and natriuretic properties revealed a possible endocrine function of the heart in the regulation of extracellular fluid volume. Since that first report intense research activity has been directed towards determining the mechanism of action of the active atrial na...

journal_title：Nature

authors： Harris PJ,Thomas D,Morgan TO

更新日期：1987-04-16 00:00:00

abstract：:Deuterostomes are a remarkably diverse super-phylum, including not only the chordates (to which we belong) but groups as disparate as the echinoderms and the hemichordates. The phylogeny of deuterostomes is now achieving some degree of stability, especially on account of new molecular data, but this leaves as conjectu...

journal_title：Nature

authors： Shu DG,Morris SC,Han J,Zhang ZF,Liu JN

更新日期：2004-07-22 00:00:00

abstract：:The 26S proteasome is the chief site of regulatory protein turnover in eukaryotic cells. It comprises one 20S catalytic complex (composed of four stacked rings of seven members) and two axially positioned 19S regulatory complexes (each containing about 18 subunits) that control substrate access to the catalytic chambe...

journal_title：Nature

authors： Lam YA,Lawson TG,Velayutham M,Zweier JL,Pickart CM

更新日期：2002-04-18 00:00:00

abstract：:Change history: In Fig. 1c of this Letter, the two graphs were duplicates. The right panel of Fig. 1c has been corrected online. ...

journal_title：Nature

authors： Lai B,Gao W,Cui K,Xie W,Tang Q,Jin W,Hu G,Ni B,Zhao K

更新日期：2018-12-01 00:00:00

abstract：:Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have b...

journal_title：Nature

authors： Mróz P,Udalski A,Skowron J,Poleski R,Kozłowski S,Szymański MK,Soszyński I,Wyrzykowski Ł,Pietrukowicz P,Ulaczyk K,Skowron D,Pawlak M

更新日期：2017-08-10 00:00:00

abstract：:Vertebrate limb formation is an evolutionarily conserved process programmed by an array of morphogenetic genes. As a result of transgene insertion, we previously identified a mutation at the mouse limb deformity (ld) locus that disrupts embryonic pattern formation, resulting in a reduction and fusion of the distal bon...

journal_title：Nature

authors： Woychik RP,Maas RL,Zeller R,Vogt TF,Leder P

更新日期：1990-08-30 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) into enucleated oocytes has emerged as a technique that can be used to derive mouse embryonic stem cell lines with defined genotypes. In this issue Byrne et al. report the derivation of two SCNT Rhesus macaca male stem cell lines designated CRES-1 and CRES-2. Molecular studies deta...

journal_title：Nature

authors： Cram DS,Song B,Trounson AO

更新日期：2007-11-22 00:00:00

abstract：:To explain the lower atmospheric CO2 concentrations during glacial periods, it has been suggested that the productivity of marine phytoplankton was stimulated by an increased flux of iron-bearing dust to the oceans. One component of this theory is that iron-an essential element/nutrient for nitrogen-fixing organisms-w...

journal_title：Nature

authors： Ganeshram RS,Pedersen TF,Calvert S,François R

更新日期：2002-01-10 00:00:00

abstract：:RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from D...

journal_title：Nature

authors： McCaffrey AP,Meuse L,Pham TT,Conklin DS,Hannon GJ,Kay MA

更新日期：2002-07-04 00:00:00

abstract：:The global burden of malaria has been substantially reduced over the past two decades. Future efforts to reduce malaria further will require moving beyond the treatment of clinical infections to targeting malaria transmission more broadly in the community. As such, the accurate identification of asymptomatic human inf...

journal_title：Nature

authors： Wu L,van den Hoogen LL,Slater H,Walker PG,Ghani AC,Drakeley CJ,Okell LC

更新日期：2015-12-03 00:00:00

abstract：:In the initiation of translation in eukaryotes, binding of the small ribosomal subunit to the messenger RNA results from recognition of the 5' cap structure (m7GpppX) of the mRNA by the cap-binding complex eIF4F. eIF4F is itself a three-subunit complex comprising the cap-binding protein eIF4E, eIF4A, an ATP-dependent ...

journal_title：Nature

authors： Craig AW,Haghighat A,Yu AT,Sonenberg N

更新日期：1998-04-02 00:00:00

abstract：:MicroRNAs (miRNAs) are approximately 22-nucleotide endogenous RNAs that often repress the expression of complementary messenger RNAs. In animals, miRNAs derive from characteristic hairpins in primary transcripts through two sequential RNase III-mediated cleavages; Drosha cleaves near the base of the stem to liberate a...

journal_title：Nature

authors： Ruby JG,Jan CH,Bartel DP

更新日期：2007-07-05 00:00:00

abstract：:Integrins are a superfamily of related molecules whose function, where known, is to mediate adhesion. The so-called very-late-activation antigen (VLA) family includes at least five distinct heterodimers, each composed of a unique alpha-subunit non-covalently associated with a common beta-subunit. Several members of th...

journal_title：Nature

authors： Groux H,Huet S,Valentin H,Pham D,Bernard A

更新日期：1989-05-11 00:00:00

abstract：:The extension of growing season at high northern latitudes seems increasingly clear from satellite observations of vegetation extent and duration. This extension is also thought to explain the observed increase in amplitude of seasonal variations in atmospheric CO2 concentration. Increased plant respiration and photos...

journal_title：Nature

authors： Barber VA,Juday GP,Finney BP

更新日期：2000-06-08 00:00:00