The cluster Terzan 5 as a remnant of a primordial building block of the Galactic bulge.

abstract：:A short exposure of primary cultures of mouse mammary tumour cells to glucocorticoids results in at least a three-fold stimulation of mammary tumour virus (MTV) production. Specific interaction of glucocorticoids with the cytoplasmic and nuclear receptors can also be demonstrated. The biological potency of various ste...

journal_title：Nature

authors： Shyamala G,Dickson C

更新日期：1976-07-08 00:00:00

abstract：:The regular occurrence of a peak due to an unidentified substance (X) in the gas chromatographic traces obtained from phenolic extracts of urine from human pregnant and non-pregnant females has been reported. The biphasic excretion of X with maxima in the luteal phase of the ovulatory cycle and relatively high levels ...

journal_title：Nature

authors： Stitch SR,Toumba JK,Groen MB,Funke CW,Leemhuis J,Vink J,Woods GF

更新日期：1980-10-23 00:00:00

abstract：:HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was largely ineffective in pre-clinical and clinical settings and was therefore abandoned. However, recently developed single-cell-based antibody cloning methods have uncovered a new generation of far more potent broadly neutralizing anti...

journal_title：Nature

authors： Caskey M,Klein F,Lorenzi JC,Seaman MS,West AP Jr,Buckley N,Kremer G,Nogueira L,Braunschweig M,Scheid JF,Horwitz JA,Shimeliovich I,Ben-Avraham S,Witmer-Pack M,Platten M,Lehmann C,Burke LA,Hawthorne T,Gorelick RJ,Walk

更新日期：2015-06-25 00:00:00

abstract：:Guided by brain-like 'spiking' computational frameworks, neuromorphic computing-brain-inspired computing for machine intelligence-promises to realize artificial intelligence while reducing the energy requirements of computing platforms. This interdisciplinary field began with the implementation of silicon circuits for...

journal_title：Nature

authors： Roy K,Jaiswal A,Panda P

更新日期：2019-11-01 00:00:00

abstract：:T cells bearing the alpha beta receptor can specifically react with target cells coated with staphylococcal enterotoxin and expressing major histocompatibility complex class II molecules; these responses depend on which variable region (V) of the receptor's beta-subunit is used. We have now examined whether a similar ...

journal_title：Nature

authors： Rust CJ,Verreck F,Vietor H,Koning F

更新日期：1990-08-09 00:00:00

abstract：:Trypanosomes of the species Trypanosoma brucei reproduce primarily by binary fission, but the frequency of enzyme electrophoretic variants in natural populations of T. brucei has provided indirect evidence for the existence of a sexual cycle. These studies, coupled with studies of restriction fragment length polymorph...

journal_title：Nature

authors： Jenni L,Marti S,Schweizer J,Betschart B,Le Page RW,Wells JM,Tait A,Paindavoine P,Pays E,Steinert M

更新日期：1986-07-10 00:00:00

abstract：:A 12 amino-acid synthetic peptide (NANP)3 comprising the immunodominant epitope of Plasmodium falciparum circumsporozoite protein was conjugated to tetanus toxoid (TT), adjuvanted with aluminium hydroxide, and administered intramuscularly in three doses at monthly intervals to 35 healthy males as a malaria vaccine. No...

journal_title：Nature

authors： Herrington DA,Clyde DF,Losonsky G,Cortesia M,Murphy JR,Davis J,Baqar S,Felix AM,Heimer EP,Gillessen D

更新日期：1987-07-16 00:00:00

abstract：:Certain cell fate decisions are specified by cell-cell interactions during the development of the nematode Caenorhabditis elegans. For example, in a wild-type hermaphrodite gonad, two cells, Z1.ppp and Z4.aaa, have the potential to become the anchor cell (AC). Intercellular communication establishes their fates and en...

journal_title：Nature

authors： Greenwald I,Seydoux G

更新日期：1990-07-12 00:00:00

abstract：:The mechanism of transformation of the overtly similar cells of the neural plate into the numerous and diverse cell types of the mature vertebrate central nervous system (CNS) can better be understood by studying the clonal development of isolated CNS precursor cells. Here I describe a culture system in which blast ce...

