Modelling vaccination strategies against foot-and-mouth disease.

abstract：:The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to cellular degeneration and death is by stochastic deregulation of gene expression. Here we directly test for increased transcriptional noise in aged tissue by di...

journal_title：Nature

authors： Bahar R,Hartmann CH,Rodriguez KA,Denny AD,Busuttil RA,Dollé ME,Calder RB,Chisholm GB,Pollock BH,Klein CA,Vijg J

更新日期：2006-06-22 00:00:00

abstract：:D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16, the product of the CDKN2 gene on human chromosome 9p21...

journal_title：Nature

authors： Lukas J,Parry D,Aagaard L,Mann DJ,Bartkova J,Strauss M,Peters G,Bartek J

更新日期：1995-06-08 00:00:00

abstract：:Inhibitory neurotransmission mediated by GABA(A) receptors can be modulated by the endogenous neurosteroids, allopregnanolone and tetrahydro-deoxycorticosterone. Neurosteroids are synthesized de novo in the brain during stress, pregnancyand after ethanol consumption, and disrupted steroid regulation of GABAergic trans...

journal_title：Nature

authors： Hosie AM,Wilkins ME,da Silva HM,Smart TG

更新日期：2006-11-23 00:00:00

abstract：:The radiation of the mammals provides a 165-million-year test case for evolutionary theories of how species occupy and then fill ecological niches. It is widely assumed that species often diverge rapidly early in their evolution, and that this is followed by a longer, drawn-out period of slower evolutionary fine-tunin...

journal_title：Nature

authors： Venditti C,Meade A,Pagel M

更新日期：2011-10-19 00:00:00

abstract：:The North Atlantic Oscillation (NAO) is the major source of variability in winter atmospheric circulation in the Northern Hemisphere, with large impacts on temperature, precipitation and storm tracks, and therefore also on strategic sectors such as insurance, renewable energy production, crop yields and water manageme...

journal_title：Nature

authors： Ortega P,Lehner F,Swingedouw D,Masson-Delmotte V,Raible CC,Casado M,Yiou P

更新日期：2015-07-02 00:00:00

abstract：:The relay of information through thalamus to cortex is dynamically gated, as illustrated by the retinogeniculocortical pathway. Important to this is the inhibitory interneuron in the lateral geniculate nucleus (LGN). For the typical neuron, synaptic information arrives through postsynaptic dendrites and is transmitted...

journal_title：Nature

authors： Cox CL,Zhou Q,Sherman SM

更新日期：1998-07-30 00:00:00

abstract：:Several functionally important genetic elements (such as the TATA box, mRNA splice sequences, poly(A) addition signal) were first detected as short segments of unexplained sequence homology within non-coding regions of different genes. A short region of unknown sequence in the intron between the human J kappa and C ka...

journal_title：Nature

authors： Emorine L,Kuehl M,Weir L,Leder P,Max EE

更新日期：1983-08-04 00:00:00

abstract：:Highly collimated parsec-scale jets, which are generally linked to the presence of an accretion disk, are commonly observed in low-mass young stellar objects. In the past two decades, a few of these jets have been directly (or indirectly) observed from higher-mass (larger than eight solar masses) young stellar objects...

journal_title：Nature

authors： McLeod AF,Reiter M,Kuiper R,Klaassen PD,Evans CJ

更新日期：2018-02-15 00:00:00

abstract：:Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have identified more than 600 variants associated with human traits, but these typically explain small fractions of phenotypic variati...

journal_title：Nature

authors： Lango Allen H,Estrada K,Lettre G,Berndt SI,Weedon MN,Rivadeneira F,Willer CJ,Jackson AU,Vedantam S,Raychaudhuri S,Ferreira T,Wood AR,Weyant RJ,Segrè AV,Speliotes EK,Wheeler E,Soranzo N,Park JH,Yang J,Gudbjartsson D

更新日期：2010-10-14 00:00:00

abstract：:The neurotransmitter dopamine has been demonstrated by biochemical, histochemical and immunocytochemical techniques to be unevenly distributed in the mammalian central nervous system. DARPP-32 (dopamine- and cyclic-AMP-regulated phosphoprotein of molecular weight 32,000) is a neuronal phosphoprotein that displays a re...

