Abstract:
:Change history: In Fig. 1c of this Letter, the two graphs were duplicates. The right panel of Fig. 1c has been corrected online.
journal_name
Naturejournal_title
Natureauthors
Lai B,Gao W,Cui K,Xie W,Tang Q,Jin W,Hu G,Ni B,Zhao Kdoi
10.1038/s41586-018-0690-1subject
Has Abstractpub_date
2018-12-01 00:00:00pages
E17issue
7735eissn
0028-0836issn
1476-4687pii
10.1038/s41586-018-0690-1journal_volume
564pub_type
杂志文章,已发布勘误相关文献
NATURE文献大全abstract::Transposable elements from prokaryotic and eukaryotic organisms are discrete DNA segments bounded by inverted or directly repeated sequences that insert into non-homologous DNA in a reaction that is independent of the general recombination functions of the host. The mechanisms proposed generally involve a staggered do...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307292a0
更新日期:1984-01-19 00:00:00
abstract::On infection of their host, temperate viruses that infect bacteria (bacteriophages; hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration o...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-1936-2
更新日期:2020-02-01 00:00:00
abstract::Inorganic nanoparticles exhibit size-dependent properties that are of interest for applications ranging from biosensing and catalysis to optics and data storage. They are readily available in a wide variety of discrete compositions and sizes. Shape-selective synthesis strategies now also yield shapes other than nanosp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02020
更新日期:2003-10-02 00:00:00
abstract::The Kondo effect--a many-body phenomenon in condensed-matter physics involving the interaction between a localized spin and free electrons--was discovered in metals containing small amounts of magnetic impurities, although it is now recognized to be of fundamental importance in a wide class of correlated electron syst...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35015509
更新日期:2000-06-15 00:00:00
abstract::Ubiquitin (Ub) has important roles in a wide range of intracellular signalling pathways. In the conventional view, ubiquitin alters the signalling activity of the target protein through covalent modification, but accumulating evidence points to the emerging role of non-covalent interaction between ubiquitin and the ta...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13140
更新日期:2014-05-01 00:00:00
abstract::Lake Victoria, together with its satellite lakes, harbours roughly 200 endemic forms of cichlid fishes that are classified as 'haplochromines' and yet the lake system is less than a million years old. This 'flock' has attracted attention because of the possibility that it evolved within the lake from one ancestral spe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/347550a0
更新日期:1990-10-11 00:00:00
abstract::Sudden cardiac death is the leading cause of death in the industrialized world, with the majority of such tragedies being due to ventricular fibrillation. Ventricular fibrillation is a frenzied and irregular disturbance of the heart rhythm that quickly renders the heart incapable of sustaining life. Rotors, electrophy...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/32170
更新日期:1998-03-05 00:00:00
abstract::Plant respiration results in an annual flux of carbon dioxide (CO2) to the atmosphere that is six times as large as that due to the emissions from fossil fuel burning, so changes in either will impact future climate. As plant respiration responds positively to temperature, a warming world may result in additional resp...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17142
更新日期:2016-03-31 00:00:00
abstract::MicroRNAs (miRNAs) mediate post-transcriptional gene regulation through association with Argonaute proteins (AGOs). Crystal structures of archaeal and bacterial homologues of AGOs have shown that the MID (middle) domain mediates the interaction with the phosphorylated 5' end of the miRNA guide strand and this interact...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09039
更新日期:2010-06-10 00:00:00
abstract::The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of germ-cell specification. stella (also called Dppa3) marks the rare founder population of the germ lineage. Here we differentiate mouse embryonic stem cells carrying a st...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08210
更新日期:2009-08-13 00:00:00
abstract::Depleted uranium is a mildly radioactive waste product that is stockpiled worldwide. The chemical reactivity of uranium complexes is well documented, including the stoichiometric activation of small molecules of biological and industrial interest such as H2O, CO2, CO, or N2 (refs 1 - 11), but catalytic transformations...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature16530
更新日期:2016-02-18 00:00:00
abstract::Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initiated by cytosine deamination by the activation-induced deaminase (AID) and completed by error-prone processing of the resulting uracils by mismatch and base excision rep...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature06547
更新日期:2008-02-14 00:00:00
abstract::Pollinators are declining worldwide and this has raised concerns for a parallel decline in the essential pollination service they provide to both crops and wild plants. Anthropogenic drivers linked to this decline include habitat changes, intensive agriculture, pesticides, invasive alien species, spread of pathogens a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature23288
更新日期:2017-08-10 00:00:00
