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NATURE文献大全abstract::Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376788a0
更新日期:1995-08-31 00:00:00
abstract::Appropriate repair of DNA lesions and the inhibition of DNA repair activities at telomeres are crucial to prevent genomic instability. By fuelling the generation of genetic alterations and by compromising cell viability, genomic instability is a driving force in cancer and ageing. Here we identify MAD2L2 (also known a...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature14216
更新日期:2015-05-28 00:00:00
abstract::Type Ia supernovae are thought to result from thermonuclear explosions of carbon-oxygen white dwarf stars. Existing models generally explain the observed properties, with the exception of the sub-luminous 1991bg-like supernovae. It has long been suspected that the merger of two white dwarfs could give rise to a type I...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08642
更新日期:2010-01-07 00:00:00
abstract::Vaccination has proved a powerful defence against a range of infectious diseases of humans and animals. However, its potential to control major epidemics of foot-and-mouth disease (FMD) in livestock is contentious. Using an individual farm-based model, we consider either national prophylactic vaccination campaigns in ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01343
更新日期:2003-01-09 00:00:00
abstract::A major goal of molecular oncology is to identify means to kill cells lacking p53 function. Most current cancer therapy is based on damaging cellular DNA by irradiation or chemicals. Recent reports support the notion that, in the event of DNA damage, the p53 tumour-suppressor protein is able to prevent cell death by s...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35091082
更新日期:2001-08-30 00:00:00
abstract::Transport of calcium ions across membranes and against a thermodynamic gradient is essential to many biological processes, including muscle contraction, the citric acid cycle, glycogen metabolism, release of neurotransmitters, vision, biological signal transduction and immune response. Synthetic systems that transport...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01209
更新日期:2002-11-28 00:00:00
abstract::Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous 'damage'-associated molecular patterns (DAMPs...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08780
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abstract::Migration of cells in higher organisms is mediated by adhesion receptors, such as integrins, that link the cell to extracellular-matrix ligands, transmitting forces and signals necessary for locomotion. Whether cells will migrate or not on a given substratum, and also their speed, depends on several variables related ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/385537a0
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abstract::T lymphocytes of the alpha/beta T-cell receptor (TCR) lineage mature in the thymus, where they undergo a series of differentiation, expansion and selection events. For normal T-cell ontogeny to occur, thymocytes must interact physically with cortical and medullary thymic stroma cells. In parallel, interactions of the ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/373350a0
更新日期:1995-01-26 00:00:00
abstract::Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature21433
更新日期:2017-03-30 00:00:00
abstract::In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose-Glut4(-/-)) mice show insulin resistance secondarily in muscle and liver. Here we show, using DNA arrays, that expression of retinol bindin...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03711
更新日期:2005-07-21 00:00:00
abstract::There has been much interest in the biochemical and biophysical processes that couple extracellular signals to alterations in gene expression. While many early events associated with the treatment of cells with growth factors have been described (for example, ion flux and protein phosphorylation), it has proved diffic...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/322552a0
更新日期:1986-08-07 00:00:00
abstract::Exchange dynamics between molecules free in solution and bound to the surface of a large supramolecular structure, a polymer, a membrane or solid support are important in many phenomena in biology and materials science. Here we present a novel and generally applicable solution NMR technique, known as dark-state exchan...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature10577
更新日期:2011-10-30 00:00:00
abstract::A significant portion of prebiotic organic matter on the early Earth may have been introduced by carbonaceous asteroids and comets. The distribution and stable-isotope composition of individual organic compounds in carbonaceous meteorites, which are thought to be derived from asteroidal parent bodies, may therefore pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/348047a0
更新日期:1990-11-01 00:00:00
abstract::Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial cells line the cerebral ventricles and generate intermediate progenitor cells that migrate into the subventricular zone (SVZ) and proliferate to increase neuronal number. The developing hu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature08845
更新日期:2010-03-25 00:00:00