journal_title：Nature

authors： Hemmings HC Jr,Greengard P,Tung HY,Cohen P

更新日期：1984-08-09 00:00:00

abstract：:The factors driving glacial changes in ocean overturning circulation are not well understood. On the basis of a comparison of 20 climate variables over the past four glacial cycles, the SPECMAP project proposed that summer insolation at high northern latitudes (that is, Milankovitch forcing) drives the same sequence o...

journal_title：Nature

authors： Lisiecki LE,Raymo ME,Curry WB

更新日期：2008-11-06 00:00:00

abstract：:The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and...

journal_title：Nature

authors： Kamikouchi A,Inagaki HK,Effertz T,Hendrich O,Fiala A,Göpfert MC,Ito K

更新日期：2009-03-12 00:00:00

abstract：:Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. Recent molecular genetic studies have indicated that amyl...

journal_title：Nature

authors： Tanzi RE,McClatchey AI,Lamperti ED,Villa-Komaroff L,Gusella JF,Neve RL

更新日期：1988-02-11 00:00:00

abstract：:A set of restriction fragments cloned into phage lambda vectors has allowed us to locate a site necessary for full rpoBC expression. We find that these genes for the two large subunits of RNA polymerase and the genes, rplL and rplJ, for two ribosomal proteins, form a single operon. ...

journal_title：Nature

authors： Linn T,Scaife J

更新日期：1978-11-02 00:00:00

abstract：:Plasmodium falciparum infected erythrocytes containing mature trophozoites and schizonts sequester along venular endothelium and are not in the peripheral circulation of patients with malaria. Knobs appear on infected erythrocytes and are the points of attachment to endothelium. Sequestration may protect the parasite ...

journal_title：Nature

authors： Roberts DD,Sherwood JA,Spitalnik SL,Panton LJ,Howard RJ,Dixit VM,Frazier WA,Miller LH,Ginsburg V

更新日期：1985-11-07 00:00:00

abstract：:Animals learn that a tone can predict the occurrence of an electric shock through classical conditioning. Mice or rats trained in this manner display fear responses, such as freezing behaviour, when they hear the conditioned tone. Studies using amygdalectomized rats have shown that the amygdala is required for both th...

journal_title：Nature

authors： Garcia R,Vouimba RM,Baudry M,Thompson RF

更新日期：1999-11-18 00:00:00

abstract：:Inositol trisphosphate is a second messenger that controls many cellular processes by generating internal calcium signals. It operates through receptors whose molecular and physiological properties closely resemble the calcium-mobilizing ryanodine receptors of muscle. This family of intracellular calcium channels disp...

journal_title：Nature

authors： Berridge MJ

更新日期：1993-01-28 00:00:00

abstract：:Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration1,2. This adaptability is lost in cultured adult endothelial cells, which do not vascularize tissues in an organotypic manner. Here, we show that transient reactivation of the embryonic-restricted ETS variant transcri...

journal_title：Nature

authors： Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ

更新日期：2020-09-01 00:00:00

abstract：:Transport vesicles derived from the Golgi apparatus are thought to mediate biosynthetic transport across the Golgi stack. These vesicles are surrounded by a protein coat whose principal constituents are coatomer (a complex of seven distinct subunits or COPs) and ADP-ribosylation factor (ARF, an N-myristylated small GT...

journal_title：Nature

authors： Orcl L,Palmer DJ,Amherdt M,Rothman JE

更新日期：1993-08-19 00:00:00

abstract：:Rates of atmospheric deposition of biologically active nitrogen (N) are two to seven times the pre-industrial rates in many developed nations because of combustion of fossil fuels and agricultural fertilization. They are expected to increase similarly over the next 50 years in industrializing nations of Asia and South...

journal_title：Nature

authors： Clark CM,Tilman D

更新日期：2008-02-07 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) neurotransmission is widespread in vertebrate and invertebrate nervous systems. Here we use a genetic approach to identify molecules specific to GABA function. On the basis of the known in vivo roles of GABAergic neurons in controlling behaviour of the nematode Caenorhabditis elegans, we...