abstract::The giant polytene chromosomes of Drosophila melanogaster have long been of interest to the geneticist because of the visible map of the genome provided by their characteristic banding patterns. An issue in the understanding of the molecular basis of chromosome banding has been whether the chromosomal DNA is replicate...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/307176a0
更新日期:1984-01-12 00:00:00
abstract::Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weak...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature750
更新日期:2002-05-23 00:00:00
abstract::Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta:...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09058
更新日期:2010-07-22 00:00:00
abstract::As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-018-0657-2
更新日期:2018-11-01 00:00:00
abstract::The human sex chromosomes share a pair of homologous genes which independently encode a cell-surface antigen defined by the monoclonal antibody 12E7 (refs 1, 2; see refs 3, 4 for review). The X-located homologue, MIC2X, escapes X-inactivation and the equivalent Y-located locus, MIC2Y, was one of the first genes shown ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/317739a0
更新日期:1985-10-24 00:00:00
abstract::The ras proto-oncogene, found in all eukaryotes so far examined, encode s a protein with guanine nucleotide-binding and GTPase activity. Gene disruption experiments in yeast indicate that ras is essential for cell growth. Anit-sense mutagenesis approaches suggest that this is also true for Dictyostelium. Most mutation...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/323340a0
更新日期:1986-09-25 00:00:00
abstract::The neurotransmitters glutamate and γ-aminobutyric acid (GABA) transmit synaptic signals by activating fast-acting ligand-gated ion channels and more slowly acting G-protein-coupled receptors (GPCRs). The GPCRs for these neurotransmitters, metabotropic glutamate (mGlu) and GABAB receptors, are atypical GPCRs with a la...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature20566
更新日期:2016-12-01 00:00:00
abstract::Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor and its substrate AMP-activated protein kinase (AMPK), kinases that coordinate metabolism with cell growth. Deletion of the Lkb1 (also called Stk11) gene in m...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09571
更新日期:2010-12-02 00:00:00
abstract::Changes in redox status are a conspicuous feature of immune responses in a variety of eukaryotes, but the associated signalling mechanisms are not well understood. In plants, attempted microbial infection triggers the rapid synthesis of nitric oxide and a parallel accumulation of reactive oxygen intermediates, the lat...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10427
更新日期:2011-10-13 00:00:00
abstract::Clathrin is the structural protein of coated membranes involved in receptor-mediated endocytosis and aspects of Golgi sorting in eukaryotic cells. We have now detected a stoichiometric complex of clathrin with a novel protein of M(r) approximately 100,000 (100K) in lysates of different mammalian cells. Formation of th...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/365459a0
更新日期:1993-09-30 00:00:00
abstract::During biosynthesis, class II molecules of the major histocompatibility complex are associated with a nonpolymorphic protein called invariant chain, Ii, which facilitates folding of class II molecules and their exit from the endoplasmic reticulum, interferes with their association with peptide and directs their post-G...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/357596a0
更新日期:1992-06-18 00:00:00
abstract::Fossil dinosaur embryos are surprisingly rare, being almost entirely restricted to Upper Cretaceous strata that record the late stages of non-avian dinosaur evolution. Notable exceptions are the oldest known embryos from the Early Jurassic South African sauropodomorph Massospondylus and Late Jurassic embryos of a ther...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature11978
更新日期:2013-04-11 00:00:00
abstract::Globular star clusters are compact and massive stellar systems old enough to have witnessed the entire history of our Galaxy, the Milky Way. Although recent results suggest that their formation may have been more complex than previously thought, they still are the best approximation to a stellar population formed over...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08581
更新日期:2009-11-26 00:00:00
abstract::Unlike the electroweak sector of the standard model of particle physics, quantum chromodynamics (QCD) is surprisingly symmetric under time reversal. As there is no obvious reason for QCD being so symmetric, this phenomenon poses a theoretical problem, often referred to as the strong CP problem. The most attractive sol...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature20115
更新日期:2016-11-03 00:00:00
abstract::Diffuse gliomas are the most common malignant brain tumours in adults and include glioblastomas and World Health Organization (WHO) grade II and grade III tumours (sometimes referred to as lower-grade gliomas). Genetic tumour profiling is used to classify disease and guide therapy1,2, but involves brain surgery for ti...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-019-0882-3
更新日期:2019-01-01 00:00:00
abstract::Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/s41586-020-2071-9
更新日期:2020-03-01 00:00:00
abstract::Histamine secretion from mast cells may be inhibited by elevated intracellular levels of cyclic AMP and by several anti-allergic drugs. These compounds are claimed to act directly on the calcium-gating mechanism activated by the anaphylactic reaction, preventing influx of Ca2+ from the external environment and so bloc...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/289186a0
更新日期:1981-01-15 00:00:00