abstract::The multi-disciplinary role of intermediate energy proton accelerators in pure and applied nuclear physics is discussed with particular reference to the experimental programmes at LAMPF (Los Alamos Meson Physics Facility) and SIN (Swiss Institute for Nuclear Research, Zurich). ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/270667a0
更新日期:1977-12-22 00:00:00
abstract::Eukaryotic transfer RNA genes have two internal discontinuous control regions, the A and B blocks, which correspond approximately to the D-stem and the pseudo-U arm of tRNA. In reconstituted transcription systems at least two components are required to direct accurate initiation by RNA polymerase (refs 4,5). However, ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304747a0
更新日期:1983-08-25 00:00:00
abstract::A rapid decrease in shear velocity in the suboceanic mantle is used to infer the thickness of the lithosphere. It is proposed that new and highly precise group velocity data constrain the solutions and imply a thickness near 70 km. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/226330a0
更新日期:1970-04-25 00:00:00
abstract::Aquifex aeolicus was one of the earliest diverging, and is one of the most thermophilic, bacteria known. It can grow on hydrogen, oxygen, carbon dioxide, and mineral salts. The complex metabolic machinery needed for A. aeolicus to function as a chemolithoautotroph (an organism which uses an inorganic carbon source for...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/32831
更新日期:1998-03-26 00:00:00
abstract::Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with comprehensive identification and relative quantification of cellular proteomes have so far appeared to be insurmountable. Here, using advances in computational proteom...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07341
更新日期:2008-10-30 00:00:00
abstract::A serine/threonine kinase, named protein kinase B (PKB) for its sequence homology to both protein kinase A and C, has previously been isolated. PKB, which is identical to the kinase Rac, was later found to be the cellular homologue of the transforming v-Akt. Here we show that PKB is activated by stimuli such as insuli...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376599a0
更新日期:1995-08-17 00:00:00
abstract::Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. Most synapses that exhibit LTP use an excitatory amino-acid neurotransmitter that acts on two types of rec...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/338500a0
更新日期:1989-04-06 00:00:00
abstract::Tau is one of the diverse group of microtubule-associated proteins that bind to microtubules and may thereby influence their structure and function. It occurs in the mammalian brain, mainly in axons, and is a component of the neurofibrillary tangles of Alzheimer's disease. Tau was recently sequenced, but there remains...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/334359a0
更新日期:1988-07-28 00:00:00
abstract::Understanding the behaviour of the dielectric constant in ferroelectric thin films remains a challenging problem. These ferroelectric materials have high static dielectric constants, and so are important for their applications in high-storage-density capacitor structures such as dynamic random access memory (DRAM). Bu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35006023
更新日期:2000-03-23 00:00:00
abstract::Endocytosis has long been thought of as simply a way for cells to internalize nutrients and membrane-associated molecules. But an explosive growth in knowledge has given a new dimension to our understanding of this process. It now seems that endocytosis is a master organizer of signalling circuits, with one of its mai...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature08910
更新日期:2010-01-28 00:00:00
abstract::Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature17160
更新日期:2016-03-24 00:00:00
abstract::The planet in the system HD209458 is the first one for which repeated transits across the stellar disk have been observed. Together with radial velocity measurements, this has led to a determination of the planet's radius and mass, confirming it to be a gas giant. But despite numerous searches for an atmospheric signa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature01448
更新日期:2003-03-13 00:00:00
abstract::Discovering evidence of behaviour in fossilized vertebrates is rare. Even rarer is evidence of behaviour in non-avialan dinosaurs that directly relates to stereotypical behaviour seen in extant birds (avians) and not previously predicted in non-avialan dinosaurs. Here we report the discovery of a new troodontid taxon ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature02898
更新日期:2004-10-14 00:00:00
abstract::Aberrant regulation of RNA stability has an important role in many disease states. Deregulated post-transcriptional modulation, such as that governed by microRNAs targeting linear sequence elements in messenger RNAs, has been implicated in the progression of many cancer types. A defining feature of RNA is its ability ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13466
更新日期:2014-09-11 00:00:00
abstract::The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Transition metal catalysis has emerged as a powerful tool with which to convert these unreactive bonds into carbon-carbon and carb...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature13389
更新日期:2014-06-05 00:00:00