journal_title：Nature

authors： McIntire SL,Jorgensen E,Horvitz HR

更新日期：1993-07-22 00:00:00

abstract：:X-chromosome inactivation results in the strictly cis-limited inactivation of many but not all genes on one of the two X chromosomes during early development in somatic cells of mammalian females. One feature of virtually all models of X inactivation is the existence of an X-inactivation centre (XIC) required in cis f...

journal_title：Nature

authors： Brown CJ,Lafreniere RG,Powers VE,Sebastio G,Ballabio A,Pettigrew AL,Ledbetter DH,Levy E,Craig IW,Willard HF

更新日期：1991-01-03 00:00:00

abstract：:Diminishing fossil fuel reserves and growing concerns about global warming indicate that sustainable sources of energy are needed in the near future. For fuels to be useful in the transportation sector, they must have specific physical properties that allow for efficient distribution, storage and combustion; these pro...

journal_title：Nature

authors： Román-Leshkov Y,Barrett CJ,Liu ZY,Dumesic JA

更新日期：2007-06-21 00:00:00

abstract：:Obesity is now so common within the world's population that it is beginning to replace undernutrition and infectious diseases as the most significant contributor to ill health. In particular, obesity is associated with diabetes mellitus, coronary heart disease, certain forms of cancer, and sleep-breathing disorders. O...

journal_title：Nature

authors： Kopelman PG

更新日期：2000-04-06 00:00:00

abstract：:The Southern Ocean is very important for the potential sequestration of carbon dioxide in the oceans and is expected to be vulnerable to changes in carbon export forced by anthropogenic climate warming. Annual phytoplankton blooms in seasonal ice zones are highly productive and are thought to contribute significantly ...

journal_title：Nature

authors： DiTullio GR,Grebmeier JM,Arrigo KR,Lizotte MP,Robinson DH,Leventer A,Barry JP,VanWoert ML,Dunbar RB

更新日期：2000-04-06 00:00:00

abstract：:The mechanical environment crucially influences many cell functions. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction, which is essential for the transduction of mechanical stimuli. Using fluorescent r...

journal_title：Nature

authors： Wang Y,Botvinick EL,Zhao Y,Berns MW,Usami S,Tsien RY,Chien S

更新日期：2005-04-21 00:00:00

abstract：:The delivery of therapeutic drugs to solid tumours may be impaired by structural and functional abnormalities in blood and lymphatic vessels. Here we provide evidence that proliferating cancer cells cause intratumour vessels to compress and collapse. By reducing this compressive mechanical force and opening vessels, c...

journal_title：Nature

authors： Padera TP,Stoll BR,Tooredman JB,Capen D,di Tomaso E,Jain RK

更新日期：2004-02-19 00:00:00

abstract：:Anti-cancer agents that have been made selective for tumour cells by exploiting the known differences in the availability of oxygen between normal and transformed cells are a promising development in cancer chemotherapy. We have recently suggested a new type of bioreductive activity which would depend on a two-electro...

journal_title：Nature

authors： Reynolds CA,King PM,Richards WG

更新日期：1988-07-07 00:00:00

abstract：:Interactions between animal viruses and antiviral antisera may exceptionally result in an apparent increase in viral infectivity. Halstead and coworkers demonstrated enhanced replication of dengue virus (a Flavivirus, family Togaviridae) in human or simian peripheral blood leucocytes carrying Fc receptors at subneutra...

journal_title：Nature

authors： Peiris JS,Porterfield JS

更新日期：1979-11-29 00:00:00

abstract：:IgE and its receptors are believed to have evolved as a mechanism to protect mammals against parasites. But other and intrinsically innocuous antigens can subvert this system to provoke an allergic response. For human populations in industrialized countries, allergy and asthma now represent a far greater threat than p...

journal_title：Nature

authors： Sutton BJ,Gould HJ

更新日期：1993-12-02 00:00:00