journal_title：Nature

authors： Temple S

更新日期：1989-08-10 00:00:00

abstract：:The dynamic response of nerve cells to synaptic activation and the spatial distribution of biochemical processes regulated by ion concentration are critically dependent on the cell-surface distribution of ion channels. In the hippocampus, intracellular calcium-ion concentration is thought to influence the biochemical ...

journal_title：Nature

authors： Regehr WG,Connor JA,Tank DW

更新日期：1989-10-12 00:00:00

abstract：:Although phytoalexins have long been inferred to be important in the defence of plants against fungal infection, there are few reports showing that they provide resistance to infection. Several plants, including grapevine, synthesize the stilbene-type phytoalexin resveratrol when attacked by pathogens. Stilbenes with ...

journal_title：Nature

authors： Hain R,Reif HJ,Krause E,Langebartels R,Kindl H,Vornam B,Wiese W,Schmelzer E,Schreier PH,Stöcker RH

更新日期：1993-01-14 00:00:00

abstract：:The Kyoto Protocol permits countries to meet part of their emission reduction obligations by cutting back on gases other than CO2 (ref. 1). This approach requires a definition of trade-offs among the radiatively active gases. The Intergovernmental Panel on Climate Change has suggested global warming potentials for thi...

journal_title：Nature

authors： Manne AS,Richels RG

更新日期：2001-04-05 00:00:00

abstract：:The recent decades-long decline in East African rainfall suggests that multidecadal variability is an important component of the climate of this vulnerable region. Prior work based on analysing the instrumental record implicates both Indian and Pacific ocean sea surface temperatures (SSTs) as possible drivers of East ...

journal_title：Nature

authors： Tierney JE,Smerdon JE,Anchukaitis KJ,Seager R

更新日期：2013-01-17 00:00:00

abstract：:SEVERAL dioecious marine brown algae have been valuable in studying chemical communication during sexual reproduction. For example, female gametes of Ectocarpus siliculosus, Cutleria multifida and Fucus serratus secrete olefinic hydrocarbons into the seawater to attract male gametes(1-3). A more complex system is foun...

journal_title：Nature

authors： Müller DG,Gassmann G,Lüning K

更新日期：1979-05-31 00:00:00

abstract：:Auroral substorms, dynamic phenomena that occur in the upper atmosphere at night, are caused by global reconfiguration of the magnetosphere, which releases stored solar wind energy. These storms are characterized by auroral brightening from dusk to midnight, followed by violent motions of distinct auroral arcs that su...

journal_title：Nature

authors： Kasahara S,Miyoshi Y,Yokota S,Mitani T,Kasahara Y,Matsuda S,Kumamoto A,Matsuoka A,Kazama Y,Frey HU,Angelopoulos V,Kurita S,Keika K,Seki K,Shinohara I

更新日期：2018-02-14 00:00:00

abstract：:The Tharsis region is the largest volcanic complex on Mars and in the Solar System. Young lava flows cover its surface (from the Amazonian period, less than 3 billion years ago) but its growth started during the Noachian era (more than 3.7 billion years ago). Its position has induced a reorientation of the planet with...

journal_title：Nature

authors： Bouley S,Baratoux D,Matsuyama I,Forget F,Séjourné A,Turbet M,Costard F

更新日期：2016-03-17 00:00:00

abstract：:The detection of electron spins associated with single defects in solids is a critical operation for a range of quantum information and measurement applications under development. So far, it has been accomplished for only two defect centres in crystalline solids: phosphorus dopants in silicon, for which electrical rea...

journal_title：Nature

authors： Yin C,Rancic M,de Boo GG,Stavrias N,McCallum JC,Sellars MJ,Rogge S

更新日期：2013-05-02 00:00:00

abstract：:The discovery of intervening sequences (introns) in DNA led Gilbert and Tonegawa to suggest that a new protein could have been produced by bringing together certain segments of pre-existing ones. However, Blake argued that if DNA was so organized that coding sequences (exons) correspond to structural as well as functi...

journal_title：Nature

authors： Go M

更新日期：1981-05-07 00:00:00

abstract：:The annual cycle in the Earth's surface temperature is extremely large-comparable in magnitude to the glacial-interglacial cycles over most of the planet. Trends in the phase and the amplitude of the annual cycle have been observed, but the causes and significance of these changes remain poorly understood-in part beca...

journal_title：Nature

authors： Stine AR,Huybers P,Fung IY

更新日期：2009-01-22 00:00:00

abstract：: ...

journal_title：Nature

authors： Woolston C

更新日期：2019-01-01 00:00:00

abstract：:Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) and ryanodine receptors (RyRs) are tetrameric intracellular Ca(2+) channels. In each of these receptor families, the pore, which is formed by carboxy-terminal transmembrane domains, is regulated by signals that are detected by large cytosolic structures. InsP(3)R gati...

journal_title：Nature

authors： Seo MD,Velamakanni S,Ishiyama N,Stathopulos PB,Rossi AM,Khan SA,Dale P,Li C,Ames JB,Ikura M,Taylor CW

更新日期：2012-01-29 00:00:00

abstract：:Understanding brain circuits begins with an appreciation of their component parts - the cells. Although GABAergic interneurons are a minority population within the brain, they are crucial for the control of inhibition. Determining the diversity of these interneurons has been a central goal of neurobiologists, but this...

journal_title：Nature

authors： Kepecs A,Fishell G

更新日期：2014-01-16 00:00:00

abstract：:Glutamate transporters are integral membrane proteins that catalyse neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons. Their mechanism of action involves transitions between extracellular (outward)-facing and intracellular (inward)-facing conformations, whereby substrate bin...

journal_title：Nature

authors： Akyuz N,Altman RB,Blanchard SC,Boudker O

更新日期：2013-10-03 00:00:00

abstract：:The two-dimensional electron system is a powerful laboratory for investigating the physics of interacting particles. Application of a large magnetic field produces massively degenerate quantum levels known as Landau levels; within a Landau level the kinetic energy of the electrons is suppressed, and electron-electron ...

journal_title：Nature

authors： Dial OE,Ashoori RC,Pfeiffer LN,West KW

更新日期：2010-03-25 00:00:00

abstract：:The silicate Earth is strongly depleted in moderately volatile elements (such as lead, zinc, indium and alkali elements) relative to CI chondrites, the meteorites that compositionally most closely resemble the Sun. This depletion may be explained qualitatively by accretion of 10 to 20 per cent of a volatile-rich body ...

journal_title：Nature

authors： Norris CA,Wood BJ

更新日期：2017-09-27 00:00:00

abstract：: ...

journal_title：Nature

authors：

更新日期：2018-11-01 00:00:00

abstract：:Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG dinucleotides induce murine B cells to proliferate and secrete immunoglobulin in vitro and in vivo. This activat...

journal_title：Nature

authors： Krieg AM,Yi AK,Matson S,Waldschmidt TJ,Bishop GA,Teasdale R,Koretzky GA,Klinman DM

更新日期：1995-04-06 00:00:00

abstract：:Increasing population and consumption are placing unprecedented demands on agriculture and natural resources. Today, approximately a billion people are chronically malnourished while our agricultural systems are concurrently degrading land, water, biodiversity and climate on a global scale. To meet the world's future ...

journal_title：Nature

authors： Foley JA,Ramankutty N,Brauman KA,Cassidy ES,Gerber JS,Johnston M,Mueller ND,O'Connell C,Ray DK,West PC,Balzer C,Bennett EM,Carpenter SR,Hill J,Monfreda C,Polasky S,Rockström J,Sheehan J,Siebert S,Tilman D,Zaks DP

更新日期：2011-10-12 00:00:00

abstract：:The global mid-ocean ridge system is the most extensive magmatic system on our planet and is the site of 75 per cent of Earth's volcanism1. The vertical extent of mid-ocean-ridge magmatic systems has been considered to be restricted: even at the ultraslow-spreading Gakkel mid-ocean ridge under the Arctic Ocean, where ...

journal_title：Nature

authors： Bennett EN,Jenner FE,Millet MA,Cashman KV,Lissenberg CJ

更新日期：2019-08-01 00:00:00

abstract：:Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die. Recent progres...

journal_title：Nature

authors： Sawyers C

更新日期：2004-11-18 00:00:00